The atlas of human acupoints and meridians has been utilized in clinical practice for almost a millennium although the anatomical structures and functions remain to be clarified. It has recently been reported that a l...
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The atlas of human acupoints and meridians has been utilized in clinical practice for almost a millennium although the anatomical structures and functions remain to be clarified. It has recently been reported that a long-distance interstitial fluid (ISF) circulatory pathway may originate from the acupoints in the extremities. As observed in living human subjects, cadavers and animals using magnetic resonance imaging and fluorescent tracers, the ISF flow pathways include at least 4 types of anatomical structures: the cutaneous-, perivenous-, periarterial-, and neural-pathways. Unlike the blood or lymphatic vessels, these ISF flow pathways are composed of highly ordered and topologically connected interstitial fibrous connective tissues that may work as guiderails for the ISF to flow actively over long distance under certain driving forces. Our experimental results demonstrated that most acupoints in the extremity endings connect with one or more ISF flow pathways and comprise a complex network of acupoint-ISF-pathways. We also found that this acupoint-ISF-pathway network can connect to visceral organs or tissues such as the pericardium and epicardium, even though the topographical geometry in human extremities does not totally match the meridian lines on the atlas that is currently used in traditional Chinese medicine. Based on our experimental data, the following working hypotheses are proposed: 1, there are one or more ISF flow pathways, including at least one cutaneous pathway, originated from an acupoint on the body surface. 2, the acupoints on the body surface specifically connect with certain visceral organs or tissues via ISF flow. And 3, the acupoint-originated ISF pathways constitute a complex connective network and can modulate the ISF and bio-signals in the microenvironments around cells in certain visceral organs or tissues from body surfaces. A comprehensive atlas will be constructed to systemically reveal the detailed anatomical structures of the acupoi
Recent whole brain mapping projects are collecting large-scale 3D images using powerful and informative modalities, such as STPT, fMOST, VISoR, or MRI. Registration of these multi-dimensional whole-brain images onto a...
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A number of machine learning (ML) approaches for drug discovery have been available that rely only on sequential (1D) and planar (2D) information without effectively using the 3D information for generating features of...
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ISBN:
(纸本)9781665429825
A number of machine learning (ML) approaches for drug discovery have been available that rely only on sequential (1D) and planar (2D) information without effectively using the 3D information for generating features of drugs. However, 3D information of small molecules can reflect relative position of atoms more directly, which affects molecular properties. In this work, we present a new deep learning model called Drug3D-DTI for drug-target interaction prediction. Drug3D-DTI takes advantage of molecular spatial information, i.e., atom proximity in three-dimensional (3D) structures. We comprehensively evaluated the performance of Drug3D-DTI on two datasets with two tasks of regression and classification. In particular, we compared Drug3D-DTI with several existing methods including the two cutting-edge methods for compound-protein interaction prediction. From the experimental results, Drug3D-DTI clearly outperformed other methods under all settings. Further, this performance improvement was validated by ablation experiments and a case study. The implementation of Drug3D-DTI is available at (https://***/zhiruiliao/Drug3D-DTI).
—Uncertainty quantification (UQ) plays a pivotal role in the reduction of uncertainties during both optimization and decision making, applied to solve a variety of real-world applications in science and engineering. ...
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Accurate prediction of sea surface temperature (SST) is of high importance in marine science, benefiting applications ranging from ecosystem protection to extreme weather forecasting and climate analysis. Wide-area SS...
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Accurate prediction of sea surface temperature (SST) is of high importance in marine science, benefiting applications ranging from ecosystem protection to extreme weather forecasting and climate analysis. Wide-area SST usually shows diverse SST patterns in different sea areas due to the changes of temperature zones and the dynamics of ocean currents. However, existing studies on SST prediction often focus on small-area predictions and lack the consideration of diverse SST patterns. Furthermore, SST shows an annual periodicity, but the periodicity is not strictly adherent to an annual cycle. Existing SST prediction methods struggle to adapt to this non-strict periodicity. To address these two issues, we proposed the Cross-Region Graph Convolutional Network with Periodicity Shift Adaptation (RGCN-PSA) model which is equipped with the Cross-Region Graph Convolutional Network module and the Periodicity Shift Adaption module. The Cross-Region Graph Convolutional Network module enhances wide-area SST prediction by learning and incorporating diverse SST patterns. Meanwhile, the periodicity Shift Adaptation module accounts for the annual periodicity and enable the model to adapt to the possible temporal shift automatically. We conduct experiments on two real-world SST datasets, and the results demonstrate that our RGCN-PSA model obviously outperforms baseline models in terms of prediction accuracy. The code of RGCN-PSA model is available at https://***/ADMIS-TONGJI/RGCN-PSA/.
Motion blur is one of the most common degradation artifacts in dynamic scene photography. This paper reviews the NTIRE 2020 Challenge on Image and Video Deblurring. In this challenge, we present the evaluation results...
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Biomedical ontology matching aims at determining the heterogeneous biomed-ical concepts, and bridging the semantic gap between heterogeneous biomedical ontologies. The foundation of a biomedical ontology matching tech...
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Quantum emitters are a key component in photonic quantum technologies. Enhancing their single-photon emission by engineering the photonic environment using cavities can improve the overall efficiency in quantum inform...
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We present the discovery and timing results of four pulsars discovered in a pilot survey at intermediate Galactic latitudes with the Five-hundred Aperture Spherical Telescope (FAST). Among these pulsars, two belong to...
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