Accurate prediction of peptide spectra is crucial for improving the efficiency and reliability of proteomic analysis,as well as for gaining insight into various biological *** this study,we introduce Deep MS Simulator...
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Accurate prediction of peptide spectra is crucial for improving the efficiency and reliability of proteomic analysis,as well as for gaining insight into various biological *** this study,we introduce Deep MS Simulator(DMSS),a novel attention-based model tailored for forecasting theoretical spectra in mass *** has undergone rigorous validation through a series of experiments,consistently demonstrating superior performance compared to current methods in forecasting theoretical *** superior ability of DMSS to distinguish extremely similar peptides highlights the potential application of incorporating our predicted intensity information into mass spectrometry search engines to enhance the accuracy of protein *** findings contribute to the advancement of proteomics analysis and highlight the potential of the DMSS as a valuable tool in the field.
Most existing researches on relation extraction focus on binary flat relations like Bomln relation between a Person and a *** a large portion of objective facts de-scribed in natural language are complex,especially in...
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Most existing researches on relation extraction focus on binary flat relations like Bomln relation between a Person and a *** a large portion of objective facts de-scribed in natural language are complex,especially in professional documents in fields such as finance and biomedicine that require precise *** example,“the GDP of the United States in 2018 grew 2.9%compared with 2017”describes a growth rate relation between two other relations about the economic index,which is beyond the expressive power of binary flat ***,we propose the nested relation extraction problem and formulate it as a directed acyclic graph(DAG)structure extraction ***,we propose a solution using the Iterative Neural Network which extracts relations layer by *** proposed solution achieves 78.98 and 97.89 FI scores on two nested relation extraction tasks,namely semantic cause-and-efFect relation extraction and formula ***,we observe that nested relations are usually expressed in long sentences where entities are mentioned repetitively,which makes the annotation difficult and ***,we extend our model to incorporate a mention-insensitive mode that only requires annotations of relations on entity concepts(instead of exact mentions)while preserving most of its *** mention-insensitive model performs better than the mention sensitive model when the random level in mention selection is higher than 0.3.
AlphaFold2(AF2)is an artificial intelligence(AI)system developed by DeepMind that can predict three-dimensional(3D)structures of proteins from amino acid sequences with atomic-level *** structure prediction is one of ...
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AlphaFold2(AF2)is an artificial intelligence(AI)system developed by DeepMind that can predict three-dimensional(3D)structures of proteins from amino acid sequences with atomic-level *** structure prediction is one of the most challenging problems in computational biology and chemistry,and has puzzled scientists for 50 *** advent of AF2 presents an unprecedented progress in protein structure prediction and has attracted much *** release of structures of more than 200 million proteins predicted by AF2 further aroused great enthusiasm in the science community,especially in the fields of biology and ***2 is thought to have a significant impact on structural biology and research areas that need protein structure information,such as drug discovery,protein design,prediction of protein function,et *** the time is not long since AF2 was developed,there are already quite a few application studies of AF2 in the fields of biology and medicine,with many of them having preliminarily proved the potential of *** better understand AF2 and promote its applications,we will in this article summarize the principle and system architecture of AF2 as well as the recipe of its success,and particularly focus on reviewing its applications in the fields of biology and *** of current AF2 prediction will also be discussed.
Object goal navigation requires an agent to navigate to a specified object in an unseen environment based on visual observations and user-specified goals. Human decision-making in navigation is sequential, planning a ...
ISBN:
(纸本)9798331314385
Object goal navigation requires an agent to navigate to a specified object in an unseen environment based on visual observations and user-specified goals. Human decision-making in navigation is sequential, planning a most likely sequence of actions toward the goal. However, existing ObjectNav methods, both end-to-end learning methods and modular methods, rely on single-step planning. They output the next action based on the current model input, which easily overlooks temporal consistency and leads to myopic planning. To this end, we aim to learn sequence planning for ObjectNav. Specifically, we propose trajectory diffusion to learn the distribution of trajectory sequences conditioned on the current observation and the goal. We utilize DDPM and automatically collected optimal trajectory segments to train the trajectory diffusion. Once the trajectory diffusion model is trained, it can generate a temporally coherent sequence of future trajectory for agent based on its current observations. Experimental results on the Gibson and MP3D datasets demonstrate that the generated trajectories effectively guide the agent, resulting in more accurate and efficient navigation. The code is available at https://***/sx-zhang/***.
Arrays of optically levitated nanoparticles with fully tunable light-induced dipole–dipole interactions have emerged as a platform for fundamental research and sensing ***,previous experiments utilized two optical tr...
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Arrays of optically levitated nanoparticles with fully tunable light-induced dipole–dipole interactions have emerged as a platform for fundamental research and sensing ***,previous experiments utilized two optical traps with identical polarization,leading to an interference ***,we demonstrate light-induced dipole–dipole interactions using two orthogonally polarized optical ***,we achieve control over the strength and polarity of the optical coupling by adjusting the polarization and propose a method to simultaneously and stably measure conservative and non-conservative coupling *** results provide a new scheme for exploring entanglement and topological phases in arrays of levitated nanoparticles.
This paper presents our error tolerable system for coreference resolution in CoNLL-2011(Pradhan et al., 2011) shared task (closed track). Different from most previous reported work, we detect mention candidates based ...
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While significant progress has been made in multi-modal learning driven by large-scale image-text datasets, there is still a noticeable gap in the availability of such datasets within the facial domain. To facilitate ...
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Real-world data is often unbalanced and exhibits long-tailed distribution over classes. Vanilla classification models trained on imbalanced datasets inherently exhibit bias towards dominant classes. Existing debiasing...
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Recently, cascade instance segmentation inspired by cascade object detection has achieved notable performance. Due to the lack of global information, many methods suffer from incomplete segmentation such as missing ed...
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The growing interest in generating recipes from food images has drawn substantial research attention in recent years. Existing works for recipe generation primarily utilize a two-stage training method—first predictin...
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ISBN:
(数字)9798331510831
ISBN:
(纸本)9798331510848
The growing interest in generating recipes from food images has drawn substantial research attention in recent years. Existing works for recipe generation primarily utilize a two-stage training method—first predicting ingredients from a food image and then generating instructions from both the image and ingredients. Large Multi-modal Models (LMMs), which have achieved notable success across a variety of vision and language tasks, shed light on generating both ingredients and instructions directly from images. Nevertheless, LMMs still face the common issue of hallu-cinations during recipe generation, leading to suboptimal performance. To tackle this issue, we propose a retrieval augmented large multimodal model for recipe generation. We first introduce Stochastic Diversified Retrieval Augmentation (SDRA) to retrieve recipes semantically related to the image from an existing datastore as a supplement, integrating them into the prompt to add diverse and rich context to the input image. Additionally, Self-Consistency Ensemble Voting mechanism is proposed to determine the most confident prediction recipes as the final output. It calculates the consistency among generated recipe candidates, which use different retrieval recipes as context for generation. Extensive experiments validate the effectiveness of our proposed method, which demonstrates state-of-the-art (SOTA) performance in recipe generation on the Recipe1M dataset.
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