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Network and Systems Medicine 2021年第1期4卷 2-50页

作者： Zanin, Massimiliano Aitya, Nadim A.A. Basilio, José Baumbach, Jan Benis, Arriel Behera, Chandan K. Bucholc, Magda Castiglione, Filippo Chouvarda, Ioanna Comte, Blandine Dao, Tien-Tuan Ding, Xuemei Pujos-Guillot, Estelle Filipovic, Nenad Finn, David P. Glass, David H. Harel, Nissim Iesmantas, Tomas Ivanoska, Ilinka Joshi, Alok Boudjeltia, Karim Zouaoui Kaoui, Badr Kaur, Daman Maguire, Liam P. McClean, Paula L. McCombe, Niamh De Miranda, João Luís Moisescu, Mihnea Alexandru Pappalardo, Francesco Polster, Annikka Prasad, Girijesh Rozman, Damjana Sacala, Ioan Sanchez-Bornot, Jose M. Schmid, Johannes A. Sharp, Trevor Solé-Casals, Jordi Spiwok, Vojtěch Spyrou, George M. Stalidzans, Egils Stres, Blaa Sustersic, Tijana Symeonidis, Ioannis Tieri, Paolo Todd, Stephen Van Steen, Kristel Veneva, Milena Wang, Da-Hui Wang, Haiying Wang, Hui Watterson, Steven Wong-Lin, Kongfatt Yang, Su Zou, Xin Schmidt, Harald H.H.W. Centro de Tecnología Biomédica Universidad Politécnica de Madrid Madrid Spain Intelligent Systems Research Centre School of Computing Engineering and Intelligent Systems Ulster University Ulster United Kingdom Center for Physiology and Pharmacology Institute of Vascular Biology and Thrombosis Research Medical University of Vienna Vienna Austria TUM School of Life Sciences Weihenstephan Technical University of Munich Freising Germany Holon Israel CNR National Research Council IAC Institute for Applied Computing Rome Italy Lab of Computing Medical Informatics and Biomedical Imaging Technologies School of Medicine Aristotle University of Thessaloniki Thessaloniki Greece Université Clermont Auvergne INRAE UNH Plateforme d'Exploration du Métabolisme MetaboHUB Clermont Clermont-Ferrand France Université de Technologie de Compiègne Compiègne France Labex MS2T Control of Technological Systems-of-Systems CNRS and Université de Technologie de Compiègne Compiègne France Faculty of Engineering University of Kragujevac Kragujevac Serbia Kragujevac Serbia Steinbeis Advanced Risk Technologies Institute Doo Kragujevac Kragujevac Serbia Pharmacology and Therapeutics School of Medicine Galway Neuroscience Centre National University of Ireland Galway Ireland School of Computing Ulster University Ulster United Kingdom Holon Israel Department of Mathematics and Natural Sciences Kaunas University of Technology Kaunas Lithuania Faculty of Computer Science and Engineering Ss. Cyril and Methodius University Skopje Macedonia Medicine Faculty Université Libre de Bruxelles CHU de Charleroi Charleroi Belgium Northern Ireland Centre for Stratified Medicine Biomedical Sciences Research Institute Ulster University Ulster United Kingdom Escola Superior de Tecnologia e Gestão Instituto Politécnico de Portalegre Portalegre Portugal Instituto Superior Técnico Universidade de Lisboa Lisboa Portugal Faculty of Automatic Control and Computers University Politehnica of B

Background: Systems Medicine is a novel approach to medicine, that is, an interdisciplinary field that considers the human body as a system, composed of multiple parts and of complex relationships at multiple levels, and further integrated into an environment. Exploring Systems Medicine implies understanding and combining concepts coming from diametral different fields, including medicine, biology, statistics, modeling and simulation, and data science. Such heterogeneity leads to semantic issues, which may slow down implementation and fruitful interaction between these highly diverse fields. Methods: In this review, we collect and explain more than100 terms related to Systems Medicine. These include both modeling and data science terms and basic systems medicine terms, along with some synthetic definitions, examples of applications, and lists of relevant references. Results: This glossary aims at being a first aid kit for the Systems Medicine researcher facing an unfamiliar term, where he/she can get a first understanding of them, and, more importantly, examples and references for digging into the topic. © Massimiliano Zanin et al., 2021;Published by Mary Ann Liebert, Inc. 2021.

关键词： Semantics

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Discovery of Four Pulsars in a Pilot Survey at Intermediate Galactic Latitudes with FAST

arXiv

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arXiv 2023年

作者： Zhi, Q.J. Bai, J.T. Dai, S. Xu, X. Dang, S.J. Shang, L.H. Zhao, R.S. Li, D. Zhu, W.W. Wang, N. Yuan, J.P. Wang, P. Zhang, L. Feng, Y. Wang, J.B. Wang, S.Q. Wu, Q.D. Dong, A.J. Yang, H. Tian, J. Zhong, W.Q. Luo, X.H. Filipović, Miroslav D. Qiao, G.J. School of Physics and Electronic Science Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal University Guiyang550001 China Xinjiang Astronomical Observatory Chinese Academy of Sciences Xinjiang Urumqi830011 China School of Science Western Sydney University Locked Bag 1797 Penrith South DCNSW2751 Australia School of Mathematical Sciences Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal University Guiyang550001 China National Astronomical Observatories Chinese Academy of Sciences Beijing100101 China University of Chinese Academy of Sciences Beijing100049 China Research Center for Intelligent Computing Platforms Zhejiang Laboratory Hangzhou311100 China Key Laboratory of Radio Astronomy Chinese Academy of Sciences Xinjiang Urumqi830011 China Xinjiang Key Laboratory of Radio Astrophysics 150 Science1-Street Xinjiang Urumqi830011 China Zhejiang Lab Zhejiang Hangzhou311121 China Institute of Optoelectronic Technology Lishui University Lishui323000 China School of Astronomy and Space Science University of Chinese Academy of Sciences Beijing100049 China School of Physics Peking University Beijing100871 China

We present the discovery and timing results of four pulsars discovered in a pilot survey at intermediate Galactic latitudes with the Five-hundred Aperture Spherical Telescope (FAST). Among these pulsars, two belong to the category of millisecond pulsars (MSPs) with spin periods of less than 20 ms. The other two fall under the classification of "mildly recycled" pulsars, with massive white dwarfs as companions. Remarkably, this small survey, covering an area of 4.7 deg2, led to the discovery of four recycled pulsars. Such success underscores the immense potential of future surveys at intermediate Galactic latitudes. In order to assess the potential yield of MSPs, we conducted population simulations and found that both FAST and Parkes new phased array feed surveys, focusing on intermediate Galactic latitudes, have the capacity to uncover several hundred new MSPs. Copyright © 2023, The Authors. All rights reserved.

关键词： Pulsars

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Perovskite Solar Cells: Unique Seamlessly Bonded CNT@Graphene Hybrid Nanostructure Introduced in an Interlayer for Efficient and Stable Perovskite Solar Cells (Adv. Funct. Mater. 32/2018)

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advanced Functional Materials 2018年第32期28卷

作者： Xuanhua Li Tengteng Tong Qinjiang Wu Shaohui Guo Qiang Song Jian Han Zhixiang Huang State Key Laboratory of Solidification Processing Research and Development Institute of Northwestern Polytechnical University In Shenzhen Center for Nano Energy Materials School of Materials Science and Engineering Northwestern Polytechnical University and Shaanxi Joint Lab of Graphene (NPU) Xi'an 710072 China Northwestern Polytechnical University‐Queen Mary University of London (NPU‐QMUL) Joint Research Institute of Advanced Materials and Structures (JRI‐AMAS) Xi'an 710072 China Key Laboratory of Intelligent Computing and Signal Processing Ministry of Education Anhui University No. 3 Feixi Road Hefei Anhui Province 230039 P. R. China

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Constructing Epidermal Rete Ridges Using Composite Hydrogel to Enhance Multiple Signaling Pathways for the Maintenance of Epidermal Stem Cell Niche

SSRN

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SSRN 2023年

作者： Shen, Zhizhong Liu, Zixian Sun, Lei Li, Meng Han, Lu Wang, Jianming Wu, Xunwei Sang, Shengbo Shanxi Key Laboratory of Micro Nano Sensors & Artificial Intelligence Perception College of Information and Computer Taiyuan University of Technology Taiyuan030024 China Key Lab of Advanced Transducers and Intelligent Control System the Ministry of Education Taiyuan University of Technology Taiyuan030024 China Shanxi Research Institute of 6D Artificial Intelligence Biomedical Science Taiyuan030031 China General Hospital of TISCO North Street Xinghualing District Taiyuan030809 China Engineering Laboratory for Biomaterials and Tissue Regeneration Ningbo Stomatology Hospital Savaid Stomatology School Hangzhou Medical College Ningbo China Department of Tissue Engineering and Regeneration School and Hospital of Stomatology Cheeloo College of Medicine Shandong University Shandong Key Laboratory of Oral Tissue Regeneration Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration Shandong Jinan China Cutaneous Biology Research Center Massachusetts General Hospital Harvard Medical School BostonMA United States

The undulating microstructure rete ridge (RR) located at the junction between the dermis and epidermis plays a crucial role in improving skin mechanical properties and maintaining skin homeostasis. However, the investigation of RR microstructures are usually neglected in current tissue engineering for skin regeneration. Here, to create an epidermal model with RR microstructures, keratinocytes were inoculated onto a patterned GelMA-PEGDA hydrogel constructed using molding technology. Furthermore, grafting acryloylated Arg-Gly-Asp (RGD) peptides on the hydrogel surface significantly improved cell adhesion, fusion, and development. RT-PCR, Western blot, and immunofluorescence staining confirmed that cells on RR microstructures exhibited higher gene and protein expression associated with epidermal stem cells. RNA sequencing analysis of cells on RR microstructure showed higher gene expression profiles related to stem cell maintenance, basement membrane formation, and epidermal development. Furthermore, RT-PCR analysis of epidermal models of various dimensions demonstrated that smaller microstructures were more conducive to epidermal stem cell marker gene expression, which is analogous to human skin. Overall, we have successfully developed a method for integrating RR microstructures into an epidermal model that mimics natural skin to maintain epidermal stem cell niche, providing a valuable reference for researching skin regeneration within the fields of tissue engineering and regenerative medicine. © 2023, The Authors. All rights reserved.

关键词： Microstructure

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Click-iG: Simultaneous Enrichment and Profiling of Intact N-linked, O-GalNAc, and O-GlcNAcylated Glycopeptides

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Angewandte Chemie 2023年第36期135卷

作者： Dr. Jialin Liu Dr. Bo Cheng Dr. Xinqi Fan Xinyue Zhou Jiankun Wang Dr. Wen Zhou Hengyu Li Dr. Wenfeng Zeng Prof. Pengyuan Yang Prof. Xing Chen College of Chemistry and Molecular Engineering Beijing National Laboratory for Molecular Sciences Peking-Tsinghua Center for Life Sciences Synthetic and Functional Biomolecules Center and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education Peking University Beijing 100871 China Institute of Biomedical Sciences and Department of Chemistry Fudan University Shanghai 200433 China Key Lab of Intelligent Information Processing of Chinese Academy of Sciences (CAS) and Institute of Computing Technology CAS Beijing 100190 China Deseased

Proteins are ubiquitously modified with glycans of varied chemical structures through distinct glycosidic linkages, making the landscape of protein glycosylation challenging to map. Profiling of intact glycopeptides with mass spectrometry (MS) has recently emerged as a powerful tool for revealing matched information of the glycosylation sites and attached glycans (i.e., intact glycosites), but is largely limited to individual glycosylation types. Herein, we describe Click-iG, which integrates metabolic labeling of glycans with clickable unnatural sugars, an optimized MS method, and a tailored version of pGlyco3 software to enable simultaneous enrichment and profiling of three types of intact glycopeptides: N-linked, mucin-type O-linked, and O-GlcNAcylated glycopeptides. We demonstrate the utility of Click-iG by the identification of thousands of intact glycosites in cell lines and living mice. From the mouse lung, heart, and spleen, a total of 2053 intact N-glycosites, 262 intact O-GalNAc glycosites, and 1947 O-GlcNAcylation sites were identified. Click-iG-enabled comprehensive coverage of the protein glycosylation landscape lays the foundation for interrogating crosstalk between different glycosylation pathways.

关键词： Glycoproteomics Glycosylation Intact Glycosites Metabolic labeling Unnatural Glycans

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Utilizing Fullerenols as Surfactant for Carbon Nanotubes Dispersions Preparation

Journal of Materials

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Journal of Materials 2017年第1期2017卷

作者： Jianlong Ji Chang Qiao Yali Liu Wendong Zhang Shengbo Sang Xing Yang Aoqun Jian Qianqian Duan Qiang Zhang Ying Liu Micro Nano System Research Center Key Lab of Advanced Transducers and Intelligent Control System of the Ministry of Education College of Information Engineering Taiyuan University of Technology Taiyuan 030024 *** Advanced Coal Mine Machinery and Equipment Collaborative Innovation Center of Shanxi Province College of Information Engineering Taiyuan University of Technology Taiyuan 030024 *** MEMS Laboratory Department of Precision Instruments and Mechanology Tsinghua University Beijing 100084 *** College of Materials Science and Engineering Taiyuan University of Technology Taiyuan 030024 ***

Dispersions of individual carbon nanotubes (CNTs) are crucial for nanodevices and polymer/CNTs nanocomposites. In this paper, stable and homogenous dispersions of individual multiwalled carbon nanotubes (MWCNTs) have been synthesized. The factors influencing the dispersibility mechanism, including the surfactant concentration and the pH value, have been investigated. SEM images display the impurities sticking on MWCNTs which have been removed. The oxygen-containing groups on the surface of MWCNTs sample have been detected through FT-IR and Raman spectra. All experimental results illustrate that using fullerenols as surfactant can greatly improve the dispersibility of MWCNTs. Moreover, the prepared dispersions exhibit good stability that the sediment percentage of fullerenols-MWCNTs is only 5.2% after 5 days.

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Dipole-Tunable Interfacial Engineering Strategy for High-Performance All-Inorganic Red Quantum-Dot Light-Emitting Diodes

SSRN

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SSRN 2023年

作者： Cai, Fensha Li, Meng Zhou, Yamei Tu, Yufei Liang, Chao Su, Zhenhuang Gao, Xingyu Zeng, Zaiping Hou, Bo Li, Zhe Aldamasy, Mahmoud H. Jiang, Xiaohong Wang, Shujie Du, Zuliang Key Lab for Special Functional Materials of Ministry of Education National & Local Joint Engineering Research Center for High-efficiency Display and Lighting Technology School of Materials Science and Engineering Collaborative Innovation Center of Nano Functional Materials and Applications Henan University Kaifeng475004 China Queen Mary University of London LondonE1 4NS United Kingdom School of Electronics Information and Intelligent Manufacturing Sias University Xinzheng China MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter School of Physics Xi’an Jiaotong University Xi’an710049 China Shanghai Advanced Research Institute Chinese Academy of Sciences 239 Zhangheng Road Shanghai201204 China School of Physics and Astronomy Cardiff University CardiffCF24 3AA United Kingdom Helmholtz-Zentrum Berlin für Materialien und Energie GmbH. Hahn-Meitner-Platz 1 Berlin14109 Germany

All-inorganic quantum dot (QD) light-emitting diodes (AI-QLEDs) with excellent stability received enormous interest in the past few years. Nevertheless, the vast energy offset and the high trap density at the NiOX/QDs interface limit hole injection leading to fluorescence quenching and hampering the performance. Here, we present self-assembled monolayers (SAMs) with phosphonic acid (PA) anchoring groups modifying NiOX hole transport layer (HTL) to tune energy level and passivate trap states. This strategy facilitates hole injection owning to the well-aligned energy level by interface dipole, downshifting the vacuum level, reducing the hole injection barrier from 0.94 eV to 0.28 eV. Meanwhile, it mitigates the interfacial recombination by passivating surface hydroxyl group (-OH) and oxygen vacancy (VO) traps in NiOX. The electron leakage from QDs toward NiOX HTL is significantly suppressed. The all-inorganic R-QLEDs exhibit one of the highest maximum luminance, external quantum efficiency and operational lifetime of 88980 cd m−2, 10.3% and 335045 h (T50@100 cd m−2), respectively. The as-proposed interface engineering provides an effective design principle for high-performance AI-QLEDs for future outdoor and optical projection-type display applications. © 2023, The Authors. All rights reserved.

关键词： Semiconductor quantum dots

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Dipole-Tunable Interfacial Engineering Strategy for High-Performance All-Inorganic Red Quantum-Dot Light-Emitting Diodes

SSRN

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SSRN 2023年

作者： Cai, Fensha Li, Meng Zhou, Yamei Tu, Yufei Liang, Chao Su, Zhenhuang Gao, Xingyu Zeng, Zaiping Hou, Bo Li, Zhe Aldamasy, Mahmoud H. Jiang, Xiaohong Du, Zuliang Wang, Shujie Key Lab for Special Functional Materials of Ministry of Education National & Local Joint Engineering Research Center for High-efficiency Display and Lighting Technology School of Materials Science and Engineering Collaborative Innovation Center of Nano Functional Materials and Applications Henan University Kaifeng475004 China Queen Mary University of London LondonE1 4NS United Kingdom School of Electronics Information and Intelligent Manufacturing Sias University Xinzheng China MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter School of Physics Xi’an Jiaotong University Xi’an710049 China Shanghai Advanced Research Institute Chinese Academy of Sciences 239 Zhangheng Road Shanghai201204 China School of Physics and Astronomy Cardiff University Wales CardiffCF24 3AA United Kingdom Helmholtz-Zentrum Berlin für Materialien und Energie GmbH. Hahn-Meitner-Platz 1 Berlin14109 Germany

All-inorganic quantum dot (QD) light-emitting diodes (AI-QLEDs) with excellent stability received enormous interest in the past few years. Nevertheless, the vast energy offset and the high trap density at the NiOX/QDs interface limit hole injection leading to fluorescence quenching and hampering the performance. Here, we present self-assembled monolayers with phosphonic acid (PA) anchoring groups modifying NiOX hole transport layer (HTL) to tune energy level and passivate trap states. This strategy facilitates hole injection owning to the well-aligned energy level by interface dipole, downshifting the vacuum level. Meanwhile, it mitigates the interfacial recombination by passivating oxygen vacancy traps in NiOX. The electron leakage from QDs toward NiOX HTL is significantly suppressed. The all-inorganic R-QLEDs exhibit record maximum luminance and external quantum efficiency of 88980 cd m−2 and 10.3%, respectively. The superior stability T50@100 cd m−2 reaches 335045 h. The as-proposed interface engineering provides an effective design principle for high-performance AI-QLEDs for future outdoor and optical projection-type display applications. © 2023, The Authors. All rights reserved.

关键词： Semiconductor quantum dots

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Water Splitting: Optical and Electrical Enhancement of Hydrogen Evolution by MoS2@MoO3Core–Shell Nanowires with Designed Tunable Plasmon Resonance (Adv. Funct. Mater. 32/2018)

引用

advanced Functional Materials 2018年第32期28卷

作者： Shaohui Guo Xuanhua Li Xingang Ren Lin Yang Jinmeng Zhu Bingqing Wei State Key Laboratory of Solidification Processing Center for Nano Energy Materials School of Materials Science and Engineering Northwestern Polytechnical University and Shaanxi Joint Lab of Graphene (NPU) Xi'an 710072 China Northwestern Polytechnical University‐Queen Mary University of London (NPU‐QMUL) Joint Research Institute of Advanced Materials and Structures (JRI‐AMAS) Xi'an 710072 China Key Laboratory of Intelligent Computing and Signal Processing Ministry of Education Anhui University No. 3 Feixi Road Hefei Anhui Province 230039 P. R. China Department of Mechanical Engineering University of Delaware Newark DE 19716 USA

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Cover Feature: Ultrasensitive, Sustainable, and Selective Electrochemical Hydrazine Detection by ALD-Developed Two-Dimensional WO3(ChemElectroChem 2/2018)

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ChemElectroChem 2017年第2期5卷

作者： Zihan Wei Zhenyin Hai Mohammad Karbalaei Akbari Prof. Jie Hu Lachlan Hyde Prof. Stephen Depuydt Prof. Francis Verpoort Prof. Serge Zhuiykov Ghent University Global Campus Department of Applied Analytical & Physical Chemistry 119 Songdomunhwa-ro Yeonsu-gu Incheon South Korea Micro and Nano System Research Center Key Lab of Advanced Transducers and Intelligent Control System (Ministry of Education) & College of Information Engineering Taiyuan University of Technology Taiyuan 030024 Shanxi PR China Factory of the Future Swinburne University of Technology Hawthorn Australia National Research Tomsk Polytechnic University Lenin Avenue 30 634050 Tomsk Russian Federation Laboratory of Organometallics Catalysis and Ordered Materials State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Center for Chemical and Material Engineering Wuhan University of Technology Wuhan P.R. China

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