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IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

作者： Kuo Guo Yifan Li Hao Chen Hong-Bin Shen Yang Yang Department of Computer Science and Engineering Shanghai Jiao Tong University and Key Laboratory of Shanghai Education Commission for Intelligent Interaction and Cognitive Engineering Shanghai China Institute of Image Processing and Pattern Recognition Shanghai Jiao Tong University and Key Laboratory of System Control and Information Processing Ministry of Education of China Shanghai China Computational Biology Department School of Computer Science Carnegie Mellon University Pittsburgh PA USA

Isoforms refer to different mRNA molecules transcribed from the same gene, which can be translated into proteins with varying structures and functions. Predicting the functions of isoforms is an essential topic in bioinformatics as it can provide valuable insights into the intricate mechanisms of gene regulation and biological processes. Conventionally, gene function labels are standardized in Gene Ontology (GO) terms. However, traditional methods for predicting isoform function are largely limited by the absence of isoform-specific labels, sparse annotations, and the vast number of GO terms. To address these issues, we propose HANIso, a deep learning-based method for isoform function prediction. HANIso leverages a pretrained protein language model to extract features from protein sequences. It also integrates heterogeneous information, such as isoform sequence features, GO annotations, and isoform interaction data, using a Heterogeneous Graph Attention Network (HAN). This allows the model to learn the importance of different sources of information and their semantic relationships through the attention mechanism. Our method can predict function labels at both the gene level and isoform level. We conduct experiments on two species datasets, and the results demonstrate that our method outperforms existing methods on both AUROC and AUPRC. HANIso has the potential to overcome the limitations of traditional methods and provide a more accurate and comprehensive understanding of isoform function.

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Watch the Speakers: A Hybrid Continuous Attribution Network for Emotion Recognition in Conversation With Emotion Disentanglement

arXiv

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arXiv 2023年

作者： Lei, Shanglin Wang, Xiaoping Dong, Guanting Li, Jiang Liu, Yingjian School of Artificial Intelligence and Automation Huazhong University of Science and Technology Wuhan430074 China Key Laboratory of Image Processing and Intelligent Control Education Ministry of China Wuhan430074 China Wuhan430074 China School of Artificial Intelligence Beijing University of Posts and Telecommunications Beijing100876 China

Emotion Recognition in Conversation (ERC) has attracted widespread attention in the natural language processing field due to its enormous potential for practical applications. Existing ERC methods face challenges in achieving generalization to diverse scenarios due to insufficient modeling of context, ambiguous capture of dialogue relationships and overfitting in speaker modeling. In this work, we present a Hybrid Continuous Attributive Network (HCAN) to address these issues in the perspective of emotional continuation and emotional attribution. Specifically, HCAN adopts a hybrid recurrent and attention-based module to model global emotion continuity. Then a novel Emotional Attribution Encoding (EAE) is proposed to model intra- and inter-emotional attribution for each utterance. Moreover, aiming to enhance the robustness of the model in speaker modeling and improve its performance in different scenarios, A comprehensive loss function emotional cognitive loss LEC is proposed to alleviate emotional drift and overcome the overfitting of the model to speaker modeling. Our model achieves state-of-the-art performance on three datasets, demonstrating the superiority of our work. Another extensive comparative experiments and ablation studies on three benchmarks are conducted to provided evidence to support the efficacy of each module. Further exploration of generalization ability experiments shows the plug- and-play nature of the EAE module in our method. © 2023, CC BY-SA.

关键词： Emotion Recognition

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Scaling properties of scale-free networks in degree-thresholding renormalization flows

arXiv

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arXiv 2021年

作者： Chen, Dan Cai, Defu Su, Housheng The School of Artificial Intelligence and Automation Huazhong University of Science and Technology Wuhan430074 China The Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China Huazhong University of Science and Technology Wuhan430074 China The State Grid Hubei Electric Power Research Institute Wuhan China

We study the statistical properties of observables of scale-free networks in the degree-thresholding renormalization (DTR) flows. For BA scale-free networks with different sizes, we find that their structural and dynamical observables have similar scaling behavior in the DTR flow. The finite-size scaling analysis confirms this view and reveals a scaling function with a single scaling exponent that collectively captures the changes of these observables. Furthermore, for the scale-free network with a single initial size, we use its DTR snapshots as the original networks in the DTR flows, then perform a similar finite-size scaling analysis. Interestingly, the initial network and its snapshots share the same scaling exponent as the BA synthetic network. Our findings have important guiding significance for analyzing the structure and dynamic behavior of large-scale networks. Such as, in large-scale simulation scenarios with high time complexity, the DTR snapshot could serve as a substitute or guide for the initial network and then quickly explore the scaling behavior of initial networks. © 2021, CC BY.

关键词： Scaling laws

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In Vitro Fertilization (IVF) cumulative pregnancy rate prediction from basic patient characteristics

arXiv

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arXiv 2019年

作者： Zhang, Bo Cui, Yuqi Wang, Meng Li, Jingjing Jin, Lei Wu, Dongrui Reproductive Medicine Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei430030 China Key Laboratory of the Ministry of Education for Image Processing and Intelligent Control School of Artificial Intelligence and Automation Huazhong University of Science and Technology Wuhan Hubei430074 China

Tens of millions of women suffer from infertility worldwide each year. In vitro fertilization (IVF) is the best choice for many such patients. However, IVF is expensive, time-consuming, and both physically and emotionally demanding. The first question that a patient usually asks before the IVF is how likely she will conceive, given her basic medical examination information. This paper proposes three approaches to predict the cumulative pregnancy rate after multiple oocyte pickup cycles. Experiments on 11,190 patients showed that first clustering the patients into different groups and then building a support vector machine model for each group can achieve the best overall performance. Our model could be a quick and economic approach for reliably estimating the cumulative pregnancy rate for a patient, given only her basic medical examination information, well before starting the actual IVF procedure. The predictions can help the patient make optimal decisions on whether to use her own oocyte or donor oocyte, how many oocyte pickup cycles she may need, whether to use embryo frozen, etc. They will also reduce the patient's cost and time to pregnancy, and improve her quality of life. Copyright © 2019, The Authors. All rights reserved.

关键词： Obstetrics

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Stability analysis and controller design of positive linear systems subject to actuator saturation

Stability analysis and controller design of positive linear ...

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Chinese control Conference (CCC)

作者： Jishi Zhang Yan Wu Yanwu Wang Zhonghu Gao School of Automation Huazhong University of Science and Technology Wuhan P.R.China Key Laboratory of Image Processing Intelligent Control of Education Ministry of China Wuhan P.R.China CSIC Wuhan Institute of Marine Electric Propulsion Wuhan P.R.China

This paper addresses the stability and stabilization problems for a class of positive linear systems in the presence of saturating actuators. The objective is to give conditions of the stability, and design state feedback control laws such that the closed-loop systems is asymptotically stable and positive at the origin with a large domain of attraction. Several sufficient conditions for stabilization and positivity are derived via the Lyapunov functions method and convex analysis in both the continuous-time and the discrete-time cases, respectively. The state feedback controller design and the estimation of domain of attraction are presented by solving a convex optimization problem with LMIs constraints. A numerical example is given to show the effectiveness of the proposed methods.

关键词： Actuators Linear systems Stability analysis Closed loop systems State feedback Bismuth

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Aperiodic sampled-data sliding-mode control of fuzzy systems with communication delays via the event-triggered method

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IEEE Transactions on Fuzzy Systems 2016年第5期24卷 1048-1057页

作者： Wen, Shiping Huang, Tingwen Yu, Xinghuo Chen, Michael Z. Q. Zeng, Zhigang School of Automation Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China Huazhong University of Science and Technology Wuhan430074 China Texas A and M University at Qatar Doha23874 Qatar Platform Technologies Research Institute RMIT University MelbourneVIC3001 Australia Department of Mechanical Engineering University of Hong Kong Hong Kong

This paper studies the aperiodic sampled-data control for the sliding-mode control (SMC) scheme of fuzzy systems with communication-induced delays via the event-triggered method. In practice, it is impossible to update control in continuous manner;thus, an event-based control technique has become popular with the advantage that the control task is executed only if it is triggered by an event. In this paper, the event-based sliding-mode control (ESMC) is designed for each linear subsystem of the global fuzzy model first. Then, the conditions for "fuzzily" amalgamated ESMC are discussed to stabilize the global fuzzy model. This ensures that the SMCis executed only when necessary. Furthermore, the results are extended to the fuzzy systems with communication-induced delays. Finally, case studies are carried out to demonstrate the effectiveness of the derived results. © 2015 IEEE.

关键词： Fuzzy systems

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Multistability of Recurrent Neural Networks with Nonmonotonic Activation Functions and Mixed Time Delays

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IEEE Transactions on Systems, Man, and Cybernetics: Systems 2016年第4期46卷 512-523页

作者： Liu, Peng Zeng, Zhigang Wang, Jun School of Automation Huazhong University of Science and Technology Wuhan430074 China Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China Wuhan430074 China Department of Mechanical and Automation Engineering Chinese University of Hong Kong Hong Kong Department of Computer Science City University of Hong Kong Kowloon Tong Hong Kong

This paper presents new theoretical results on the multistability analysis of a class of recurrent neural networks with nonmonotonic activation functions and mixed time delays. Several sufficient conditions are derived for ascertaining the existence of 3n equilibrium points and the exponential stability of 2n equilibrium points via state space partition by using the geometrical properties of activation functions and algebraic properties of nonsingular M-matrix. Compared with existing results, the conditions herein are much more computable with one order less linear matrix inequalities. Furthermore, the attraction basins of these exponentially stable equilibrium points are estimated. It is revealed that the attraction basins of the 2n equilibrium points can be larger than their originally partitioned subspaces. Three numerical examples are elaborated with typical nonmonotonic activation functions to substantiate the efficacy and characteristics of the theoretical results. © 2015 IEEE.

关键词： Recurrent neural networks

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Robust semi-global coordinated tracking of linear multi-agent systems with input saturation

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International Journal of Robust and Nonlinear control 2015年第14期25卷 2375-2390页

作者： Su, Housheng Chen, Michael Z. Q. Chen, Guanrong School of Automation Image Processing and Intelligent Control Key Laboratory of Education Ministry of China Huazhong University of Science and Technology Luoyu Road 1037 Wuhan430074 China Department of Mechanical Engineering University of Hong Kong Hong Kong Hong Kong Department of Electronic Engineering City University of Hong Kong Hong Kong Hong Kong

This paper investigates the problem of coordinated tracking of a linear multi-agent system subject to actuator magnitude saturation and dead zone characteristic with input additive uncertainties and disturbances. Distributed consensus and swarm tracking protocols are developed from a low-and-high gain feedback approach. Under the assumption that each agent is asymptotically null controllable with bounded controls, it is shown that robust semi-global consensus tracking and swarm tracking of the multi-agent system can always be reached provided that the networks are connected. Numerical examples are provided to illustrate the theoretical results. Copyright © 2014 John Wiley & Sons, Ltd.

关键词： Multi agent systems

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A delay system method to design of event-triggered control of networked control systems

A delay system method to design of event-triggered control o...

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IEEE Conference on Decision and control

作者： Dong Yue Engang Tian Qing-Long Han Department of Control Science and Engineering and the Key Laboratory of Ministry of Education for Image Processing and Intelligent Control Huazhong University of Science and Technology Hubei 430074 China School of Electrical and Automation Engineering Nanjing Normal University 78 Bancang Street Nanjing 210042 China Center for Intelligent and Networked Systems and the School of Information and Communication Technology Central Queensland University Rockhampton Qld 4702 Australia

ISBN: (纸本)9781612848006

The event-triggered H_(infinity) control design is investigated for networked control systems with uncertainties and transmission delays. A novel event-triggering scheme is proposed, which has some advantages over traditional ones with a continuous detector. Considering the effect of the transmission delay, a delay system model for the analysis is firstly constructed. Then, based on the model and Lyapunov functional method, criteria for the stability with an H_(infinity) norm bound and criteria for the co-design of both the feedback gain and the trigger parameters are derived. In order to solve the feedback gain and the trigger parameters, the linear matrix inequality technique is employed. From the simulation example, it can be concluded that the proposed event-triggering scheme is superior to some other event-triggering schemes in some existing literature.

关键词： feedback gain Networked control systems Event trigger Delay systems Scheme Co-design control systems design control

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Sample Weighted Gradient Regularization for Source-Free Domain Adaptation

SSRN

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SSRN 2024年

作者： Long, Yunchong Xu, Bingrong Zhang, Qingyong Yin, Jianhua Zeng, Zhigang School of Automation Wuhan University of Technology Wuhan430070 China Intelligent Transportation Systems Research Center Wuhan University of Technology Wuhan430063 China The Engineering Research Center of Transportation Information and Safety Ministry of Education Wuhan430063 China School of Artificial Intelligence and Automation Huazhong University of Science and Technology Wuhan430074 China The Key Laboratory of Image Processing and Intelligent Control Education Ministry of China Wuhan430074 China

Conventional Domain Adaptation(DA) algorithms typically rely on access to the source data,which may not always be practical due to privacy concerns or limited storage *** address these challenges,Source-Free Domain Adaptation(SFDA) has emerged as an alternative that relies solely on a pre-trained source model rather than the actual source *** SFDA,pseudo-label supervised learning is commonly employed and initially plays a significant role in enhancing model performance during the early stages of target domain ***,as adaptation progresses,the performance can stagnate or even deteriorate due to the noise inherent in pseudo-labels,a phenomenon known as Confirmation *** noise present in target domain pseudo-labels introduces additional uncertainty and overfitting risks to the *** this study,a novel framework named Sample Weighted Gradient Regularization (SWGR) was introduced to tackle this *** first propose the label Uncertainty Estimation Metric (LUEM),a reweighting strategy that assesses the reliability of *** metric evaluates label uncertainty from both the source domain pre-trained model and spatial distribution of target domain samples,allowing the model to achieve improved cross-domain transfer performance with high-confidence samples in the target domain. Additionally,we impose a constraint on the gradient descent process of the total loss function in the form of an inequality to prevent entropy from *** Gradient Regularization eliminates overfitting while also guiding the model in lowering prediction uncertainty *** approach reduces the uncertainty in the target domain and enhances the model's generalization *** results demonstrate that our method surpasses competing SFDA approaches and even outperforms many traditional DA methods which require extensive amounts of source domain data. © 2024, The Authors. All rights reserved.

关键词： Self-supervised learning

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