Hypertension,among diabetes,obesity and others,is one of the common human diseases that is genetically expressed as complex traits to which genetic,environmental,and demographic factors contribute *** the underlying g...
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Hypertension,among diabetes,obesity and others,is one of the common human diseases that is genetically expressed as complex traits to which genetic,environmental,and demographic factors contribute *** the underlying genes and examining their interactions, a crucial step in understanding the molecular pathogenesis of complex diseases,is both a statistical and a computational challenge,stressing the need for novel strategies to move this process *** this paper we propose a new method to study the association of multiple gene interactions for complex *** method is carried out by two ***,we sequentially select additionally associated SNP loci combinations by minimizing the p-value of a test based on an information measure,measure of information ***,this approach is called MID ***,the significance of the selected associated loci combinations is assessed by an x *** MID method is model-free and nonparametric,it is easy to compute and *** capability of the MID method is confirmed by applying it to investigate the multiple gene interactions on risk of hypertension in northern Han Chinese,where thirty-three SNP loci with three-genotype in eleven candidate genes are *** results are consistent with those of Gu et al（2006）.Additionally,we get some other new *** indicates that our idea is indeed feasible and useful in practice.
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