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A Mechanical Biosensor Based on Magnetic-Mediated Sensitization for 5-Ht Detection

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SSRN 2024年

作者： Zhao, Dong Yao, Penglong Yan, Zhaosheng Jian, Aoqun Bai, Jinsuo Wang, Haoyu Guo, Xing Sang, Shengbo Zhou, Chuangang Dong, Xiushan Shanxi Key Laboratory of Micro Nano Sensors & Artificial Intelligence Perception College of Electronic Information And Optical Engineering Taiyuan University of Technology Taiyuan030024 China Key Lab of Advanced Transducers and Intelligent Control System the Ministry of Education Taiyuan University of Technology Taiyuan030024 China Taiyuan University of Technology China Shanxi Academy of Medical Sciences China

The real-time detection of neurotransmitters had attracted more attention due to the potential to provide vital information for pathology research, disease diagnosis, and clinical efficacy evaluation. Here, a magnetic-mediated biosensor was developed to improve sensitivity for detection of serotonin (5-HT). The PDMS membrane doped with magnetic particles serves as a conversion element, enhancing the deformation of the thin film caused by surface stress under the action of a magnetic field and amplifying the resistance response signal of the biosensor. The 5-HT detection associated with neurotransmitter diseases serve as a proof of concept revealing the magnetic sensitization. The detection limit of the 5-HT was decreased to 3.21 nM in the linear range of 5-500 nM, which was lower than that of the biosensor without magnetic field. The clinical 5-HT samples were also been accurately detected, indicating a positive application potential of the as-prepared magnetic-mediated biosensor. All these results reveal the high sensitivity and practicality of the as-prepared magnetic-mediated biosensor and provide a new method for neurotransmitter diseases diagnosis. © 2024, The Authors. All rights reserved.

关键词： Biosensors

Far-field three-dimensional deep-subwavelength focal spot with azimuthal polarization

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arXiv

arXiv 2019年

作者： Nie, Zhongquan Liu, Jiawei Liu, Xiaofei Yan, Weichao Zhang, Yanxiang Tian, Yanting Liu, Shaoding Jia, Baohua Key Lab of Advanced Transducers and Intelligent Control System Ministry of Education and Shanxi Province College of Physics and Optoelectronics Taiyuan University of Technology Taiyuan030024 Department of Physics Harbin Institute of Technology Harbin150001 China Centre for Micro-Photonics Faculty of Science Engineering and Technology Swinburne University of Technology HawthornVIC3122 Australia

This work focuses on the generation of far-field super-resolved pure-azimuthal focal field based on the fast Fourier transform. A self-designed differential filter is first pioneered to robustly reconfigure a doughnut-shaped azimuthal focal field into a bright one with a sub-wavelength lateral scale (∼0.392λ), which offers a 27.3% reduction ratio relative to that of tightly focused azimuthal polarization modulated by a spiral phase plate. By further uniting the versatile differential filter with spatially shifted beam approach, in addition to allowing for an extremely sharper focal spot, whose size is in turn reduced to 0.228λ and 0.286λ in the transverse as well as axial directions, the parasitic sidelobes are also lowered to an inessential level (3/128). The relevant phase profiles are further exhibited to unravel the annihilation of field singularity and locally linear (i.e. azimuthal) polarization. Our scheme opens a promising route toward efficiently steer and tailor the redistribution of the focal field. Copyright © 2019, The Authors. All rights reserved.

关键词： Fast Fourier transforms

Lasing in self-assembled biophotonic network

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arXiv

arXiv 2021年

作者： Gong, Chaoyang Qiao, Zhen Zhu, Song Wang, Wenjie Chen, Yu-Cheng School of Electrical and Electronic Engineering Nanyang Technological University 50 Nanyang Avenue 639798 Singapore Key Lab of Advanced Transducers and Intelligent Control System of Ministry of Education Taiyuan University of Technology 79 Yingze Street Taiyuan030024 China School of Chemical and Biomedical Engineering Nanyang Technological University 62 Nanyang Drive 637459 Singapore

Mode competition is conventionally regarded as an unwanted phenomenon that induces instability of laser emission. Here, we experimentally demonstrate that the random dynamics behavior of mode competition provides hidden information of the intracavity topology. We introduced the concept of self-assembled biophotonics networks, where human insulin protein with network topology was sandwiched in a Fabry-Perot (FP) cavity. The optical coupling between insulin fibrils and enables strong mode competition. Thanks to the optical feedback provided by the FP cavity, the interaction between the light and insulin network was enhanced. Subtle changes in the network will cause significant changes in laser mode dynamics. By recording the transverse mode dynamics, we reconstruct a graph that reveals the optical correlation in the insulin network. Our results indicate that the graph represents an intrinsic feature and can sensitivity respond to the stimulus. The unclonable and sensitively responsive property of the biophotonic lasing network can potentially be employed in applications in sensing and information encryption. © 2021, CC BY-NC-ND.

关键词： Insulin

High Sensitivity Submicron Scale Temperature Sensor Based on Perovskite Nanoplatelet Lasers

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SSRN 2024年

作者： Zhao, Ruofan Tao, Jianxun Xi, Yuying Chen, Jiangzhao Ji, Ting Wang, Wenyan Wen, Rong Cui, Yanxia Chen, Junsheng Lia, Guohui College of Physics and Optoelectronics Key Laboratory of Interface Science and Engineering in Advanced Materials Key lab of Advanced Transducers and Intelligent Control System of Ministry of Education Taiyuan University of Technology Taiyuan030024 China School of Materials Science and Engineering Kunming University of Science and Technology Kunming650093 China Shanxi-Zheda institute of advanced materials and chemical engineering China Nano-Science Center Department of Chemistry University of Copenhagen Universitetsparken 5 CopenhagenDK-2100 Denmark

Submicron scale temperature sensors are crucial for a range of applications, particularly in micro and nanoscale environments. One promising solution involves the use of active whispering gallery mode (WGM) microresonators. These resonators can be remotely excited and read out using free-space structures, simplifying the process of sensing. In this study, we present a submicron-scale temperature sensor with a remarkable sensitivity up to 190 pm/℃ based on a triangular CH3NH3PbI3 nanoplatelet (NPL) laser. Notably, as temperature changes, the peak wavelength of the laser line shifts linearly. This unique characteristic allows for precise temperature sensing by tracking the peak wavelength of the NPL laser. The optical modes are confined within the perovskite NPL, which measures just 85 nanometers in height, due to total internal reflection. Our NPL laser boasts several key features, including a high Q-factor of ~ 2610 and a low laser threshold of about 19.8 µJ cm−2. The combination of exceptional sensitivity and ultra-small size makes our WGM device an ideal candidate for integration into systems that demand compact temperature sensors. This advancement paves the way for significant progress in the development of ultrasmall temperature sensors, opening new possibilities across various fields. © 2024, The Authors. All rights reserved.

关键词： Perovskite

Corrigendum to “Influence of Na doping on the magnetic properties of LaFeO 3 powders and dielectric properties of LaFeO 3 ceramics prepared by citric sol-gel method” [Ceram. Int. 43 (2017) 7922–7928]

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Ceramics International 2017年第18期43卷 17247-17247页

作者： Ensi Cao Yanrong Qin Tingting Cui Li Sun Wentao Hao Yongjia Zhang Key Lab. of Advanced Transducers & Intelligent Control System College of Physics & Optoelectronics Taiyuan University of Technology Taiyuan 030024 People's Republic of China

Highly Sensitive and Rapidly Responding Room-Temperature NH3 Gas Sensor that is Based on Exfoliated Black Phosphorus

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SSRN 2022年

作者： Han, Dan Han, Xiaomei Zhang, Xiaqin Wang, Weili Li, Donghui Li, Hongwei Sang, Shengbo Shanxi Province Cancer Hospital Chinese Academy of Medical Sciences Cancer Hospital Shanxi Medical University Taiyuan030000 China Shanxi Key Laboratory of Micro Nano Sensors & Artificial Intelligence Perception College of Information and Computer Taiyuan University of Technology Taiyuan030024 China Key Lab of Advanced Transducers and Intelligent Control System The Ministry of Education Taiyuan University of Technology Taiyuan030024 China

Black phosphorus (BP) has recently attracted significant interest in gas sensing because of its outstanding electronic and optical properties. In this paper, we demonstrated a series of gas sensors for detecting NH3 at room temperature that were based on BP nanosheets that were exfoliated for various durations. The BP nanosheet gas sensors showed excellent sensitivity for the detection of NH3 down to 100 ppb (~32%) under ambient conditions compared to previous reports. The BP nanosheets that were exfoliated for 60 min showed the highest response to 100 ppm NH3, namely, 121%, which was 2.5 times greater than the response of ground BP. The corresponding sensor also exhibited a stable response in the humidity range of 22% RH to 35% RH, which is the typical humidity range for non-rainy days. Moreover, the prepared NH3 gas sensor showed high selectivity, fast response and recovery, and excellent repeatability. According to various experimental and theoretical studies, the response and binding energy of BP towards NOx were higher than those towards NH3. However, very interestingly, the response of the exfoliated BP nanosheets to NH3 was higher than that to NOx in our work. The selectivity transformation from NOx to NH3 was mainly caused by the different layer spacing of the ground BP and the change in spacing between the BP nanosheet layers with different exfoliation times, increased oxygen incorporation, phosphate ions and defects that is induced by the liquid-phase exfoliation process, which led to the variations in its band gap and surface states. © 2022, The Authors. All rights reserved.

关键词： Nanosheets

A Novel Magnetoelastic Biosensor Based on Pdms/Fesib/Qds Composite Film for African Swine Fever Virus Detections

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SSRN 2024年

作者： Liu, Yuanhang Sang, Shengbo Zhao, Dong Ge, Yang Xue, Juanjuan Duan, Qianqian Guo, Xing Shanxi Key Laboratory of Micro Nano Sensors & Artificial Intelligence Perception College of Electronic Information and Optical Engineering Taiyuan University of Technology Taiyuan030024 China Key Lab of Advanced Transducers and Intelligent Control System of The Ministry of Education Taiyuan University of Technology Taiyuan030024 China Shanxi Research Institute of 6D Artificial Intelligence Biomedical Science Taiyuan030024 China

African swine fever (ASF) is a highly contagious and severe hemorrhagic disease caused by the African swine fever virus (ASFV). The continuous spread of ASFV affects the safety of global meat supply, so the establishment of sensitive and specific detection methods for ASFV has become an important hot spot in food safety. Herein, we developed a flexible magnetoelastic (ME) biosensor based on PDMS/FeSiB/QDs composite films for the detection of ASFV. Based on the high luminescence performance of CsPbBr3 quantum dots and the excellent magnetoelastic effect of FeSiB, flexible ME biosensors convert stress signals generated by antibody-antigen-specific binding into optical and electromagnetic signals. The nanostructures covalently linked by quantum dots and PDMS provide biomodification sites for ASFV antibodies, simplifying the functionalization modification process compared to conventional biosensors. The deformation of the PDMS film is amplified and conversion of surface stress signal to electrical signal is enhanced by exposing the biosensor to a uniform magnetic field. The experimental results proved that the flexible ME biosensor has wide linear range of 10 ng/mL - 100 μg/mL, and the detection limit is as low as 0.7933 ng/mL. Moreover, the flexible ME biosensor have also shown to good stability, sensitivity and specificity. © 2024, The Authors. All rights reserved.

关键词： Biosensors

A Novel Sensitization Mechanism of Stress-Electric-Coupled Biosensor Originated in Magnetostrictive Effect

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SSRN 2022年

作者： Sang, Shengbo Ge, Yang Ji, Jianglong Yuan, Zhongyun Dong, Xiushan Zhou, Chuangang Xiao, Pengli Tan, Qiuyun Zhao, Dong MicroNano System Research Center Key Lab of Advanced Transducers and Intelligent Control System The Ministry of Education College of Information and Computer Taiyuan University of Technology Taiyuan030024 China School of Electrical Engineering College of Engineering Science Hanyang University Seoul04763 Korea Republic of Shanxi Bethune Hospital Taiyuan030024 China Six-dimensional Artificial Intelligence Biomedical Research Institute Taiyuan030024 China

The stress-electric coupling based on receptor functionalization provides a new paradigm for the development of biosensor. However, the gravity factor of sensitive element usually shows difficult to be avoided due to its suppression to biosensor sensitivity. Herein, a magnetic-sensitization biosensing system with multi-physical field coupling of stress, magnetism and electricity was proposed to highly detect biomolecules. The gravitational interference of sensitive membrane was conquered by doping the TbDyFe with magnetostrictive effect into polydimethylsiloxane (PDMS) and applying magnetic field, showing great contributions to magnetic sensitization. The magnetic sensitization of the biosensor was proved by the collab.ration of experiment and simulation. The detections of urine protein and urine sugar associated with kidney disease were realized with limits of detection (LOD) of 0.21 ng/mL and 0.45 nM by using the magnetic-sensitization biosensor. The prepared biosensor exhibited the high specificity, selectivity, stability and repeatability. Especially, the HSA and glucose in real samples can be accurately detect, showing good practicability of the prepared biosensor. This study provides a way to improve the sensitivity of the mechanical biosensor. © 2022, The Authors. All rights reserved.

关键词： Silicones

Application of the High-Q Bouncing Ball Model Based on Fabry-Pérot Cavity for Alcohol Gas Concentration Detection

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SSRN 2023年

作者： Sang, Luxiao Wang, Teng Zhao, Biao Ding, Jinyu Jian, Aoqun Sang, Shengbo Shanxi Key Laboratory of Micro Nano Sensors & Artificial Intelligence Perception College of Electronic Information and Optical Engineering Taiyuan University of Technology Taiyuan030024 China Key Lab of Advanced Transducers and Intelligent Control System Ministry of Education Taiyuan University of Technology Taiyuan030024 China Shanxi Research Institute of 6D Artificial Intelligence Biomedical Science Taiyuan030031 China

This paper presents a method to enhance the Q factor of Fabry-Pérot cavities using a vertical dielectric interface (DI) made of silicon and air, which generates a bouncing ball model. The method is applied to detect alcohol gas concentrations with high resolution. Specifically, we introduce a 450 µm-thick silicon wafer into the Fabry-Pérot (FP) cavity, where it is positioned at an angle of inclination. This addition considerably augments the light-matter interaction, effectively confining the light within the cavity. The Q factor of the FP cavity with DI is always higher than that of the open FP cavity in the inclination angle range of 0 to 1°. Moreover, the effective mode area of the FP cavity with DI is smaller. Furthermore, the FP cavity with DI reduces the effective mode area and diminishes the lateral walk-off loss experienced in the open FP cavity. Finally, we experimentally verified the effectiveness of this method by detecting alcohol gas concentrations ranging from 28.5 ppm to 142.5 ppm and achieving a Q factor improvement from 5.9×104 to 1.2×105. The system sensitivity was calculated to be 0.5294 pm/ppm, and the resolution obtained was 28.5 ppm. © 2023, The Authors. All rights reserved.

关键词： Silicon wafers