Determining the functional roles of proteins is a vital task to understand life at molecular level and has great biomedical and pharmaceutical implications. With the development of novel high-throughput techniques, en...
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The Area Under the ROC Curve (AUC) is a well-known metric for evaluating instance-level long-tail learning problems. In the past two decades, many AUC optimization methods have been proposed to improve model performan...
Non-small cell lung cancer (NSCLC) is a malignant tumor, and contains three major subtypes which are difficult to be distinguished at early stages of NSCLC. Many pathways work together to perform certain functions in ...
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ISBN:
(纸本)9781509016129
Non-small cell lung cancer (NSCLC) is a malignant tumor, and contains three major subtypes which are difficult to be distinguished at early stages of NSCLC. Many pathways work together to perform certain functions in cells. One might expect the high level of co-appearance or repression of pathways to distinguish different subtypes of NSCLC. However, it is difficult to detect coordinated regulations of pathways by existing methods. In our work, the coordinated regulations of pathways are detected using modified higher logic analysis of gene expression data. Specifically, we identify the genes whose regulation obeys a logic function by the modified higher logic analysis, which focuses on the relationships among the gene triplets that are not evident when genes are examined in a pairwise fashion. Then, the relationships among genes are mapped to pathways to predict the coordinated regulated relationships among pathways. By comparing coordinated regulations of pathways, we find that the regulation patterns of pathways which are associated with cell death are different in three subtypes of NSCLC. This method allows us to uncover co-appearance or repression of pathways in high level, and it has a potential to distinguish the subtypes for complex diseases.
This paper proposes a novel bandpass filter for L-band based on CRLH TL, which is mainly formed by coupling a high-pass characteristic module with a low-pass characteristic module in a cascade. The high-pass module co...
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Recently, more and more approaches are emerging to solve the cross-view matching problem where reference samples and query samples are from different views. In this paper, inspired by Graph Embedding, we propose a uni...
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Block transform coding using discrete cosine transform is the most popular approach for image compression. However, many annoying blocking artifacts are generated due to coarse quantization on transform coefficients i...
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Engineering optimization in the intelligence swarm remains to be a challenge. Recently, a novel optimization method based on number-theory and particle swarm, good lattice swarm optimization algorithm(GLSO), is introd...
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Engineering optimization in the intelligence swarm remains to be a challenge. Recently, a novel optimization method based on number-theory and particle swarm, good lattice swarm optimization algorithm(GLSO), is introduced, which intends to produce faster and better global search ability and more accurate convergence because it has a solid theoretical basis. In this paper, four models of constructing good point set are introduced and the GLSO based on new models is rewritten. Some applications of the new model on constrained engineering via employing a penalty function approach suggest that the presented algorithm is potentially a powerful search technique for solving complex engineering design optimization problems.
PLSA(Probabilistic Latent Semantic Analysis) is a popular topic modeling technique for exploring document collections. Due to the increasing prevalence of large datasets, there is a need to improve the scalab.lity of ...
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World Wide Web has developed to an inherently distributed information system,which brings people great trouble in finding needed information although huge amount of information availab.e on the *** search engine is a ...
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World Wide Web has developed to an inherently distributed information system,which brings people great trouble in finding needed information although huge amount of information availab.e on the *** search engine is a very important tool for people to obtain information on the webs,but the low-precision and low-recall exist widely in current search *** effective and accurate intelligent search engine based on the expert systems technology has become the most important research *** paper analyzes the WWW with different granularities according to quotient space theory,gives summarization of search engine and describes an expert system built by Visual Prolog.
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