The rapid developments of chip-based technology have greatly improved human genetics and made routine the access of thousands of single nucleotide polymorphisms (SNPs) contributing to an informatics challenge. The cha...
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ISBN:
(纸本)9781450328104
The rapid developments of chip-based technology have greatly improved human genetics and made routine the access of thousands of single nucleotide polymorphisms (SNPs) contributing to an informatics challenge. The characterization and interpretation of genes and gene-gene interactions that affect the susceptibility of common, complex multifactorial diseases is a computational and statistical challenge in genome-wide association studies (GWAS). Various methods have been proposed, but they have dificulty to be directly applied to GWAS caused by excessive search space and intensive computational burden. In this paper, we propose an ant colony optimization (ACO) based algorithm by combining the pheromone updating rule with the heuristic information. We tested power performance of our algorithm by conducting suficient experiments including a wide range of simulated datasets experiments and a real genome-wide dataset experiment. Experimental results demonstrate that our algorithm is time efficient and gain good performance in the term of the power of prediction accuracy. Copyright 2014 ACM.
Dynamic Bayesian Network (DBN) is a graphical model for representing temporal stochastic processes. Learning the structure of DBN is a fundamental step for parameter learning, inference and application. For large scal...
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The past decade has witnessed the rapid development of search engines, which has become an indispensable part of everyday life. However, people are no longer satisfied with accessing to ordinary information, and they ...
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Extensive studies have shown that many complex diseases are influenced by interaction of certain genes, while due to the limitations and drawbacks of adopting logistic regression (LR) to detect epistasis in human Geno...
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The workflow model is the abstract expression of the workflow or the business process. Following the WfMC reference model, a PKI-based lightweight workflow model named as PBLW is put forward in this paper. The framewo...
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Fabric pattern is a folk art of artificial fabrics pattern design which includes apparels (known as clothes and hats), and crafts (known as carpets and tapestries). Although image processing, information retrieval and...
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Gabor filters are generally regarded as the most bionic filters corresponding to the visual perception of human. Their filtered coefficients thus are widely utilized to represent the texture information of irises. How...
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Gabor filters are generally regarded as the most bionic filters corresponding to the visual perception of human. Their filtered coefficients thus are widely utilized to represent the texture information of irises. However, these wavelet-based iris representations are inevitably being misaligned in iris matching stage. In this paper, we try to improve the characteristics of bionic Gabor representations of each iris via combining the local Gabor features and the key-point descriptors of Scale Invariant Feature Transformation (SIFT), which respectively simulate the process of visual object class recognition in frequency and spatial domains. A localized approach of Gabor features is used to avoid the blocking effect in the process of image division, meanwhile a SIFT key point selection strategy is provided to remove the noises and probable misaligned key points. For the combination of these iris features, we propose a support vector regression based fusion rule, which may fuse their matching scores to a scalar score to make classification decision. The experiments on three public and self-developed iris datasets validate the discriminative ability of our multiple bionic iris features, and also demonstrate that the fusion system outperforms some state-of-the-art methods.
Untraceability is an important aspect of RFID security. A BRS-based approach for modeling RFID untraceability is provided in this paper. Elements in a RFID protocol can be represented as bigraphs, communications betwe...
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Untraceability is an important aspect of RFID security. A BRS-based approach for modeling RFID untraceability is provided in this paper. Elements in a RFID protocol can be represented as bigraphs, communications between elements can be represented as reaction rules. RFID untraceability can be represented as behavioral congruences. We take a RFID air interface protocol as a case study and show the usability of this approach.
A novel dynamic time delay neural network is proposed for ultrasonic motors identification and control in this paper. By introducing time delay neurons, the neural network identifier and controller of ultrasonic motor...
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The deconvolution of infiltrating immune cells and stromal cells from complex tumor tissues is significant for studying the impact of these cells on tumor development, as well as assisting cancer therapies. Integratin...
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ISBN:
(纸本)9781665429825
The deconvolution of infiltrating immune cells and stromal cells from complex tumor tissues is significant for studying the impact of these cells on tumor development, as well as assisting cancer therapies. Integrating cell-specific marker genes from several references, we put forward an AutoEncoder-based matrix factorization method to estimate the cell proportion in heterogeneous samples. The proportion predicted by our method achieved over 0.95 Pearson correlation coefficient (PCC) with the ground truth. Moreover, through analyzing association between cell proportion of tumor tissues and clinical information of the tumor patients, we found that the proportion of cancer-associated fibroblast (CAF) gradually increased with the progress of tumor, and the proportion of B cell in tissues was significantly related to the five-year survival rate of tumor patients.
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