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Z16b,a natural compound from Ganoderma cochlear is a novel RyR2 stabilizer preventing catecholaminergic polymorphic ventricular tachycardia

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中国药理学报（英文版） 2022年第9期43卷 2340-2350页

作者： Jiang-fan Wan Gang Wang Fu-ying Qin Dan-ling Huang Yan Wang Ai-ling Su Hai-ping Zhang Yang Liu Shao-yin Zeng Chao-liang Wei Yong-xian Cheng Jie Liu Guangdong Key Laboratory of Genome Stability and Human Disease Prevention Department of PathophysiologySchool of MedicineShenzhen UniversityShenzhen 518000China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China Guangdong Key Laboratory of Genome Stability and Human Disease Prevention Department of PathophysiologySchool of MedicineShenzhen UniversityShenzhen 518000China School of Pharmaceutical Sciences Shenzhen University Health Science CenterShenzhen 518000China Center for Translation Medicine Research and Development Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518000China Center for High Performance Computing Joint Engineering Research Center for Health Big Data Intelligent Analysis TechnologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518000China Guangdong Cardiovascular Institute Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510000China Guangdong Provincial key laboratory of South China Structure Heart Disease Department of Pediatric CardiologyGuangdong Cardiovascular InstituteGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510000China

Catecholaminergic polymorphic ventricular tachycardia(CPVT)is an inherited,lethal ventricular arrhythmia triggered by *** in genes that encode cardiac ryanodine receptor(RyR2)and proteins that regulate RyR2 activity cause enhanced diastolic Ca2+release(leak)through the RyR2 channels,resulting in *** therapies for CPVT are *** found that Z16b,a meroterpenoid isolated from Ganoderma cochlear,inhibited Ca2+spark frequency(CaSF)in R2474S/+cardiomyocytes in a dose-dependent manner,with an IC50 of 3.2 μM.Z16b also dose-dependently suppressed abnormal post-pacing Ca2+release *** injection(i.p.)of epinephrine and caffeine stimulated sustained ventricular tachycardia in all R2474S/+mice,while pretreatment with Z16b(0.5 mg/kg,i.p.)prevented ventricular arrhythmia in 9 of 10 mice,and Z16b administration immediately after the onset of VT abolished sVT in 9 of 12 *** translational significance,Z16b significantly inhibited CaSF and abnormal Ca2+release events in human CPVT ***,Z16b interacts with RyR2,enhancing the"zipping"state of the N-terminal and central domains of RyR2.A molecular docking simulation and point mutation and pulldown assays identified Z16b forms hydrogen bonds with Arg626,His1670,and Gln2126 in RyR2 as a triangle shape that anchors the NTD and CD interaction and thus stabilizes RyR2 in a tight"zipping"*** findings support that Z16b is a novel RyR2 stabilizer that can prevent *** may also serve as a lead compound with a new scaffold for the design of safer and more efficient drugs for treating CPVT.

关键词： arrhythmia catecholaminergic polymorphic ventricular tachycardia natural product ryanodine receptor induced pluripotent stem cell-derived cardiomyocytes

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Research on the optimization of blanking process for the circuit breaker positioning plate

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Engineering Letters 2021年第4期29卷 1585-1594页

作者： Zheng, Qingchun Liu, Jiaqi Liu, Jingna Zhu, Peihao Ma, Wenpeng Gao, Zhongyu Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control School of Mechanical Engineering Tianjin University of Technology Tianjin300384 China

This paper, through the theory of multi-objective parameter optimization, the finite-element analysis and central composite test of the blanking process of the locating plate of the breaker are carried out. The optimal blanking process parameters of the positioning plate of the circuit breaker are determined, and the influence laws of the independent variable blanking gap, the punch edge radius and the blanking speed on the maximum blanking force and the length of the bright belt are obtained. The experimental results show that the production efficiency of the positioning plate of the circuit breaker is increased by 25%, and the actual machining error is only 4%, which provides a certain guiding significance for optimizing the blanking process parameters. © 2021, International Association of Engineers. All rights reserved.

关键词： Multiobjective optimization

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The polishing surface quality of single crystal diamond with GO green-enhanced diamond hybrid slurry and material removal mechanism analysis

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Wear 2025年 574-575卷

作者： Wang, Zixuan Hou, Xueyan Zhao, Ji Yao, Jie Yu, Tianbiao Qu, Sheng Zhao, Jun School of Mechanical Engineering and Automation Northeastern University Shenyang110819 China Liaoning Provincial Key Laboratory of High-end Equipment Intelligent Design and Manufacturing Technology Shenyang110819 China School of Physics Liaoning University Shenyang110036 China School of Mechanical Engineering Shenyang University of Technology Shenyang110870 China School of Advanced Manufacturing Sun Yat-sen University Shenzhen518107 China

Single crystal diamonds, which have extremely high hardness and brittleness, can provide lower power consumption and higher frequencies for electronic devices compared with other semiconductor materials. The chemical mechanical polishing method is usually used to realize the flattening of single crystal diamond workpiece. However, the conventional oxidants may cause damage to polishing tools and experimental equipment, and even lead to environmental pollution. Therefore, a graphene oxide green-enhanced diamond hybrid slurry was introduced in this study for single crystal diamond polishing with quartz glass as a polishing disk. The effect of graphene oxide on polishing surface quality was analyzed, and the polishing experiments were carried out with different polishing pressures and durations to investigate the influence of varying process parameters. The molecular dynamics method was used to simulate the formation and removal process of graphene oxide-induced degraded layer on single crystal diamond surface. The scratched morphologies on single crystal diamond surfaces were obtained, and the amorphization degree was analyzed to reveal the subsurface damage mechanism. The simulation shows that the oxygen-containing functional groups from graphene oxide chemically react with the carbon atoms on the single crystal diamond surface, removing in the form of CO, CO2, or adhering to the abrasive grains. Also, the chemical adsorption reduced the activation energy of carbon atoms in single crystal diamond, and made it more loosely arranged and easier to be removed by mechanical scratching, which explained the experimental results. © 2025 Elsevier B.V.

关键词： Single crystals

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A Tendon-Driven Actuator with Cantilever Initiated Variable Stiffness Used for Robotic Fingers

SSRN

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SSRN 2024年

作者： Li, Chenning Yang, Shangkui Branson, David T. Song, Zhibin Sun, Tao Dai, Jiansheng Kang, Rongjie Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education School of Mechanical Engineering Tianjin University Tianjin300072 China Advanced Manufacturing Technology Research Group Faculty of Engineering University of Nottingham NottinghamNG7 2RD United Kingdom Beijing Institute of Technology China Shenzhen Key Laboratory of Intelligent Robotics and Flexible Manufacturing Systems Southern University of Science and Technology Shenzhen518055 China

Variable stiffness actuators (VSAs) have emerged as a key actuation technology known for their bionic performance and task adaptability. However, current VSAs often exhibit relatively large sizes, making them possible for use in robotic arms and legs but less convenient for integrations into robotic hands. This paper introduces a compact design of a tendon-driven variable stiffness actuator (TVSA) based on an adjustable cantilever mechanism, which can be embedded into a robotic finger. This implementation endows the robotic finger with the decoupled regulation of joint position and stiffness. A concise and computationally efficient stiffness mapping model from the TVSA to the finger joints is then established, providing a theoretical foundation for the stiffness regulation of the tendon-driven fingers. A prototype of a robotic hand equipped with the presented TVSA demonstrates safe interactions with various objects with diverse shapes, weights and stiffness. © 2024, The Authors. All rights reserved.

关键词： Stiffness

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Acoustic scene classification by enhanced high- frequency weak signal characteristic spectrum 8

Acoustic scene classification by enhanced high- frequency we...

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8th International Conference on computing and Pattern Recognition, ICCPR 2019

作者： Hao, Wenjie Zhao, Lasheng Zhang, Qiang Key Laboratory of Advanced Design Intelligent Computing Ministry of Education Dalian University China

ISBN: (纸本)9781450376570

In the acoustic scene classification task, the method of using melspectrogram to express the acoustic scene information is widely applied. However, mel-spectrogram has defects and it ignores important information about some acoustic scenes. The paper improves the mel-spectrogram and its generation algorithm. Including: I. For the sensitivity of the acoustic scene to highfrequency acoustic signals, the paper changes the filter design method of Mel Frequency Cepstrum Coefficient (MFCC). This method preserves more high frequency information by applying the equal-height triangular filter banks and increasing the number of the filters. II. Based on the previous step, an enhancement algorithm is proposed for the problem of the lack of highfrequency weak signals in the characteristic spectrum. The algorithm performs nonlinear mapping on the mel-spectrogram, which makes the transformed high-frequency weak signal feature information more obvious. The algorithm is verified by DCASE 2018 acoustic scene classification dataset and LITIS ROUEN dataset. The experimental results demonstrate the effectiveness of the proposed algorithm. © 2019 Association for computing Machinery.

关键词： Spectrographs

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Convolutional neural network-assisted recognition of nanoscale L1_(2) ordered structures in face-centred cubic alloys

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npj Computational Materials 2021年第1期7卷 60-68页

作者： Yue Li Xuyang Zhou Timoteo Colnaghi Ye Wei Andreas Marek Hongxiang Li Stefan Bauer Markus Rampp Leigh T.Stephenson Max-Planck Institut für Eisenforschung GmbH Max-Planck-Straße 140237 DüsseldorfGermany Max Planck Computing and Data Facility Gießenbachstraße 285748 GarchingGermany State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing100083 BeijingChina Max Planck Institute for Intelligent Systems Max-Planck-Ring 472076 TübingenGermany

Nanoscale L12-type ordered structures are widely used in face-centered cubic(FCC)alloys to exploit their hardening capacity and thereby improve mechanical *** fine-scale particles are typically fully coherent with matrix with the same atomic configuration disregarding chemical species,which makes them challenging to be *** distribution maps(SDMs)are used to probe local order by interrogating the three-dimensional(3D)distribution of atoms within reconstructed atom probe tomography(APT)***,it is almost impossible to manually analyze the complete point cloud(>10 million)in search for the partial crystallographic information retained within the ***,we proposed an intelligent L1_(2)-ordered structure recognition method based on convolutional neural networks(CNNs).The SDMs of a simulated L1_(2)-ordered structure and the FCC matrix were firstly *** simulated images combined with a small amount of experimental data were used to train a CNN-based L1_(2)-ordered structure recognition ***,the approach was successfully applied to reveal the 3D distribution of L1_(2)–typeδ′–Al3(LiMg)nanoparticles with an average radius of 2.54 nm in a FCC Al-Li-Mg *** minimum radius of detectable nanodomain is even down to 5Å.The proposed CNN-APT method is promising to be extended to recognize other nanoscale ordered structures and even more-challenging short-range ordered phenomena in the near future.

关键词： alloys ordered cubic

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Robust H Sliding Mode Controller design of a Class of Time-Delayed Discrete Conic-Type Nonlinear Systems

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IEEE Transactions on Systems, Man, and Cybernetics: Systems 2021年第2期51卷 885-892页

作者： He, Shuping Lyu, Weizhi Liu, Fei Key Laboratory of Intelligent Computing and Signal Processing Ministry of Education Anhui University Hefei China Key Laboratory of Advanced Process Control for Light Industry Ministry of Education Jiangnan University Wuxi China

This paper studies the {H}_{ {\infty }} sliding mode control (SMC) problem for a class of discrete-time conic-type nonlinear systems with time-delays and uncertainties. The nonlinear terms satisfy the conic-type constraint condition that lies in a know hyper-sphere with an uncertain center. By choosing a proper Lyapunov candidate, sufficient conditions are derived to ensure the asymptotic stability of the sliding mode dynamics while achieving a prescribed {H}_{ {\infty }} disturbance attenuation level and finally converted into a minimization problem. The controller is constructed to guarantee the discrete-time reach condition and maintain the states on the prespecified sliding surface. A simulation result and a practical example related to the Chua's circuit are given at last to show the validity of our SMC strategy. © 2013 IEEE.

关键词： Time delay

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Exploration and Practice of Hierarchical Graduation Project under the Background of Science Collaborative Education and Engineering Education Accreditation 21

Exploration and Practice of Hierarchical Graduation Project ...

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Proceedings of the 5th International Conference on Advances in Artificial Intelligence

作者： Lilan Gao Yansong Tan Yanfang Sun Linwei Lv Bin Li Qijun Gao Xiaofei Wang Yijiao Zhao School of Mechanical Engineering_Tianjin Key Laboratory for Advanced Mechatronic System Design and intelligent Control_National Demonstration Center for Experimental Mechanical and Electrical Engineering Education Tianjin University of Technology China School of Mechanical Engineering_Tianjin Key Laboratory for Advanced Mechatronic System Design and intelligent Control Tianjin University of Technology China National Demonstration Center for Experimental Mechanical and Electrical Engineering Education Tianjin University of Technology China

ISBN: (纸本)9781450390699

Graduation project is an important integrated practice segment for undergraduate education, since the quality of undergraduate education can be directly evaluated by the quality of graduation project. Under the background of science collaborative education and engineering education accreditation, it is necessary to explore an intelligent and integrated graduation project system to train students by all sorts of engineering and research projects, thus improve students' practical ability and innovation ability. This paper first analyzed the problems of the graduation project in the major of process equipment and control engineering, then introduced a novel hierarchical graduation project system to adapt to the concept of science collaborative education and engineering education. By putting the novel graduation project system into effect, the quality of graduation project has significantly improved.

关键词： Science collaborative education Hierarchical graduation project Engineering education accreditation Education reform

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Structural Optimization of a Magnetically Operated Actuator Mechanism for 10kV Circuit Breaker

Structural Optimization of a Magnetically Operated Actuator ...

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System Simulation Technology and its Application (CCSSTA), IEEE China Conference on

作者： Chao Liang He Tian Guanqiao Zhao Jiangping Li Ziliang Zhu Ruixuan Shen Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control School of Mechanical Engineering Tianjin University of Technology Tianjin China National Demonstration Center for Experimental Mechanical and Electrical Engineering Education (Tianjin University of Technology) Tianjin China Tianjin Sanyuan Power Equipment Manufacturing Co. Ltd Tianjin China

ISBN: (数字)9798350366600

ISBN: (纸本)9798350366617

As the demand for reliable power supply in power systems grows, ensuring the performance of circuit breaker operating mechanisms is crucial. This performance is pivotal to the stability of the power grid, the speed of fault recovery, and the equipment’s lifespan. In this paper, we introduce a structural optimization plan for a new magnetic control operating mechanism designed for 10kV circuit breakers. Employing three-dimensional and mathematical modeling, complemented by finite element analysis with Maxwell software, we delved into an in-depth study of the mechanism’s structure, performance, and materials. We further conducted a parametric design and comparative analysis of key components. The simulation results, which exclude the spring load, demonstrate that the optimized circuit breaker can achieve a closing velocity of 3.07 m/s, an electromagnetic force peaking at 2.7 kN, and a closure time minimized to 8.5 ms. These enhancements notably improve the mechanism’s closing efficiency. Consequently, our research introduces a novel perspective to the field of reliability studies for magnetic control operating mechanisms.

关键词： Magnetic cores Circuit breakers Magnetic domains Power system stability Power system reliability Magnetic analysis Magnetosphere Integrated circuit reliability Magnetic circuits Optimization

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Simultaneous Q-Space Sampling Optimization and Reconstruction for Fast and High-Fidelity Diffusion Magnetic Resonance Imaging

Simultaneous Q-Space Sampling Optimization and Reconstructio...

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IEEE International Symposium on Biomedical Imaging

作者： Jing Yang Jian Cheng Cheng Li Wenxin Fan Juan Zou Ruoyou Wu Qiegen Liu Hairong Zheng Shanshan Wang Paul C. Lauterbur Research Center for Biomedical Imaging Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen China University of Chinese Academy of Sciences Beijing China State Key Laboratory of Software Development Environment Beihang University Beijing China Key Laboratory of Data Science and Intelligent Computing Institute of International Innovation Beihang University Hangzhou China Department of Electronic Information Engineering Nanchang University Nanchang China

ISBN: (数字)9798350313338

ISBN: (纸本)9798350313345

Diffusion Magnetic Resonance Imaging (dMRI) plays a crucial role in the noninvasive investigation of tissue microstructural properties and structural connectivity in the in vivo human brain. However, to effectively capture the intricate characteristics of water diffusion at various directions and scales, it is important to employ comprehensive q-space sampling. Unfortunately, this requirement leads to long scan times, limiting the clinical applicability of dMRI. To address this challenge, we propose SSOR, a Simultaneous q-Space sampling Optimization and Reconstruction framework. We jointly optimize a subset of q-space samples using a continuous representation of spherical harmonic functions and a reconstruction network. Additionally, we integrate the unique properties of diffusion magnetic resonance imaging (dMRI) in both the q-space and image domains by applying l1-norm and total-variation *** experiments conducted on HCP data demonstrate that SSOR has promising strengths both quantitatively and qualitatively and exhibits robustness to noise.

关键词： Water In vivo Limiting Magnetic resonance imaging Harmonic analysis Robustness Image reconstruction

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