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Photodynamic therapy-triggered on-demand drug release from ROS-responsive core-cross-linked micelles toward synergistic anti-cancer treatment

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Nano Research 2019年第5期12卷 999-1008页

作者： Yongjuan Li Jian Hu Xun Liu Yong Liu Shixian Lv Juanjuan Dang Yong Ji Jinlin He Lichen Yin Institute of Functional Nano and Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123China College of Chemistry Chemical Engineering and Materials ScienceSuzhou Key Laboratory of Macromolecular Design and Precision SynthesisJiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationSoochow UniversitySuzhou 215123China Department of Biomedical Engineering University of Groningen and University Medical Center GroningenAntonius Deusinglaan 19713 AV Groningen The Netherlands Department of Cardiothoracic Surgery Wuxi Peoples Hospital Affiliated to Nanjing Medical UniversityWuxi 214023China

polymeric micelles have demonstrated wide utility for chemodrug delivery,which however,still suffer from shortcomings such as undesired drug loading,disassembly upon dilution,pre-leakage of drug cargoes during systemic circulation,and lack of cancer-selective drug ***,a poly(ethylene glycol)(PEG)-polyphosphoester-based,reactive oxygen species (ROS)-responsive,core-cross-linked (CCL) micellar system was developed to encapsulate both chemodrug (doxorubicin,Dox) and photosensitizer (chlorin e6,Ce6).The hydrophobic core of the micelles was cross-linked via a thioketal (TK)-containing linker,which notably enhanced the drug loading and micelle *** tumor cells,far-red light irradiation of Ce6 generated ROS to cleave the TK linkers and disrupt the micelle *** such,micelles were destabilized and Dox release was promoted,which thereafter imparted synergistic anti-cancer effect with ROS-mediated photodynamic *** study provides an effective approach to realize the precise control over drug loading,formulation stability,and cancer-selective drug release using polymeric micelles,and would render promising utilities for the programmed anti-cancer combination therapy.

关键词： core-cross-linked micelles on-demand drug release photodynamic therapy reactive oxygen species (ROS) responsiveness synergistic an ti-cancer therapy

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Stepwise 3D-spatio-temporal magnesium cationic niche: Nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification

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Bioactive Materials 2021年第2期6卷 503-519页

作者： Jie Shen Bo Chen Xinyun Zhai Wei Qiao Shuilin Wu Xuanyong Liu Ying Zhao Changshun Ruan Haobo Pan Paul K.Chu Kenneth M.C.Cheung Kelvin W.K.Yeung Department of Orthopaedics and Traumatology The University of Hong KongHong KongChina Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma Department of Orthopaedics and Traumatologythe University of Hong Kong-Shenzhen HospitalShenzhenChina Shanghai Institute of Traumatology and Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesRuijin HospitalSchool of MedicineShanghai Jiaotong UniversityShanghaiChina School of Materials Science and Engineering Nankai UniversityTianjinChina School of Materials Science&Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin UniversityTianjinChina Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials Science&EngineeringHubei UniversityWuhanChina State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghaiChina Cixi Center of Biomaterials Surface Engineering Shanghai Institute of CeramicsChinese Academy of SciencesNingboChina Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenChina Department of Physics Department of Materials Science&Engineeringand Department of Biomedical EngineeringCity University of Hong KongHong KongChina

The fate of cells and subsequent bone regeneration is highly correlated with temporospatial coordination of chemical,biological,or physical cues within a local tissue *** understanding of how mammalian cells react to local tissue microenvironment is paramount important when designing next generation of biomaterials for tissue *** study aims to investigate that the regulation of magnesium cationic(Mg^2+)tissue microenvironment is able to convince early-stage bone regeneration and its mechanism undergoes intramembranous *** was discovered that moderate Mg^2+content niche(~4.11 mM)led to superior bone regeneration,while Mg^2+-free and strong Mg^2+content(~16.44 mM)discouraged cell adhesion,proliferation and osteogenic differentiation,thereby bone formation was rarely *** magnesium ions diffused into free Mg zone from concentrated zone in late time point,new bone formation on free Mg zone became significant through intramembranous *** study successfully demonstrates that magnesium cationic microenvironment serves as an effective biochemical cue and is able to modulate the process of bony tissue *** knowledge of how a Mg^2+cationic microenvironment intertwines with cells and subsequent bone formation gained from this study may provide a new insight to develop the next generation of tissuerepairing biomaterials.

关键词： Nanocomposite Magnesium ion Microenvironment 3D scaffold Bone tissue regeneration

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In Situ Controlled Construction of a Hierarchical Supramolecular Chiral Liquid-Crystalline polymer Assembly

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advanced Materials 2020年第24期132卷 9756-9764页

作者： Cheng, Xiaoxiao Miao, Tengfei Yin, Lu Ji, Yujin Li, Youyong Zhang, Zhengbiao Zhang, Wei Zhu, Xiulin State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou215123 China Soochow University Suzhou215123 China

Hierarchical supramolecular chiral liquid-crystalline (LC) polymer assemblies are challenging to construct in situ in a controlled manner. Now, polymerization-induced chiral self-assembly (PICSA) is reported. Hierarchical supramolecular chiral azobenzene-containing block copolymer (Azo-BCP) assemblies were constructed with π–π stacking interactions occurring in the layered structure of Azo smectic phases. The evolution of chirality from terminal alkyl chain to Azo mesogen building blocks and further induction of supramolecular chirality in LC BCPassemblies during PICSA is achieved. Morphologies such as spheres, worms, helical fibers, lamellae, and vesicles were observed. The morphological transition had a crucial effect on the chiral expression of Azo-BCP assemblies. The supramolecular chirality of Azo- BCP assemblies destroyed by 365 nm UV irradiation can be recovered by heating–cooling treatment;this dynamic reversible achiral–chiral switching can be repeated at least five times. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

关键词： Azobenzene

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Correction: Construction of perfluorohexane/IR780@liposome coating on Ti for rapid bacteria killing under permeable near infrared light

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Biomaterials science 2023年第15期11卷 5347-5348页

作者： Xiuhua Wang Lei Tan Xiangmei Liu Zhenduo Cui Xianjin Yang Kelvin W K Yeung Paul K Chu Shuilin Wu Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer Materials School of Materials Science & Engineering Hubei University Wuhan 430062 China. School of Materials Science & Engineering Tianjin University Tianjin 300072 China. shuilin.wu@***. Department of Orthopaedics & Traumatology Li KaShing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong 999077 China. Department of Physics and Department of Materials Science and Engineering City University of Hong Kong Tat Chee Avenue Kowloon Hong Kong 999077 China.

Correction for 'Construction of perfluorohexane/IR780@liposome coating on Ti for rapid bacteria killing under permeable near infrared light' by Xiuhua Wang , , 2018, , 2460-2471, https://***/10.1039/C8BM00602D.

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Nano-sheet stacked flower-like MoO₂ with synergistic adsorption-catalysis for wide-temperature lithium-sulfur batteries

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Electrochimica Acta 2025年 535卷

作者： Cheng-Wei Zhu Hai Huang Jin Wei Yan Yu-Han Yuan Ye Zeng Gui-Fang Li Jian-Chun Weng Xiao-Hong Fan Yi Li Qi-Hui Wu Ding-Rong Deng Jimei University College of Marine Equipment and Mechanical Engineering Key Laboratory of Energy Cleaning Utilization Development Cleaning Combustion and Energy Utilization Research Center of Fujian Province Xiamen Key Laboratory of Marine Corrosion and Smart Protective Materials Xiamen Fujian 361021 China Jiangsu Key Lab of Advanced Functional Polymer Design and Application Department of Polymer Science and Engineering College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 China

Li-S batteries have been regarded as future energy storage solutions due to their high theoretical energy density and eco-friendliness. However, practical uses face obstacles such as the polysulfide shuttle effect and slow reaction rates at extreme temperatures. In this research, dendritic assembly MoO₂ nanosheets (DA-MoO₂) with flower-like structures were produced through a two-step solvothermal method and assessed as sulfur host materials for Li-S batteries. The hierarchical structure of DA-MoO₂ resulted in a large specific surface area (216.92 m² g -1 ) and numerous mesopores (3–4 nm), significantly enhancing polysulfide adsorption capability to mitigate the shuttle effect. This architectural design successfully reduces irreversible capacity loss due to intense shuttle effect at high temperatures while enhancing sulfur usage. Moreover, the plentiful catalytic active sites in DA-MoO₂ enhance slow redox reaction kinetics at low temperatures, allowing Li-S batteries to perform well across a wide temperature range. According to electrochemical evaluations, DA-MoO₂ maintains excellent functionality in severe environments: After 100 cycles, it holds a capacity of 542 mAh g⁻¹ at –20 °C and a 1C rate, and it could potentially perform well at -40 °C. At room temperature (2C), the capacity decreases by only 0.06 % per cycle across 300 cycles. Interestingly, the electrode maintains a steady capacity of 1161.05 mAh g⁻¹ at 60 °C and 2C rate, with a low decay rate of 0.019 % per cycle. These outcomes provide a feasible approach for wide-temperature-range energy storage applications, greatly outperforming the performance of traditional Super P and pure MoO₂ electrodes. DA-MoO₂ is positioned as a promising contender for enhanced Li-S battery systems operating under challenging environmental circumstances due to the synergistic integration of structural benefits and catalytic performance.

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Heteroatom Substitution Strategy Modulates Thermodynamics Towards Chemically Recyclable Polyesters and Monomeric Unit Sequence by Temperature Switching

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Angewandte Chemie 2024年第24期136卷

作者： Da Zhang Xin Wang Zhengbiao Zhang Nikos Hadjichristidis State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 China State Key Laboratory of Radiation Medicine and Protection Soochow University Suzhou 215123 China Polymer Synthesis Laboratory KAUST Catalysis Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology (KAUST) Thuwal 23955 Saudi Arabia Note: Prof. Nikos Hadjichristidis is an Honorary Visiting Professor at Soochow University.

In this paper, we proposed a heteroatom substitution strategy (HSS) in the δ -valerolactone (VL) system to modulate thermodynamics toward chemically recyclable polyesters. Three VL-based monomers containing different heteroatoms (M 1 (N), M 2 (S), and M 3 (O)), instead of C-5 carbon, were designed and synthesized to verify our proposed HSS. All three monomers undergo organocatalytic living/controlled ROP and controllable depolymerization. Impressively, the resulting P(M 1 ) achieved over 99 % monomer recovery under both mild solution depolymerization and high vacuum pyrolysis conditions without any side reactions, and the recycled monomers can be polymerized again forming new polymers. The systematic study of the relationship between heteroatom substitution and recyclability shows that introducing heteroatoms does change the thermodynamics of the monomers (Δ H p o , Δ S p o and T c values), thereby adjusting the polymerizability and depolymerizability. DFT calculations found that the introduction of heteroatoms adjusts the ring strain by changing the angular strain of the monomers, and the order of their angular strain (M 2 >M 1 >M 3 ) is consistent with the order of the experimentally obtained enthalpy change. Notably, the one-pot/one-step copolymerization of two of each of the three monomers enables the synthesis of sequence-controlled copolymers from gradient to random to block structures, by simply switching the copolymerization temperature.

关键词： heteroatom ring-opening polymerization chemically recyclable sequence-control polyesters

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Corrigendum to “The second network of soft-nanoparticles in linear polymers of the same chemistry” [polymer 283 (2023) 126216]

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polymer 2023年 285卷

作者： Xikai Ouyang Jintian Luo Tao Li Yihui Zhu Wancheng Yu Jinlin He Pengfei Zhang GengXin Liu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Center for Advanced Low-dimension Materials College of Material Science and Engineering Donghua University Shanghai 201620 China School of Chemistry and Chemical Engineering Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province Zhejiang Sci-Tech University Hangzhou 310018 China State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials Soochow University Suzhou 215123 China College of Chemistry Chemical Engineering and Materials Science Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis Soochow University Suzhou Jiangsu 215123 China National Synchrotron Radiation Laboratory Anhui Provincial Engineering Laboratory of Advanced Functional Polymer Film CAS Key Laboratory of Soft Matter Chemistry University of Science and Technology of China Hefei 230026 China

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H-shaped miktobrush copolymer nanoassembly facilitates ultrafast nucleus delivery for multi-stimuli-cooperative tumour suppression

Research Square

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Research Square 2021年

作者： Chen, Huabing Zhang, Miya Dai, Wenxue Yang, Tao Li, Ting Xu, Tao Deng, Yibin Yang, Hong Ke, Hengte Zhao, Youliang State Key Laboratory of Radiation Medicine and Protection Soochow University Suzhou215123 China Jiangsu Key Laboratory of Neuropsychiatric Diseases College of Pharmaceutical Sciences Soochow University Suzhou215123 China Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou215123 China State Key Laboratory of Radiation Medicine and Protection Soochow University Suzhou215123 China Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases College of Pharmaceutical Sciences Soochow University Suzhou215123 China

The potencies of antitumour compounds are often compromised by their restricted subcellular delivery to nucleus, although a variety of smart vehicles have been extensively designed to release drug in endocytic organelles. A major challenge remains in exploring the nanocarriers with robust and spatiotemporal responsiveness for yielding efficient subcellular targeting due to tumour heterogeneity. Herein, we show an H-shaped miktobrush copolymer nanoassembly (NAs) with ultrafast nucleus delivery for multi-stimuli-cooperative suppression against primary and metastatic triple-negative breast cancer (TNBC) models. The micellar NAs display acidity- and glutathione-responsive drug releases through the protonation and disulfide-bridge cleavage, which are further amplified by irreversible photo-controlled oxidation and phase transition in a ratiometric manner, leading to rapid morphological destruction and ultrafast cytoplasmic translocation into the nucleus from the lysosomes in a few minutes. These micellar NAs thus show a distinctly enhanced cooperativity of photochemotherapeutic efficacy through considerable apoptotic behavior, potently suppressing subcutaneous and orthotopic TNBC models, together with enhanced survival rates. Moreover, these NAs yield preferable anti-metastatic efficacy through the inhibition of metastasis-relevant proteins as compared to chemotherapy and surgical resection. These results provide the insight into multi-stimuli-responsive polymers for ultrafast nucleus delivery against aggressive tumours. © 2021, CC BY.

关键词： Chemotherapy

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Ultra-Sensitive Optical Fiber Spr Biosensor for Precise Prostate Cancer Diagnosis by Label-Free Detection of Mirna-21

SSRN

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SSRN 2025年

作者： Wang, Jiale Deng, Minghua Niu, Kunpeng Wang, Chuanquan Wang, Ning Li, Jinhua Xia, Binyun Ding, Liyun Yang, Huan Chen, Xiaohan Zhu, Jiayi National Engineering Research Center of Fiber Optic Sensing Technology and Networks Wuhan University of Technology Wuhan430070 China School of Computer and Information Engineering Hubei Normal University Huangshi China Hubei Optical Fundamental Research Center Wuhan China Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry Key Laboratory for the Green Preparation and Application of Functional Materials Ministry of Education Hubei Key Laboratory of Polymer Materials School of Materials Science and Engineering Hubei University Wuhan430062 China School of Physical Science and Technology Lanzhou University Lanzhou730000 China Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan430030 China

Efficient and rapid identification of miRNA-21 may be conducive to the early diagnosis of prostate cancer. In this work, a label-free and highly sensitive optical fiber Surface Plasmon Resonance (SPR) biosensor was developed for detecting the miRNA-21, which was fabricated simply by coating a layer of Au film and AuNPs onto a multi-mode-single-mode-multi-mode (MSM) optical fiber, and then biofunctionalized with ssDNA enabling the quantification of miRNA-21. The working principle involves initiating the change of the effective refractive index (RI) around the optical fiber's surface, which was caused by nucleic acid hybridization between the ssDNA and the miRNA-21. As a result, the interaction would result in a noticeable shift of the SPR wavelengths in the transmission spectra. In the experiment, a substantial enhancement was exhibited in the RI sensitivity of the optical fiber sensor due to the surface plasmon resonance (SPR) coupling effect of AuNPs and the Au film, measuring approximately 3021.48 nm/RIU. Excitingly, the biosensors, which have a simple composition, were experimentally verified to have an ultra-low limit of detection (LOD) of 10-20 M, significantly lower than current detection methods. And trace miRNA-21 was enabled for detection without RNA amplification. The SPR sensors were also experimentally proved with excellent linearity, specificity and stability. When employed to detect the serum samples, the results indicated that the proposed sensors could brilliantly distinguish clinical patients with and without prostate cancer. Compared to the commonly used PSA quantification in clinical practice, the method developed in this work has higher detection accuracy. The proposed sensing platform processes the merits of simple configuration as well as low cost and may be applied for the precise diagnosis of prostate cancer. © 2025, The Authors. All rights reserved.

关键词： Surface plasmon resonance

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High sensitivity detection of chromate (CrO 4 2− ) ions by using N, P-carbon dot-functionalized solution-gated graphene transistors

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Microchemical Journal 2025年 214卷

作者： Zhanpeng Ren Peng Song Jianying Wang Junqi Dong Tingting Yu Yanzhuo Gou Xianbao Wang Jinhua Li Key Laboratory for the Green Preparation and Application of Functional Materials Ministry of Education Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry Hubei Key Laboratory of Polymer Materials School of New Energy and Electrical Engineering School of Materials Science and Engineering Hubei University Wuhan 430062 PR China

Chromate (CrO 4 2− ) ions, pervasive in industrial effluents and water sources, are potent carcinogens that can cause severe health issues like organ damage and cancer. Conventional detection methods for chromate ions are time-consuming and costly, with limited sensitivity, often failing to detect low concentrations for environmental and health safety. To address these issues, utilizing N and P doped carbon dots (N, P-CDs) as gate electrode probes, we have developed a new solution-gated graphene transistor (SGGT). The N, P-CDs, with a diameter of 4.2 nm, have rich functional groups like amino groups, carboxyl groups, and phosphate groups etc., which show the specific identification of CrO 4 2− ions. The N, P-CDs are anchored onto the gold gate through mercaptoacetic acid (MAA). The CDs-SGGT sensors of CrO 4 2− ions exhibit excellent selectivity, ultra-high sensitivity, and stability. The limit of detection (LOD) of sensors is as low as 2.69 × 10 −19 M, outperforming conventional sensing methods. Furthermore, from 10 −19 to 10 −9 M, the sensors have a broad linear detection range. The N, P-CDs-SGGT sensor’s capability for real-time and real-sample detection of CrO 4 2− ions offers a significant advancement in the field.

关键词： Carbon dots Chromate ions Graphene High selectivity High sensitivity Transistor

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