Stimuli-responsive polymeric aggregates have attracted wide attention due to their multipurpose applications involving the enhanced selectivity and efficiency of drug delivery to targeting sites.1-7 Some dually and mu...
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Stimuli-responsive polymeric aggregates have attracted wide attention due to their multipurpose applications involving the enhanced selectivity and efficiency of drug delivery to targeting sites.1-7 Some dually and multiply stimuli-sensitive copolymers have been synthesized and self-assembled into functional aggregates with great potential in smart release systems,in which various internal and external stimuli have been applied to induce the dissociation or morphology changes of copolymer aggregates and
The ever growing biomedical technology such as regenerative medicine and controlled drug release intimately relies on the development of advancedfunctional biomaterials,among which aliphatic polycarbonates and polype...
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The ever growing biomedical technology such as regenerative medicine and controlled drug release intimately relies on the development of advancedfunctional biomaterials,among which aliphatic polycarbonates and polypeptides due to their excellent biocompatibility and biodegradability have received the most *** the past years,various types of functional polycarbonates and polypeptides
The ever growing biomedical technology such as regenerative medicine and controlled drug release intimately relies on the development of advancedfunctional biomaterials,among which aliphatic polyc
The ever growing biomedical technology such as regenerative medicine and controlled drug release intimately relies on the development of advancedfunctional biomaterials,among which aliphatic polyc
Star-shaped polymers refer to one kind of branched polymer in which multiple linear polymeric chains are attached to a central core1,*** unique chain topology imparts valuable properties dependin
Star-shaped polymers refer to one kind of branched polymer in which multiple linear polymeric chains are attached to a central core1,*** unique chain topology imparts valuable properties dependin
The ＂living＇/controlled radical polymerization （LRP） of styrene （St） at room temperature is rarely reported. In this work, copper（0） （Cu（0））-mediated radical polymerization of St at room temperature was in...
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The ＂living＇/controlled radical polymerization （LRP） of styrene （St） at room temperature is rarely reported. In this work, copper（0） （Cu（0））-mediated radical polymerization of St at room temperature was investigated in detail. Dimethyl sulfoxide （DMSO）, N,N-dimethylformamide （DMF） as well as a binary solvent, tetrahydrofuravdl,l,l,3,3,3-hexafluoro-2- propanol were used as the solvents, respectively. Methyl-2-bromopropionate and ethyl 2-bromoisobutyrate were used as the initiators, respectively. The polymerization proceeded smoothly with moderate conversions at room temperature. It was found that DMF was a good solvent with the essential features of LRP, while DMSO was a poor solvent with uncontrollable molecular weights. Besides, the match among the initiator, solvent and molar ratios of reactants can modulate the livingness of the polymerization, and the proper selection of ligand was also crucial to a controlled process. This work provided a first example of Cu（0）-mediated radical polymerization of St at room temperature, which would enrich and strength the LRP technique.
Star-shaped polymers refer to one kind of branched polymer in which multiple linear polymeric chains are attached to a central core1,*** unique chain topology imparts valuable properties depending critically on the mo...
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Star-shaped polymers refer to one kind of branched polymer in which multiple linear polymeric chains are attached to a central core1,*** unique chain topology imparts valuable properties depending critically on the molecular parameters such as number of arms,molecular weight of each arm,chemical identity of each arm,and *** general,with the growth of living anionic
The current micellar drugs suffer a lot from low in vivo stability,premature drug release,inefficient tumor cell uptake,as well as slow drug release in the tumor site and inside the tumor cells,which would not only gr...
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The current micellar drugs suffer a lot from low in vivo stability,premature drug release,inefficient tumor cell uptake,as well as slow drug release in the tumor site and inside the tumor cells,which would not only greatly reduce their therapeutic efficacy but also induce systemic side ***,we report on cRGD-directed,NIR-responsive and robust AuNR/PEG-PCL hybrid nanoparticles (cRGD-HNs) for targeted chemotherapy of human glioma xenografts in mice [1].
＂Click chemistry＂ is, by definition, a general functionalization methodology （GFM） and its marriage with living anionic polymerization is particularly powerful in precise macromolecular synthesis. This paper repor...
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＂Click chemistry＂ is, by definition, a general functionalization methodology （GFM） and its marriage with living anionic polymerization is particularly powerful in precise macromolecular synthesis. This paper reports the synthesis of a ＂clickable＂ middle-chain azide-functionalized polystyrene （mPS-N3） by anionic polymerization and its application in the preparation of novel shape amphiphiles based on polyhedral oligomeric silsesquioxane （POSS）. The mPS-N3 was synthesized by coupling living poly（styryl）lithium chains （PSLi） with 3-chloropropylmethyldichlorosilane and subsequent nucleophilic substitution of the chloro group in the presence of sodium azide. Excess PSLi was end-capped with ethylene oxide to facilitate its removal by flash chromatography. The raPS-N3 was then derived into a giant lipid-like shape amphiphile in two steps following a sequential ＂click＂ strategy. The copper（I）-catalyzed azide-alkyne cycloaddition between mPS-N3 and alkyne-functionalized vinyl-substituted POSS derivative （VPOSS-alkyne） ensured quantitative ligation to give polystyrene with VPOSS tethered at the middle of the chain （mPS-VPOSS）. The thiol-ene reaction with 1-thioglycerol transforms the vinyl groups on the POSS periphery to hydroxyls, resulting in an amphiphilic shape amphiphile, mPS-DPOSS. This synthetic approach is highly efficient and modular. It demonstrates the ＂click＂ philosophy of facile complex molecule construction from a library of simple building blocks and also suggests that mPS-N3 can be used as a versatile ＂clickable＂ motif in polymer science for the precise synthesis of complex macromolecules.
A series of acceptor-donor-acceptor alternative small molecules were synthesized containing electron-donating central building moieties of phenothiazine, 2,7-carbazole and thieno[3,4-b]thiophene and electron-accepting...
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A series of acceptor-donor-acceptor alternative small molecules were synthesized containing electron-donating central building moieties of phenothiazine, 2,7-carbazole and thieno[3,4-b]thiophene and electron-accepting moie- ties of tetrazine on both sides. The various conformations of the central blocks, with the coplanarity in an order of phenothiazine〈2,7-carbazole〈thieno[3,4-b]thiophene, have an obvious influence on the optical, electrochemical property and the crystallinity of small molecule. In addition, the blend films between small molecule and （6,6）-phenyl-C6rbutyric acid methyl ester offered significantly various morphologies, changing from uniform sur- face to interpenetrated networks. As a result, the bulk heterojunction photovoltaic devices based on the three small molecules provided varied performance, and the highest coplanar molecule based device exhibited the best photo- voltaic performance.
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