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Research Progress of 3D Printing technology for Pharmaceutical Preparation

Recent Patents on Engineering 2024年第2期18卷 127-139页

作者： Tang, Liqiang Xie, Baocheng Key Laboratory of Advanced Manufacturing and Intelligent Technology Harbin University of Science and Technology Ministry of Education Harbin150080 China

Pharmaceutical preparation is a kind of finished pharmaceutical product made by combining raw materials with various auxiliary materials in a certain form. At present, the field of pharmaceutical preparations can meet most drug needs, but there are some limitations. It is difficult to realize the production of personalized preparations. Because 3D printing technology has the ability of precise dose control and flexible shape customization, it can realize precise control of drug dosage, release behavior and local targeting in pharmaceutical preparations. Therefore, in medicine, 3D printing technology is increasingly used in the field of pharmaceutical preparations. 3D printing technology provides an important means for new drug printing and personalized drug customization of pharmaceutical preparations in the medical field. The 3D printing technology of drugs will inject fresh vitality into individualized drug delivery. Therefore, the development trend of 3D printing technology for pharmaceutical preparations has attracted more and more attention. In order to optimize the wide application of 3D printing technology in pharmaceutical preparation, 3D printing technology such as inkjet 3D printing technology, extrusion 3D printing technology and laser 3D printing technology were studied. In this paper, the selection, classification and introduction of 3D printing technology such as inkjet 3D printing technology, extrusion 3D printing technology and laser 3D printing technology in pharmaceutical preparations are reviewed. Through the investigation of various patents of 3D printing technology applied to pharmaceutical preparation in medicine, this paper summarizes and analyzes the main problems of 3D printing technology applied to pharmaceutical preparations, such as printing stability, production quality, etc. In addition, the development trend of 3D printing technology is also discussed. Optimization of various 3D printing technologies applied to pharmaceutical preparati

关键词： Extrusion

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MoS2 synaptic transistor with one-step manufacture

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Science China(Information Sciences) 2025年第1期68卷 357-365页

作者： Yihao GUO Yang WANG Wenjie DENG Yi WU Jingtao LI Kexin LI Yuehui ZHAO Songlin YU Xiaoting WANG Yongzhe ZHANG Hui YAN Key Laboratory of Optoelectronics Technology of Education Ministry of China Faculty of Information TechnologyBeijing University of Technology Key Laboratory of Advanced Functional Materials Ministry of Education Faculty of Materials and ManufacturingBeijing University of Technology The 11th Research Institute of Electronics Technology Group Corporation

The synaptic transistor,which is a neuromorphic device with brain-like functions,has garnered significant attention due to characteristics such as low energy consumption,high integration,multiple functions,and high computational ***,the current synaptic transistor possesses a complicated structure and involves complex manufacturing steps,which is not conducive to low-cost,large-scale bionic ***,we introduce a simple MoS2synaptic transistor exhibiting robust synaptic *** transistor utilizes magnetron sputtering manufacture to combine the process of device metal electrode deposition and the introduction of defect states,which helps streamline the manufacturing process into a single *** long-term potentiation and long-term depression in photoelectric coordination are initially ***,biological functions,such as double pulse facilitation and the transformation behavior of short-term memory to long-term memory,are thoroughly evaluated,along with learning-forgetting-relearning ***,the device exhibits robust synaptic plasticity until incident light angles down to 30° to imitate the multi-to-one axon-cellular ***,a classical simulation of Pavlov's dog conditioned reflex is demonstrated along with the multiview extraction *** experimental results demonstrate a promising synaptic transistor with a simple structure,manufacturing technique,and excellent *** further indicates the potential for large-scale integration of bionic neuromorphic systems.

关键词： process optimization artificial synaptic device one-stepmanufacture synaptic plasticity bionic simulation

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Recent research on magnetic machinery

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Recent Patents on Engineering 2024年第3期18卷 1-12页

作者： Lu, Zikang Xie, Baocheng Key Laboratory of Advanced Manufacturing and Intelligent Technology Ministry of Education Harbin University of Science and Technology Harbin150080 China

As a clean energy source, magnetic energy is a significant power source of mechanical equipment, which affects the direction of control mode and mechanical structure of mechanical equipment. Magnetic machinery is widely used in industrial power systems and automatic control systems as the power source of mechanical equipment transmission parts or actuators. Magnetic machinery is essential to make mechanical equipment easy to control, energy saving and environmental protection, simple structure, and so on. In order to innovate the control mode of mechanical equipment and optimize the types of traditional mechanical systems, magnetic machinery developed magnetic coupling, magnetic gear, magnetic spring, and other magnetic machinery. The characteristics of magnetic machines with different functions are analyzed based on the types of magnetic machines. Therefore, this aspect's development and application are getting more attention in recent years. To innovate the control mode of mechanical equipment and optimize the types of traditional mechanical structures, magnetic types of machinery, such as magnetic coupling, magnetic gear, and magnetic spring, are making continuous progress. New magnetic machines are also being developed. This paper summarizes the typical patents on three kinds of magnetic machinery: Magnetic coupling, magnetic gear and magnetic spring. In addition, the advantages of existing magnetic machinery are summarized, the current situation of magnetic machinery is analyzed, and the development of magnetic machinery is summarized. Through the analysis of enormous patents of magnetic coupling, magnetic gear, and magnetic spring, it is concluded that although there are many kinds of magnetic machinery, there are no systematic and mature design theories and methods. The development trend of magnetic machinery is also discussed. The research on magnetic machinery helps innovate mechanical equipment's control mode and optimize the types of traditional mechanica

关键词： Magnetic couplings

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Tracked robot with underactuated tension-driven RRP transformable mechanism:ideas and design

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Frontiers of Mechanical Engineering 2024年第1期19卷 85-104页

作者： Ran XU Chao LIU School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Key Laboratory of Vehicle Advanced Manufacturing Measuring and Control Technology(Ministry of Education)Beijing Jiaotong UniversityBeijing 100044China

Robots with transformable tracked mechanisms are widely used in complex terrains because of their high adaptability,and many studies on novel locomotion mechanisms have been conducted to make them able to climb higher *** underactuated transformable mechanisms for tracked robots could decrease the number of actuators used while maintaining the flexibility and obstacle-crossing capability of these robots,and increasing their cost ***,the underactuated tracked robots have appreciable research *** this paper,a novel tracked robot with a newly proposed underactuated revolute‒revolute‒prismatic(RRP)transformable mechanism,which is inspired by the sit-up actions of humans,was *** newly proposed tracked robot has only two actuators installed on the track pulleys for moving and does not need extra actuators for ***,it could concentrate the track belt’s tension toward one side,and the unbalanced tension would drive the linkage mechanisms to change its *** this method,the proposed underactuated design could change its external shape to create support points with the terrain and move its center of mass actively at the same time while climbing obstacles or crossing other kinds of terrains,thus greatly improving the climbing capability of the *** geometry and kinematic relationships of the robot and the crossing strategies for three kinds of typical obstacles are *** the basis of such crossing motions,the parameters of links in the robot are designed to make sure the robot has sufficient stability while climbing ***-crossing dynamic simulations were run and analyzed to prove the feasibility of the robot.A prototype was built and *** show that the proposed robot could climb platforms with heights up to 33.3%of the robot’s length or cross gaps with widths up to 43.5%of the robot’s length.

关键词： mechanical design tracked robot underactuated mechanisms RRP mechanism obstacle crossing strategy

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Plasma characteristics and material erosion mechanism in multi-channel wire electrical discharge machining

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Chinese Journal of Aeronautics 2024年第10期37卷 508-525页

作者： Guokang SU Chuanyun ZHANG Junfei LI Xiaolei CHEN Guixian LIU Yongjun ZHANG State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006China Guangdong Key Laboratory of Advanced Manufacturing Technology of Marine Energy Equipment Guangdong University of TechnologyGuangzhou 510006China Guangzhou Key Laboratory of Nontraditional Machining Technology and Equipment Guangdong University of TechnologyGuangzhou 510006China School of Mechanical Engineering Xi’an Technological UniversityXi’an 710021China

Multi-channel wire electrical discharge machining(MC-WEDM)is an advanced and high-efficiency machining technology,but its material erosion mechanism remains *** this study,dual-channel wire electrical discharge machining was utilized as a case study to investigate the impact of the plunging current on both the plasma characteristics and material erosion under complex discharge *** analysis was conducted on the charged particles in the plasma,revealing that the plunging current can influence the trajectory of the plasma by modifying the selfmagnetic *** particle tracking method was employed to simulate the motion of electrons,revealing that in MC-WEDM,electrons exhibited a larger and more uniform *** evolution of the plasma within a single-pulse discharge was observed using high-speed photography technology,and the discharge signals collected from different channels were *** was observed that the plasma in MC-WEDM experienced more intense back-and-forth sweeping on the workpiece surface,facilitating the ejection of molten metal from the molten *** oscillating plasma exhibits a larger processing area and a more uniform distribution of energy,resulting in the formation of larger and shallower discharge ***,the influence of the amplitude and time point of the plunging current on the volume and area of the discharge craters was ***,MC-WEDM significantly reduced the occurrence of holes and micro-cracks and exhibited a thinner recast layer in the continuous discharge experiment.

关键词： Multi-channel WEDM Discharge observation Plunging current Plasma characteristics Material erosion Discharge crater

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A Review on Combined Strategy of Non-invasive Brain Stimulation and Robotic Therapy

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Chinese Journal of Mechanical Engineering 2024年第5期37卷 1-18页

作者： Leiyu Zhang Yawei Chang Feiran Zhang Jianfeng Li Beijing Key Laboratory of Advanced Manufacturing Technology Beijing University of TechnologyBeijing 100124China Wuhan Second Ship Design and Research Institute Wuhan 430064China

Stroke is a major cause of death and disability among adults in China,and an efficient rehabilitation strategy has been an urgent demand for post-stroke *** non-invasive brain stimulation(NBS)can modulate the excitability of the cerebral cortex and provide after-effects apart from immediate effects to regain extremity motor functions,whereas robotic therapy provides high-intensity and long-duration repetitive movements to stimulate the cerebral cortex *** combined strategy of the two techniques is widely regarded as a promising application for stroke patients with *** magnetic stimulation(TMS)and transcranial electrical stimulation(TES)are important methods of *** recovery principles,stimulation parameters,and clinical applications have been *** combined treatments of rTMS/tDCS and robotic therapy are analyzed and discussed to overcome the application barriers of the two *** future development trend and the key technical problems are expounded for the clinical applications.

关键词： Stroke Non-invasive brain stimulation Robotic therapy Combined strategy

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Single-atom Co-N_(4)catalytic sites anchored on N-doped ordered mesoporous carbon for excellent Zn-air batteries

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Journal of Materials Science & technology 2023年第8期139卷 224-231页

作者： Na Li Le Li Jiawei Xia Muhammad Arif Shilong Zhou Fengxiang Yin Guangyu He Haiqun Chen Key Laboratory of Advanced Catalytic Materials and Technology Advanced Catalysis and Green Manufacturing Collaborative Innovation CenterChangzhou UniversityChangzhou 213164China

Developing efficient transition metal-nitrogen-carbon(TM-N-C)catalysts with abundant accessible active sites has been in the limelight in recent years due to their exceptional application potential in Zn-air bat-teries(ZABs).Herein,we report the simple and environmentally-friendly fabrication of a single-atom Co electrocatalyst,Co-SA/N-C_(900),via in-suit pyrolysis of the co-precursor containing sucrose,dicyandiamide,and Co *** Co single atoms coordinated with adjacent N atoms are anchored on the doped ordered mesoporous carbon,generating the atomic Co-N_(4)***-SA/N-C_(900)displays high oxygen reduction reaction(ORR)activity with an onset potential of 0.96 V and a half-wave potential of 0.87 ***,the liquid ZAB with Co-SA/N-C_(900)catalyst exhibits exceptional discharge specific capacity of 706.38 mAh g^(-1),peak power density of 191.11 mW cm^(-2),and excellent stability at high current densities up to 100 mA cm^(-2),surpassing commercial Pt/*** to the density functional theory(DFT)study,the Co-N_(4)moi-ety with graphitic N dopants can decrease the rate-determining step(RDS)energy barrier and thus accel-erate the ORR *** study offers experimental and theoretical guidelines for the rational design of TM-N-C catalysts for practical implementation with notable ORR activity for application in ZABs.

关键词： Single-atom electrocatalyst Co-N_(4)active sites Oxygen reduction reaction Zn-air battery DFT study

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Path Tracking controller Design of Automated Parking Systems via NMPC with an Instructible Solution

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 353-367页

作者： Liang Chen Zhaobo Qin Manjiang Hu Yougang Bian Xiaoyan Peng State Key Laboratory of Advanced Design and Manufacturing Technology for Vehicle College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China Wuxi Intelligent Control Research Institute of Hunan University Wuxi 214115China

Parking difficulties have become a social issue that people have to *** parking system is practicable for quick par operations without a driver which can also greatly reduces the probability of parking *** paper proposes a Lyapunov-based nonlinear model predictive controller embedding an instructable solution which is generated by the modified rear-wheel feedback method(RF-LNMPC)in order to improve the overall path tracking accuracy in parking ***,A discrete-time RF-LNMPC considering the position and attitude of the parking vehicle is proposed to increase the success rate of automated parking ***,the RF-LNMPC problem with a multi-objective cost function is solved by the Interior-Point Optimization,of which the iterative initial values are described as the instructable solutions calculated by combining modified rear-wheel feedback to improve the performance of local optimal ***,the details on the computation of the terminal constraint and terminal cost for the linear time-varying case is *** closed-loop stability is verified via Lyapunov techniques by considering the terminal constraint and terminal cost ***,the proposed RF-LNMPC is implemented on a selfdriving Lincoln MKZ platform and the experiment results have shown improved performance in parallel and vertical parking *** Monte Carlo analysis also demonstrates good stability and repeatability of the proposed method which can be applied in practical use in the near future.

关键词： Automated parking Path tracking controller Nonlinear model predictive control Monte Carlo analysis

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Microscopic strengthening and failure mechanisms of graphene/Al composite: A molecular dynamics study

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Progress in Natural Science:Materials International 2024年第4期34卷 720-730页

作者： Huijuan Guo Xiaoyan Sun Liang Chen Yuhui Zhao Kaiqiang Shen Xiangshan Kong State Key Laboratory of Advanced Equipment and Technology for Metal Forming Shandong University Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education) Shandong University Intelligent Manufacturing Department Yantai Engineering and Technology College

This study focused on the microscopic strengthening and failure mechanisms of the Al matrix reinforced by graphene(Gr), and the effects of number of layers, chirality, and arrangement of Gr were calculated based on the molecular dynamics simulation. The results revealed that the Young's modulus and yield strength were significantly enhanced by the addition of Gr. In Gr/Al composites with monolayer Gr, the zigzag Gr exhibited a better ultimate strain than the armchair Gr, indicating that the plastic deformation was affected by the chirality, and the dislocation hindrance and load transfer were the dominated strengthening mechanisms. The crack in the armchair Gr was limited to follow straight paths, while that in zigzag Gr extended in a petal-like manner across multiple directions. In Gr/Al composite with multilayer Gr, the dispersing Gr showed a stronger strengthening effect than the stacking Gr, and the strengthening effect increased with increasing the volume fraction of Gr. The dispersing Gr strongly hindered the movement of dislocations, while the Al matrix in the composite with stacking Gr could retard the folding of Gr. Moreover, Gr nanosheets fractured layer by layer rather than simultaneously fractured in the Gr/Al composites with multilayer Gr.

关键词： Molecular dynamics Gr/Al composites Strengthening Failure

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Performance Analysis of a Hexagon Rolling Mechanism with Single Degree of Freedom

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Journal of Mechanisms and Robotics 2025年第8期17卷 081001页

作者： Zhang, Qianqian Li, Yezhuo Yan, Shaoze Yao, Yan-An Department of Mechanical Engineering Tsinghua University Beijing100084 China School of Mechanical Electronic and Control Engineering Key Laboratory of Vehicle Advanced Manufacturing Measuring and Control Technology Beijing Jiaotong University Beijing100044 China

This article presents a comprehensive performance analysis of the step-climbing and passive rolling modes of a hexagon rolling mechanism with single-degree-of-freedom, based on its structural characteristics and the constraints of centroid stability. First, a step-climbing model, incorporating motion parameters and support distance parameters, is established by leveraging the symmetrical posture movement characteristics of the hexagon rolling mechanism. Building on this foundation, the impact of each parameter on the mechanism's step-climbing ability is thoroughly analyzed, and the maximum height achievable during step climbing is also examined. Subsequently, the existence and sufficient conditions for the hexagon rolling mechanism to achieve passive rolling are analyzed using the centroid fluctuation curve and its slope curves. The analysis results indicate that, due to its unique coupling structure design, the hexagon rolling mechanism possesses a passive rolling capability that is not available in conventional planar linkage mechanisms. Finally, the correctness of the theoretical model is validated through both simulation and prototype experiments. Copyright © 2025 by ASME.

关键词： Degrees of freedom (mechanics)

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