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Biocompatible chitosan/polyethylene glycol/multi-walled carbon nanotube composite scaffolds for neural tissue engineering

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第1期23卷 58-73页

作者： Shengbo SANG Rong CHENG Yanyan CAO Yayun YAN Zhizhong SHEN Yajing ZHAO Yanqing HAN Shanxi Key Laboratory of Micro Nano Sensors&Artificial Intelligence Perception College of Information and ComputerTaiyuan University of TechnologyTaiyuan030024China Key Lab of Advanced Transducers and Intelligent Control System of the Ministry of Education Taiyuan University of TechnologyTaiyuan030024China College of Information Science and Engineering Hebei North UniversityZhangjiakou075000China Shanxi Six-Dimensional Artificial Intelligence Biomedical Research Institute Taiyuan030031China Department of Neurology Shanxi Provincial Cardiovascular HospitalTaiyuan030024China

Carbon nanotube(CNT)composite materials are very attractive for use in neural tissue engineering and biosensor *** scaffolds are excellent mimics of extracellular matrix due to their hydrophilicity,viscosity,and *** can also impart conductivity to other insulating materials improve mechanical stability guide neuronal cell behavior and trigger axon *** performance of chitosan(CS)/polyethylene glycol(PEG)composite scaffolds could be optimized by introducing multi-walled CNTs(MWCNTs).CS/PEG/CNT composite scaffolds with CNT content of 1%,3%,and 5%(1%=0.01 g/mL)were prepared by *** physical and chemical properties and biocompatibility were *** electron microscopy(SEM)showed that the composite scaffolds had a highly connected porous *** electron microscope(TEM)and Raman spectroscopy proved that the CNTs were well dispersed in the CS/PEG matrix and combined with the CS/PEG nanofiber *** enhanced the elastic modulus of the *** porosity of the scaffolds ranged from 83%to 96%.They reached a stable water swelling state within 24 h,and swelling decreased with increasing MWCNT *** electrical conductivity and cell adhesion rate of the scaffolds increased with increasing MWCNT *** showed that rat pheochromocytoma(PC12)cells grown in the scaffolds had characteristics similar to nerve *** measured changes in the expression of nerve cell markers by quantitative real-time polymerase chain reaction(qRT-PCR),and found that PC12 cells cultured in the scaffolds expressed growth-associated protein 43(GAP43),nerve growth factor receptor(NGFR),and class IIIβ-tubulin(TUBB3)*** research showed that the prepared CS/PEG/CNT scaffold has good biocompatibility and can be further applied to neural tissue engineering research.

关键词： Multi-walled carbon nanotube(MWCNT) Cell-scaffold PC12 cells Biocompatibility

Brillouin Frequency Shift Extraction by Bidirectional Integration of Brillouin Gain Spectrum

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SSRN

SSRN 2023年

作者： Liu, Shuangshuang Zhang, Jianzhong Ma, Zhe Liang, Zefeng Han, Jinfeng Xu, Jinglang Zhang, Mingjiang Key Laboratory of Advanced Transducers and Intelligent Control System Ministry of Education and Shanxi Province Taiyuan University of Technology Taiyuan030024 China College of Electronic Information and Optical Engineering Taiyuan University ofTechnology Taiyuan030024 China College of Physics Taiyuan University of Technology Taiyuan030024 China Shanxi-Zheda Institute of Advanced Materials and ChemicalEngineering Taiyuan030024 China

A novel Brillouin frequency shift (BFS) extraction approach based on bidirectional integration is proposed and investigated for mitigating the fluctuations in Brillouin optical time domain reflectometer (BOTDR) system. The proposed method involves calculating the BFS through the forward and backward integrations of the original Brillouin gain spectrum (BGS) data. The findings from both simulations and experiments demonstrate that bidirectional integration achieves superior BFS accuracy compared to Lorentzian curve fitting. To further evaluate its performance, the root mean square error of BFS is measured under the different signal-to-noise ratios (SNRs) and frequency steps and the results show that bidirectional integration has higher tolerance for low SNR. Specifically, bidirectional integration achieves a BFS accuracy of 0.853 MHz under SNR of 5.22 dB and significantly reduces the measurement time by 85.86%. Additionally, the introduced coefficient k characterizes the influence on the BGS compression, with bidirectional integration exhibiting a narrower full width at half maximum of BGS (52.74 MHz) compared to Lorentzian curve fitting (67.45 MHz). © 2023, The Authors. All rights reserved.

关键词： Extraction

High-performance chiral all-optical logic gate based on topological edge states of valley photonic crystal

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arXiv 2022年

作者： Wang, Xiaorong Fei, Hongming Lin, Han Wu, Min Kang, Lijuan Zhang, Mingda Liu, Xin Yang, Yibiao Xiao, Liantuan College of Physics Taiyuan University of Technology Taiyuan030024 China Key Laboratory of Advanced Transducers and Intelligent Control System Ministry of Education Taiyuan University of Technology Taiyuan030024 China School of Science RMIT University MelbourneVIC3000 Australia Swinburne University of Technology HawthornVIC3122 Australia

For all-optical communication and information processing, it is necessary to develop all-optical logic gates based on photonic structures that can directly perform logic operations. All-optical logic gates have been demonstrated based on conventional waveguides and interferometry, as well as photonic crystal structures. Nonetheless, any defects in those structures will introduce high scattering loss, which compromises the fidelity and contrast ratio of the information process. Based on the spin-valley locking effect that can achieve defect-immune unidirectional transmission of topological edge states in valley photonic crystals (VPCs), we propose a high-performance all-optical logic OR gate based on a VPC structure. By tuning the working bandwidth of the two input channels, we prevent interference between the two channels to achieve a stable and high-fidelity output. The transmittance of both channels is higher than 0.8, and a high contrast ratio of 28.8 dB is achieved. Moreover, the chirality of the logic gate originated from the spin-valley locking effect allows using different circularly polarized light as inputs, representing "1" or "0", which is highly desired in quantum computing. The device's footprint is 18 × 12 μm 2, allowing high-density on-chip integration. In addition, this design can be experimentally fabricated using current nanofabrication techniques and will have potential applications in optical communication, information processing, and quantum computing. Copyright © 2022, The Authors. All rights reserved.

关键词： Logic gates

Omnidirectional Conformal Cloak Without Geometrical Dispersion

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Physical Review Applied 2019年第6期12卷 064009-064009页

作者： Yichao Liu Fei Sun Sailing He Key Lab of Advanced Transducers and Intelligent Control System Ministry of Education and Shanxi Province College of Physics and Optoelectronics Taiyuan University of Technology Taiyuan 030024 China State Key Laboratory of Modern Optical Instrumentations Centre for Optical and Electromagnetic Research JORCEP East Building #5 Zijingang Campus Zhejiang University Hangzhou 310058 China Department of Electromagnetic Engineering School of Electrical Engineering Royal Institute of Technology (KTH) S-100 44 Stockholm Sweden

The phase delay problem of invisibility cloaks designed by optical conformal mapping is referred to the optical path difference between the waves in upper and lower Riemann sheets. As the frequency changes, the phase delay varies accordingly (here, we call it geometrical dispersion), which restricts the cloaks to working only at some discrete frequencies. Here, we solve the phase-delay problem by placing an optically null medium in the lower Riemann sheet. The conformal cloaks designed by using our method have many advantages, such as a continuous working band (no geometrical dispersion), omnidirectionality, robustness under frequency shifts, and no need for any complex materials that are both anisotropic and inhomogeneous. We also design metallic microchannels to realize our cloaks.

关键词： Optical cloaking Devices Optical materials & elements Optical conformal mapping

Design of wavelength division multiplexing devices based on tunable edge states of valley photonic crystals

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arXiv 2022年

作者： Han, YuHui Fei, HongMing Lin, Han Zhang, MingDa Liu, Xin Wang, XiaoRong Cao, BinZhao Yang, YiBiao Xiao, LianTuan Department of Physics and Optoelectronics Taiyuan University of Technology Taiyuan030024 China Key Laboratory of Advanced Transducers and Intelligent Control System Ministry of Education Taiyuan University of Technology Taiyuan030024 China Centre for Translational Atomaterials Faculty of Science Engineering and Technology Swinburne University of Technology HawthornVIC3122 Australia

Wavelength division multiplexing (WDM) devices are key elements of Photonic integrated circuits (PICs). Conventional WDM devices based on silicon waveguides and photonic crystals have limited transmittance due to high loss introduced by the strong backward scattering from defects. In addition, it is challenging to reduce the footprint of those devices. Here we theoretically demonstrate a WDM device in the telecommunication range based on all-dielectric silicon topological valley photonic crystal (VPC) structures. We tune its effective refractive index by tuning the physical parameters of the lattice in the silicon substrate, which can continuously tune the working wavelength range of the topological edge states, which allows designing WDM devices with different channels. The WDM device has two channels (1470 nm-1523 nm and 1548 nm-1609 nm), with contrast ratios of 22.4 dB and 24.9 dB, respectively. The principle of manipulating the working bandwidth of the topological edge states can be generally applied in designing different integratable photonic devices, thus it will find broad applications. Copyright © 2022, The Authors. All rights reserved.

关键词： Photonic devices

Noninvasive super-resolution imaging through scattering media

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arXiv 2019年

作者： Wang, Dong Sahoo, Sujit Kumar Dang, Cuong Nanyang Technological University Singapore 50 Nanyang Avenue 639798 Singapore Key Laboratory of Advanced Transducers and Intelligent Control System Ministry of Education Shanxi Province College of Physics and Optoelectronics Taiyuan University of Technology Taiyuan030024 China School of Electrical Sciences Indian Institute of Technology Goa Goa 403401 India

Super-resolution imaging with advanced optical systems has been revolutionizing technical analysis in various fields from biological to physical sciences. However, many objects are hidden by strongly scattering media such as rough wall corners or biological tissues that scramble light paths, create speckle patterns and hinder object’s visualization, let alone super-resolution imaging. Here, we realize a method to do non-invasive super-resolution imaging through scattering media based on stochastic optical scattering localization imaging (SOSLI) technique. Simply by capturing multiple speckle patterns of photo-switchable emitters in our demonstration, the stochastic approach utilizes the speckle correlation properties of scattering media to retrieve an image with more than five-fold resolution enhancement compared to the diffraction limit, while posing no fundamental limit in achieving higher spatial resolution. More importantly, we demonstrate our SOSLI to do non-invasive super-resolution imaging through not only optical diffusers, i.e. static scattering media, but also biological tissues, i.e. dynamic scattering media with decorrelation of up to 80%. Our approach paves the way to non-invasively visualize various samples behind scattering media at unprecedented levels of detail. Copyright © 2019, The Authors. All rights reserved.

关键词： Stochastic systems

A Mechanical Biosensor Based on Magnetic-Mediated Sensitization for 5-Ht Detection

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SSRN

SSRN 2024年

作者： Zhao, Dong Yao, Penglong Yan, Zhaosheng Jian, Aoqun Bai, Jinsuo Wang, Haoyu Guo, Xing Sang, Shengbo Zhou, Chuangang Dong, Xiushan Shanxi Key Laboratory of Micro Nano Sensors & Artificial Intelligence Perception College of Electronic Information And Optical Engineering Taiyuan University of Technology Taiyuan030024 China Key Lab of Advanced Transducers and Intelligent Control System the Ministry of Education Taiyuan University of Technology Taiyuan030024 China Taiyuan University of Technology China Shanxi Academy of Medical Sciences China

The real-time detection of neurotransmitters had attracted more attention due to the potential to provide vital information for pathology research, disease diagnosis, and clinical efficacy evaluation. Here, a magnetic-mediated biosensor was developed to improve sensitivity for detection of serotonin (5-HT). The PDMS membrane doped with magnetic particles serves as a conversion element, enhancing the deformation of the thin film caused by surface stress under the action of a magnetic field and amplifying the resistance response signal of the biosensor. The 5-HT detection associated with neurotransmitter diseases serve as a proof of concept revealing the magnetic sensitization. The detection limit of the 5-HT was decreased to 3.21 nM in the linear range of 5-500 nM, which was lower than that of the biosensor without magnetic field. The clinical 5-HT samples were also been accurately detected, indicating a positive application potential of the as-prepared magnetic-mediated biosensor. All these results reveal the high sensitivity and practicality of the as-prepared magnetic-mediated biosensor and provide a new method for neurotransmitter diseases diagnosis. © 2024, The Authors. All rights reserved.

关键词： Biosensors

High Sensitivity Submicron Scale Temperature Sensor Based on Perovskite Nanoplatelet Lasers

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SSRN

SSRN 2024年

作者： Zhao, Ruofan Tao, Jianxun Xi, Yuying Chen, Jiangzhao Ji, Ting Wang, Wenyan Wen, Rong Cui, Yanxia Chen, Junsheng Lia, Guohui College of Physics and Optoelectronics Key Laboratory of Interface Science and Engineering in Advanced Materials Key lab of Advanced Transducers and Intelligent Control System of Ministry of Education Taiyuan University of Technology Taiyuan030024 China School of Materials Science and Engineering Kunming University of Science and Technology Kunming650093 China Shanxi-Zheda institute of advanced materials and chemical engineering China Nano-Science Center Department of Chemistry University of Copenhagen Universitetsparken 5 CopenhagenDK-2100 Denmark

Submicron scale temperature sensors are crucial for a range of applications, particularly in micro and nanoscale environments. One promising solution involves the use of active whispering gallery mode (WGM) microresonators. These resonators can be remotely excited and read out using free-space structures, simplifying the process of sensing. In this study, we present a submicron-scale temperature sensor with a remarkable sensitivity up to 190 pm/℃ based on a triangular CH3NH3PbI3 nanoplatelet (NPL) laser. Notably, as temperature changes, the peak wavelength of the laser line shifts linearly. This unique characteristic allows for precise temperature sensing by tracking the peak wavelength of the NPL laser. The optical modes are confined within the perovskite NPL, which measures just 85 nanometers in height, due to total internal reflection. Our NPL laser boasts several key features, including a high Q-factor of ~ 2610 and a low laser threshold of about 19.8 µJ cm−2. The combination of exceptional sensitivity and ultra-small size makes our WGM device an ideal candidate for integration into systems that demand compact temperature sensors. This advancement paves the way for significant progress in the development of ultrasmall temperature sensors, opening new possibilities across various fields. © 2024, The Authors. All rights reserved.

关键词： Perovskite

0.75 Gbit/s high-speed classical key distribution with mode-shift keying chaos synchronization of Fabry-Perot lasers

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arXiv 2020年

作者： Gao, Hua Wang, Anbang Wang, Longsheng Jia, Zhiwei Guo, Yuanyuan Gao, Zhensen Yan, Lianshan Qin, Yuwen Wang, Yuncai Key Laboratory of Advanced Transducers and Intelligent Control System Ministry of Education and Shanxi Province Taiyuan China College of Physics and Optoelectronics Taiyuan University of Technology Taiyuan China School of Information Engineering Guangdong University of Technology Guangzhou China Guangdong Provincial Key Laboratory of Photonics Information Technology Guangzhou China Center for Information Photonics and Communications School of Information Science and Technology Southwest Jiaotong University Chengdu China

High-speed physical key distribution is diligently pursued for secure communication. In this paper, we propose and experimentally demonstrate a scheme of high-speed key distribution using mode-shift keying chaos synchronization between two multi-longitudinal-mode Fabry–Perot lasers commonly driven by a super-luminescent diode. Legitimate users dynamically select one of the longitudinal modes according to private control codes to achieve mode-shift keying chaos synchronization. The two remote chaotic light waveforms are quantized to generate two raw random bit streams, and then those bits corresponding to chaos synchronization are sifted as shared keys by comparing the control codes. In this method, the transition time, i.e., the chaos synchronization recovery time is determined by the rising time of the control codes rather than the laser transition response time, so the key distribution rate is improved greatly. Our experiment achieved a 0.75-Gbit/s key distribution rate with a bit error rate of 3.8 × 10-3 over 160-km fiber transmission with dispersion compensation. The entropy rate of the laser chaos is evaluated as 16 Gbit/s, which determines the ultimate final key rate together with the key generation ratio. It is therefore believed that the method pays a way for Gbit/s physical key distribution. © 2020, CC0.

关键词： Synchronization