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A New Staining Method Using Different Targeted Fluorescent Carbon Dots For Tissue Sections Analysis and Diagnosis

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SSRN 2024年

作者： Duan, Qianqian Guo, Qingxia Xi, Yanfeng Su, Hong Xue, Juanjuan Zhang, Qi Guo, Xing Han, Haixuan Zhou, Yangming Sang, Shengbo Wang, Xiaojuan Shanxi Key Laboratory of Artificial Intelligence & Micro Nano Sensors College of Integrated Circuits Taiyuan University of Technology Taiyuan030024 China Key Lab of Advanced Transducers and Intelligent Control System Ministry of Education Taiyuan University of Technology Taiyuan030024 China Department of Pathology Shanxi Tumour Hospital Shanxi Taiyuan030024 China

Visualization imaging of tissue sections is a crucial method for pathological diagnosis of tumour. Carbon dots (CDs) targeting specific organelles have attracted a lot of attention due to their inexpensive raw materials and excellent luminescent property, and they are expected to be used for labeling of nuclei and cytoplasm in tissue sections. In this paper, nuclear targeting carbon dots (N-CDs) with green fluorescence and cytoplasmic targeting carbon dots (C-CDs) with red fluorescence were prepared to achieve co-staining imaging of tissue sections. The two CDs had good fluorescent stability, and their targeting performance and mechanism were studied by cells co-staining and digestion experiments. The section staining method with N-CDs&C-CDs were developed, which is low-cost, simple operation, and time saving. The stained tissues structure distribution were very clear and the information of nucleus and cytoplasm could be extracted. The morphology features and statistic nucleus-cytoplasmic ratio were significantly different and consistent with the results of H&E staining. Therefore, N-CDs&C-CDs are expected to be potential alternative dyes to H&E, and a new method of tissue section staining by dual channel imaging of N-CDs&C-CDs has been developed. These results provide an important research idea for exploring the morphological differences between different cells on tissue sections, quickly and more accurately identifying sections, quantifying the ratio nucleus-cytoplasmic on sections, and then improving the efficiency of clinical diagnosis. © 2024, The Authors. All rights reserved.

关键词： Fluorescence imaging

Simultaneous Strain and Temperature Measurement Based on Chaotic Brillouin Optical Correlation-Domain Analysis in Large-Effective-Area Fibers

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Photonic Sensors 2021年第4期11卷 377-386页

作者： Xiaocheng ZHANG Shuangshuang LIU Jianzhong ZHANG Lijun QIAO Tao WANG Shaohua GAO Mingjiang ZHANG Key Laboratory of Advanced Transducers and Intelligent Control System of Ministry of Education Taiyuan University of TechnologyTaiyuan 030024China College of Physics and Optoelectronics Institute of Optoelectronic EngineeringTaiyuan University of TechnologyTaiyuan 030024China

Chaotic Brillouin optical correlation domain analysis(BOCDA)has been proposed and experimentally demonstrated with the advantage of high spatial ***,it faces the same issue of the temperature and strain *** this paper,the simultaneous measurement of temperature and strain can be preliminarily achieved by analyzing the two Brillouin frequencies of the chaotic laser in a large-effective-area fiber(LEAF).A temperature resolution of 1℃ and a strain resolution of 20μξ can be obtained with a spatial resolution of *** actual temperature and strain measurement errors are 0.37℃ and 10μξ,respectively,which are within the maximum measurement errors.

关键词： Brillouin scattering simultaneous strain and temperature measurement chaotic laser BOCDA LEAF

Passivation of degradation path enables high performance perovskite nanoplatelet lasers with high operational stability

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Photonics Research 2022年第6期10卷 1440-1452页

作者： GUOHUI LI HUIHUI PI YANFU WEI BOLIN ZHOU YA GAO RONG WEN YUYING HAO HAN ZHANG BENG S.ONG YANXIA CUI College of Physics and Optoelectronics Key Laboratory of Interface Science and Engineering in Advanced MaterialsKey Laboratory of Advanced Transducers and Intelligent Control System of Ministry of EducationTaiyuan University of TechnologyTaiyuan 030024China Collaborative Innovation Centre for Optoelectronic Science and Technology Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceCollege of Physics and Optoelectronic EngineeringShenzhen Key Laboratory of Micro-Nano Photonic Information TechnologyGuangdong Laboratory of Artificial Intelligence and Digital Economy(SZ)Shenzhen UniversityShenzhen 518060China Department of Chemistry Research Centre of Excellence for Organic ElectronicsInstitute of Advanced MaterialsHong Kong Baptist UniversityKowloon TongHong KongChina

MAPbI_(3)perovskite has attracted widespread interests for developing low-cost near infrared semiconductor gain ***,it faces the instability issue under operation conditions,which remains a critical *** is found that the instability of the MAPbI_(3)nanoplatelet laser comes from the thermal-induced degradation progressing from the surface defects towards neighboring *** using PbI_(2) passivation,the defect-initiated degradation is significantly suppressed and the nanoplatelet degrades in a layer-by-layer way,enabling the MAPbI_(3)laser to sustain for 4500 s(2.7×10^(7) pulses),which is nearly three times longer than that of the nanoplatelet laser without ***,the PbI_(2) passivated MAPbI_(3)nanoplatelet laser with the nanoplatelet cavity displays a maximum quality factor up to∼7800,the highest reported for all MAPbI_(3)nanoplatelet ***,a high stability MAPbI_(3)nanoplatelet laser that can last for 8500 s(5.1×10^(7) pulses)is demonstrated based on a dual passivation strategy,by retarding the defect-initiated degradation and surface-initiated degradation *** work provides in-depth insights for understanding the operating degradation of perovskite lasers,and the dual passivation strategy paves the way for developing high stability near infrared semiconductor laser media.

关键词： stability initiated high

Design of a Novel Autonomous Docking system With a Supporting Robotic Fish

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Design of a Novel Autonomous Docking System With a Supportin...

IEEE International Conference on Real-time Computing and Robotics (RCAR)

作者： Huijie Dong Chunyang Zhao Tiezhu Qiao Jian Wang Di Chen Yan Meng Junzhi Yu Ministry of Education Key Laboratory of Advanced Transducers and Intelligent Control System Taiyuan University of Technology Taiyuan China Institute of Automation Laboratory of Cognitive and Decision Intelligence for Complex System Chinese Academy of Sciences Beijing China Department of Advanced Manufacturing and Robotics College of Engineering State Key Laboratory for Turbulence and Complex Systems Peking University Beijing China College of Electronics and Information Engineering Guangdong Ocean University Zhanjiang China

Underwater supporting robots serving as a relay of energy supplements and communication for other underwater equipment are promising for ocean exploration, development, and protection. This paper proposes a novel autonomous docking system centered on a designed supporting robotic fish named ‘CourierFish’. Specifically, CourierFish is capable of docking with a surface dock station for supplying itself and docking with a seafloor platform for supporting equipment in the platform. A visual navigation scheme integrating LED and ArUco markers is presented for accurate localization. The control approach for docking motion is also illustrated. Simulations and aquatic experiments are performed to verify the feasibility of the proposed docking system. The obtained results lay a solid foundation for the construction of various underwater equipment and robot networks.

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Noise-induced dynamics and photon statistics in bimodal quantum-dot micropillar lasers

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arXiv

arXiv 2023年

作者： Guo, Yanqiang Zhang, Jianfei Guo, Xiaomin Reitzenstein, Stephan Xiao, Liantuan Key Laboratory of Advanced Transducers and Intelligent Control System Ministry of Education College of Physics Taiyuan University of Technology Taiyuan030024 China State Key Laboratory of Cryptology Beijing100878 China Institut für Festkörperphysik Technical University of Berlin Hardenbergstr. 36 BerlinD-10623 Germany

Emission characteristics of quantum-dot micropillar lasers are located at the intersection of nanophotonics and nonlinear dynamics, which provides an ideal platform for studying the optical interface between classical and quantum systems. In this work, a noise-induced bimodal quantum-dot micropillar laser with orthogonal dual-mode outputs is modeled, and nonlinear dynamics, stochastic mode jumping and quantum statistics with the variation of stochastic noise intensity are investigated. Noise-induced effects lead to the emergence of two intensity bifurcation points for the strong and the weak mode, and the maximum output power of the strong mode becomes larger as the noise intensity increases. The anti-correlation of the two modes reaches the maximum at the second intensity bifurcation point. The dual-mode stochastic jumping frequency and effective bandwidth can exceed 100 GHz and 30 GHz under the noise-induced effect. Moreover, the noise-induced photon correlations of both modes simultaneously exhibit super-thermal bunching effects (g(2)(0) > 2) in the low injection current region. The g(2)(0)-value of the strong mode can reach over 6 in the high injection current region. Photon bunching (g(2)(0) > 1) of both modes is observed over a wide range of noise intensities and injection currents. In the presence of the noise-induced effect, the photon number distribution of the strong or the weak mode is a mixture of Bose-Einstein and Poisson distributions. As the noise intensity increases, the photon number distribution of the strong mode is dominated by the Bose-Einstein distribution, and the proportion of the Poisson distribution is increased in the high injection current region, while that of the weak mode is reduced. Our results contribute to the development preparation of super-bunching quantum integrated light sources for improving the spatiotemporal resolution of quantum sensing measurements and enhancing the security of optical communication. Copyright © 2023, The

关键词： Dynamics

Tunable Mid-Infrared Sensing Based on Graphene-Metal Hybrid Structure

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SSRN 2024年

作者： Wang, Xiaowei Chen, Zhihui Feng, Guang Wang, Yang Li, Shan Yang, Yibiao Key Lab of Advanced Transducers and Intelligent Control System Ministry of Education and Shanxi Province College of Electronic Information and Optical Engineering Taiyuan University of Technology Taiyuan030024 China Taiyuan Institute of Technology Taiyuan030008 China Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of Biotechnology Shanxi University Taiyuan030006 China

Improving the emission efficiency of molecules or quantum dots is one of the effective means to improve the sensitivity of sensing. Here we provide a graphene-metal hybrid structure to achieve sensitivity detection in mid-infrared. The graphene-metal hybrid structure well coupling with a dipole source in mid-infrared was constructed. And then the high quality resonance peak can be detected. For different molecular detection applications, the resonance window can be controlled by geometrical parameters of metal structure in the mid-infrared range. Meanwhile the resonance wavelengths can be adjusted with graphene's chemical potential which can be controled through a varying gate voltage, and the emission enhancement ratio was 501 times on average. The hybrid structures also show excellent results in different background refractive indices. The sensitivity of the hybrid structure as a refractive index sensor reaches 6233 nm/RIU. All of our analyses show that the hybrid structure can be used as a better mid-infrared sensor. © 2024, The Authors. All rights reserved.

关键词： Graphene

Optical encryption using structural uncorrelated characteristics of biological scattering media

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Optica Acta: International Journal of Optics 2023年第1期70卷 69-76页

作者： Aiping Zhai Qing Han Teng Zhang Wenjing Zhao Dong Wang a College of Physics and Optoelectronics Taiyuan University of Technology Taiyuan People’s Republic of China a College of Physics and Optoelectronics Taiyuan University of Technology Taiyuan People’s Republic of Chinab Key Laboratory of Advanced Transducers and Intelligent Control System Ministry of Education and Shanxi Province Taiyuan University of Technology Taiyuan People’s Republic of China

ABSTRACTABSTRACTInspired by the unique internal structures with inherent anisotropy in biological tissues and their dynamic scattering characteristic, a simple and easy-to-fabricate optical encryption technique using structural uncorrelated characteristics of biological tissues was proposed. It can generate unique keys with the random characteristics of the tissues and transforms multiple image plaintexts into speckle-like ciphertexts. The optical encryptions of grayscale images are demonstrated utilizing the uncorrelated characteristics of shallot and chicken breast respectively. Ciphertext-only-attack is resisted by phase retrieval due to the inherent dynamic randomness of biological tissues and the complexity of the plaintexts. Besides, once the unique PSF keys is recorded by the optical setup, the encryption can be accomplished, either online using the setup, or offline through performing convolutions on the plaintexts with pre-recorded uncorrelated PSFs to yield ciphertexts. Therefore, it is very secure, simple, and flexible to guarantee the promising potentials for information encryption of grayscale images and/or videos.

关键词： Optical encryption structural uncorrelated characteristics biological tissues grayscale images

A Mechanical Biosensor Based on Magnetic-Mediated Sensitization for 5-Ht Detection

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SSRN 2024年

作者： Zhao, Dong Yao, Penglong Yan, Zhaosheng Jian, Aoqun Bai, Jinsuo Wang, Haoyu Guo, Xing Sang, Shengbo Zhou, Chuangang Dong, Xiushan Shanxi Key Laboratory of Micro Nano Sensors & Artificial Intelligence Perception College of Electronic Information And Optical Engineering Taiyuan University of Technology Taiyuan030024 China Key Lab of Advanced Transducers and Intelligent Control System the Ministry of Education Taiyuan University of Technology Taiyuan030024 China Taiyuan University of Technology China Shanxi Academy of Medical Sciences China

The real-time detection of neurotransmitters had attracted more attention due to the potential to provide vital information for pathology research, disease diagnosis, and clinical efficacy evaluation. Here, a magnetic-mediated biosensor was developed to improve sensitivity for detection of serotonin (5-HT). The PDMS membrane doped with magnetic particles serves as a conversion element, enhancing the deformation of the thin film caused by surface stress under the action of a magnetic field and amplifying the resistance response signal of the biosensor. The 5-HT detection associated with neurotransmitter diseases serve as a proof of concept revealing the magnetic sensitization. The detection limit of the 5-HT was decreased to 3.21 nM in the linear range of 5-500 nM, which was lower than that of the biosensor without magnetic field. The clinical 5-HT samples were also been accurately detected, indicating a positive application potential of the as-prepared magnetic-mediated biosensor. All these results reveal the high sensitivity and practicality of the as-prepared magnetic-mediated biosensor and provide a new method for neurotransmitter diseases diagnosis. © 2024, The Authors. All rights reserved.

关键词： Biosensors

High Sensitivity Submicron Scale Temperature Sensor Based on Perovskite Nanoplatelet Lasers

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SSRN 2024年

作者： Zhao, Ruofan Tao, Jianxun Xi, Yuying Chen, Jiangzhao Ji, Ting Wang, Wenyan Wen, Rong Cui, Yanxia Chen, Junsheng Lia, Guohui College of Physics and Optoelectronics Key Laboratory of Interface Science and Engineering in Advanced Materials Key lab of Advanced Transducers and Intelligent Control System of Ministry of Education Taiyuan University of Technology Taiyuan030024 China School of Materials Science and Engineering Kunming University of Science and Technology Kunming650093 China Shanxi-Zheda institute of advanced materials and chemical engineering China Nano-Science Center Department of Chemistry University of Copenhagen Universitetsparken 5 CopenhagenDK-2100 Denmark

Submicron scale temperature sensors are crucial for a range of applications, particularly in micro and nanoscale environments. One promising solution involves the use of active whispering gallery mode (WGM) microresonators. These resonators can be remotely excited and read out using free-space structures, simplifying the process of sensing. In this study, we present a submicron-scale temperature sensor with a remarkable sensitivity up to 190 pm/℃ based on a triangular CH3NH3PbI3 nanoplatelet (NPL) laser. Notably, as temperature changes, the peak wavelength of the laser line shifts linearly. This unique characteristic allows for precise temperature sensing by tracking the peak wavelength of the NPL laser. The optical modes are confined within the perovskite NPL, which measures just 85 nanometers in height, due to total internal reflection. Our NPL laser boasts several key features, including a high Q-factor of ~ 2610 and a low laser threshold of about 19.8 µJ cm−2. The combination of exceptional sensitivity and ultra-small size makes our WGM device an ideal candidate for integration into systems that demand compact temperature sensors. This advancement paves the way for significant progress in the development of ultrasmall temperature sensors, opening new possibilities across various fields. © 2024, The Authors. All rights reserved.

关键词： Perovskite