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Any-Angle Routing Algorithm for Microfluidic Biochips Driven by Flow Path

Jisuanji Yanjiu yu Fazhan/Computer Research and Development 2025年第4期62卷 978-988页

作者： Youlin, Pan Shuai, Guo Xing, Huang Genggeng, Liu College of Computer and Data Science Fuzhou University Fuzhou350116 China Engineering Research Center of Big Data Intelligence Fuzhou University Ministry of Education Fuzhou350116 China Fujian Key Laboratory of Network Computing and Intelligent Information Processing Fuzhou University Fuzhou350116 China School of Computer Science Northwestern Polytechnical University Xi’an710072 China

Continuous-flow microfluidic biochips (CFMBs) have become a hot research topic in recent years due to their ability to perform biochemical assays automatically and efficiently. For the first time, PathDriver+ takes the requirements of the actual fluid transportation into account in the design process of CFMBs and implements the actual fluid transport and removal, and plans separate flow paths for each transport task, which have been neglected in previous work. However, PathDriver+ does not take full advantage of the flexibility of CFMBs routing because it only considers the optimization of flow channel length for the global routing in the mesh model, except for the detailed routing. In addition, PathDriver+ only considers the X architecture, while the existing work shows that the any-angle routing can utilize the routing resources more efficiently and shorten the flow channel length. To address the above issues, we propose a flow path-driven arbitrary angle routing algorithm, which can improve the utilization of routing resources and reduce the flow channel length while considering the actual fluid transportation requirements. The proposed algorithm constructs a search graph based on constrained Delaunay triangulation to improve the search efficiency of routing solutions while ensuring the routing quality. Then, a Dijkstra-based flow path routing method is used on the constructed search graph to generate a routing result with a short channel length quickly. In addition, in the routing process, channel reuse strategy and intersection optimization strategy are proposed for the flow path reuse and intersection number optimization problems, respectively, to further improve the quality of routing results. The experimental results show that compared with the latest work PathDriver+, the length of channels, the number of ports used, and the number of channel intersections are significantly reduced by 33.21%, 11.04%, and 44.79%, respectively, and the channel reuse rate is i

关键词： High level synthesis

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Control Logic Routing for Continuous-Flow Microfluidic Biochips Based on Deep Reinforcement Learning

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Jisuanji Yanjiu yu Fazhan/Computer Research and Development 2025年第4期62卷 950-962页

作者： Cai, Huayang Huang, Xing Liu, Genggeng College of Computer and Data Science Fuzhou University Fuzhou350116 China Engineering Research Center of Big Data Intelligence Fuzhou University Ministry of Education Fuzhou350116 China Fujian Key Laboratory of Network Computing and Intelligent Information Processing Fuzhou University Fuzhou350116 China School of Computer Science Northwestern Polytechnical University Xi’an710072 China

With the advancement of electronic design automation, continuous-flow microfluidic biochips have become one of the most promising platforms for biochemical experiments. This chip manipulates fluid samples in milliliters or nanoliters by utilizing internal microvalves and microchannels, and thus automatically performs basic biochemical experiments, such as mixing and detection. To achieve the correct bioassay function, the microvalves deployed inside the chip are usually managed by a multiplexer-based control logic, and valves receive control signals from a core input through the control channel for accurate switching. Since biochemical reactions typically require high sensitivity, the length of control paths connecting each valve needs to be reduced to ensure immediate signal propagation, and thus to reduce the signal propagation delay. In addition, to reduce the fabrication cost of chips, a vital issue to be addressed in the logic architecture design is how to effectively reduce the total channel length within the control logic. To address the above issues, we propose a deep reinforcement learning-based control logic routing algorithm to minimize the signal propagation delay and total control channel length, thereby automatically constructing an efficient control channel network. The algorithm employs the dueling deep Q-network architecture as the agent of the deep reinforcement learning framework to evaluate the tradeoff between signal propagation delay and total channel length. Besides, the diagonal channel routing is implemented for the first time for control logic, thus fundamentally improving the efficiency of valve switching operations and reducing the fabrication cost of the chip. The experimental results demonstrate that the proposed algorithm can effectively construct a high-performance and low-cost control logic architecture. © 2025 Science Press. All rights reserved.

关键词： Deep reinforcement learning

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A privacy-aware and fair self-exchanging self-trading scheme for IoT data based on smart contract

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International Journal of Grid and Utility computing 2025年第3期16卷 191-201页

作者： Chen, Yuling Yin, Hongyan Zhang, Yaocheng Ren, Wei Ren, Yi Guizhou Provincial Key Laboratory of Public Big Data Guizhou University Guizhou Guiyang550022 China College of Computer Science & Technology Guizhou University Guizhou Guiyang550022 China Technical Center of Beijing Customs No. 16 Ronghuazhonglu Road BDA Beijing100176 China Wuhan430074 China School of Computing Science University of East Anglia Norwich United Kingdom

With the development of the era of big data, the demand for data sharing and usage is increasing, especially in the era of the internet of things, thus putting forward a keen demand for data exchanging and data trading. However, the existing data exchanging and trading platforms are usually centralised and users have to trust platforms. This paper proposes a secure and fair exchanging and trading protocol based on blockchain and smart contracts, especially, self-governance without relying on centralised trust. By using the protocol, it can guarantee fairness to defend against trade cheating, and security for data confidentiality. It can also guarantee efficiency by transferring data links instead of data between data owners and data buyers. The extensive analysis justified that the proposed scheme can facilitate self-exchanging and self-trading for big data in a secure, fair and efficient manner. Copyright © 2025 Inderscience Enterprises Ltd.

关键词： Smart contract

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Task Offloading Scheduling and Privacy Protection Optimization in Vehicular Edge computing Based on Double Deep Q-Network 18th

Task Offloading Scheduling and Privacy Protection Optimizat...

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18th China Conference on Wireless Sensor Networks, CWSN 2024

作者： Weifeng, Lu Saijun, Yang Jia, Xu Lijie, Xu Lingyun, Jiang Jiangsu Key Laboratory of Big Data Security and Intelligent Processing Nanjing University of Posts and Telecommunications Xianlin Street Jiangsu Nanjing210023 China

ISBN: (纸本)9789819621859

As the applications and services within vehicular networking systems become increasingly diverse, vehicles with limited computing resources face challenges in handling these computationally intensive and latency-sensitive tasks. In this paper, we propose an improved Task Offloading Scheduling Strategy based on a Double Deep Q-Network (TOSDDQN) for a dynamic multi-vehicle, multi-edge unit task offloading environment in vehicular networking. This strategy designs communication models and computational models aimed at minimizing the total system overhead in processing tasks. To further protect the privacy of vehicle users, a Distributed Training Algorithm based on Federated Learning (DTAFL) is proposed. Comparative experimental results indicate that, compared to three other task offloading schemes, our approach reduces the average system overhead in processing tasks by 11%–36%. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： Computation offloading

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TASK ARITHMETIC IN TRUST REGION: A TRAINING-FREE MODEL MERGING APPROACH TO NAVIGATE KNOWLEDGE CONFLICTS

arXiv

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arXiv 2025年

作者： Sun, Wenju Li, Qingyong Wang, Wen Geng, Yangli-Ao Li, Boyang Key Laboratory of Big Data & Artificial Intelligence in Transportation Beijing Jiaotong University Beijing100044 China College of Computing and Data Science Nanyang Technological University 639798 Singapore

Multi-task model merging offers an efficient solution for integrating knowledge from multiple fine-tuned models, mitigating the significant computational and storage demands associated with multi-task training. As a key technique in this field, Task Arithmetic (TA) defines task vectors by subtracting the pre-trained model (θpre) from the fine-tuned task models in parameter space, then adjusting the weight between these task vectors and θpre to balance task-generalized and task-specific knowledge. Despite the promising performance of TA, conflicts can arise among the task vectors, particularly when different tasks require distinct model adaptations. In this paper, we formally define this issue as knowledge conflicts, characterized by the performance degradation of one task after merging with a model fine-tuned for another task. Through in-depth analysis, we show that these conflicts stem primarily from the components of task vectors that align with the gradient of task-specific losses at θpre. To address this, we propose Task Arithmetic in Trust Region (TATR), which defines the trust region as dimensions in the model parameter space that cause only small changes (corresponding to the task vector components with gradient orthogonal direction) in the task-specific losses. Restricting parameter merging within this trust region, TATR can effectively alleviate knowledge conflicts. Moreover, TATR serves as both an independent approach and a plug-and-play module compatible with a wide range of TA-based methods. Extensive empirical evaluations on eight distinct datasets robustly demonstrate that TATR improves the multi-task performance of several TA-based model merging methods by an observable margin. Copyright © 2025, The Authors. All rights reserved.

关键词： Vectors

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Diagnosis model for mouse lung cancer based on terahertz spectroscopy and a transformer network

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Optics Express 2025年第11期33卷 23178-23193页

作者： Jianwei Li Shisheng Zhao Xuxu Ma Ziyu Li Xichuan Li Hebei Key Laboratory of Big Data Computing School of Artificial Intelligence Hebei University of Technology Tianjin 300401 China School of Life Sciences Tianjin Normal University Tianjin 300387 China

Terahertz time-domain spectroscopy technology offers a non-destructive and non-invasive approach to elucidating microstructure and chemical properties of cancer tissues, providing significant advantages for early diagnosis and monitoring. However, challenges such as the presence of outliers, sample class imbalance, and limited diagnostic accuracy persist. To enhance dataset quality, the boxplots were applied to identify and remove abnormal data, and the Savitzky-Golay filter was employed for spectral denoising in this paper. A high-quality dataset comprising 1,028 spectra from normal mouse lung tissues and 1,547 spectra from mouse lung cancer tissues was obtained. To address the shortage of normal lung tissue samples, a Wasserstein generative adversarial network with gradient penalty was utilized. Furthermore, to improve diagnostic accuracy, we developed a novel diagnostic model, MSFPT-Net. This model integrated seven distinct terahertz spectral features and employed a feature pyramid network to extract multi-scale representations, alongside a Transformer network to capture long-range dependencies within spectral sequences. The processed features were subsequently input into a fully connected network to achieve precise lung cancer diagnosis. Experimental results indicate that MSFPT-Net achieves outstanding performance across six evaluation metrics and opens new possibilities for lung cancer diagnosis and treatment.

关键词： Absorption coefficient Deep learning Extinction coefficients Machine learning Neural networks Refractive index

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Exploring the Robustness: Hierarchical Federated Learning Framework for Object Detection of UAV Cluster

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IEEE Transactions on Mobile computing 2025年

作者： Li, Xingyu Zhang, Wenzhe Liu, Linfeng Xu, Jia Nanjing University of Posts and Telecommunications School of Computer Science and Technology Nanjing210023 China Jiangsu Key Laboratory of Big Data Security and Intelligent Processing Nanjing210023 China

The deployment of Unmanned Aerial Vehicle (UAV) cluster is an available solution for object detection missions. In the harsh environment, UAV cluster could suffer from some significant threats (e.g., forest fire hazards, electromagnetic interference, and ground-to-air attacks), which could lead to the destruction of UAVs and loss of data. To this end, we propose a Hierarchical Federated Learning Framework for Object Detection (HFL-OD) to enhance the robustness of UAV cluster conducting object detection missions. In HFL-OD, UAVs are grouped through a Three-Dimensional (3D) graph coloring method, and an intragroup backup mechanism is provided to prevent the data loss caused by the destruction of UAVs. Besides, a dynamic server selection mechanism deals with the potential destruction of servers (cluster server and group servers) by adaptively reassigning the server roles. To further improve the robustness and mission efficiency of UAV cluster, a twotier federated learning framework is introduced to make a proper trade-off between object detection accuracy and communication/computational overhead. This framework is built on the concept of hierarchical federated learning by implementing both intragroup parameter aggregation and global parameter aggregation. Extensive simulations and comparisons demonstrate the superior performance of our proposed HFL-OD, i.e., the robustness of UAV cluster conducting object detection missions can be significantly improved, and the communication/computational overhead is effectively reduced. © 2002-2012 IEEE.

关键词： Fire hazards

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AMHF-TP: Multifunctional therapeutic peptides prediction based on multi-granularity hierarchical features

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Quantitative Biology 2025年第1期 44-58页

作者： Shouheng Tuo YanLing Zhu Jiangkun Lin Jiewei Jiang School of Computer Science and Technology Xi'an University of Posts and Telecommunications Shaanxi Key Laboratory of Network Data Analysis and Intelligent Processing Xi'an Key Laboratory of Big Data and Intelligent Computing School of Electronic Engineering Xi'an University of Posts and Telecommunications

Multifunctional therapeutic peptides(MFTP) hold immense potential in diverse therapeutic contexts, yet their prediction and identification remain challenging due to the limitations of traditional methodologies, such as extensive training durations, limited sample sizes, and inadequate generalization capabilities. To address these issues, we present AMHF-TP, an advanced method for MFTP recognition that utilizes attention mechanisms and multi-granularity hierarchical features to enhance performance. The AMHF-TP is composed of four key components: a migration learning module that leverages pretrained models to extract atomic compositional features of MFTP sequences; a convolutional neural network and selfattention module that refine feature extraction from amino acid sequences and their secondary structures; a hypergraph module that constructs a hypergraph for complex similarity representation between MFTP sequences; and a hierarchical feature extraction module that integrates multimodal peptide sequence features. Compared with leading methods,the proposed AMHF-TP demonstrates superior precision, accuracy, and coverage, underscoring its effectiveness and robustness in MFTP recognition. The comparative analysis of separate hierarchical models and the combined model, as well as with five contemporary models, reveals AMHF-TP's exceptional performance and stability in recognition tasks.

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DreamFuse: Adaptive Image Fusion with Diffusion Transformer

arXiv

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arXiv 2025年

作者： Huang, Junjia Yan, Pengxiang Liu, Jiyang Wu, Jie Wang, Zhao Wang, Yitong Lin, Liang Li, Guanbin Sun Yat-sen University China ByteDance Intelligent Creation China Peng Cheng Laboratory China Guangdong Key Laboratory of Big Data Analysis and Processing China

Image fusion seeks to seamlessly integrate foreground objects with background scenes, producing realistic and harmonious fused images. Unlike existing methods that directly insert objects into the background, adaptive and interactive fusion remains a challenging yet appealing task. It requires the foreground to adjust or interact with the background context, enabling more coherent integration. To address this, we propose an iterative human-in-the-loop data generation pipeline, which leverages limited initial data with diverse textual prompts to generate fusion datasets across various scenarios and interactions, including placement, holding, wearing, and style transfer. Building on this, we introduce DreamFuse, a novel approach based on the Diffusion Transformer (DiT) model, to generate consistent and harmonious fused images with both foreground and background information. DreamFuse employs a Positional Affine mechanism to inject the size and position of the foreground into the background, enabling effective foreground-background interaction through shared attention. Furthermore, we apply Localized Direct Preference Optimization guided by human feedback to refine DreamFuse, enhancing background consistency and foreground harmony. DreamFuse achieves harmonious fusion while generalizing to text-driven attribute editing of the fused results. Experimental results demonstrate that our method outperforms state-of-the-art approaches across multiple metrics. Copyright © 2025, The Authors. All rights reserved.

关键词： Image fusion

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Medical Image Segmentation Based on 3d Pdc with Swin Transformer

SSRN

引用

SSRN 2025年

作者： Fan, Lin Ding, Xiaojia Wang, Zhongmin Wang, Hai Zhang, Rong School of Computer Science and Technology Xi’an University of Posts and Telecommunications Shaanxi Xi’an710121 China Shaanxi Key Laboratory of Network Data Analysis and Intelligent Processing Shaanxi Xi’an710121 China Xi’an Key Laboratory of Big Data and Intelligent Computing Shaanxi Xi’an710121 China The School of Information Science and Technology Northwest University Shaanxi Xi’an710121 China

3D medical image segmentation is vital for disease diagnosis and effective treatment strategies. Despite the advancements in Convolutional Neural Networks (CNN), their fixed receptive fields constrain global context modeling, leading to suboptimal performance, particularly with complex shapes and multi-scale variations. Transformer enhances the global modeling capability through self-attention mechanism. However, challenges persist in capturing fine-grained local features and extracting edge features. To overcome these issues, In this study, a dual-path encoder is proposed, which consists of a 3D PDC and a Swin Transformer and is combined with a CNN for the decoder. The 3D PDC module extracts local features by calculating the differences between neighboring pixels. To improve the ability of capturing edge structures, three 3D PDC variants (3D CPDC, 3D APDC, and 3D RPDC) are proposed to optimize the processing ability of complex edges, multi-directional edges, and multi-scale structures, respectively. After performance evaluation, the selected CARV combinations (3D CPDC, 3D APDC, 3D RPDC, and 3D ordinary convolution) achieve a compromise between high segmentation accuracy and low computational cost. The Swin Transformer encoder captures global context using a hierarchical shift-window mechanism, while the CNN decoder fuses features progressively to produce precise pixel-level segmentation. The proposed method exceeds the performance of existing state-of-the-art techniques, as shown by experiments conducted on the BTCV, FLARE21, and AMOS22 datasets. © 2025, The Authors. All rights reserved.

关键词： Image segmentation

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