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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (vol 50, pg 1412, 2018)

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NATURE GENETICS 2018年第12期50卷 1755-1755页

作者： Evangelou, Evangelos Warren, Helen R. Mosen-Ansorena, David Mifsud, Borbala Pazoki, Raha Gao, He Ntritsos, Georgios Dimou, Niki Cabrera, Claudia P. Karaman, Ibrahim Fu Liang Ng Evangelou, Marina Witkowska, Katarzyna Tzanis, Evan Hellwege, Jacklyn N. Giri, Ayush Edwards, Digna R. Velez Sun, Yan V. Cho, Kelly Gaziano, J. Michael Wilson, Peter W. F. Tsao, Philip S. Kovesdy, Csaba P. Esko, Tonu Magi, Reedik Milani, Lili Almgren, Peter Boutin, Thibaud Debette, Stephanie Ding, Jun Giulianini, Franco Holliday, Elizabeth G. Jackson, Anne U. Li-Gao, Ruifang Lin, Wei-Yu Luan, Jian'an Mangino, Massimo Oldmeadow, Christopher Prins, Bram Peter Qian, Yong Sargurupremraj, Muralidharan Shah, Nabi Surendran, Praveen Theriault, Sebastien Verweij, Niek Willems, Sara M. Zhao, Jing-Hua Amouyel, Philippe Connell, John de Mutsert, Renee Doney, Alex S. F. Farrall, Martin Menni, Cristina Morris, Andrew D. Noordam, Raymond Pare, Guillaume Poulter, Neil R. Shields, Denis C. Stanton, Alice Thom, Simon Abecasis, Goncalo Amin, Najaf Arking, Dan E. Ayers, Kristin L. Barbieri, Caterina M. Batini, Chiara Bis, Joshua C. Blake, Tineka Bochud, Murielle Boehnke, Michael Boerwinkle, Eric Boomsma, Dorret I. Bottinger, Erwin P. Braund, Peter S. Brumat, Marco Campbell, Archie Campbell, Harry Chakravarti, Aravinda Chambers, John C. Chauhan, Ganesh Ciullo, Marina Cocca, Massimiliano Collins, Francis Cordell, Heather J. Davies, Gail de Borst, Martin H. de Geus, Eco J. Deary, Ian J. Deelen, Joris Del Greco, Fabiola M. Demirkale, Cumhur Yusuf Dorr, Marcus Ehret, Georg B. Elosua, Roberto Enroth, Stefan Erzurumluoglu, A. Mesut Ferreira, Teresa Franberg, Mattias Franco, Oscar H. Gandin, Ilaria Gasparini, Paolo Giedraitis, Vilmantas Gieger, Christian Girotto, Giorgia Goel, Anuj Gow, Alan J. Gudnason, Vilmundur Guo, Xiuqing Gyllensten, Ulf Hamsten, Anders Harris, Tamara B. Harris, Sarah E. Hartman, Catharina A. Havulinna, Aki S. Hicks, Andrew A. Hofer, Edith Hofman, Albert Hottenga, Jouke-Jan Huffman, Jennifer E. Hwang, Shih-Jen Ingelsson, Erik James, Alan Jansen Department of Epidemiology and Biostatistics Imperial College London London UK Department of Hygiene and Epidemiology University of Ioannina Medical School Ioannina Greece William Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK National Institute for Health Research Barts Cardiovascular Biomedical Research Center Queen Mary University of London London UK MRC-PHE Centre for Environment and Health Imperial College London London UK Department of Mathematics Imperial College London London UK Division of Epidemiology Department of Medicine Institute for Medicine and Public Health Vanderbilt Genetics Institute Vanderbilt University Medical Center Tennessee Valley Healthcare System (626)/Vanderbilt University Nashville TN USA Vanderbilt Genetics Institute Vanderbilt Epidemiology Center Department of Obstetrics and Gynecology Vanderbilt University Medical Center Tennessee Valley Health Systems VA Nashville TN USA Department of Epidemiology Emory University Rollins School of Public Health Atlanta GA USA Department of Biomedical Informatics Emory University School of Medicine Atlanta GA USA Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC) VA Boston Healthcare System Boston MA USA Division of Aging Department of Medicine Brigham and Women’s Hospital Department of Medicine Harvard Medical School Boston MA USA Atlanta VAMC and Emory Clinical Cardiovascular Research Institute Atlanta GA USA VA Palo Alto Health Care System Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA USA Nephrology Section Memphis VA Medical Center and University of Tennessee Health Science Center Memphis TN USA Estonian Genome Center University of Tartu Tartu Estonia Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA Department Clinical Sciences Malmö Lund University Malmö Sweden MRC Human Genetics Un

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

关键词： Cardiovascular diseases Genome informatics Genome-wide association studies

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Context-specific miRNA regulation network predicts cancer prognosis

Context-specific miRNA regulation network predicts cancer pr...

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IEEE International Conference on Systems Biology

作者： Xionghui Zhou Juan Liu Changning Liu Simon Rayner Fengji Liang Jingfang Ju Yinghui Li Shanguang Chen Jianghui Xiong School of Computer Science Wuhan University Wuhan China Bioinformatics Research Group Key Laboratory of Intelligent Information Processing Advanced Computing Research Laboratory Institute of Computing Technology Chinese Academy of Sciences (CAS) Beijing China Bioinformatics Group State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences (CAS) Wuhan China Bioinformatics Group and Data Coordination Center State Key Laboratory of Space Medicine Fundamentals and Application China Astronaut Research and Training Center Beijing China Department of Pathology Stony Brook University Medical Center New York USA

MicroRNAs can regulate hundreds of target genes and play a pivotal role in a broad range of biological process. However, relatively little is known about how these highly connected miRNAs-target networks are remodelled in the context of various diseases. Here we examine the dynamic alteration of context-specific miRNA regulation to determine whether modified microRNAs regulation on specific biological processes is a useful information source for predicting cancer prognosis. A new concept, Context-specific miRNA activity (CoMi activity) is introduced to describe the statistical difference between the expression level of a miRNA's target genes and non-targets genes within a given gene set (context).

关键词： Breast cancer Context Correlation Biological processes Metastasis Tumors

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Enhancing Sequential Personalized Product Search with External Out-of-sequence Knowledge

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ACM Transactions on Information Systems 1000年

作者： Jiongnan Liu Zhicheng Dou Jian-Yun Nie Zhenlin Chen Guoyu Tang Sulong Xu Ji-Rong Wen Gaoling School of Artificial Intelligence Renmin University of China China DIRO University de Montreal Canada *** Inc China Gaoling School of Artificial Intelligence Renmin University of China China Engineering Research Center of Next-Generation Intelligent Search and Recommendation Ministry of Education China and Beijing Key Laboratory of Big Data Management and Analysis Methods China

A key challenge in personalized product search is to capture user’s preferences. Recent work attempted to model sequences of user historical behaviors, i.e., product purchase histories, to build user profiles and to personalize results accordingly. Although these approaches have demonstrated promising retrieval performances, we notice that most of them focus solely on the intra-sequence interactions between items. However, as there is usually a small amount of historical behavior data, the user profiles learned by these approaches could be very sensitive to the noise included in it. To tackle this problem, we propose incorporating out-of-sequence external information to enhance user modeling. More specifically, we inject the external item-item relations (e.g., belonging to the same brand), and query-query relations (e.g., the semantic similarities between them), into the intra-sequence interaction to learn better user profiles. In addition, we devise two auxiliary decoders, with the historical item sequence reconstruction task and the global item similarity prediction task, to further improve the reliability of user modeling. Experimental results on two datasets from simulated and real user search logs respectively show that the proposed personalized product search method outperforms existing approaches.

关键词： personalized product search sequential model graph

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Genetic and Evolutionary computing 1

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丛书名： Advances in intelligent Systems and computing

1000年

作者： Jeng-Shyang Pan Jerry Chun-Wei Lin Bixia Sui Shih-Pang Tseng

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A Relation-Constraint Link Prediction Model for Dynamic Knowledge Graphs with Entity Drift

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ACM Transactions on Knowledge Discovery from data 1000年

作者： Xiulin Zheng Peipei Li Zan Zhang Jia Wu Xindong Wu Key Laboratory of Knowledge Engineering with Big Data (the Ministry of Education of China) Hefei University of Technology China and School of Computer Science and Information Engineering Hefei University of Technology China School of Computing Faculty of Science and Engineering Macquarie University Australia

Knowledge Graphs (KGs) often suffer from incompleteness and this issue motivates the task of Knowledge Graph Completion (KGC). Traditional KGC models mainly concentrate on static KGs with a fixed set of entities and relations, or dynamic KGs with temporal characteristics, faltering in their generalization to constantly evolving KGs with possible irregular entity drift. Thus, in this paper, we propose a novel link prediction model based on the embedding representation to handle the incompleteness of KGs with entity drift, termed as DCEL. Unlike traditional link prediction, DCEL could generate precise embeddings for drifted entity without imposing any regular temporal characteristic. The drifted entity is added into the KG with its links to the existing entity predicted in an incremental fashion with no requirement to retrain the whole KG for computational efficiency. In terms of DCEL model, it fully takes advantages of unstructured textual description, and is composed of four modules, namely MRC (Machine Reading Comprehension), RCAA (Relation Constraint Attentive Aggregator), RSA (Relation Specific Alignment) and RCEO (Relation Constraint Embedding Optimization). Specifically, the MRC module is first employed to extract short texts from long and redundant descriptions. Then, RCAA is used to aggregate the embeddings of textual description of drifted entity and the pre-trained word embeddings learned from corpus to a single text-based entity embedding while shielding the impact of noise and irrelevant information. After that, RSA is applied to align the text-based entity embedding to graph-based space to obtain the corresponding graph-based entity embedding, and then the learned embeddings are fed into the gate structure to be optimized based on the RCEO to improve the accuracy of representation learning. Finally, the graph-based model TransE is used to perform link prediction for drifted entity. Extensive experiments conducted on benchmark datasets in terms of evaluat

关键词： dynamic knowledge graph entity drift link prediction relation constraint

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Model Pruning-enabled Federated Split Learning for Resource-constrained Devices in Artificial Intelligence Empowered Edge computing Environment

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ACM Transactions on Sensor Networks 1000年

作者： Yongzhe Jia Bowen Liu Xuyun Zhang Fei Dai Arif Khan Lianyong Qi Wanchun Dou State Key Laboratory for Novel Software Technology Department of Computer Science and Technology Nanjing University Nanjing China Department of Computing Macquarie University Sydney Australia College of Big Data and Intelligent Engineering Southwest Forestry University Kunming China M3S Empirical Software Engineering Research Unit University of Oulu Oulu Finland College of Computer Science and Technology China University of Petroleum East China - Qingdao Campus Qingdao China

Distributed Collaborative Machine Learning (DCML) has emerged in artificial intelligence-empowered edge computing environments, such as the Industrial Internet of Things (IIoT), to process tremendous data generated by smart devices. However, parallel DCML frameworks require resource-constrained devices to update the entire Deep Neural Network (DNN) models and are vulnerable to reconstruction attacks. Concurrently, the serial DCML frameworks suffer from training efficiency problems due to their serial training nature. In this paper, we propose a Model Pruning-enabled Federated Split Learning framework (MP-FSL) to reduce resource consumption with a secure and efficient training scheme. Specifically, MP-FSL compresses DNN models by adaptive channel pruning and splits each compressed model into two parts that are assigned to the client and the server. Meanwhile, MP-FSL adopts a novel aggregation algorithm to aggregate the pruned heterogeneous models. We implement MP-FSL with a real FL platform to evaluate its performance. The experimental results show that MP-FSL outperforms the state-of-the-art frameworks in model accuracy by up to 1.35%, while concurrently reducing storage and computational resource consumption by up to 32.2% and 26.73%, respectively. These results demonstrate that MP-FSL is a comprehensive solution to the challenges faced by DCML, with superior performance in both reduced resource consumption and enhanced model performance.

关键词： Federated learning split learning model pruning edge computing

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Distributed Computation Offloading and Power Control for UAV-Enabled Internet of Medical Things

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ACM Transactions on Internet Technology 1000年

作者： Jiakun Gao Xiaolong Xu Lianyong Qi Wanchun Dou Xiaoyu Xia Xiaokang Zhou School of Software Nanjing University of Information Science and Technology NanJing China School of Software Nanjing University of Information Science and Technology NanJing China and Jiangsu Province Engineering Research Center of Advanced Computing and Intelligent Services Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology (CICAEET) Nanjing University of Information Science and Technology Nanjing China College of Computer Science and Technology China University of Petroleum (East China) QingDao China and State Key Laboratory for Novel Software Technology Nanjing University Nanjing China State Key Laboratory for Novel Software Technology Nanjing University Nanjing China School of Computer Technology RMIT University Victoria Australia Faculty of Data Science Shiga University Hikone Japan

The advancement of the Internet of Medical Things (IoMT) has led to the emergence of various health and emotion care services, e.g., health monitoring. To cater to increasing computational requirements of IoMT services, Mobile Edge computing (MEC) has emerged as an indispensable technology in smart health. Benefiting from the cost-effectiveness of deployment, unmanned aerial vehicles (UAVs) equipped with MEC servers in Non-Orthogonal Multiple Access (NOMA) have emerged as a promising solution for providing smart health services in proximity to medical devices (MDs). However, the escalating number of MDs and the limited availability of communication resources of UAVs give rise to a significant increase in transmission latency. Moreover, due to the limited communication range of UAVs, the geographically-distributed MDs lead to workload imbalance of UAVs, which deteriorates the service response delay. To this end, this paper proposes a UAV-enabled Distributed computation Offloading and Power control method with Multi-Agent, named DOPMA, for NOMA-based IoMT environment. Specifically, this paper introduces computation and transmission queue models to analyze the dynamic characteristics of task execution latency and energy consumption. Moreover, a credit assignment scheme-based reward function is designed considering both system-level rewards and rewards tailored to each MD, and an improved multi-agent deep deterministic policy gradient algorithm is developed to derive offloading and power control decisions independently. Extensive simulations demonstrate that the proposed method outperforms existing schemes, achieving \(7.1\%\) reduction in energy consumption and \(16\%\) decrease in average delay.

关键词： Internet of Medical Things (IoMT) Mobile Edge computing (MEC) Unmanned Aerial Vehicles (UAV) Non-Orthogonal Multiple Access (NOMA)

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Large-Scale Tensorized Multi-View Kernel Subspace Clustering

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ACM Transactions on intelligent Systems and Technology 1000年

作者： Guang-Yu Zhang Dong Huang Chang-Dong Wang College of Mathematics and Informatics South China Agricultural University China School of Computer Science and Engineering Sun Yat-sen University Guangxi Key Laboratory of Digital Infrastructure Guangxi Zhuang Autonomous Region Information Center Guangdong Key Laboratory of Big Data Analysis and Processing Key Laboratory of Machine Intelligence and Advanced Computing Ministry of Education China

The Anchor-based Multi-view Subspace Clustering (AMSC) has turned into a favourable tool for large-scale multi-view clustering. However, there still exist some limitations to the current AMSC approaches. First, they typically recover anchor graph structure in the original linear space, restricting their feasibility for nonlinear scenarios. Second, they usually overlook the potential benefits of jointly capturing the inter-view and intra-view information for enhancing the anchor representation learning. Third, these approaches mostly perform anchor-based subspace learning by a specific matrix norm, neglecting the latent high-order correlation across different views. To overcome these limitations, this paper presents an efficient and effective approach termed Large-scale Tensorized Multi-view Kernel Subspace Clustering (LTKMSC). Different from the existing AMSC approaches, our LTKMSC approach exploits both inter-view and intra-view awareness for anchor-based representation building. Concretely, the low-rank tensor learning is leveraged to capture the high-order correlation (i.e., the inter-view complementary information) among distinct views, upon which the \(l_{1,2}\) norm is imposed to explore the intra-view anchor graph structure in each view. Moreover, the kernel learning technique is leveraged to explore the nonlinear anchor-sample relationships embedded in multiple views. With the unified objective function formulated, an efficient optimization algorithm that enjoys low computational complexity is further designed. Extensive experiments on a variety of multi-view datasets have confirmed the efficiency and effectiveness of our approach when compared with the other competitive approaches.

关键词： data clustering Multi-view clustering Large-scale clustering Tensorized kernel subspace clustering Inter-view and intra-view awareness

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