检索结果-内蒙古大学图书馆

A Deep Self-learning Classification Framework for Incomplete Medical Patents with Multi-label 15th

学校读者我要写书评

暂无评论

A Deep Self-learning Classification Framework for Incomplete...

15th International Conference on Natural Computation, Fuzzy Systems and Knowledge Discovery, ICNC-FSKD 2019, co-located with the 5th International Conference on Harmony Search, Soft Computing and Applications, ICHSA 2019

作者： Luo, Mengzhen Shi, Xiaoyu Ji, Qianqian Shang, Mingsheng He, Xianbo Tao, Weiguo The Computer School of China West Normal University NanchongSichuan637002 China Chongqing Key Laboratory of Big Data and Intelligent Computing Chongqing Institute of Green and Intelligent Technology Chinese Academy of Sciences Chongqing400714 China

ISBN: (纸本)9783030325909

The classification of medical patents play an important role for pharmaceutical company, since medical patens with well labeled can significantly accelerate the process of new drug research. The previous studies using machine learning methods focus on classification the medical patents with single label. However, the classification of medical patents is a multi-label task, and the available data are always incomplete with losing the part information of patents. In this paper, we propose a deep self-learning classification framework that can deal with the incomplete medical patterns with multi-label issue. It consists of a text processor and patent classifier. For the text processor, a professional medical text thesaurus is built via GloVe method, which can learn more specialized vocabulary. For the patent classifier, we adopt a bidirectional long short term memory (Bi-LSTM) model to construct our patent classifier, which can learn the hidden knowledge from medical patents and associate with appropriate labels to medical patents automatically. Furthermore, an advanced focal loss function is design to further improve the classification accuracy. Experiments on the Thomson Reuters dataset demonstrate that our proposed method outperform the other existing methods in terms of precision and recall, when dealing with incomplete medical patents with multi-label issue.. © 2020, Springer Nature Switzerland AG.

关键词： Long short-term memory

Z16b,a natural compound from Ganoderma cochlear is a novel RyR2 stabilizer preventing catecholaminergic polymorphic ventricular tachycardia

学校读者我要写书评

暂无评论

中国药理学报（英文版） 2022年第9期43卷 2340-2350页

作者： Jiang-fan Wan Gang Wang Fu-ying Qin Dan-ling Huang Yan Wang Ai-ling Su Hai-ping Zhang Yang Liu Shao-yin Zeng Chao-liang Wei Yong-xian Cheng Jie Liu Guangdong Key Laboratory of Genome Stability and Human Disease Prevention Department of PathophysiologySchool of MedicineShenzhen UniversityShenzhen 518000China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China Guangdong Key Laboratory of Genome Stability and Human Disease Prevention Department of PathophysiologySchool of MedicineShenzhen UniversityShenzhen 518000China School of Pharmaceutical Sciences Shenzhen University Health Science CenterShenzhen 518000China Center for Translation Medicine Research and Development Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518000China Center for High Performance Computing Joint Engineering Research Center for Health Big Data Intelligent Analysis TechnologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518000China Guangdong Cardiovascular Institute Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510000China Guangdong Provincial key laboratory of South China Structure Heart Disease Department of Pediatric CardiologyGuangdong Cardiovascular InstituteGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510000China

Catecholaminergic polymorphic ventricular tachycardia(CPVT)is an inherited,lethal ventricular arrhythmia triggered by *** in genes that encode cardiac ryanodine receptor(RyR2)and proteins that regulate RyR2 activity cause enhanced diastolic Ca2+release(leak)through the RyR2 channels,resulting in *** therapies for CPVT are *** found that Z16b,a meroterpenoid isolated from Ganoderma cochlear,inhibited Ca2+spark frequency(CaSF)in R2474S/+cardiomyocytes in a dose-dependent manner,with an IC50 of 3.2 μM.Z16b also dose-dependently suppressed abnormal post-pacing Ca2+release *** injection(i.p.)of epinephrine and caffeine stimulated sustained ventricular tachycardia in all R2474S/+mice,while pretreatment with Z16b(0.5 mg/kg,i.p.)prevented ventricular arrhythmia in 9 of 10 mice,and Z16b administration immediately after the onset of VT abolished sVT in 9 of 12 *** translational significance,Z16b significantly inhibited CaSF and abnormal Ca2+release events in human CPVT ***,Z16b interacts with RyR2,enhancing the"zipping"state of the N-terminal and central domains of RyR2.A molecular docking simulation and point mutation and pulldown assays identified Z16b forms hydrogen bonds with Arg626,His1670,and Gln2126 in RyR2 as a triangle shape that anchors the NTD and CD interaction and thus stabilizes RyR2 in a tight"zipping"*** findings support that Z16b is a novel RyR2 stabilizer that can prevent *** may also serve as a lead compound with a new scaffold for the design of safer and more efficient drugs for treating CPVT.

关键词： arrhythmia catecholaminergic polymorphic ventricular tachycardia natural product ryanodine receptor induced pluripotent stem cell-derived cardiomyocytes

Forensicability Assessment of Questioned Images in Recapturing Detection

学校读者我要写书评

暂无评论

arXiv 2022年

作者： Chen, Changsheng Zhao, Lin Cai, Rizhao Yu, Zitong Huang, Jiwu Kot, Alex C. The Guangdong Key Laboratory of Intelligent Information Processing and Shenzhen Key Laboratory of Media Security National Engineering Laboratory for Big Data System Computing Technology College of Electronics and Information Engineering Shenzhen University Shenzhen China Shenzhen Institute of Artificial Intelligence and Robotics for Society China The Department of Electrical and Electrics Engineering Nanyang Technological University Singapore639798 Singapore

Recapture detection of face and document images is an important forensic task. With deep learning, the performances of face anti-spoofing (FAS) and recaptured document detection have been improved significantly. However, the performances are not yet satisfactory on samples with weak forensic cues. The amount of forensic cues can be quantified to allow a reliable forensic result. In this work, we propose a forensicability assessment network to quantify the forensicability of the questioned samples. The low-forensicability samples are rejected before the actual recapturing detection process to improve the efficiency of recapturing detection systems. We first extract forensicability features related to both image quality assessment and forensic tasks. By exploiting domain knowledge of the forensic application in image quality and forensic features, we define three task-specific forensicability classes and the initialized locations in the feature space. Based on the extracted features and the defined centers, we train the proposed forensic assessment network (FANet) with cross-entropy loss and update the centers with a momentum-based update method. We integrate the trained FANet with practical recapturing detection schemes in face anti-spoofing (FAS) and recaptured document detection tasks. Experimental results show that, for a generic CNN-based FAS scheme, FANet reduces the EERs from 33.75% to 19.23% under ROSE to IDIAP protocol by rejecting samples with the lowest 30% forensicability scores. The performance of FAS schemes is poor in the rejected samples, with EER as high as 56.48%. Similar performances in rejecting low-forensicability samples have been observed for the state-of-the-art approaches in FAS and recaptured document detection tasks. To the best of our knowledge, this is the first work that assesses the forensicability of recaptured document images and improves the system efficiency. Copyright © 2022, The Authors. All rights reserved.

关键词： Image quality

Cross-View Fuzziness and Intra-view Uncertainty-Based Weight Reconstruction for Multi-view Feature Selection 11th

学校读者我要写书评

暂无评论

Cross-View Fuzziness and Intra-view Uncertainty-Based Weigh...

11th International Joint Conference on Rough Sets, IJCRS 2025

作者： Xiang, Biao Chen, Hongmei Mi, Yong Sang, Binbin Horng, Shi-Jinn Li, Tianrui Institute of Artificial Intelligence School of Computing and Artificial Intelligence Southwest Jiaotong University Chengdu611756 China National Engineering Laboratory of Integrated Transportation Big Data Application Technology Southwest Jiaotong University Chengdu611756 China Engineering Research Center of Sustainable Urban Intelligent Transportation Ministry of Education Southwest Jiaotong University Chengdu611756 China Manufacturing Industry Chains Collaboration and Information Support Technology Key Laboratory of Sichuan Province Southwest Jiaotong University Chengdu611756 China College of Computer and Information Science Chongqing Normal University Chongqing401331 China Department of Computer Science and Information Engineering Asia University Taichung41354 Taiwan

ISBN: (纸本)9783031927430

Weight assignment is a universal and indispensable process in multi-view feature selection. However, most existing methods overlook the fuzziness and uncertainty implied in multi-view data. This may result in improper weight assignment, degrading the quality of selected features. A cross-view fuzziness and intra-view uncertainty-based weight reconstruction method (CFIUWR) is proposed for multi-view feature selection. With the fuzzy rough set theory, fuzzy approximation operators recognize cross-view fuzziness and intra-view uncertainty, which are evaluated by classification-related measurement. Cross-view fuzziness and intra-view uncertainty are incorporated to develop a reconstruction mechanism for view and feature weights. An optimization algorithm is derived, guaranteeing rapid convergence. Comparisons with state-of-the-art methods on several real-world datasets demonstrate the superiority of the CFIUWR. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.

关键词： Rough set theory

An Original Design of robotic-Assisted Flexible Nasotracheal Intubation System

学校读者我要写书评

暂无评论

An Original Design of Robotic-Assisted Flexible Nasotracheal...

2023 IEEE International Conference on robotics and Biomimetics, ROBIO 2023

作者： Liu, He Liu, Shi-Qi Xie, Xiao-Liang Li, Ye Zhou, Xiao-Hu Feng, Zhen-Qiu Li, Guo-Tao Ma, Xi-Yao Hou, Zeng-Guang Yuan, Yong-Yi Cui, Yong Tian, Yu-Hong Dai, Pu Chinese Academy of Sciences State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of Automation Beijing100190 China University of Chinese Academy of Sciences School of Artificial Intelligence Beijing100049 China Chinese Academy of Sciences Joint Engineering Research Center for Health Big Data Intelligent Analysis Technology Shenzhen Institutes of Advanced Technology Shenzhen518055 China The Sixth Medical Center of Pla General Hospital College of Otolaryngology Head and Neck Surgery Beijing100853 China The 983th Hospital of Joint Logistic Support Force Department of Otolaryngology Tianjin300142 China

ISBN: (纸本)9798350325706

Nasotracheal intubation is a crucial emergency procedure that can improve the survival rate of injured patients. Compared to orotracheal intubation, nasotracheal intubation offers greater stability and comfort. However, due to the large curvature of the cavity, the procedure is highly challenging and requires skilled medical staff, which can be a shortage in emergencies and delay patient rescue. To solve this problem, a flexible and portable robot for nasotracheal intubation has been developed in this paper. The robot incorporates a continuum catheter, allowing the shape of the endotracheal tube's distal section to be controllable and making it easier to pass through the nasal cavity into the trachea. An endoscope is integrated into the distal section of the catheter to make the intubation process more intuitive, allowing doctors to observe the injuries through endoscopic images and adjust the treatment plan. Additionally, the robot is designed with a quick-detachable structure, enabling aseptic and low-cost intubation procedures. The structure and circuitry of the robot are designed for portability, with a smaller size and lower power consumption, which can work for a long time just powered by batteries. Finally, experiments on a mannequin validate that the robotic system effectively reduces the difficulty of tracheal intubation, enabling even non-medically trained operators to complete the procedure with the assistance of the robot. © 2023 IEEE.

关键词：

Transverse Velocity Field Measurement in High-Resolution Solar Images Based on Deep Learning

学校读者我要写书评

暂无评论

arXiv 2023年

作者： Shang, Zhen-Hong Mu, Si-Yu Ji, Kai-Fan Qiang, Zhen-Ping Faculty of Information Engineering and Automation Kunming University of Science and Technology Kunming650500 China Yunnan Key Laboratory of Artificial Intelligence Kunming University of Science and Technology Kunming650500 China Yunnan Observatories Chinese Academy of Sciences Kunming650216 China College of Big Data and Intelligent Engineering Southwest Forestry University Kunming650224 China

To address the problem of the low accuracy of transverse velocity field measurements for small targets in high-resolution solar images, we proposed a novel velocity field measurement method for high-resolution solar images based on PWCNet. This method transforms the transverse velocity field measurements into an optical flow field prediction problem. We evaluated the performance of the proposed method using the Hα and TiO datasets obtained from New Vacuum Solar Telescope (NVST) observations. The experimental results show that our method effectively predicts the optical flow of small targets in images compared with several typical machine- and deep-learning methods. On the Hα dataset, the proposed method improves the image structure similarity from 0.9182 to 0.9587 and reduces the mean of residuals from 24.9931 to 15.2818;on the TiO dataset, the proposed method improves the image structure similarity from 0.9289 to 0.9628 and reduces the mean of residuals from 25.9908 to 17.0194. The optical flow predicted using the proposed method can provide accurate data for the atmospheric motion information of solar images. The code implementing the proposed method is available on https:// ***/lygmsy123/transverse-velocity-field-measurement. Copyright © 2023, The Authors. All rights reserved.

关键词： Deep learning

BioT5: Enriching Cross-modal Integration in Biology with Chemical Knowledge and Natural Language Associations

学校读者我要写书评

暂无评论

arXiv 2023年

作者： Pei, Qizhi Zhang, Wei Zhu, Jinhua Wu, Kehan Gao, Kaiyuan Wu, Lijun Xia, Yingce Yan, Rui Gaoling School of Artificial Intelligence Renmin University of China China University of Science and Technology of China China Huazhong University of Science and Technology China Microsoft Research United States Engineering Research Center of Next-Generation Intelligent Search and Recommendation Ministry of Education China Beijing Key Laboratory of Big Data Management and Analysis Methods China

Recent advancements in biological research leverage the integration of molecules, proteins, and natural language to enhance drug discovery. However, current models exhibit several limitations, such as the generation of invalid molecular SMILES, underutilization of contextual information, and equal treatment of structured and unstructured knowledge. To address these issues, we propose BioT5, a comprehensive pretraining framework that enriches cross-modal integration in biology with chemical knowledge and natural language associations. BioT5 utilizes SELFIES for 100% robust molecular representations and extracts knowledge from the surrounding context of bio-entities in unstructured biological literature. Furthermore, BioT5 distinguishes between structured and unstructured knowledge, leading to more effective utilization of information. After fine-tuning, BioT5 shows superior performance across a wide range of tasks, demonstrating its strong capability of capturing underlying relations and properties of bio-entities. Our code is available at https://***/QizhiPei/BioT5. Copyright © 2023, The Authors. All rights reserved.

关键词： Integration

Online Attentive Kernel-Based Temporal Difference Learning

学校读者我要写书评

暂无评论

arXiv 2022年

作者： Yang, Guang Chen, Xingguo Yang, Shangdong Wang, Huihui Dong, Shaokang Gao, Yang The the Jiangsu Key Laboratory of Big Data Security & Intelligent Processing Nanjing University of Posts and Telecommunications National Engineering Laboratory for Agri-Product Quality Traceability Beijing Technology and Business University China The State Key Laboratory for Novel Software Technology Nanjing University China The PCA Lab Key Lab of Intelligent Perception and Systems for High-Dimensional Information Ministry of Education Jiangsu Key Lab of Image and Video Understanding for Social Security School of Computer Science and Engineering Nanjing University of Science and Technology China

With rising uncertainty in the real world, online Reinforcement Learning (RL) has been receiving increasing attention due to its fast learning capability and improving data efficiency. However, online RL often suffers from complex Value Function Approximation (VFA) and catastrophic interference, creating difficulty for the deep neural network to be applied to an online RL algorithm in a fully online setting. Therefore, a simpler and more adaptive approach is introduced to evaluate value function with the kernel-based model. Sparse representations are superior at handling interference, indicating that competitive sparse representations should be learnable, non-prior, non-truncated and explicit when compared with current sparse representation methods. Moreover, in learning sparse representations, attention mechanisms are utilized to represent the degree of sparsification, and a smooth attentive function is introduced into the kernel-based VFA. In this paper, we propose an Online Attentive Kernel-Based Temporal Difference (OAKTD) algorithm using two-timescale optimization and provide convergence analysis of our proposed algorithm. Experimental evaluations showed that OAKTD outperformed several Online Kernel-based Temporal Difference (OKTD) learning algorithms in addition to the Temporal Difference (TD) learning algorithm with Tile Coding on public Mountain Car, Acrobot, CartPole and Puddle World tasks. Copyright © 2022, The Authors. All rights reserved.

关键词： Learning algorithms

Efficient EK-means: Extended K-means Clustering for Categorical data with High Processing Speed 4

学校读者我要写书评

暂无评论

Efficient EK-means: Extended K-means Clustering for Categori...

4th International Conference on data Mining, Communications and Information Technology, DMCIT 2020

作者： Xi, Chen Shuo, Peng HunanProvincial Key Laboratory of Intelligent Processing of Big Data on Transportation School of Computer and Communication Engineering Changsha University of Scienceandtechnology No. 960 Wanjiali South Road Hunan Province China

The typical representative of the hard clustering algorithm, K-means, is one of the fastest processing algorithms with good scalability. However, it cannot deal with categorical attributes, which is one of the important indicators to measure the pros and cons. Due to the lack of processing capabilities on categorical attributes, k-means has a large limit on data processing capabilities. This paper proposes a clustering algorithm extends from K-means. This algorithm introduces the concept of a Pseudo-mean distance calculation formula and a counting-table so that categorical attributes can be processed while reducing the time cost as much as possible. Experimental results illustrate the proposed Pseudo-means can extend the processing range of k-means to category-type data, and the counting table also effectively reduces the time cost. © Published under licence by IOP Publishing Ltd.

关键词： Cost reduction