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27-Hydroxycholesterol/liver X receptor/apolipoprotein E mediates zearalenone-induced intestinal immunosuppression:A key target potentially linking zearalenone and cancer

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Journal of Pharmaceutical Analysis 2024年第3期14卷 371-388页

作者： Haonan Ruan Jing Zhang Yunyun Wang Ying Huang Jiashuo Wu Chunjiao He Tongwei Ke Jiaoyang Luo Meihua Yang Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of EducationInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100193China

Zearalenone(ZEN)is a mycotoxin that extensively contaminates food and feed,posing a significant threat to public ***,the mechanisms behind ZEN-induced intestinal immunotoxicity remain *** this study,Sprague-Dawley(SD)rats were exposed to ZEN at a dosage of 5 mg/kg/day *** a duration of 14 *** results demonstrated that ZEN exposure led to notable pathological alterations and immunosuppression within the ***,ZEN exposure caused a significant reduction in the levels of apolipoprotein E(ApoE)and liver X receptor(LXR)(P<0.05).Conversely,it upregulated the levels of myeloid-derived suppressor cells(MDSCs)markers(P<0.05)and decreased the presence of 27-hydroxycholesterol(27-HC)in the intestine(P<0.05).It was observed that ApoE or LXR agonists were able to mitigate the immunosuppressive effects induced by ***,a bioinformatics analysis highlighted that the downregulation of ApoE might elevate the susceptibility to colorectal,breast,and lung *** findings underscore the crucial role of the 27-HC/LXR/ApoE axis disruption in ZEN-induced MDSCs proliferation and subsequent inhibition of T lymphocyte activation within the rat ***,ApoE may emerge as a pivotal target linking ZEN exposure to cancer development.

关键词： Zearalenone Intestinal immunosuppression Apolipoprotein E Bioinformatics analysis Cancer

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Rhizosphere microbial markers (micro-markers): A new physical examination indicator for traditional Chinese medicines

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Chinese Herbal Medicines 2024年第2期16卷 180-189页

作者： Kailin Yang Yaping Zheng Kangmeng Sun Xinyan Wu Zheng Zhang Chunnian He Peigen Xiao Institute of Medicinal Plant Development Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of EducationBeijing 100193China

Rhizosphere microorganisms,as one of the most important components of the soil microbiota and plant holobiont,play a key role in the medicinal plant-soil ecosystem,which are closely related to the growth,adaptability,nutrient absorption,stress tolerance and pathogen resistance of host *** recent years,with the wide application of molecular biology and omics technologies,the outcomes of rhizosphere microorganisms on the health,biomass production and secondary metabolite biosynthesis of medicinal plants have received extensive ***,whether or to what extent rhizosphere microorganisms can contribute to the construction of the quality evaluation system of Chinese medicinal materials is still *** on the significant role of rhizosphere microbes in the survival and quality formation of medicinal plants,this paper proposed a new concept of rhizosphere microbial markers(micro-markers),expounded the relevant research methods and ideas of applying the new concept,highlighted the importance of micro-markers in the quality evaluation and control system of traditional Chinese medicines(TCMs),and introduced the potential value in soil environmental assessment,plant pest control and quality assessment of *** provides reference for developing ecological planting of TCMs and ensuring the production of high quality TCMs by regulating rhizosphere microbial communities.

关键词： physical examination indicator quality evaluation quality formation of medicinal plants rhizosphere microorganisms rhizosphere microbial markers

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PMGA:A plant mitochondrial genome annotator

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Plant Communications 2025年第3期6卷 4-7页

作者： Jingling Li Yang Ni Qianqi Lu Haimei Chen Chang Liu State Key Laboratory for Quality Assurance and Sustainable Use of Dao-Di Herbs Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal MedicineMinistry of Education of ChinaInstitute of Medicinal Plant DevelopmentChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100193P.R.China

Dear Editor,Plant mitochondria are essential organelles of plant cells and play crucial roles in oxidative phosphorylation and diverse metabolic processes(Wang et al.,2024).Mitochondria have an endosymbiotic origin,likely from a proteobacterial lineage that branched off before the divergence of known alphaproteobacterial groups(Martijn et al.,2018),and contain their own genetic materials,known as plant mitochondrial genomes(PMGs).PMGs exhibit unique features that may result from mechanisms different from those of nuclei and plastids,such as DNA repair(Chevigny et al.,2020),mRNA splicing(Novikova and Belfort.2017;Guo et al.,2020),transcription regulation,and foreign sequence *** advances in genome editing technologies have facilitated targeted modifications of PMGs,enabling the functional characterization of mitochondrial genes and the generation of desirable phenotypes(Forner et al.,2023;Xu et al.,2024).Accurate annotations of PMGs are a prerequisite for basic and applied research on mitochondria,such as studies of PMG evolution or targeted breeding of new crop varieties by PMG engineering.

关键词： alphaproteobacterial groups martijn proteobacterial lineage plant cells annotations plant mitochondrial genomes pmgs pmgs plant mitochondrial genome metabolic processes wang oxidative phosphorylation

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Perspective and challenges of mycorrhizal symbiosis in orchid medicinal plants

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Chinese Herbal Medicines 2024年第2期16卷 172-179页

作者： Chunyan Leng Mengyan Hou Yongmei Xing Juan Chen Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine Ministry of EducationInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China

The family Orchidaceae is of the most diverse taxon in the plant kingdom,and most of its members are highly valuable herbal *** have a unique mycorrhizal symbiotic relationship with specific fungi for carbohydrate and nutrient supplies in their whole *** large-scale cultivation of the medicinal plant Gastodia elata is a successful example of using mycorrhizal symbiotic *** this review,we adopted *** and Dendrobium officinale as examples to describe the characteristics of orchid mycorrhiza and mycorrhizal benefits for host plants’growth and health(*** and abiotic stress and secondary metabolite accumulation).The challenges in applying mycorrhizal technology to the cultivation of orchid medicinal plants in the future were also *** review aims to serve as a theoretical guide for the cultivation of mycorrhizal technology in medicinal orchid plants.

关键词： Dendrobium officinale Kimura&Migo ecological cultivation Gastodia elata Blume mycorrhiza orchid medicinal plants symbiosis mechanisms

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Analysis of fungal composition in different layers of Bantou agarwood-forming trunk of Aquilaria sinensis revealing presence of Aspergillus-inhibiting substances in agarwood sites

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Chinese Herbal Medicines 2025年第2期17卷 315-321页

作者： Xuyu Chen Yun Yang Yangyang Liu Chun Sui Jianhe Wei Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine&Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization Hainan Branch of Institute of Medicinal Plant DevelopmentChinese Academy of Medicinal Sciences&Peking Union Medical CollegeHaikou 570311China Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of Education&National Engineering Laboratory for Breeding of Endangered Medicinal MaterialsInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China

Objective:The objective of this study was to analyse fungal composition and exploit application potential in the Bantou(BT)agarwood-forming trunk of Aquilaria ***:BT agarwood is a naturally formed agarwood that was collected after *** genomic DNA of the fungi in BT agarwood was extracted by the hexadecyltrimethy ammonium bromide(CTAB)method,followed by PCR amplification and library *** effective tags were obtained by the HiSeq2500 platform,and the data were subjected to bioinformatics and statistical ***:A total of 7850040 effective tags were obtained,Ascomycota was the most abundant fungus at the phylum level,with a relative abundance of 56.36%–61.44%,followed by Basidiomycota,with a relative abundance of 10.49%–20.39%.Dothideomycetes,Agaricomycetes and Sordariomycetes were dominant at the class level,accounting for 26.21%–33.88%,8.40%–17.66%,and 18.41%–24.11%,***,Phaeoacremonium and Hermatomyces were dominant at the genus level,with relative abundances of 6.25%–7.64%,1.95%–9.05%and 1.5%–5.4%,*** and richness analysis showed that the fungal composition in the agarwood formation sites(agarwood layer,upper agarwood layer and lower agarwood layer)were significantly lower than those in the decomposing layer and the healthy *** is,the fungal diversity and richness were significantly reduced during agarwood formation by the action of open *** fungal community structure in the decomposing layer and agarwood formation sites obviously differed from that in the healthy *** number of Aspergillus taxa in agarwood formation sites decreased significantly(healthy layer is 0.5%,decomposing layer is 0.022%,upper agarwood layer is 0.012%,agarwood layer is 0.01%,and lower agarwood layer is 0.013%),indicating that agarwood may contain potential substances to inhibit the growth of ***:Agarwood from agarwood formation sites contains potential substances that

关键词： Aspergillus Aquilaria sinensis(Lour.)Gilg Bantou agarwood fungal composition

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Improved extraction efficiency of bakuchiol with antioxidant and whitening bioactivities from the seeds of Psoralea corylifolia L.

Science of Traditional Chinese Medicine

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Science of Traditional Chinese Medicine 2023年第2期1卷 123-128页

作者： Tian Qin Jinjun Liu Yongxian Bi Yanduo Wang Jianzi Liu Gang Ding Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of EducationInstitute ofMedicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Zhejiang Yige Enterprise Management Group Co LtdHangzhouChina

Background:Mining new whitening ingredients from plants is an effective way to develop new cosmetic ***,as one of the main active ingredients from the seeds of Psoralea corylifolia L,displays whitening,antioxidant,antiaging,and free radical-scavenging activities and attracts wide attention especially in the cosmetics ***,environmentally friendly extraction technologies with high efficiency and high product purity remain to be developed for the scale production of ***:In this study,a new approach(acetic acid–steaming–assisted technique)was developed to improve the extraction efficiency of ***:The factors influencing the extraction efficiency of bakuchiol,including seed powder granularity,acetic acid volume,temperature,and time,were optimized based on single-factor ***:The extraction conditions were optimized as steaming the seed powder(100 g)of 40–100meshes with acetic acid(50 mL)for 10 minutes,from which a crude extract(25.1 g)containing bakuchiol was *** purity(99.1)of bakuchiol(6.02 g)was then prepared by silica gel column chromatography in a one-step *** method established in this study had higher extraction rate than other *** antioxidant potential of bakuchiol was evaluated based on the ABTS free radical scavenging activity and ferric reducing antioxidant ***,bakuchiol demonstrated stronger tyrosinase inhibitory activity than the positive control(arbutin).Conclusions:Compared with the available methods,the method established in this study has increased extraction rate of bakuchiol and is environmentally friendly and economical,demonstrating the potential for industrial production.

关键词： Seeds of Psoralea corylifolia L. Bakuchiol Acetic acid-steaming Separation Structural elucidation Antioxidant and tyrosinase inhibitory activities

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Highly Efficient Heavy-Metal-Ion Removal from Shellfish Processing Liquid with Low Protein and Polysaccharide Loss by Hybrid Mesoporous Silica Diol-APDC-SBA15

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Journal of Ocean University of China 2023年第1期22卷 221-228页

作者： QI Yanxia SONG Yang LIU Chang QI Shizhe WANG Haibo CAO Jijuan ZHAO Qiancheng College of Food Science and Engineering Dalian Ocean UniversityDalian 116023China Liaoning Provincial Aquatic Products Analyzing Testing and Processing Technology Scientific Service CenterDalian 116023China Key Laboratory of Biotechnology and Bioresources Utilization of Ministry of Education Dalian Minzu UniversityDalian 116600China Collaborative Innovation Center of Seafood Deep Processing Dalian Polytechnic UniversityDalian 116034China Dalian Key Laboratory of Marine Bioactive Substances Development and High Value Utilization Dalian 116034China

Heavy metal ions in shellfish products are harmful to human health,and their removal with low nutrient loss remains ***,a new type of mesoporous silica(SBA15),modified internally with ammonium pyrrolidine dithiocarbamate(APDC)and externally with alkyl-diol groups,which was named as Diol-APDC-SBA15,was successfully developed and characterized by powder X-ray diffraction patterns,nitrogen adsorption,and Fourier transform infrared *** solutions with lead,chromium,cadmium,and copper were used to investigate the adsorption capacity of ***-APDC-SBA15 was adopted to remove heavy metals from cooking liquids of clams(Ruditapes philippinarum),hydrolysate liquids of oysters(Ostrea gigas Thunberg),and polysaccharide solution from the cooking liquid of *** efficiencies of removing heavy metal ions and the loss rates of proteins and polysaccharides were *** results showed that the adsorption capacities of Diol-APDCSBA15 for Pb,Cr,Cd,and Cu in standard heavy-metal solutions were 161.4,166.1,29.6,and 60.2mgg^(−1),*** removal efficiency of Diol-APDC-SBA15 for Pb in the three shellfish processing liquids ranged from 60.5%to 99.6%.The Cr removal efficiency was above 99.9%in the oyster hydrolysate ***,the percentages of polysaccharide loss were 5.5%and 3.7%in the cooking liquid of clam and polysaccharide solution,respectively,and the protein loss was 1.2%in the oyster hydrolysate ***,the Diol-APDC-SBA15 material exhibits a great potential application in the removal of heavy metals from shellfish processing liquids with low losses of proteins and polysaccharides.

关键词： heavy-metal removal modified mesoporous silica shellfish processing liquid protein polysaccharide

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Five new spirosterol saponins from Allii Macrostemonis Bulbus

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Chinese Journal of Natural Medicines 2023年第3期21卷 226-232页

作者： WANG Rong WANG Lulu ZHANG Manli GUO Yadi ZHANG Jing MA Guoxu College of Chinese Medicinal Materials Jilin Agricultural UniversityChangchun 130118China College of Medicine Changchun University of Science and TechnologyChangchun 130600China Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine Institute of Medicinal Plant DevelopmentPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100193China

Five new spirostanol saponins(1−5)and seven known compounds(6−12)were isolated from the n-butanol fraction of 75%ethanol extract of Allii Macrostemonis *** identification and structural elucidation of all the isolates were performed through extensive 1D and 2D NMR experiments,HR-ESI-MS data analysis and comparisons with literature *** evaluation showed that compounds 6−11 exhibited certain scavenging effects on ABTS radical,where compounds 6,7 and 11 had IC50 values of 0.208,0.057 and 0.014 mg·mL−1,respectively.

关键词： Allii Macrostemonis Bulbus Spirosterol saponin Antioxidant

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A composite arctigenin/caffeine/glucose formulation enhances anti-fatigue effect

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Food Bioscience 2022年第5期49卷 584-592页

作者： Wanbo Zeng Le Sun Huimin Zhu Xiaowen Wu Lijia Xu Liang Xu State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and ToxicologyBeijing100850China Institute of Medicinal Plant Development Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing100193China Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of EducationBeijing100193China

Fatigue is a comprehensive response to a variety of physiological and biochemical changes in the *** strategies addressing relevant key factors simultaneously may enhance anti-fatigue *** this study,we aimed to develop new anti-fatigue agents with combining strategy based on bioinformatics *** indicated PI3k-Akt,cAMP,and p53 signaling pathway-related energy metabolism and antioxidant capacity were involved in exercise-induced physiological changes.A new representative complex agent(Z-005,containing arctigenin,caffeine,and glucose)addressing these key factors as well as central excitation was developed and tested.Z-005 showed a synergistic effect,greatly enhancing anti-fatigue efficiency than single components,in a mouse running wheel *** exhaustion distances were 2.40-fold greater than the control in the Z-005 group.Z-005 excited the central nervous system,increased the plasma superoxide dismutase and catalase concentrations,reduced lactic acid accumulation,maintained the glycogen ***,the expression of key genes in PI3K,cAMP,and p53 pathways,as well as the phosphorylation of adenosine monophosphate-activated protein kinase(AMPK)were proved with enhancement by Z-005 *** composite formulation thus represents a new and practicable combined strategy for fatigue prevention,and the study findings can contribute to the development of treatments for fatigue-related sub-health.

关键词： Bioinformatics analysis Anti-fatigue Arctigenin Antioxidant capacity PI3k-akt

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Genome-wide analysis of UGT gene family identified key gene for the biosynthesis of bioactive flavonol glycosides in Epimedium pubescens Maxim

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Synthetic and Systems Biotechnology 2022年第4期7卷 1095-1107页

作者： Yu Yao Jiajun Gu Yanjiao Luo Yuanyue Wang Yongzhen Pang Guoan Shen Baolin Guo Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicines Ministry of EducationInstitute of Medicinal Plant DevelopmentChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing100193China Institute of Animal Science Chinese Academy of Agricultural SciencesBeijing100193China

Epimedium pubescens *** a well-known traditional Chinese medicinal herb with flavonol glycosides as the major pharmaceutically active ***-glycosyltransferases(UGTs)are a group of enzymes responsible for the glycosylation of flavonoid *** this study,a genome-wide analysis was performed to identify UGT family genes in *** a result,a total of 339 putative UGT genes were identified,which represents the largest UGT gene family known thus far,implying a significant expansion of the UGT gene family in *** EpUGTs were unevenly distributed across six chromosomes,and they were classified into 17 major *** expression profiles showed that UGT genes were differentially expressed in roots,leaves,flowers,shoots and *** particular,several EpUGTs were highly induced by high light intensity,which was consistent with the accumulation level of bioactive flavonoids in *** UGT79 genes that were preferentially expressed in roots or leaves were successfully expressed in ***,and only the recombinant EpGT60 protein was found to be active toward 8-prenylkaempferol and icaritin to produce the key bioactive compounds baohuoside II and baohuoside *** optimal temperature,pH,k_(m) and V_(max) were determined for the recombinant EpGT60 *** addition,expression of recombinant EpGT60 in *** cell culture led to successful production of baohuoside II when fed *** study provides a foundation for further functional characterization of UGT genes in *** and provides key candidate genes for bioengineering bioactive flavonoids in ***.

关键词： Epimedium pubescens Maxim Flavonoids UDP-glycosyltransferase Phylogenetic analysis EpGT60

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