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Highland barley improves lipid metabolism, liver injury, antioxidant capacities and liver functions in high-fat/cholesterol diet mice based on gut microbiota and LC-MS metabonomics

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Food Bioscience 2022年第6期50卷 982-1003页

作者： Xiang Li Yan Du Zhaoxin Tu Chengping Zhang Li Wang The Key Laboratory of Industrial Biotechnology Ministry of EducationJiangnan UniversityLihu Road 1800Wuxi214122China National Engineering Research Center for Cereal Fermentation and Food Biomanufacturing Jiangnan UniversityLihu Road 1800Wuxi214122China Jiangsu Provincial Engineering Research Center for Bioactive Product Processing Jiangnan UniversityLihu Road 1800Wuxi214122China Qinghai Huashi Technology Investment Management Co. Ltd(Qinghai Engineering Technology Research Institute for Comprehensive Utilization of Highland Barley Resources)XiningQinghai810016China

Highland barley (HB) possesses a series of properties such as regulating lipid metabolism and attenuating liver injury. Our study aimed to investigate the effect of HB, highland barley bran (HBB), whole grain highland barley (WGHB) on lipid metabolism, liver inflammation, gut microbiota and metabolite profiles in high-fat/cholesterol (HFCD) diet mice. 5 treatment groups were fed a normal control diet or a HFCD with or without HB supplementation for 10 weeks. The results showed that HB especially HBB significantly improved lipid parameters, liver function and injury and blood glucose indexes related to hyperlipidemia compared with HFCD group. In addition, HBB recovered the disorder of gut microbiota by increasing Bacteroidetes /Firmicutes ratio and Lactobacillus and Allobaculum abundances, and decreasing Proteobacteria abundance related to lipid metabolism bacteria. HBB enhanced the levels of 6 short chain fatty acids induced by HFCD. Fecal metabolomics analysis showed that the important differential metabolites between HBB group and HFCD group were deoxycholic acid, myclobutanil and cis -4-Hydroxy-D-proline, and the important differential metabolic pathways were arachidonic acid metabolism, tyrosine metabolism and bile secretion. Results suggested that HBB was an effective dietary intervention candidate to ameliorate hyperlipidemia.

关键词： Highland barley Lipid metabolism High-fat/cholesterol diet Gut microbiota Metabolomics

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Isolation and Identification of Flavonoids from Artemisia persica

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Chemistry of Natural Compounds 2025年第1期61卷 153-155页

作者： Umaraliev, J. Turak, A. Ganiev, A. A. Begmatov, N. B. Zhao, Bo Bobakulov, Kh. M. Abdullaev, N. D. Zhao, J. State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and the Key Laboratory of Plant Resources and Chemistry of Arid Zone Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences Urumqi P. R. China University of Chinese Academy of Sciences Beijing P. R. China S. Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of Sciences of the Republic of Uzbekistan Tashkent Uzbekistan National Research University Tashkent Institute of Irrigation and Agricultural Mechanization Engineers Tashkent Uzbekistan

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Network pharmacology and experimental investigation of the protective effect of Shuxuetong injection against diabetic nephropathy and encephalopathy in db/db mice

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Phytomedicine Plus 2024年第1期4卷 100521-100521页

作者： Liu, Jia Geng, Yifei Pan, Yunfeng Sun, Xiao Zheng, Shunliang Zhang, Zhiwei Huang, Jisheng Luo, Yun Sun, Xiaobo Guizhou University of Traditional Chinese Medicine Guiyang 550025 China Institute of Medicinal Plant Development Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100193 China Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine China Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine Ministry of Education China Mudanjiang Youbo Pharmceutical Co. Ltd. Mudanjiang 157013 China

Objective: To investigate the protective effects and mechanism of Shuxuetong injection on diabetic nephropathy and encephalopathy in db/db mice by integrating animal experiments and network pharmacology. Materials and methods: Thirty 4-week-old male db/db mice with type 2 diabetes were divided into model group and Shuxuetong injection group, and the age-matched db/m group was the control group after 16 weeks of feeding. In this study, Shuxuetong injection tail intravenous injection (2 mL/kg) lasted for 2 weeks form 16th to18th, and the whole experimental period was two weeks. Systematic network pharmacology involves the identification of active components and targets. Finally, we used ELISA to verify the inflammatory factors affected by the core pathway. Results: Histopathological analysis showed that Shuxuetong injection reducing hypertrophy of kidney tissues and basement membrane, as well as improving learning and memory impairment and decreasing hippocampal neuronal apoptosis induced by diabetes. It also significantly reduced blood urea nitrogen and creatinine levels as well as urinary microalbumin excretion rates. We found the core pathway was the “AGE-RAGE signaling pathway in diabetic complications”. This map showed that the pathway could affect the expression of inflammatory factors such as MCP-1, IκBα. ELISA demonstrated that Shuxuetong injection suppressed the expression of MCP-1 (P < 0.05).Moreover, Shuxuetong injection could inhibit the expressions of IκBα, increase the expressions of Akt, thereby effectiveiy alleviate the diabetic nephropathy. Conclusions: By studying pharmacodynamics and the analyzing of network pharmacology, the protective effect of Shuxuetong injection on diabetic nephrotic encephalopathy was preliminarily verified, and the possible targets and pathways were predicted, providing valuable evidence for further exploration of the therapeutic mechanism of Shuxuetong injection in capillaries. © 2023

关键词： Diabetic encephalopathy Diabetic nephropathy Network pharmacology Shuxuetong injection

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Compound Danshen Tablets ameliorate myocardial ischemia/reperfusion injury-induced ventricular remodeling by regulating autophagy via AMPK/mTOR signaling pathway

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Chinese Herbal Medicines 2024年

作者： Li, Qiaoyu Luo, Yun Guo, Haibiao Liu, Wenxiu Yu, Hui Li, Chuyuan Chen, Rongchang Sun, Xiaobo Institute of Medicinal Plant Development Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100193 China Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine Beijing 100193 China Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine Ministry of Education Beijing 100193 China NMPA Key Laboratory for Research and Evaluation of Pharmacovigilance Beijing 100193 China Guangzhou Baiyunshan Hutchison Whampoa Chinese Medicine Co. Ltd Guangzhou 510515 China

Objective: Left ventricular remodeling induced by myocardial ischemia/reperfusion injury (MI/RI) is a common cardiac dysfunction. Accumulating evidence has demonstrated that autophagy plays a vital role in protecting against ventricular remodeling. This study aims to investigate the performance of compound Danshen Tablets (CDT) in rescuing ventricular remodeling and whether autophagy as the potential mechanism. Methods: The left anterior descending arteries of rats were temporarily ligated for 30 min to construct the MI/RI model. Ventricular remodeling was induced by reperfusion for 28 d, during which the MI/RI rats were administered CDT (300 mg/kg and 600 mg/kg), atorvastatin (2 mg/kg), and diltiazem (16 mg/kg). Cardiac function and structure were examined by echocardiography. Immunohistochemistry, Masson's trichrome staining, and hematoxylin-eosin (H & E) staining were utilized to assess the fibrosis and histological alterations in the heart tissue. The expression of autophagy-related proteins was detected using Western blotting. Results: CDT attenuated the cardiac dysfunction, structural changes, histopathological changes and fibrosis induced by MI/RI. CDT significantly enhanced the level of Beclin1 and microtubule-associated protein 1 light chain 3 beta (LC3β), and reduced p62 levels in MI/RI rats. Moreover, CDT significantly increased the phosphorylation of AMP-activated protein kinase (AMPK) and inhibited mammalian target of rapamycin (mTOR) phosphorylation. Conclusion: CDT ameliorated MI/RI-induced ventricular remodeling by activating autophagy and improving autophagic flux via the AMPK/mTOR signaling pathway. © 2024 Tianjin Press of Chinese Herbal Medicines

关键词： AMPK/mTOR signaling pathway autophagy Compound Danshen Tablet myocardial ischemia/reperfusion injury ventricular remodelling

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Transcriptome and Metabolome Analysis Reveals Stage-Specific Metabolite Accumulation During Maturity of Chinese Black Truffle Tuber Indicum

SSRN

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SSRN 2023年

作者： Chen, Juan Li, Yang Xing, Yong-Mei Murat, Claude Kohler, Annegret Zhou, Dong-Yu Yu, Fu-Qiang Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine Ministry of Education Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union Medical College Beijing China Université de Lorraine INRAE UMR Interactions Arbres/Microorganismes INRAE Grand Est - Nancy Champenoux France Key Laboratory for Fungal Diversity and Green Development The Germplasm Bank of Wild Species Kunming Kunming Institute Botany Chinese Academy of Sciences Yunnan China

T uber indicum is the most economically important member of Tuber, with the highest production and widest distribution in China. However, the overexploitation of immature ascocarps not only have driven wild resources of the species toward extinction, but also has caused enconomic losses and a decline in the reputation of *** quality. In this study, stage-specific metabolites of T. indicum in relation to nutritional quality and the mechanism of their accumulations were explored by transcriptome and metabolome analysis at five harvest times, representing four maturation stages. A total of 663 compounds were identified in T. indicum ascocarps by a widely targeted metabolomic approach. Lipid compounds are the most prominent metabolites (18%) in our samples and also are higher accumulation at the immature stage than at mature stage, representing 30.16% differential accumulated metabolites in this stage. Levels of some of the amino acids, such as S-(methyl) glutathione, S-adenosylmethionine, which are known truffle aroma precursors, were increased at the mature stage. The gene expression level related to the biosynthesis of volatile organic compounds were verified by qPCR. This study contributes to the preliminary understanding of metabolites variations in T. indicum ascocarps during maturity for quality evaluation and truffle biology. © 2023, The Authors. All rights reserved.

关键词： Metabolites

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Transcriptome and Metabolome Analysis Reveals Stage-Specific Metabolite Accumulation During Maturity of Chinese Black Truffle Tuber Indicum

SSRN

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SSRN 2023年

作者： Chen, Juan Li, Yang Xing, Yong-Mei Murat, Claude Kohler, Annegret Zhou, Dong-Yu Yu, Fu-Qiang Key Laboratory of Bioactive Substances Resource Utilization of Chinese Herbal Medicine Ministry of Education Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union Medical College Beijing China Université de Lorraine INRAE UMR Interactions Arbres/Microorganismes INRAE Grand Est - Nancy Champenoux France Key Laboratory for Fungal Diversity and Green Development The Germplasm Bank of Wild Species Kunming Kunming Institute Botany Chinese Academy of Sciences Yunnan China

关键词： Metabolites

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Corrigendum to "Over-expression of α-synuclein 98 triggers intracellular oxidative stress and enhances susceptibility to rotenone" [Neurosci. Lett. 491 (2011) 148-152]

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Neuroscience letters 2025年 856-858卷 138238页

作者： Kai-Li Ma Yu-He Yuan Lian-Kun Song Ning Han Nai-Hong Chen Department of Pharmacology Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization Ministry of Education) 1 Xiannongtan Street Xuanwu District Beijing 100050 PR China. Department of Pharmacology Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization Ministry of Education) 1 Xiannongtan Street Xuanwu District Beijing 100050 PR China. Electronic address: chennh@***.

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Enzyme-Linked Immunosorbent Assay and Immunochromatographic Strip for Rapid Detection of Atrazine in Three Medicinal Herbal Roots

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World Journal of Traditional Chinese Medicine 2021年第1期7卷 97-103页

作者： Yu-Dan Wang Jia-An Qin Liu Wu Bao-Min Wang Sergei Eremin Shi-Hai Yang Mei-Hua Yang Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of EducationInstitute of Medicinal Plant DevelopmentChinese Academy of Medical SciencesPeking Union Medical CollegeBeijingChina College of Traditional Chinese Medicine Jilin Agricultural UniversityChangchunChina College of Agronomy and Biotechnology China Agricultural UniversityBeijingChina Department of Chemical Enzymology Faculty of Chemistry M.V.Lomonosov Moscow State University Leninsky Gory1119991 MoscowRussia

Objectives:An enzyme-linked immunosorbent assay(ELISA)and colloidal gold-based immunochromatographic(ICG)strip assay will be developed for the rapid and high-throughput detection of atrazine(ATZ)in medicinal ***:A monoclonal antibody against ATZ was obtained after the immunization of mice,cell fusion,and hybridoma screening,and the antibody was used to develop direct competitive ELISA(dcELISA)and the ICG strip ***:Both dcELISA and ICG strip methods were established,optimized,and validated for the detection of ATZ in Salviae miltiorrhizae radix et rhizome,Astragali radix,and Isatidis *** had a half-maximum inhibition concentration of 10.56 ng/m L(Salviae miltiorrhizae radix et rhizome),7.6 ng/m L(Astragali radix),and 8.15 ng/m L(Isatidis radix).The limit of detection(LOD)of the ICG strip assay was 12.5 ng/mL(Salviae miltiorrhizae radix et rhizome),12.5 ng/mL(Astragali radix),and 6.25 ng/mL(Isatidis radix)in different herb *** to the recognition characteristics of the monoclonal antibody for the pesticides ATZ,propazine,sebuthylazine,and prometryn,the detection results of real samples by the two immunoassays were confirmed by liquid chromatography–tandem mass spectrometry,which proved the accuracy and reliability of the established ***:The proposed dcELISA and ICG strip methods were suitable for the rapid,convenient,and high-throughput detection of ATZ in these medicinal herbs.

关键词： Astragali radix atrazine isatidis radix monoclonal antibody salviae miltiorrhizae radix et rhizome

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New Sulfoxide-Containing Derivatives from the Resin of Ferula sinkiangensis

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Planta Medica 2021年第6期88卷 420-428页

作者： Junchi Wang Haoli Yan Xiaoshuang Huo Lingyu Li Huijuan Wang Meng Zhang Xiaojin Li Yaqin Zhao Gang Chen Jianyong Si The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of Education Institute of Medicinal Plant Development Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China Center for Food and Drug Evaluation & Inspection of Henan Zhengzhou China Xinjiang Institute of Chinese Materia Medica and Ethical Materia Medica Urumqi China

Four undescribed sulfoxide-containing derivatives, sinkiangenoxides A and B, (2

关键词： Apiaceae sulfoxide structural elucidation cytotoxic NO release

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The complete chloroplast genome ofFlemingia strictaRoxb. ex Ait. 1812 (Phaseoleae, Fabaceae)

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Mitochondrial DNA Part B 2024年第8期9卷

作者： Yisha Cai Haimei Chen Jinghong Zhang a School of Medicine Huaqiao University Fujian Chinab State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-Di Herbs Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of Education of China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China b State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-Di Herbs Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of Education of China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China a School of Medicine Huaqiao University Fujian China

Flemingia strictaRoxb. ex Ait. 1812 belongs to the Phaseoleae tribe within the Fabaceae family and has significant pharmaceutical value. In this study, we reported the complete chloroplast genome ofF. strictausing the Illumina DNA sequencing data. The chloroplast genome was 152,940 bp and encoded 111 unique genes, including 77 protein-coding genes (PCGs), 30 transfer RNA (tRNA) genes, and 4 ribosomal RNA (rRNA) genes. The phylogenetic analysis confirmed thatF. strictawas closely related toFlemingia prostrataandFlemingia macrophylla. The chloroplast genome ofF. strictacould provide critical information for the molecular breeding ofF. strictaand be used as a reference genome for other species of Phaseoleae.

关键词： chloroplast genome Phaseoleae Flemingia stricta phylogenetic analysis

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