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Noise-Consistent Hypergraph Autoencoder Based on Contrastive Learning for Cancer ceRNA Association Prediction in Complex Biological Regulatory Networks

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Journal of chemical information and modeling 2025年第12期65卷 2025 Jun 12页

作者： Xin-Fei Wang Lan Huang Yan Wang Ren-Chu Guan Zhu-Hong You Feng-Feng Zhou Yu-Qing Li Zi-Qi Zhao Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education College of Computer Science and Technology Jilin University Changchun 130012 China. School of Computer Science Northwestern Polytechnical University Xi'an 710072 China. Faculty of Arts and Science University of Toronto Toronto Ontario M4Y 0C9 Canada.

Competitive endogenous RNA (ceRNA) regulatory networks (CENA) have advanced our understanding of noncoding RNAs' roles in complex diseases, providing a theoretical basis for disease mechanisms. Existing ceRNA-disease association prediction methods are limited by traditional graph structures' inability to model long-range dependencies in biological networks. While hypergraph models partially address this, they often fail to effectively handle graph-level and node-level noise, hindering improvements in predictive performance. To address these challenges, we propose a Noise-Consistent hypeRgraph AutoEncoder framework with denoising strategies, termed NCRAE, aimed at achieving robust node embeddings in ceRNA regulatory networks and enabling the precise prediction of cancer-related ceRNA biomarkers. NCRAE employs a multiview contrastive learning strategy, integrating graph-level and node-level corruption with clean feature references to significantly enhance the robustness of hypergraph feature learning. Furthermore, to mitigate potential biases introduced by contrastive learning, NCRAE incorporates a noise consistency loss constraint, dynamically adjusting the weights of each component to further optimize the model's noise resistance and generalization ability. Combined with hypergraph convolution and Fourier KAN techniques, NCRAE achieves effective node embedding learning. Experiments on cancer-related ceRNA data sets show that NCRAE outperforms existing methods, especially in noisy conditions, demonstrating its robustness and predictive capability. Case studies further illustrate its practical value in cancer biomarker prediction, providing a powerful tool for cancer biomarker discovery.

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UAV-enabled Wireless Powered Communication Networks: A Joint Scheduling and Trajectory Optimization Approach

UAV-enabled Wireless Powered Communication Networks: A Joint...

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IEEE Symposium on Computers and Communications (ISCC)

作者： Ziwen An Yanheng Liu Geng Sun Hongyang Pan Aimin Wang College of Computer Science and Technology Jilin University Changchun China Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University Changchun China

ISBN: (数字)9781665497923

ISBN: (纸本)9781665497930

Unmanned aerial vehicle (UAV)-enabled wireless powered communication networks (WPCN) are promising technologies in Internet of Things (IoTs). However, energy-constrained devices and connectivity in complex environments are two major challenges for IoTs. We consider a UAV-enabled WPCN scenario that a UAV can connect with the ground IoT devices (IoTDs). To connect and fly faster, UAV needs to be scheduled reasonably and the corresponding trajectory should be optimized. Thus, we formulate a UAV scheduling and trajectory optimization problem (USTOP) to minimize the total time so that improving the charging and transmission efficiency. Since conventional methods are difficult to solve USTOP, we propose an improved simulated annealing (ISA) with the variable size changing mechanism, the conflict resolution mechanism and the hybrid evolution method to solve it. Simulation results verify the effectiveness and performance of ISA under different scales of the network, and the stability of the proposed algorithm is verified.

关键词： Wireless communication Computers Annealing Simulation Simulated annealing Autonomous aerial vehicles Stability analysis

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Low-altitude Friendly-Jamming for Satellite-Maritime Communications via Generative AI-enabled Deep Reinforcement Learning

arXiv

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arXiv 2025年

作者： Huang, Jiawei Wang, Aimin Sun, Geng Li, Jiahui Wang, Jiacheng Niyato, Dusit Leung, Victor C.M. College of Computer Science and Technology Jilin University Changchun130012 China Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University Changchun130012 China College of Computer Science and Technology Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University Changchun130012 China College of Computing and Data Science Nanyang Technological University Singapore639798 Singapore Artificial Intelligence Research Institute Shenzhen MSU-BIT University Shenzhen518115 China College of Computer Science and Software Engineering Shenzhen University Shenzhen518060 China Department of Electrical and Computer Engineering The University of British Columbia VancouverV6T 1Z4 Canada

Low Earth Orbit (LEO) satellites can be used to assist maritime wireless communications for data transmission across wide-ranging areas. However, extensive coverage of LEO satellites, combined with openness of channels, can cause the communication process to suffer from security risks. This paper presents a low-altitude friendly-jamming LEO satellite-maritime communication system enabled by a unmanned aerial vehicle (UAV) to ensure data security at the physical layer. Since such a system requires trade-off policies that balance the secrecy rate and energy consumption of the UAV to meet evolving scenario demands, we formulate a secure satellite-maritime communication multi-objective optimization problem (SSMCMOP). In order to solve the dynamic and long-term optimization problem, we reformulate it into a Markov decision process. We then propose a transformer-enhanced soft actor critic (TransSAC) algorithm, which is a generative artificial intelligence-enable deep reinforcement learning approach to solve the reformulated problem, so that capturing global dependencies and diversely exploring weights. Simulation results demonstrate that the TransSAC outperforms various baselines, and achieves an optimal secrecy rate while effectively minimizing the energy consumption of the UAV. Moreover, the results find more suitable constraint values for the system. Copyright © 2025, The Authors. All rights reserved.

关键词： Multiobjective optimization

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SpatioTemporal Learning for Human Pose Estimation in Sparsely-Labeled Videos 39

SpatioTemporal Learning for Human Pose Estimation in Sparsel...

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39th Annual AAAI Conference on Artificial Intelligence, AAAI 2025

作者： Jiao, Yingying Wang, Zhigang Wu, Sifan Fan, Shaojing Liu, Zhenguang Xu, Zhuoyue Wu, Zheqi College of Computer Science and Technology Jilin University China Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University China College of Computer Science and Technology Zhejiang Gongshang University China School of Computing National University of Singapore Singapore The State Key Laboratory of Blockchain and Data Security Zhejiang University China Institute of Blockchain and Data Security China

ISBN: (纸本)157735897X

Human pose estimation in videos remains a challenge, largely due to the reliance on extensive manual annotation of large datasets, which is expensive and labor-intensive. Furthermore, existing approaches often struggle to capture long-range temporal dependencies and overlook the complementary relationship between temporal pose heatmaps and visual features. To address these limitations, we introduce STDPose, a novel framework that enhances human pose estimation by learning spatiotemporal dynamics in sparsely-labeled videos. STDPose incorporates two key innovations: 1) A novel Dynamic-Aware Mask to capture long-range motion context, allowing for a nuanced understanding of pose changes. 2) A system for encoding and aggregating spatiotemporal representations and motion dynamics to effectively model spatiotemporal relationships, improving the accuracy and robustness of pose estimation. STDPose establishes a new performance benchmark for both video pose propagation (i.e., propagating pose annotations from labeled frames to unlabeled frames) and pose estimation tasks, across three large-scale evaluation datasets. Additionally, utilizing pseudo-labels generated by pose propagation, STDPose achieves competitive performance with only 26.7% labeled data. Copyright © 2025, Association for the Advancement of Artificial Intelligence (***). All rights reserved.

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HVIS: A Human-like Vision and Inference System for Human Motion Prediction 39

HVIS: A Human-like Vision and Inference System for Human Mot...

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39th Annual AAAI Conference on Artificial Intelligence, AAAI 2025

作者： Lyu, Kedi Chen, Haipeng Liu, Zhenguang Yin, Yifang Lin, Yukang Jiao, Yingying College of Computer Science and Technology Jilin University Changchun China Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University Changchun China The State Key Laboratory of Blockchain and Data Security Zhejiang University Hangzhou China Institute of Blockchain and Data Security Hangzhou China A*STAR Singapore Tsinghua Shenzhen International Graduate School Nanshan District Shenzhen China

ISBN: (纸本)157735897X

Grasping the intricacies of human motion, which involve perceiving spatio-temporal dependence and multi-scale effects, is essential for predicting human motion. While humans inherently possess the requisite skills to navigate this issue, it proves to be markedly more challenging for machines to emulate. To bridge the gap, we propose the Human-like Vision and Inference System (HVIS) for human motion prediction, which is designed to emulate human observation and forecast future movements. HVIS comprises two components: the human-like vision encode (HVE) module and the human-like motion inference (HMI) module. The HVE module mimics and refines the human visual process, incorporating a retina-analog component that captures spatiotemporal information separately to avoid unnecessary crosstalk. Additionally, a visual cortex-analogy component is designed to hierarchically extract and treat complex motion features, focusing on both global and local features of human poses. The HMI is employed to simulate the multi-stage learning model of the human brain. The spontaneous learning network simulates the neuronal fracture generation process for the adversarial generation of future motions. Subsequently, the deliberate learning network is optimized for hard-to-train joints to prevent misleading learning. Experimental results demonstrate that our method achieves new state-of-the-art performance, significantly outperforming existing methods by 19.8% on Human3.6M, 15.7% on CMU Mocap, and 11.1% on G3D. Copyright © 2025, Association for the Advancement of Artificial Intelligence (***). All rights reserved.

关键词： Adversarial machine learning

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HVIS: A Human-like Vision and Inference System for Human Motion Prediction

arXiv

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arXiv 2025年

关键词： Motion estimation

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SpatioTemporal Learning for Human Pose Estimation in Sparsely-Labeled Videos

arXiv

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arXiv 2025年

关键词： Large datasets

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Method for Preoperative Prediction of Microvascular Invasion of Hepatocellular Carcinoma

Method for Preoperative Prediction of Microvascular Invasion...

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2022 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2022

作者： Zhao, Chen Bai, Tian Chu, Tongjia Wei, Feng Zhang, Fa Jilin University College of Computer Science and Technology Changchun China Ministry of Education Jilin University Key Laboratory of Symbolic Computation and Knowledge Engineering Changchun China First Hospital of Jilin University General Surgery Center Hepatobiliary and Pancreas Department Changchun China School of Medical Technology Beijing Institute of Technology Beijing China

ISBN: (纸本)9781665468190

Microvascular invasion (MVI) in hepatocellular carcinoma (HCC) is of great guiding significance for the formulating treatment strategies and accessing the prognosis before the surgery. However, in traditional medicine, the gold standard for the diagnosis of MVI is obtained by examining pathological images which can only be obtained by sampling and sectioning tumors after surgery. At this time, MVI results have lost the timeliness of guiding tumor resection surgery. In order to solve this problem, existing studies began to use deep learning-based methods for preoperative prediction of MVI using non-invasive imaging. Most of these methods adopt the fusion methods of multi-sequence images to predict MVI, but fail to make full use of the characteristics of multiply sequences as prior knowledge to combine into the model, resulting in no further improvement of prediction performance. So we propose a multi-sequence image difference and correlation deep learning model. The model can extract the difference and correlation information between sequences from different scales and combine them into the model. To validate proposed model, we collected a data set consists of 120 HCC patients, including 50 MVI-positive patients. Compared with existing studies, our method has greatly improved in all evaluation metrics. © 2022 IEEE.

关键词： Forecasting

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Optimizing Human Pose Estimation Through Focused Human and Joint Regions 39

Optimizing Human Pose Estimation Through Focused Human and J...

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39th Annual AAAI Conference on Artificial Intelligence, AAAI 2025

作者： Jiao, Yingying Wang, Zhigang Liu, Zhenguang Fan, Shaojing Wu, Sifan Wu, Zheqi Xu, Zhuoyue College of Computer Science and Technology Jilin University China Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University China College of Computer Science and Technology Zhejiang Gongshang University China The State Key Laboratory of Blockchain and Data Security Zhejiang University China Institute of Blockchain and Data Security China School of Computing National University of Singapore Singapore

ISBN: (纸本)157735897X

Human pose estimation has given rise to a broad spectrum of novel and compelling applications, including action recognition, sports analysis, as well as surveillance. However, accurate video pose estimation remains an open challenge. One aspect that has been overlooked so far is that existing methods learn motion clues from all pixels rather than focusing on the target human body, making them easily misled and disrupted by unimportant information such as background changes or movements of other people. Additionally, while the current Transformer-based pose estimation methods has demonstrated impressive performance with global modeling, they struggle with local context perception and precise positional identification. In this paper, we try to tackle these challenges from three aspects: (1) We propose a bilayer Human-keypoint Mask module that performs coarse-to-fine visual token refinement, which gradually zooms in on the target human body and keypoints while masking out unimportant figure regions. (2) We further introduce a novel deformable cross attention mechanism and a bidirectional separation strategy to adaptively aggregate spatial and temporal motion clues from constrained surrounding contexts. (3) We mathematically formulate the deformable cross attention, constraining that the model focuses solely on the regions centered at the target person body. Empirically, our method achieves state-of-the-art performance on three large-scale benchmark datasets. A remarkable highlight is that our method achieves an 84.8 mean Average Precision (mAP) on the challenging wrist joint, which significantly outperforms the 81.5 mAP achieved by the current state-of-the-art method on the PoseTrack2017 dataset. Copyright © 2025, Association for the Advancement of Artificial Intelligence (***). All rights reserved.

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TC-GAT: Graph Attention Network for Temporal Causality Discovery

TC-GAT: Graph Attention Network for Temporal Causality Disco...

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International Joint Conference on Neural Networks (IJCNN)

作者： Xiaosong Yuan Ke Chen Wanli Zuo Yijia Zhang College of Computer Science and Technology Jilin University Changchun China Key Laboratory of Symbolic Computation and Knowledge Engineering MOE Changchun China *** Inc Beijing China College of Electronic Countermeasures National University of Defense Technology Hefei China

The present study explores the intricacies of causal relationship extraction, a vital component in the pursuit of causality knowledge. Causality is frequently intertwined with temporal elements, as the progression from cause to effect is not instantaneous but rather ensconced in a temporal dimension. Thus, the extraction of temporal causality holds paramount significance in the field. In light of this, we propose a method for extracting causality from the text that integrates both temporal and causal relations, with a particular focus on the time aspect. To this end, we first compile a dataset that encompasses temporal relationships. Subsequently, we present a novel model, TC-GAT, which employs a graph attention mechanism to assign weights to the temporal relationships and leverages a causal knowledge graph to determine the adjacency matrix. Additionally, we implement an equilibrium mechanism to regulate the interplay between temporal and causal relations. Our experiments demonstrate that our proposed method significantly surpasses baseline models in the task of causality extraction.

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