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Superiority of light synchronization modulation for the vascular targeted photodynamic therapy

Photodiagnosis and Photodynamic Therapy 2017年 17卷 A63-A64页

作者： Hu, X.M. He, L.H. Mo, Y. Zhao, Y. Zheng, R.H. School of Life Science Key Laboratory of Convergence Medical Engineering System and Healthcare Technology The Ministry of Industry and Information Technology Beijing Institute of Technology Beijing China Medical Center Tsinghua University Beijing China Department of Hydraulic Engineering Tsinghua University Beijing China

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MR fluid interface of endovascular catheterization based on haptic sensation

MR fluid interface of endovascular catheterization based on ...

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IEEE International Conference on Mechatronics and Automation

作者： Yu Song Shuxiang Guo Linshuai Zhang Xuanchun Yin Graduate School of Engineering Kagawa University Takamatsu Japan Department of Intelligent Mechanical Systems Engineering Kagawa University Takamatsu Kagawa Japan Key Laboratory of Convergence Medical Engineering System and Healthcare Technology Beijing Institute of Technology Beijing China

ISBN: (纸本)9781509023974

During the teleoperated robot assisted catheter interventional neurosurgery, to improve the transparency between the patient side (slave side) and the remote control side (mast side) have been obtained plenty of attention. In this research we hypothesized that the slave catheter interventional robot fully complied with the dynamics command which comes from the master site. This paper is concerned with the design and implementation of a master side by Magnetorheological (MR) fluid, which can reflect the dynamic changes of the insertion resistance force, when the catheter goes through the blood vessel to the lesions. Experimental results showed that MR Fluid actuated haptic interface has a benefit to describe the blood viscous force during the endovascular catheterization.

关键词： Fluids Catheters Haptic interfaces Surgery Force Magnetic fields Dynamics

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Communication between Spherical Underwater Robots based on the acoustic communication methods

Communication between Spherical Underwater Robots based on t...

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IEEE International Conference on Mechatronics and Automation

作者： Yaxin Li Shuxiang Guo Graduate School of Engineering Kagawa University Kagawa JAPAN Department of Intelligent Mechanical Systems Engineering Kagawa University Kagawa JAPAN Key Laboratory of Convergence Medical Engineering System and Healthcare Technology Beijing Institute of Technology Haidian District Beijing China

ISBN: (纸本)9781509023974

This paper depicts an underwater acoustic communication system for Spherical Underwater Robots (SURs). The communication system will be integrated into the multiple SURs system to realize the communication between SURs and the cooperation of multi-SUR system. There are two main trial method adopted in this communication system, which are tamed spread spectrum and Frequency Hopping Multiple Access (FHMA) as well as Quadrature Phase Shift keying-Code Division Multiple Access (QPSK-CDMA) method. The Micron Data Modem is employed as the communication module. The communication system consisted of channel encoding and decoding, spread spectrum modulation and demodulation, pairs of communication modules. The experiments results testify that the developed system is feasible and reliable to realize the underwater communication due to the low BER (Bit Error Ratio).

关键词： Underwater acoustics Robots Phase shift keying Acoustic communication (telecommunication) Bandwidth Oceans

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Design and Performance Evaluation of a Novel Mechanism with Screw Jet Motion for a Hybrid Microrobot Driven by Rotational Magnetic Field

Design and Performance Evaluation of a Novel Mechanism with ...

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IEEE International Conference on Mechatronics and Automation

作者： Qiang Fu Shuxiang Guo Graduate School of Engineering Kagawa University Takamatsu Kagawa 761-0396 Japan Key Laboratory of Convergence Medical Engineering System and Healthcare Technology The Ministry of Industry and Information Technology School of Life Science and Technology Beijing Institute of Technology Haidian District Beijing 100081 China

ISBN: (纸本)9781509023974

Wireless microrobots are endowed with promising future for medical tasks. In this paper, a novel mechanism with screw jet motion for a hybrid microrobot. The microrobot has a compact structure. It consists of an outer shell, a screw structure and an o-ring magnet as an actuator, which is fitted inside the microrobot. It is driven by a rotational magnetic field which is generated by three-axis Helmholtz coils. While the microrobot is in the magnetic field, the actuator is conversion of synchronous rotation with a rotating field using a "screw jet motion" to pull fluid through the centre of the microrobot. The experimental results indicated the microrobot can realize the flexible motion with good performance.

关键词： Screw jet motion Hybrid microrobot Rotational magnetic field three-axis Helmholtz coils

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Gene expression imputation across multiple brain regions provides insights into schizophrenia risk (vol 51, pg 659, 2019)

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NATURE GENETICS 2019年第6期51卷 1068-1068页

作者： Huckins, Laura M. Dobbyn, Amanda Ruderfer, Douglas M. Hoffman, Gabriel Wang, Weiqing Pardinas, Antonio F. Rajagopal, Veera M. Als, Thomas D. Nguyen, Hoang T. Girdhar, Kiran Boocock, James Roussos, Panos Fromer, Menachem Kramer, Robin Domenici, Enrico Gamazon, Eric R. Purcell, Shaun Demontis, Ditte Borglum, Anders D. Walters, James T. R. O'Donovan, Michael C. Sullivan, Patrick Owen, Michael J. Devlin, Bernie Sieberts, Solveig K. Cox, Nancy J. Im, Hae Kyung Sklar, Pamela Stahl, Eli A. Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai New York NY USA Department of Genetics and Genomics Icahn School of Medicine at Mount Sinai New York NY USA Department of Psychiatry Icahn School of Medicine at Mount Sinai New York NY USA Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai New York NY USA Vanderbilt University Medical Center Nashville TN USA MRC Centre for Neuropsychiatric Genetics and Genomics Cardiff University Cardiff UK Department of Biomedicine Aarhus University Aarhus Denmark The Lundbeck Foundation Initiative for Integrative Psychiatric Research iPSYCH Denmark Center for Integrative Sequencing Aarhus University Aarhus Denmark Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles CA USA Human Brain Collection Core National Institute of Mental Health Bethesda MD USA Laboratory of Neurogenomic Biomarkers Centre for Integrative Biology (CIBIO) University of Trento Trento Italy Clare Hall University of Cambridge Cambridge UK University of North Carolina at Chapel Hill Chapel Hill NC USA Karolinska Institutet Stockholm Sweden Department of Psychiatry University of Pittsburgh Pittsburgh PA USA Systems Biology Sage Bionetworks Seattle WA USA Section of Genetic Medicine Department of Medicine University of Chicago Chicago IL USA Integrated Technology Research Laboratories Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Japan Neuropsychiatry Section Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Neuropsychiatric Signaling Program Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Psychiatry JJ Peters Virginia Medical Center Bronx NY USA Department of Neuroscience Icahn School of Medicine at Mount Sinai New York New York NY USA Friedman Brain Institute

Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex genome-wide association study (GWAS) loci and may disentangle the role of different tissues in disease development. We used the largest eQTL reference panel for the dorso-lateral prefrontal cortex (DLPFC) to create a set of gene expression predictors and demonstrate their utility. We applied DLPFC and 12 GTEx-brain predictors to 40,299 schizophrenia cases and 65,264 matched controls for a large transcriptomic imputation study of schizophrenia. We identified 413 genic associations across 13 brain regions. Stepwise conditioning identified 67 non-MHC genes, of which 14 did not fall within previous GWAS loci. We identified 36 significantly enriched pathways, including hexosaminidase-A deficiency, and multiple porphyric disorder pathways. We investigated developmental expression patterns among the 67 non-MHC genes and identified specific groups of pre- and postnatal expression.

关键词： Gene expression Genome-wide association studies Schizophrenia Transcriptomics

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A VR-based Self-rehabilitation system

A VR-based Self-rehabilitation System

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IEEE International Conference on Mechatronics and Automation

作者： Shuxiang Guo Yi Liu Ying Zhang Songyuan Zhang Keiji Yamamoto Key Laboratory of Convergence Medical Engineering System and Healthcare Technology The Ministry of Industry and Information Technology School of Life Science and Technology Beijing Institute of Technology Haidian District Beijing 100081 China Graduate School of Engineering Kagawa University Hayashi-cho Takamatsu 761-0396 Japan

ISBN: (纸本)9781509023974

This paper proposed a VR-based self-rehabilitation system which utilizes the virtual training model rendered by OpenGL and collects electromyography (EMG) signals from the subjects to perform hand motion recognition. EMG signals are biomedical signals generated in muscles and can be applied in many fields such as clinical diagnosis and biomedical applications. The subjects were asked to manipulate a haptic device (Phantom Premium) to operate a virtual hand to catch a ball in the virtual environment which displayed on the computer's screen. A dry electrode was attached on the subject's skin to collect sEMG signals and recognize the action of grasping. Once caught by subjects, the virtual ball will appear in another location at random on the computer's screen. Therefore, the subject needs to manipulate the Phantom to the new destination and catch the ball once again. Combining sEMG with VR technology, the proposed self-rehabilitation system could provide enhanced visual feedback about movement trajectory, which is beneficial to improve motor function task learning and execution compared with traditional therapy. By this method, stroke patients can realize self-rehabilitation exercise of upper limb at home. The effectiveness of the proposed rehabilitation system has been verified by experiments.

关键词： Self-rehabilitation Virtual Reality Surface electromyography Butterworth filter OpenGL

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A Novel Variable Stiffness Actuator-based Exoskeleton Device for Home Rehabilitation

A Novel Variable Stiffness Actuator-based Exoskeleton Device...

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IEEE International Conference on Mechatronics and Automation

作者： Ying Zhang Shuxiang Guo Guohua Cao Songyuan Zhang Yi Liu Graduate School of Engineering Kagawa University Hayashi-cho Takamatsu 761-0396 Japan Key Laboratory of Convergence Medical Engineering System and Healthcare Technology The Ministry of Industry and InformationTechnology School of Life Science and Technology Beijing Institute of Technology Haidian District Beijing 100081 China School of Mechanical Engineering Changchun University of Science and Technology Changchun Jilin China

ISBN: (纸本)9781509023974

Most exoskeleton devices for upper-limb rehabilitation are heavy and bulky. The present study develops a light and wearable exoskeleton device for passive and resistance training that can potentially be used in home rehabilitation. Stroke patients may prefer to rehabilitate at home considering the inconvenience of regularly attending rehabilitation centres. In this paper, a novel training device combined with a variable stiffness actuator (VSA) is developed with safe-consideration. First, compared with traditional actuators with very high mechanical impedance, actuators with adaptive compliances can guarantee patients' safety, especially spasm happen. Second, it is composed of 4 degrees of freedom to move and 2 others degrees to adjust to the patient. Moreover it allows you to put the weight of the system on shoulders because this device can be wear just like a bag, so the patients can create a fully portable device, and very low cost. The processed EMG signals can be used to verify that the rehabilitation device could provide the power assist to the patients.

关键词： Rehabilitation device Compliant actuator Series elastic actuator Variable stiffness actuator

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An interventional surgical robot system with force feedback

An interventional surgical robot system with force feedback

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IEEE International Conference on Robotics and Biomimetics

作者： Feiyu Jia Shuxiang Guo Yuan Wang Key Laboratory of Convergence Medical Engineering System and Healthcare Technology Beijing Institute of Technology

ISBN: (纸本)9781467396769

The interventional surgery is a kind of minimally invasive treatment. To achieve the real-time diagnosis and strengthen the doctor operation sense of reality and the operation efficiency, the accurate control of force feedback plays an important role. Based this, we utilize the Phantom Omni as the master manipulator and construct the master-slave robot system with the force feedback closed-loop control. We put forward tracking control strategy and realtime force feedback control strategy. By measuring the proximal guide wire force and the force between the surgeon's hand and the handle used on the Phantom, the force feedback closed-loop control can effectively eliminate the loss of mechanical impedance of force feedback information. And the novel interventional surgical robot system will simulate the procedure of the doctor's hand to operate the guide wire, and providing haptic feedback to the doctor. In this paper, the experimental results show that the accuracy control of force feedback is greatly enhanced in the aspect of security and the operation efficiency.

关键词： Wires Force feedback Catheters Force medical services Phantoms Robots

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Calibration of a three-dimensional photodynamic therapy illumination system and its segmentation assessment for port-wine stains

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Photonics and Lasers in Medicine 2016年第3期5卷 195-202页

作者： Feng, Yun Hu, Xiaoming Zhou, Ya Wang, Yong School of Software Beijing Institute of Technology No. 5 Zhong Guan Cun South Street Haidian District Beijing China School of Life Science Key Laboratory of Convergence Medical Engineering System and Healthcare Technology Ministry of Industry and Information Technology Beijing Institute of Technology No. 5 Zhong Guan Cun South Street Haidian District Beijing China School of Optoelectronics Beijing Institute of Technology No. 5 Zhong Guan Cun South Street Haidian District Beijing China

The uniformity of light dosimetry is an important parameter that affects the efficacy of photodynamic therapy (PDT). Although this uniformity can be improved by a three-dimensional (3D) digital PDT illumination system, it has a low field-of-view (FOV) utilization rate. A checkerboard calibration method using color coding is proposed to calibrate both the projector and camera of the system with a broad common FOV. Experiments reveal that the proposed method increases the utilization rate by up to three times compared with noncolor-coding methods with almost the same accuracy. A fine distinction of phantom lesions in the 3D system can be obtained by clustering, which may be used to optimize the treatment and light-dosimetry evaluation. © 2016 Walter de Gruyter GmbH, Berlin/Boston.

关键词： Calibration

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The 5th International Conference on Biomedical engineering and Biotechnology (ICBEB 2016) Abstracts

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BMC medical IMAGING 2016年第SUPPL 1期16卷 65-65页

作者： [Anonymous] Department of MRI Shandong Medical Imaging Research Institute Affiliated to Shandong University Jinan Shandong 250021 People’s Republic of China Department of Interventional Radiology Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 People’s Republic of China College of Information Science and Technology Engr. Research Center of Digitized Textile & Fashion Tech. for Ministry of Education Donghua University Shanghai 201620 China Intelligent multimedia information processing Lab College of Software Northeastern University Shenyang Liaoning Province 110004 China Institute of Biomedical and Health Engineering Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China School of Computer Science and Technology Nanjing Normal University Nanjing China Department of Electrical Engineering The City College of New York CUNY New York USA Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing Nanjing China School of Electronic Science and Engineering Nanjing University Nanjing Jiangsu 210046 China College of Engineering Nanyang Technological University Singapore 639798 Singapore School of Electronic Information Shanghai Dianji University Shanghai China School of Natural Sciences and Mathematics Shepherd University Shepherdstown WV 25443 USA Davis College of Agriculture Natural Resources and Design West Virginia University Morgantown WV 26505 USA State Key Laboratory of Millimeter Waves Southeast University Nanjing 210096 China Center of Medical Physics and Technology Hefei Institutes of Physical Science Chinese Academy of Sciences Hefei China College of Agricultural and Life Sciences University of Florida Gainesville FL 32611 USA Courant Institute of Mathematical Sciences New York University New York NY 10012 USA Translational Imaging Division & MRI Unit Columbia University and New York State Psychiatric Institute New York NY 10032 USA Guangxi Key Laboratory of Manufacturing System & Adv

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