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Knowledge based machine reading comprehension

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arXiv 2018年

作者： Sun, Yibo Guo, Daya Tang, Duyu Duan, Nan Yan, Zhao Feng, Xiaocheng Qin, Bing Harbin Institute of Technology Harbin China Microsoft Research Asia Beijing China Guangdong Key Laboratory of Big Data Analysis and Processing Guangzhou China Beihang University Beijing China

Machine reading comprehension (MRC) requires reasoning about both the knowledge involved in a document and knowledge about the world. However, existing datasets are typically dominated by questions that can be well solved by context matching, which fail to test this capability. To encourage the progress on knowledge-based reasoning in MRC, we present knowledge-based MRC in this paper, and build a new dataset consisting of 40,047 question-answer pairs. The annotation of this dataset is designed so that successfully answering the questions requires understanding and the knowledge involved in a document. We implement a framework consisting of both a question answering model and a question generation model, both of which take the knowledge extracted from the document as well as relevant facts from an external knowledge base such as Freebase/ProBase/Reverb/NELL. Results show that incorporating side information from external KB improves the accuracy of the baseline question answer system. We compare it with a standard MRC model BiDAF, and also provide the difficulty of the dataset and lay out remaining challenges. Copyright © 2018, The Authors. All rights reserved.

关键词： Knowledge based systems

AI-skin: Skin disease recognition based on self-learning and wide data collection through a closed loop framework

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arXiv 2019年

作者： Chen, Min Zhou, Ping Wu, Di Hu, Long Hassan, Mohammad Mehedi Alamri, Atif School of Computer Science and Technology Huazhong University of Science and Technology Wuhan China School of Data and Computer Science Sun Yat-sen University Guangzhou China Guangdong Province Key Laboratory of Big Data Analysis and Processing Guangzhou China Chair of Pervasive and Mobile Computing Information Systems Department College of Computer and Information Sciences King Saud University Riyadh11543 Saudi Arabia Chair of Pervasive and Mobile Computing Software Engineering Department CCIS King Saud University Riyadh11543 Saudi Arabia

There are a lot of hidden dangers in the change of human skin conditions, such as the sunburn caused by long-time exposure to ultraviolet radiation, which not only has aesthetic impact causing psychological depression and lack of selfconfidence, but also may even be life-threatening due to skin canceration. Current skin disease researches adopt the auto-classification system for improving the accuracy rate of skin disease classification. However, the excessive dependence on the image sample database is unable to provide individualized diagnosis service for different population groups. To overcome this problem, a medical AI framework based on data width evolution and self-learning is put forward in this paper to provide skin disease medical service meeting the requirement of real time, extendibility and individualization. First, the wide collection of data in the close-loop information flow of user and remote medical data center is discussed. Next, a data set filter algorithm based on information entropy is given, to lighten the load of edge node and meanwhile improve the learning ability of remote cloud analysis model. In addition, the framework provides an external algorithm load module, which can be compatible with the application requirements according to the model selected. Three kinds of deep learning model, i.e. LeNet-5, AlexNet and VGG16, are loaded and compared, which have verified the universality of the algorithm load module. The experiment platform for the proposed real-time, individualized and extensible skin disease recognition system is built. And the system's computation and communication delay under the interaction scenario between tester and remote data center are analyzed. It is demonstrated that the system we put forward is reliable and effective. Copyright © 2019, The Authors. All rights reserved.

关键词： data acquisition

Radiomics based on dual-energy CT for noninvasive prediction of cervical lymph node metastases in patients with nasopharyngeal carcinoma

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Radiography (London, England : 1995) 2025年第4期31卷 102989页

作者： L Li D Yang Y Wu R Sun Y Qin M Kang X Deng M Bu Z Li Z Zeng X Zeng M Jiang B T Chen Department of Radiology First Affiliated Hospital of Guangxi Medical University Nanning 530021 Guangxi PR China. Department of Radiology Guizhou Provincial People Hospital No.83 East Zhongshan Road Nanming District Guizhou Province 550000 Guiyang PR China Engineering Research Center of Text Computing & Cognitive Intelligence Ministry of Education Key Laboratory of Intelligent Medical Image Analysis and Precise Diagnosis of Guizhou Province State Key Laboratory of Public Big Data College of Computer Science and Technology Guizhou University No. 2870 Huaxi Avenue South Guiyang 550025 Guizhou PR China. Department of Radiology Guizhou Provincial People Hospital No.83 East Zhongshan Road Nanming District Guizhou Province 550000 Guiyang PR China. Department of Nuclear Medicine First Affiliated Hospital of Guangxi Medical University Nanning 530021 Guangxi PR China. Department of Radiation Oncology First Affiliated Hospital of Guangxi Medical University Nanning 530021 Guangxi PR China. Department of Radiology Guizhou Provincial People Hospital No.83 East Zhongshan Road Nanming District Guizhou Province 550000 Guiyang PR China. Electronic address: zengxianchun04@***. Department of Radiology First Affiliated Hospital of Guangxi Medical University Nanning 530021 Guangxi PR China. Electronic address: jmlgxmu@***. Department of Diagnostic Radiology City of Hope National Medical Center Duarte CA USA.

INTRODUCTION:To develop and validate a machine learning model based on dual-energy computed tomography (DECT) for predicting cervical lymph node metastases (CLNM) in patients diagnosed with nasopharyngeal carcinoma (NPC). METHODS:This prospective single-center study enrolled patients with NPC and the study assessment included both DECT and 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT). Radiomics features were extracted from each region of interest (ROI) for cervical lymph nodes using arterial and venous phase images at 100 keV and 150 keV, either individually as non-fusion models or combined as fusion models on the DECT images. The performance of the random forest (RF) models, combined with radiomics features, was evaluated by area under the receiver operating characteristic curve (AUC) analysis. DeLong's test was employed to compare model performances, while decision curve analysis (DCA) assessed the clinical utility of the predictive models. RESULTS:Sixty-six patients with NPC were included for analysis, which was divided into a training set (n = 42) and a validation set (n = 22). A total of 13 radiomic models were constructed (4 non-fusion models and 9 fusion models). In the non-fusion models, when the threshold value exceeded 0.4, the venous phase at 100 keV (V100) (AUC, 0.9667; 95 % confidence interval [95 % CI], 0.9363-0.9901) model exhibited a higher net benefit than other non-fusion models. The V100 + V150 fusion model achieved the best performance, with an AUC of 0.9697 (95 % CI, 0.9393-0.9907). CONCLUSION:DECT-based radiomics effectively diagnosed CLNM in patients with NPC and may potentially be a valuable tool for clinical decision-making. IMPLICATIONS FOR PRACTICE:This study improved pre-operative evaluation, treatment strategy selection, and prognostic evaluation for patients with nasopharyngeal carcinoma by combining DECT and radiomics to predict cervical lymph node status prior to treatment.

关键词： Cervical lymph node metastases (CLNM) Dual-energy computed tomography (DECT) Machine learning model Nasopharyngeal carcinoma (NPC) Radiomics

Why is the Winner the Best?

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Why is the Winner the Best?

Conference on Computer Vision and Pattern Recognition (CVPR)

作者： M. Eisenmann A. Reinke V. Weru M. D. Tizabi F. Isensee T. J. Adler S. Ali V. Andrearczyk M. Aubreville U. Baid S. Bakas N. Balu S. Bano J. Bernal S. Bodenstedt A. Casella V. Cheplygina M. Daum M. De Bruijne A. Depeursinge R. Dorent J. Egger D. G. Ellis S. Engelhardt M. Ganz N. Ghatwary G. Girard P. Godau A. Gupta L. Hansen K. Harada M. Heinrich N. Heller A. Hering A. Huaulmé P. Jannin A. E. Kavur O. Kodym M. Kozubek J. Li H. Li J. Ma C. Martín-Isla B. Menze A. Noble V. Oreiller N. Padoy S. Pati K. Payette T. Rädsch J. Rafael-Patiño V. Singh Bawa S. Speidel C. H. Sudre K. Van Wijnen M. Wagner D. Wei A. Yamlahi M. H. Yap C. Yuan M. Zenk A. Zia D. Zimmerer D. Aydogan B. Bhattarai L. Bloch R. Brüngel J. Cho C. Choi Q. Dou I. Ezhov C. M. Friedrich C. Fuller R. R. Gaire A. Galdran Á. García Faura M. Grammatikopoulou S. Hong M. Jahanifar I. Jang A. Kadkhodamohammadi I. Kang F. Kofler S. Kondo H. Kuijf M. Li M. Luu T. Martinčič P. Morais M. A. Naser B. Oliveira D. Owen S. Pang J. Park S. Park S. Płotka E. Puybareau N. Rajpoot K. Ryu N. Saeed A. Shephard P. Shi D. Štepec R. Subedi G. Tochon H. R. Torres H. Urien J. L. Vilaça K. A. Wahid H. Wang J. Wang L. Wang X. Wang B. Wiestler M. Wodzinski F. Xia J. Xie Z. Xiong S. Yang Y. Yang Z. Zhao K. Maier-Hein P. F. Jäger A. Kopp-Schneider L. Maier-Hein Division of Intelligent Medical Systems German Cancer Research Center (DKFZ) Heidelberg Germany Helmholtz Imaging German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Mathematics and Computer Science Heidelberg University Heidelberg Germany Division of Biostatistics German Cancer Research Center (DKFZ) Heidelberg Germany Division of Medical Image Computing German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Engineering and Physical Sciences School of Computing University of Leeds Leeds UK Institute of Informatics School of Management HES-SO Valais-Wallis University of Applied Sciences and Arts Western Switzerland Sierre Switzerland Department of Nuclear Medicine and Molecular Imaging Lausanne University Hospital Lausanne Switzerland Technische Hochschule Ingolstadt Ingolstadt Germany Center for Artificial Intelligence and Data Science for Integrated Diagnostics (AI2D) and Center for Biomedical Image Computing and Analytics (CBICA) University of Pennsylvania Philadelphia PA USA Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Department of Radiology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Department of Radiology University of Washington Seattle WA USA Department of Computer Science Wellcome/EPSRC Centre for Interventional and Surgical Sciences (WEISS) University College London London UK Universitat Autònoma de Barcelona & Computer Vision Center Barcelona Spain Division of Translational Surgical Oncology National Center for Tumor Diseases (NCT/UCC) Dresden Dresden Germany Department of Advanced Robotics Istituto Italiano di Tecnologia Italy Department of Electronics Information and Bioengineering Politecnico di Milano Milan Italy IT University of Copenhagen Copenhagen Denmark Department of General Visceral and Transplantation Surgery Heidelberg University Hospital Heidelberg Germany Department of Radiology and Nuc

International benchmarking competitions have become fundamental for the comparative performance assessment of image analysis methods. However, little attention has been given to investigating what can be learnt from these competitions. Do they really generate scientific progress? What are common and successful participation strategies? What makes a solution superior to a competing method? To address this gap in the literature, we performed a multicenter study with all 80 competitions that were conducted in the scope of IEEE ISBI 2021 and MICCAI 2021. Statistical analyses performed based on comprehensive descriptions of the submitted algorithms linked to their rank as well as the underlying participation strategies revealed common characteristics of winning solutions. These typically include the use of multi-task learning (63%) and/or multi-stage pipelines (61%), and a focus on augmentation (100%), image preprocessing (97%), data curation (79%), and post-processing (66%). The “typical” lead of a winning team is a computer scientist with a doctoral degree, five years of experience in biomedical image analysis, and four years of experience in deep learning. Two core general development strategies stood out for highly-ranked teams: the reflection of the metrics in the method design and the focus on analyzing and handling failure cases. According to the organizers, 43% of the winning algorithms exceeded the state of the art but only 11% completely solved the respective domain problem. The insights of our study could help researchers (1) improve algorithm development strategies when approaching new problems, and (2) focus on open research questions revealed by this work.

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Automated assessment of necrosis tumor ratio in colorectal cancer using an artificial intelligence-based digital pathology analysis

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Medicine Advances

Medicine Advances 2023年第1期1卷

作者： Huifen Ye Yunrui Ye Yiting Wang Tong Tong Su Yao Yao Xu Qingru Hu Yulin Liu Changhong Liang Guangyi Wang Ke Zhao Xinjuan Fan Yanfen Cui Zaiyi Liu Department of Radiology Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China The Second School of Clinical Medicine Southern Medical University Guangzhou China Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application Guangzhou China Contribution: Conceptualization (equal) Methodology (equal) Visualization (equal) Writing - original draft (equal) Contribution: Data curation (equal) Investigation (equal) Validation (equal) Writing - original draft (equal) Department of Pathology The Sixth Affiliated Hospital of Sun Yat-sen University Guangzhou China Contribution: Data curation (equal) Investigation (equal) Validation (equal) Formal analysis (equal) Department of Radiology Fudan University Shanghai Cancer Center Shanghai China Department of Oncology Shanghai Medical College Shanghai China Contribution: Data curation (equal) Investigation (equal) Validation (equal) Department of Pathology Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China Contribution: Formal analysis (equal) Contribution: Formal analysis (equal) Supervision (equal) Writing - review & editing (equal) Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou China Xinjuan Fan Department of Pathology The Sixth Affiliated Hospital of Sun Yat-Sen University 26 Erheng Road Guangzhou 510655 China. Yanfen Cui Department of Radiology Shanxi Cancer Hospital Shanxi Medical University No. 3 Xinjie West Alley Taiyuan 030013 China. Zaiyi Liu Department of Radiology Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences) Southern Medical University 106 Zhongshan Er Road Guangzhou 510080 China. Contribution: Formal analysis (equal) Methodology (equal) Writing - original draft (equal) Writing - review & editing (equal) Ke Zhao Depa

Background With the advance in digital pathology and artificial intelligence (AI)-powered approaches, necrosis is proposed as a marker of poor prognosis in colorectal cancer (CRC). However, most previous studies quantified necrosis merely as a tissue type and patch-level segmentation. Thus, it was worth exploring and validating the prognostic and predictive value of necrosis proportion with a pixel-level segmentation in large multicenter cohorts. Methods A semantic segmentation model was trained with 12 tissue types labeled by pathologists. Segmentation was performed using the U-net model with a subsequently derived necrosis tumor ratio (NTR). We proposed the NTR score (NTR-low or NTR-high) to evaluate the prognostic and predictive value of necrosis for disease-free survival (DFS) and overall survival (OS) in the development ( N = 443) and validation cohorts ( N = 333) using 75% as a threshold. Results The 2-category NTR was an independent prognostic factor and NTR-low was associated with significant prolonged DFS (unadjusted HR for high vs. low 1.72 [95% CI 1.19–2.49] and 1.98 [1.22–3.23] in the development and validation cohorts). Similar trends were observed for OS. The prognostic value of NTR was maintained in the multivariate analysis for both cohorts. Furthermore, a stratified analysis showed that NTR-high was a high risk with adjuvant chemotherapy for OS in stage II CRC ( p = 0.047). Conclusion AI-based pixel-level quantified NTR has a stable prognostic value in CRC associated with unfavorable survival. Additionally, adjuvant chemotherapy provided survival benefits for patients with a high NTR score in stage II CRC.

关键词： artificial intelligence colorectal cancer digital pathology necrosis whole-slide images

Rapid Artificial Intelligence Solutions in a Pandemic - The COVID-19-20 Lung CT Lesion Segmentation Challenge

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Research Square

Research Square 2021年 rs3rs-571332页

作者： Roth, Holger R. Xu, Ziyue Diez, Carlos Tor Jacob, Ramon Sanchez Zember, Jonathan Molto, Jose Li, Wenqi Xu, Sheng Turkbey, Baris Turkbey, Evrim Yang, Dong Harouni, Ahmed Rieke, Nicola Hu, Shishuai Isensee, Fabian Tang, Claire Yu, Qinji Sölter, Jan Zheng, Tong Liauchuk, Vitali Zhou, Ziqi Moltz, Jan Hendrik Oliveira, Bruno Xia, Yong Maier-Hein, Klaus H. Li, Qikai Husch, Andreas Zhang, Luyang Kovalev, Vassili Kang, Li Hering, Alessa Vilaça, João L. Flores, Mona Xu, Daguang Wood, Bradford Linguraru, Marius George NVIDIA BethesdaMD United States Sheikh Zayed Institute for Pediatric Surgical Innovation Children’s National Hospital WashingtonDC United States Division of Diagnostic Imaging and Radiology Children’s National Hospital WashingtonDC United States Radiology and Imaging Sciences National Institutes of Health Clinical Center BethesdaMD United States School of Computer Science and Engineering Northwestern Polytechnical University China Heidelberg Germany Lynbrook High School San JoseCA United States Shanghai Jiao Tong University China Luxembourg Centre for Systems Biomedicine University of Luxembourg Luxembourg School of Informatics Nagoya University Japan Biomedical Image Analysis Department United Institute of Informatics Problems Belarus Guangdong Key Laboratory of Intelligent Information Processing Shenzhen University China Fraunhofer Institute for Digital Medicine MEVIS Bremen Germany School of Medicine University of Minho Braga Portugal ICVS/3B’s - PT Government Associate Laboratory Braga/Guimarães Portugal Algoritmi Center School of Engineering University of Minho Guimarães Portugal Heidelberg Germany Fraunhofer Institute for Digital Medicine MEVIS Lübeck Germany 2Ai – Polytechnic Institute of Cávado and Ave Barcelos Portugal School of Medicine and Health Sciences George Washington University WashingtonDC United States

Artificial intelligence (AI) methods for the automatic detection and quantification of COVID-19 lesions in chest computed tomography (CT) might play an important role in the monitoring and management of the disease. We organized an international challenge and competition for the development and comparison of AI algorithms for this task, which we supported with public data and state-of-the-art benchmark methods. Board Certified Radiologists annotated 295 public images from two sources (A and B) for algorithms training (n=199, source A), validation (n=50, source A) and testing (n=23, source A;n=23, source B). There were 1,096 registered teams of which 225 and 98 completed the validation and testing phases, respectively. The challenge showed that AI models could be rapidly designed by diverse teams with the potential to measure disease or facilitate timely and patient-specific interventions. This paper provides an overview and the major outcomes of the COVID-19 Lung CT Lesion Segmentation Challenge - 2020. © 2021, CC BY.

关键词： COVID-19

CNN-based invertible wavelet scattering for the investigation of diffusion properties of the in vivo human heart in diffusion tensor imaging

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arXiv 2019年

作者： Deng, Zeyu Wang, Lihui Kuai, Zixiang Chen, Qijian Cheng, Xinyu Yang, Feng Yang, Jie Zhu, Yuemin Key Laboratory of Intelligent Medical Image Analysis and Precise Diagnosis of Guizhou Province College of Computer Science and Technology Guizhou University Guiyang550025 China Imaging Center Harbin Medical University Cancer Hospital Harbin150081 China School of Computer and Information Technology Beijing Jiaotong University Beijing100044 China Institute of Image Processing and Pattern Recognition Shanghai Jiao Tong University Shanghai200240 China University Lyon INSA Lyon CNRS Inserm IRP Metislab CREATIS UMR5220 U1206 LyonF-69621 France

In vivo diffusion tensor imaging (DTI) is a promising technique to investigate noninvasively the fiber structures of the in vivo human heart. However, signal loss due to motions remains a persistent problem in in vivo cardiac DTI. We propose a novel motion-compensation method for investigating in vivo myocardium structures in DTI with free-breathing acquisitions. The method is based on an invertible Wavelet Scattering achieved by means of Convolutional Neural Network (WSCNN). It consists of first extracting translation-invariant wavelet scattering features from DW images acquired at different trigger delays and then mapping the fused scattering features into motion-compensated spatial DW images by performing an inverse wavelet scattering transform achieved using CNN. The results on both simulated and acquired in vivo cardiac DW images showed that the proposed WSCNN method effectively compensates for motion-induced signal loss and produces in vivo cardiac DW images with better quality and more coherent fiber structures with respect to existing methods, which makes it an interesting method for measuring correctly the diffusion properties of the in vivo human heart in DTI under free breathing. Copyright © 2019, The Authors. All rights reserved.

关键词： Diffusion tensor imaging

A data tamper protection method based on block chain 5

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A data tamper protection method based on block chain

5th International Conference on Information Science and Cloud Computing, ISCC 2017

作者： Zhou, Fuken Yu, Zepeng Xie, Yongjie Chen, Tian'en Liao, Yongfa Department of Computer Science Guangdong Neusoft Institute Foshan 528000 China Guangdong Key Laboratory of Big Data Analysis and Processing Guangzhou 510006 China

data centric storage with network as the carrier is vulnerable to external attacks, resulting in data loss and tampering. We propose a method of tamper proofing for block chaining data without centralization and centralization. According to the technology principle of bitcoin block chain, the network data information is protected by block chain encryption technology, and the security of high information tamper resistant is realized. A block chain data storage algorithm based on hash table is hereby proposed, which can get enough address space to save all the data, and make block chain form a time sequence to achieve the safe transmission of data. The research results show that the data protection method has very high tamper resistance ability because of the high security of encrypted digital block chaining technology. The block chain implements the value transfer without relying on centralized organization. © Copyright owned by the author(s).

关键词： Digital storage

Research on the Brain-inspired Cross-modal Neural Cognitive Computing Framework

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arXiv 2018年

作者： Liu, Yang Key Laboratory of Big Data Analysis and Processing of Henan province Intelligent Technology and Application Engineering Research Centre of Henan province College of Computer Science and Information Engineering Henan University Kaifeng475004 China

To address modeling problems of brain-inspired intelligence, this thesis is focused on researching in the semantic-oriented framework design for multimedia and multimodal information. The Multimedia Neural Cognitive Computing (MNCC) model was designed based on the nervous mechanism and cognitive architecture. Furthermore, the semantic-oriented hierarchical Cross-modal Neural Cognitive Computing (CNCC) framework was proposed based on MNCC model, and formal description and analysis for CNCC framework was given. It would effectively improve the performance of semantic processing for multimedia and cross-modal information, and has far-reaching significance for exploration and realization brain-inspired computing. Copyright © 2018, The Authors. All rights reserved.

关键词： Semantics