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44th ACM/IEEE International Conference on Software Engineering, ICSE 2024

作者： Song, Xiaohu Wang, Ying Cheng, Xiao Liang, Guangtai Wang, Qianxiang Zhu, Zhiliang Northeastern University Shenyang China Huawei Cloud Computing Technologies Co. Ltd. Beijing China Northeastern University National Frontiers Science Center for Industrial Intelligence and Systems Optimization Key Laboratory of Data Analytics and Optimization for Smart Industry Shenyang China

ISBN: (纸本)9798400702174

Numerous third-party libraries introduced into client projects are not actually required, resulting in modern software being gradually bloated. Software developers may spend much unnecessary effort to manage the bloated dependencies: keeping the library versions up-to-date, making sure that heterogeneous licenses are compatible, and resolving dependency conflict or vulnerability issues. However, the prior debloating techniques can easily produce false alarms of bloated dependencies since they are less effective in analyzing Java reflections. Besides, the solutions given by the existing approaches for removing bloated dependencies may induce new issues that are not conducive to dependency management. To address the above limitations, in this paper, we developed a technique, Slimming, to remove bloated dependencies from software projects reliably. Slimming statically analyzes the Java reflections that are commonly leveraged by popular frameworks (e.g., Spring Boot) and resolves the reflective targets via parsing configuration files (*. xml, *. ym1 and *. properties). By modeling string manipulations, Slimming fully resolves the string arguments of our concerned reflection APIs to identify all the required dependencies. More importantly, it helps developers analyze the debloating solutions by weighing the benefits against the costs of dependency management. Our evaluation results show that the static reflection analysis capability of Slimming outperforms all the other existing techniques with 97.0% of Precision and 98.8% of Recall. Compared with the prior debloating techniques, Slimming can reliably remove the bloated dependencies with a 100% test passing ratio and improve the rationality of debloating solutions. In our large-scale study in the Maven ecosystem, Slimming reported 484 bloated dependencies to 66 open-source projects. 38 reports (57.6%) have been confirmed by developers. © 2024 ACM.

关键词： Java programming language

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Reynosin protects neuronal cells from microglial neuroinflammation by suppressing NLRP3 inflammasome activation mediated by NADPH oxidase

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Chinese Journal of Natural Medicines 2024年第6期22卷 486-500页

作者： YANG Yanqiu CHE Yue FANG Mingxia YAO Xiaohu ZHOU Di WANG Feng CHEN Gang LIANG Dong LI Ning HOU Yue Key Laboratory of Bioresource Research and Development of Liaoning Province College of Life and Health SciencesNorth-eastern UniversityShenyang 110000China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Key Laboratory of Data Analytics and Optimization for Smart IndustryMinistry of EducationNortheastern UniversityShenyang 110000China School of Traditional Chinese Materia Medica Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning provinceKey Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang CityShenyang Pharmaceutical UniversityShenyang 110000China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541000China

Neuroinflammation,mediated by the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing-3(NLRP3)inflammasome,is a significant contributor to the pathogenesis of neurodegenerative diseases(NDDs).Reynos-in,a natural sesquiterpene lactone(SL),exhibits a broad spectrum of pharmacological effects,suggesting its potential therapeutic ***,the effects and mechanism of reynosin on neuroinflammation remain *** current study explores the effects and mechanisms of reynosin on neuroinflammation using mice and BV-2 microglial cells treated with lipopolysaccharide(LPS).Our findings reveal that reynosin effectively reduces microglial inflammation in vitro,as demonstrated by decreased CD11b expression and lowered interleukin-1 beta(IL-1β)and interleukin-18(IL-18)mRNA and protein ***,in vivo,results showed a re-duction in the number of Iba-1 positive cells and alleviation of morphological alterations,alongside decreased expressions of IL-1βand *** analysis indicates that reynosin inhibits NLRP3 inflammasome activation,evidenced by reduced transcription of NLRP3 and caspase-1,diminished NLRP3 protein expression,inhibited apoptosis-associated speck-like protein containing a CARD(ASC)oli-gomerization,and decreased caspase-1 ***,reynosin curtailed the activation of nicotinamide adenine dinuc-leotide phosphate(NADPH)oxidase,demonstrated by reduced NADP^(+)and NADPH levels,downregulation of gp91^(phox) mRNA,pro-tein expression,suppression of p47^(phox) expression and translocation to the ***,reynosin exhibited a neuroprotective effect against microglial inflammation in vivo and in *** collective findings underscore reynosin’s capacity to mitigate mi-croglial inflammation by inhibiting the NLRP3 inflammasome,thus highlighting its potential as a therapeutic agent for managing neuroinflammation.

关键词： Microglia NLRP3 inflammasome Reactive oxygen species NADPH oxidase Neuron Reynosin

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Superradiant growth anomaly magnification in evolution of vector bosonic condensates bounded by a Kerr black hole with near-horizon reflection

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Science China(Physics,Mechanics & Astronomy) 2025年第4期68卷 62-81页

作者： Nayun Jia Yin-Da Guo Gui-Rong Liang Zhan-Feng Mai Xin Zhang Department of Physics Southern University of Science and TechnologyShenzhen 518055China Key Laboratory of Cosmology and Astrophysics(Liaoning)&College of Sciences Northeastern UniversityShenyang 110819China Institute of Frontier and Interdisciplinary Science Key Laboratory of Particle Physics and Particle Irradiation(Ministry of Education)Shandong UniversityQingdao 266237China School of Materials Science and Physics China University of Mining and TechnologyXuzhou 221116China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Key Laboratory of Data Analytics and Optimization for Smart Industry(Ministry of Education) Northeastern UniversityShenyang 110819China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Northeastern UniversityShenyang 110819China

Ultralight vector particles can form evolving condensates around a Kerr black hole(BH)due to superradiant *** study the effect of near-horizon reflection on the evolution of this system:by matching three pieces of asymptotic expansions of the Proca equation in Kerr metric and considering the leading order in the electric mode,we present explicit analytical expressions for the corrected spectrum and the superradiant instability ***,in high-spin BH cases,we identify an anomalous situation where the superradiance rate is temporarily increased by the reflection parameter R,which also occurs in the scalar scenario,but is largely magnified in vector condensates due to a faster growth rate in dominant *** point out that the condition for the growth anomaly in the adiabatic case is that information carried per particle exceeds a certain value δ1/δN>2πκ_(B)√(1+R)/(1-R).We further construct several featured quantities to illustrate it,and formalize the anomalyinduced gravitational wave strain deformation.

关键词： superradiance ultralight boson black hole gravitational wave near-horizon reflection

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Unraveling the early universe’s equation of state and primordial black hole production with PTA,BBN,and CMB observations

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Chinese Physics C 2024年第12期48卷 212-220页

作者： Qing-Hua Zhu Zhi-Chao Zhao Sai Wang Xin Zhang Department of Physics and Chongqing Key Laboratory for Strongly Coupled Physics Chongqing UniversityChongqing 401331China Department of Applied Physics College of ScienceChina Agricultural UniversityQinghua East RoadBeijing 100083China Theoretical Physics Division Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Key Laboratory of Cosmology and Astrophysics(Liaoning)&College of Sciences Northeastern UniversityShenyang 110819China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Northeastern UniversityShenyang 110819China Key Laboratory of Data Analytics and Optimization for Smart Industry(Ministry of Education) Northeastern UniversityShenyang 110819China

Pulsar timing array(PTA)data releases show strong evidence for a stochastic gravitational-wave background in the nanohertz *** the signal is interpreted by a scenario of scalar-induced gravitational waves(SIGWs),we encounter overproduction of primordial black holes(PBHs).We wonder if varying the equation of state(EoS)of the early Universe can resolve this issue and thereby lead to a consistent interpretation of the PTA *** a data combination of PTA,big-bang nucleosynthesis,and cosmic microwave background,we find that an epoch with EoS w~O(10^(-2))between the end of inflation and the onset of radiation domination can significantly suppress the production of PBHs,leading to alleviation of the PBH-overproduction *** the inferred interval w=0.44_(-0.40)^(+0.52)at 95%confidence level,our scenario can interpret the PTA data just as well as the conventional scenario of SIGWs produced during the radiation domination.

关键词： physics of the early universe gravitational waves primordial black hole pulsar timing arrays

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Network pharmacology and single-cell transcriptomic analysis with molecular docking to elucidate the potential compounds and targets of Polygonum cuspidatum *** *** hepatocellular carcinoma

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iLIVER 2024年第3期3卷 41-51页

作者： Wenze Wu Yuzhu Shi Yongzi Wu Rui Zhang Xinyan Wu Weidi Zhao Zhiyuan Chen Gang Ye Key Laboratory of Bioresource Research and Development of Liaoning Province College of Life and Health SciencesNational Frontiers Science Center for Industrial Intelligence and Systems OptimizationKey Laboratory of Data Analytics and Optimization for Smart IndustryMinistry of EducationNortheastern UniversityShenyang 110169China College of Veterinary Medicine Sichuan Agricultural UniversityChengdu 625014China School of Physical Education Shanxi UniversityTaiyuan 030006China

Background and aims:Polygonum cuspidatum *** Zucc.(***)and its active components have been clinically proven to have anti-hepatocellular carcinoma ***,the potential targets of *** for these effects have not yet been ***:We used network pharmacology and single-cell transcriptomic analysis with molecular docking to elucidate the active components and targets of *** for hepatocellular ***:CDK1,ESR1,HSP90A11,and MAPK1 were shown to be the key targets of *** for hepatocellular *** was found to be likely correlated with the improved abnormal expression of CDK1 and ESR1 and the poor prognosis of HSP90AA1 and ***1 was identified as the most potential antihepatocellular carcinoma target of *** the active components of ***,physcion diglucoside was found to have the most potential to treat hepatocellular carcinoma by targeting ***:Our study provides novel insights into the anti-hepatocellular carcinoma pharmacological effects of ***,which could serve as a scientific basis for its development as a medicinal resource and the targeting of CDK1 for hepatocellular carcinoma treatment.

关键词： Hepatocellular carcinoma Network pharmacology Molecular dynamics simulation Molecular docking Polygonum cuspidatum Single-cell transcriptomic analysis

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Evolutionary Direction Learning With Multivariate Gaussian Probabilistic Model for Multiobjective optimization

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IEEE Transactions on Evolutionary Computation 2025年

作者： Wang, Xianpeng Zhang, Jingchuan Tang, Lixin Liu, Yaxue Ministry of Education National Frontiers Science Center for Industrial Intelligence and Systems Optimization Shenyang110819 China Ministry of Education Key Laboratory of Data Analytics and Optimization for Smart Industry Northeastern University Shenyang110819 China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Shenyang110819 China Liaoning Key Laboratory of Manufacturing System and Logistics Optimization Liaoning Engineering Laboratory of Data Analytics and Optimization for Smart Industry Shenyang110819 China

In recent years, utilizing data from the evolutionary process of multiobjective evolutionary algorithms (MOEAs) to learn knowledge and guide evolutionary search has become a popular research topic. However, existing knowledge learning (KL) frameworks often suffer from the low quality of collected datasets and the inefficiency of model construction, which significantly limits their effectiveness. To address this issue, this paper proposes a novel evolutionary direction learning (EDL) framework, which aims to learn the evolutionary direction (ED) knowledge for each objective to enhance the population generation of MOEAs. The proposed EDL incorporates an effective data collection method based on objective improvement to generate high-quality datasets, based on which a multivariate Gaussian probabilistic model is employed to learn ED knowledge for each objective through a data fusion modeling approach. Besides, a knowledge assignment method is designed to select the most suitable ED knowledge to guide the evolution of solutions. Experimental results on both synthetic and real-world problems demonstrate that the proposed EDL framework can accelerate the convergence of MOEAs and significantly improve their performance. A comparison of the proposed EDL with three state-of-the-art KL frameworks indicates that EDL is a highly competitive learning framework, achieving superior performance with larger datasets and impressive efficiency. © 1997-2012 IEEE.

关键词： Contrastive Learning

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Solid state recycling of used aluminum alloy beverage cans by thermomechanical consolidation

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Heat Treatment and Surface Engineering 2022年第1期4卷 90-98页

作者： Wang, Ziyi Yu, Yuanping Jin, Yu Li, Zhuolun Sun, Song Xu, Haoran Wu, Chengxun Zhang, Deliang School of Material Science and Engineering Northeastern University Shenyang China Key Laboratory of Data Analytics and Optimization for Smart Industry (Northeastern University) Ministry of Education Shenyang China

Solid-state recycling of used aluminum alloy beverage cans was accomplished by thermomechanical consolidation of the sheet fragments produced by shredding the cans. Different samples were obtained using two thermomechanical consolidation routes, one involving direct hot extrusion of a sheet fragment compact and the other involving upset hot-forging of a sheet fragment compact followed by hot extrusion of the forged ingot. The microstructures and mechanical properties of the samples were investigated. It was found that the samples contained less pores and exhibited better mechanical properties with a higher extrusion temperature and involving upset forging than with only hot extrusion, the highest tensile strength is 209.5 MPa and the largest elongation to fracture is 29.1%. The surface layers of the samples exhibited a clearly higher strength and tensile ductility than the interior. They also showed significantly different fracture behaviors, with the former being like fully ductile fracture and the latter involving delamination of the sheet fragments, suggesting that the bonding between the fragments is significantly stronger in the surface layer, possibly due to a higher amount of plastic deformation in it. Overall, the best quality solid state recycled material has tensile properties comparable with those of wrought aluminum alloy with the same composition. © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

关键词： mechanical properties microstructure solid state recycling thermomechanical consolidation of sheet fragments Used aluminum beverage cans

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Visualization and simulation of steel metallurgy processes

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International Journal of Minerals,Metallurgy and Materials 2021年第8期28卷 1387-1396页

作者： Te Xu Guang Song Yang Yang Pei-xin Ge Li-xin Tang Key Laboratory of Data Analytics and Optimization for Smart Industry(Northeastern University) Ministry of EducationShenyang 110819China Liaoning Engineering Laboratory of Operations Analytics and Optimization for Smart Industry Northeastern UniversityShenyang 110819China Liaoning Key Laboratory of Manufacturing System and Logistics Shenyang 110819China Institute of Industrial&Systems Engineering Northeastern UniversityShenyang 110819China

Steel production involves the transfer and transformation of material and energy at different levels, structures, and scales, and this process incurs substantial information in the material and energy dimensions. Given the black-box feature of iron and steel production processes, process visualization plays an important role and inevitably benefits parameter correction, technical support decision-making, personnel training, and other aspects of the steel metallurgy industry. The technological characteristics of the entire process in the steel industry were analyzed in this study, a visualization technology route based on virtual reality(VR) was built, and the important components of visual simulation system for steel industry and the important technical points needed to realize the system were proposed. On the foundation, a visual simulation model for the process scheduling of the iron and steel enterprise raw materials' field, slab, and hot rolling processes was built, and a visualization simulation platform of the iron and steel metallurgy plant-wide process, including ironmaking, steelmaking, hot rolling, and cold rolling, was developed. Lastly, the effectiveness of platform was illustrated by practical application.

关键词： virtual reality steel metallurgy plant-wide visualization

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Bumpless Transfer Control of Switched Time-Delay Linear Systems with State-dependent Switching 41

Bumpless Transfer Control of Switched Time-Delay Linear Syst...

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第41届中国控制会议

作者： Jinghan Li Jun Zhao State Key Laboratory of Synthetical Automation for Process Industries Northeastern University Key Laboratory of Data Analytics and Optimization for Smart Industry (Northeastern University) Ministry of Education College of Information Science and Engineering Northeastern University

ISBN: (数字)9789887581536

ISBN: (纸本)9781665482561

This paper deals with the bumpless transfer control for switched time-delay *** time-delay bumpless transfer performance for switched linear system is provided,which can suppress control bumps caused by the current state and the time-delay state at the switching ***,by utilizing the multiple Lyapunov functions,under the co-design of the state-dependent switching law and the time-delay controller,a sufficient condition guaranteeing bumpless transfer control of switched time-delay systems is *** effectiveness of the result is validated by an *** result shows that our method reduces the bumpy amplitude while ensuring the stability of the switched time-delay system.

关键词： Switched Systems Time-delay State-dependent Bumpless Transfer

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Dissipative Tracking Control of T-S Fuzzy Switched Systems under Bumpless Transfer Performance 41

Dissipative Tracking Control of T-S Fuzzy Switched Systems u...

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第41届中国控制会议

作者： Guangxu He Jun Zhao State Key Laboratory of Synthetical Automation for Process Industries Northeastern University Key Laboratory of Data Analytics and Optimization for Smart Industry (Northeastern University) Ministry of Education Collee of Information Science and Engineering Northeastern University

ISBN: (数字)9789887581536

ISBN: (纸本)9781665482561

This paper studies the tracking control problem of the T-S fuzzy switched systems with the α-dissipativity and the bumpless transfer *** on the reference system,the fuzzy tracking controller will be designed by using the parallel distributed compensation *** sufficient conditions in terms of linear matrix inequalities are obtained to guarantee the adissipative tracking bumpless transfer performance via the co-design of the bumpless transfer controller and the state-dependent switching law,even if the tracking problem of each fuzzy subsystems is not ***,an example is given to validate the effectiveness of the results.

关键词： T-S fuzzy switched systems α-dissipative tracking bumpless transfer control

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