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A quinolinyl analog of resveratrol improves neuronal damage after ischemic stroke by promoting Parkin-mediated mitophagy

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Chinese Journal of Natural Medicines 2025年第2期23卷 214-224页

作者： Qingqi Meng Yan Mi Libin Xu Yeshu Liu Dong Liang Yongping Wang Yan Wang Yueyang Liu Guoliang Chen Yue Hou Key Laboratory of Bioresource Research and Development of Liaoning Province College of Life and Health SciencesNational Frontiers Science Center for Industrial Intelligence and Systems OptimizationKey Laboratory of Data Analytics and Optimization for Smart IndustryMinistry of EducationNortheastern UniversityShenyang 110167China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China Shenyang Key Laboratory of Vascular Biology Science and Research CenterDepartment of PharmacologyShenyang Medical CollegeShenyang 110034China Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of Education School of Pharmaceutical EngineeringShenyang Pharmaceutical UniversityShenyang 110016China

Ischemic stroke(IS)is a prevalent neurological disorder often resulting in significant disability or ***,extracted from Polygonum cuspidatum *** Zucc.(commonly known as Japanese knotweed),has been recognized for its potent neuroprotective ***,the neuroprotective efficacy of its derivative,(E)-4-(3,5-dimethoxystyryl)quinoline(RV02),against ischemic stroke remains inadequately *** study aimed to evaluate the protective effects of RV02 on neuronal ischemia-reperfusion injury both in vitro and in *** research utilized an animal model of middle cerebral artery occlusion/reperfusion and SH-SY5Y cells subjected to oxygen-glucose deprivation and reperfusion to simulate ischemic *** findings demonstrate that RV02 attenuates neuronal mitochondrial damage and scavenges reactive oxygen species(ROS)through mitophagy ***,Parkin knockdown was found to abolish RV02's ability to activate mitophagy and neuroprotection in *** results suggest that RV02 shows promise as a neuroprotective agent,with the activation of Parkin-mediated mitophagy potentially serving as the primary mechanism underlying its neuroprotective effects.

关键词： (E)-4-(3 5-dimethoxystyryl)quinoline Resveratrol Ischemic stroke Mitophagy Parkin

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The Mass Assembly History for Galaxies with MaNGA

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Research in Astronomy and Astrophysics 2024年第3期24卷 58-69页

作者： Xue Ge Hong-Tao Wang Cheng-Long Lei Yun-Jun Guo Yi-Long Jiang Xiao-Xiao Cao School of Physics and Information Engineering Jiangsu Second Normal University Jiangsu Province Engineering Research Center of Basic Education Big Data Application Jiangsu Second Normal University Key Laboratory of Modern Astronomy and Astrophysics Nanjing UniversityMinistry of Education School of Science Langfang Normal University

How galaxies assemble masses through their own star formation or interaction with the external environment is still an important topic in the field of galaxy formation and *** use Value Added Catalogs with galaxy features that are spatially and temporally resolved from Sloan Digital Sky Survey data Release 17 to investigate the mass growth histories of early-type galaxies(ETGs)and late-type galaxies(LTGs).We find that the mass growth of ETGs is earlier than that of LTGs for massive galaxies(M_(*)>10^(10)M_⊙),while low-mass(M_(*)≤10^(10)M_⊙)ETGs have statistically similar mass assembly histories as low-mass *** stellar metallicity of all massive galaxies shows a negative gradient and basically does not change with ***,in low-mass galaxies,the stellar metallicity gradient of elliptical galaxies is negative,and the stellar metallicity gradient of lenticular and spiral galaxies evolves from positive to *** are not all in a high-density environment,but exhibit mass *** the tidal strength increases,the star formation rate of low-mass ETGs rapidly *** results support a picture where massive galaxies exhibit inside-out quenching mode,while low-mass galaxies show outside-in quenching *** effects play an important role in regulating the mass assembly histories of low-mass ETGs.

关键词： Galaxy evolution-galaxies star formation-Galaxy formation

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A Cloud Model-Based Collaborative Filtering Approach for Sparse data Recommendation Systems 5

A Cloud Model-Based Collaborative Filtering Approach for Spa...

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5th International Symposium on Computer engineering and Intelligent Communications, ISCEIC 2024

作者： Guo, Xuepin Cui, Xinyu School of Information Science and Technology Hainan Normal University Haikou571158 China Key Laboratory of Data Science and Education Ministry of Education Haikou571158 China

ISBN: (纸本)9798331518677

Collaborative filtering is one of the most prominent recommendation methods, particularly excelling in recommending nonlinear resources. However, with the rapid increase in the number of users and items, the scarcity of co-rated items makes user similarity metrics less reliable. To address this, we first predict the ratings of unrated items based on item similarity, thereby increasing the number of co-rated items among users. Then, we employ user similarity measures to identify the nearest neighbor set for each user, and finally, generate recommendations for the target user. The results indicate that this method improves recommendation quality to a certain extent. © 2024 IEEE.

关键词： Collaborative filtering

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Facile synthesis of W-Mo bimetallic oxides with high adsorption properties from secondary resources

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Tungsten 2024年第4期6卷 806-820页

作者： Jia-Li Cheng Yang-Si Liu Xiao-Li Xi Zuo-Ren Nie Collaborative Innovation Center of Capital Resource-Recycling Material Technology College of Materials Science and EngineeringBeijing University of TechnologyBeijing100124China National Engineering Laboratory for Industrial Big-Data Application Technology Beijing University of TechnologyBeijing100124China Key Laboratory of Advanced Functional Materials Ministry of EducationBeijing University of TechnologyBeijing100124China

A simple solvothermal method was used to obtain W-Mo bimetallic oxides from W-Mo alloy scrap,and pure metal powders were also used as the raw materials to simulate *** products had a sea urchin-like structure with abundant oxygen vacancies and the products prepared at low temperatures forms a sosoloid resembling orthorhombic W_(0.4)Mo_(0.6)O_(3).The WMo bimetallic oxide prepared at the reaction temperature of 120℃exhibited excellent selective adsorption performance for methylene blue(MB),which the adsorption rate of MB reached 99%in 12 min and the adsorption rate reached 90%after6 adsorption *** the W-Mo molar ratio is 1:3,the maximum adsorption capacity of sample for MB can reach1148 mg·g^(-1).The adsorption process followed the Langmuir and pseudo-second-order models,which is surface-controlled monolayer *** experimental results show the feasibility of preparing W-Mo bimetal oxide products from pure materials and *** process is simple and effective,which offered a potential approach for secondary resource recycling and reusing.

关键词： W-Mo bimetallic oxide Oxygen vacancy Selective adsorption W-Mo alloy scrap Solvothermal

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HUSS:A Heuristic Method for Understanding the Semantic Structure of Spreadsheets

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data Intelligence 2023年第3期5卷 537-559页

作者： Xindong Wu Hao Chen Chenyang Bu Shengwei Ji Zan Zhang Victor S.Sheng Key Laboratory of Knowledge Engineering with Big Data(the Ministry of Education of China) Hefei University of TechnologyChinaSchool of Computer Science and Information EngineeringHefei University of TechnologyHefeiChina Research Institute of Artificial Intelligence Zhejiang LabHangzhouChina Department of Computer Science Texas Tech UniversityLubbockTX 79409USA

Spreadsheets contain a lot of valuable data and have many practical *** key technology of these practical applications is how to make machines understand the semantic structure of spreadsheets,e.g.,identifying cell function types and discovering relationships between cell *** existing methods for understanding the semantic structure of spreadsheets do not make use of the semantic information of cells.A few studies do,but they ignore the layout structure information of spreadsheets,which affects the performance of cell function classification and the discovery of different relationship types of cell *** this paper,we propose a Heuristic algorithm for Understanding the Semantic Structure of spreadsheets(HUSS).Specifically,for improving the cell function classification,we propose an error correction mechanism(ECM)based on an existing cell function classification model[11]and the layout features of *** improving the table structure analysis,we propose five types of heuristic rules to extract four different types of cell pairs,based on the cell style and spatial location *** experimental results on five real-world datasets demonstrate that HUSS can effectively understand the semantic structure of spreadsheets and outperforms corresponding baselines.

关键词： Spreadsheet semantic structure Information extraction Heuristics Cell function analysis Table structure analysis

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Research on collaborative filtering recommendation algorithm based on comprehensive cloud model similarity

Research on collaborative filtering recommendation algorithm...

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2024 International Conference on Algorithms, High Performance Computing, and Artificial Intelligence, AHPCAI 2024

作者： Cui, Xinyu Guo, Xuepin Luo, Ziqiang School of Information Science and Technology Hainan Normal University Haikou571158 China Key Laboratory of Data Science and Education of Ministry of Education Haikou571158 China

ISBN: (纸本)9781510685840

Collaborative filtering recommendation system is one of the core technologies for product recommendations on e-commerce platforms. The method used to measure user similarity directly impacts the accuracy of the recommendation algorithm. Addressing deficiencies in similarity calculation within collaborative filtering recommendation algorithms, this paper proposes a comprehensive similarity measurement method based on the cloud model's "mutual membership degree - shape". This method overcomes the limitation of strict matching of object attributes, effectively utilizes cloud model parameters and data statistics to more accurately reflect user preferences, thus providing more precise recommendations to users. Experimental results demonstrate that this approach has significantly improved recommendation accuracy to a certain extent. © 2024 SPIE.

关键词： Cloud platforms

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Benefit of aerosol reduction to winter wheat during china's clean air action:A case study of Henan Province

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Journal of Environmental Sciences 2024年第7期141卷 90-101页

作者： Yang Bai Pengfei Zhao Xueyang Chen Lijun Wang Wenjuan Chang Jianzhong Guo Jiayao Wang College of Geography and Environmental Science Henan UniversityKaifeng 475004China Henan Industrial Technology Academy of Spatio-Temporal Big Data Henan UniversityZhengzhou 475000China Henan Technology Innovation Center of Spatio-Temporal Big Data Henan UniversityZhengzhou 450046China Key Laboratory of Geospatial Technology for the Middle and Lower Yellow River Regions(Henan University) Ministry of EducationKaifeng 475000China

A strongly declining aerosol radiative effect has been observed in china since 2013 after implementing the clean air action,yet its impact on wheat(Triticum aestivum L.)production remains *** use satellite measures and a biophysical crop model to assess the impact of aerosol-induced radiative perturbations on winter wheat production in the agricultural belt of Henan province from 2013 to *** calibrating parameters with the extended Fourier Amplitude Sensitivity Test(EFAST)and the generalized likelihood uncertainty estimation(GLUE)method,the DSSAT CERES-Wheat model was able to simulate crop biomass and yield more *** found that the aerosol negatively impacted wheat biomass by 21.87%and yield by 22.48%from 2006 to 2018,and the biomass effects from planting to anthesis were more significant compared to anthesis to *** to the strict clean air action,under all-sky conditions,the surface solar shortwave radiation(SSR)in 2018 increased by about 7.08%over 2006-2013 during the wheat growing *** a result of the improvement of crop photosynthesis,winter wheat biomass and yield increased by an average of 5.46%and 2.9%,*** findings show that crop carbon uptake and yield will benefit from the clean air action in china,helping to ensure national food and health security.

关键词： Haze pollution Clean air action Aerosol-induced radiative perturbation Wheat production DSSAT model

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Multiparticipant Federated Feature Selection Algorithm With Particle Swarm Optimization for Imbalanced data Under Privacy Protection

IEEE Transactions on Artificial Intelligence

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IEEE Transactions on Artificial Intelligence 2023年第5期4卷 1002-1016页

作者： Hu, Ying Zhang, Yong Gong, Dunwei Sun, Xiaoyan China University of Mining and Technology School of Information and Control Engineering Xuzhou221008 China Jilin University Key Laboratory of Symbolic Computation and Knowledge Engineering Ministry of Education Changchun130012 China

In the real world, data describing the same learning task may be distributed in different institutions (called participants), and these participants cannot share their own data due to the need of privacy protection. How to select an optimal feature subset on the basis of ensuring the data privacy of each participant is an important and challenging topic. At the same time, data on part participants show imbalanced or even miss some classes, further increasing the difficulty of solving this kind of problem. In view of this, by introducing a trusted third party to process and integrate optimal information from participants, this article proposes a multiparticipant federated evolutionary feature selection algorithm for imbalanced data under privacy protection. First, a multilevel joint sample filling strategy with multiple participants (called sampling-rough selection-fine tuning strategy) is proposed to fill imbalanced or empty classes on each participant while ensuring data privacy. Then, a federated evolutionary feature selection method based on particle swarm optimization (PSO) is proposed by periodically sharing the optimal feature subsets obtained by PSOs on participants. Finally, the proposed algorithm is applied to 15 test datasets, and compared with several typical imbalanced feature selection algorithms and two kinds of ensemble feature selection algorithms. The experimental results show that the proposed algorithm can significantly promote the ability of each participant on processing imbalanced datasets, and improve the classification accuracy of obtained feature subsets while protecting the participants' data privacy. © 2020 IEEE.

关键词： Clustering algorithms

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Two efficient beamforming methods for hybrid IRS-aided AF relay wireless networks

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Science china(Information Sciences) 2025年第4期68卷 363-379页

作者： Xuehui WANG Qingbo LI Wen ZHU Feng SHU Mengxing HUANG Fuhui ZHOU Riqing CHEN Cunhua PAN Yongpeng WU Jiangzhou WANG School of Mathematics and Statistics Hainan Normal University Key Laboratory of Data Science and Smart Education Ministry of Education Hainan Normal University School of Information and Communication Engineering Hainan University Collaborative Innovation Center of Information Technology Hainan University School of Electronic and Optical Engineering Nanjing University of Science and Technology College of Electronic and Information Engineering Nanjing University of Aeronautics and Astronautics Digital Fujian Institute of Big Data for Agriculture Fujian Agriculture and Forestry University National Mobile Communications Research Laboratory Southeast University Shanghai Key Laboratory of Navigation and Location Based Services Shanghai Jiao Tong University School of Engineering University of Kent

Owing to its ability to mitigate the double-fading effect by amplifying the reflected signal, the active intelligent reflecting surface(IRS) has garnered significant attention. In this paper, an amplify-and-forward(AF) relay network assisted by a hybrid IRS consisting of both passive and active units is developed. A signal-to-noise ratio(SNR) maximization problem is formulated, where the AF relay beamforming matrix and the hybrid IRS reflecting coefficient matrices for two-time slots need to be optimized. To address the SNR maximization problem, this paper proposes both a high-performance(HP) method and a low-complexity(LC) method. The HP method is based on the semidefinite relaxation and fractional programming(SDR-FP)algorithm, with rank-1 solutions obtained through Gaussian randomization. For the LC method, the amplification coefficient of each active IRS element is assumed to be equal. The SNR maximization problem is then addressed using the whitening filter,generalized power iteration, and generalized Rayleigh-Ritz(WF-GPI-GRR) approach. Simulation results show that compared with the benchmarks, such as the passive IRS-aided AF relay network, the proposed HP-SDR-FP and WF-GPI-GRR methods achieve significant rate improvements. In particular, the HP-SDR-FP and WF-GPI-GRR methods yield more than a 135.0%rate gain when the transmit power Ps of the source is 10 dBm. Furthermore, the proposed HP-SDR-FP method outperforms the WF-GPI-GRR method in terms of rate performance.

关键词： double-fading intelligent reflecting surface active elements passive elements hybrid IRS AF relay

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A GMM approach in coupling internal data and external summary information with heterogeneous data populations

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Science china Mathematics 2024年第5期67卷 1115-1132页

作者： Jun Shao Jinyi Wang Lei Wang Key Laboratory of Advanced Theory and Application in Statistics and Data Science(East China Normal University) Ministry of EducationShanghai 200062China School of Statistics East China Normal UniversityShanghai 200062China Department of Statistics University of Wisconsin-MadisonWI 53706USA School of Statistics and Data Science KLMDASRLEBPS and LPMCNankai UniversityTianjin 300071China

Because of advances in data collection and storage,statistical analysis in modern scientific research and practice now has opportunities to utilize external information such as summary statistics from similar studies.A likelihood approach based on a parametric model assumption has been developed in the literature to utilize external summary information when the populations for external and main internal data are assumed to be the *** this article,we instead consider the generalized estimation equation(GEE)approach for statistical inference,which is semiparametric or nonparametric,and show how to utilize external summary information even when internal and external data populations are not the *** approach is coupling the internal data and external summary information to form additional estimation equations and then applying the generalized method of moments(GMM).We show that the proposed GMM estimator is asymptotically normal and,under some conditions,is more efficient than the GEE estimator without using external summary *** of the asymptotic covariance matrix of the GMM estimators are also *** results are obtained to confirm our theory and quantify the improvements by utilizing external *** example is also included for illustration.

关键词： adjustment for heterogeneity constraint data integration generalized method of moments summarystatistic

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