检索结果-内蒙古大学图书馆

POS0851 IDENTIFICATION OF HUB GENES AND PATHWAYS IN DERMATOMYOSITIS BY BIOINFORMATICS ANALYSIS

Annals of the Rheumatic Diseases 2021年 80卷 680-680页

作者： C. Zheng S.X. Zhang R. Zhao L. Cheng T. Kong X. Sun S. Feng Q. Wang X. Li Q. Yu P.F. He Shanxi Medical University School of Management Taiyuan China The Second Hospital of Shanxi Medical University Department of Rheumatology Taiyuan China Shanxi Li Xiaofeng Medical Groups Department of Rheumatology Taiyuan China Ministry of Education Key Laboratory of Cellular Physiology at Shanxi Medical University Taiyuan China Shanxi Medical University School of Humanities and Social Sciences Taiyuan China Shanxi Medical University Basic Medical College Taiyuan China Shanxi Medical University Medical Data Sciences/School of Management Taiyuan China Shanxi Medical University Medical Data Sciences Taiyuan China

Background: Dermatomyositis (DM) is a chronic systemic autoimmune disease characterized by inflammatory infiltrates in the skin and muscle 1 . The genes and pathways in the inflamed myopathies in patients with DM are poorly understood 2 . Objectives: To identify the key genes and pathways associated with DM and further discover its pathogenesis. Methods: Muscle tissue gene expression profile (GSE143323) were acquired from the GEO database, which included 39 DM samples and 20 normal samples. The differentially expressed genes (DEGs) in DM muscle tissue were screened by adopting the R software. Gene ontology (GO) and Kyoto Encyclopedia of Genome (KEGG) pathway enrichment analysis was performed by Metascape online analysis tool. A protein-protein interaction (PPI) network was then constructed by STRING software using the genes in significantly different pathways. Network of DEGs was analyzed by Cytoscape software. And degree of nodes was used to screen key genes. Results: Totally, 126 DEGs were obtained, which contained 122 up-regulated and 4 down-regulated. GO analysis revealed that most of the DEGs were significantly enriched in type I interferon signaling pathway, response to interferon-gamma, collagen-containing extracellular matrix, response to interferon-alpha and bacterium, positive regulation of cell death, leukocyte chemotaxis. KEGG pathway analysis showed that upregulated DEGs enhanced pathways associated with the hepatitis C, complement and coagulation cascades, p53 signaling pathway, RIG-I-like receptor signaling, Osteoclast differentiation, and AGE-RAGE signaling pathway. Ten hub genes were identified in DM, they were ISG15, IRF7, STAT1, MX1, OASL, OAS2, OAS1, OAS3, GBP1, and IRF9 according to the Cytoscape software and cytoHubba plugin. Conclusion: The findings from this bioinformatics network analysis study identified the key hub genes that might provide new molecular markers for its diagnosis and treatment. References: [1]Olazagasti JM, Niewold TB, Reed

关键词：

来源：评论

学校读者我要写书评

暂无评论

π–π Interaction-Induced Organic Long-wavelength Room-Temperature Phosphorescence forIn VivoAtherosclerotic Plaque Imaging

引用

Angewandte Chemie 2023年第2期136卷

作者： Yufan Zhang Jisen Li Jiliang Zhao Xuefei Li Zhimei Wang Yicheng Huang Prof. Hongkai Zhang Prof. Qian Liu Prof. Yunxiang Lei Prof. Dan Ding Frontiers Science Center for Cell Responses State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials Ministry of Education College of Life Sciences Nankai University 300071 Tianjin China Contribution: Conceptualization (equal) Data curation (equal) Formal analysis (lead) Writing - original draft (lead) Contribution: Conceptualization (equal) Data curation (equal) Formal analysis (equal) Contribution: Investigation (equal) Methodology (equal) Contribution: Conceptualization (supporting) Software (equal) School of Chemistry and Materials Engineering Wenzhou University 325035 Wenzhou China Contribution: Investigation (supporting) Methodology (supporting) Contribution: Conceptualization (supporting) Data curation (supporting) Department of Urology Tianjin First Central Hospital 300192 Tianjin China Contribution: Data curation (supporting) Software (supporting) Contribution: Visualization (lead) Writing - review & editing (supporting) Contribution: Funding acquisition (lead) Writing - review & editing (lead)

Room-temperature phosphorescent (RTP) materials have great potential for in vivo imaging because they can circumvent the autofluorescence of biological tissues. In this study, a class of organic-doped long-wavelength (≈600 nm) RTP materials with benzo[c][1,2,5] thiadiazole as a guest was constructed. Both host and guest molecules have simple structures and can be directly purchased commercially at a low cost. Owing to the long phosphorescence wavelength of the doping system, it exhibited good tissue penetration (10 mm). Notably, these RTP nanoparticles were successfully used to image atherosclerotic plaques, with a signal-to-background ratio (SBR) of 44.52. This study provides a new approach for constructing inexpensive red organic phosphorescent materials and a new method for imaging cardiovascular diseases using these materials.

关键词： Atherosclerotic Plaque Imaging Benzo[c][1,2,5] Thiadiazole Guest Host-Guest Doped Systems Room Temperature Phosphorescence

来源：评论

学校读者我要写书评

暂无评论

POS0458 IDENTIFICATION OF HUB GENES AND MOLECULAR PATHWAYS IN PATIENTS WITH RHEUMATOID ARTHRITIS BY BIOINFORMATICS ANALYSIS

引用

Annals of the Rheumatic Diseases 2021年 80卷 460-460页

作者： L. Cheng S.X. Zhang S. Song C. Zheng X. Sun S. Feng T. Kong G. Shi X. Li P.F. He Q. Yu Shanxi Medical University School of Management Taiyuan China Shanxi Medical University Department of Rheumatology Taiyuan China Shanxi Li Xiaofeng Medical Groups Department of Rheumatology Taiyuan China Ministry of Education Key laboratory of Cellular Physiology at Shanxi Medical University Taiyuan China Shanxi Medical University Basic Medical College Taiyuan China Shanxi Medical University Institute of Medical Data Sciences Taiyuan China

Background: Rheumatoid arthritis (RA) is a chronic, inflammatory synovitis based systemic disease of unknown etiology 1 . The genes and pathways in the inflamed synovium of RA patients are poorly understood. Objectives: This study aims to identify differentially expressed genes (DEGs) associated with the progression of synovitis in RA using bioinformatics analysis and explore its pathogenesis 2 . Methods: RA expression profile microarray data GSE89408 were acquired from the public gene chip database (GEO), including 152 synovial tissue samples from RA and 28 healthy synovial tissue samples. The DEGs of RA synovial tissues were screened by adopting the R software. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed. Protein-protein interaction (PPI) networks were assembled with Cytoscape software. Results: A total of 654 DEGs (268 up-regulated genes and 386 down-regulated genes) were obtained by the differential analysis. The GO enrichment results showed that the up-regulated genes were significantly enriched in the biological processes of myeloid leukocyte activation, cellular response to interferon-gamma and immune response-regulating signaling pathway, and the down-regulated genes were significantly enriched in the biological processes of extracellular matrix, retinoid metabolic process and regulation of lipid metabolic process. The KEGG annotation showed the up-regulated genes mainly participated in the staphylococcus aureus infection, chemokine signaling pathway, lysosome signaling pathway and the down-regulated genes mainly participated in the PPAR signaling pathway, AMPK signaling pathway, ECM-receptor interaction and so on. The 9 hub genes (PTPRC, TLR2, tyrobp, CTSS, CCL2, CCR5, B2M, fcgr1a and PPBP) were obtained based on the String database model by using the Cytoscape software and cytoHubba plugin 3 . Conclusion: The findings identified the molecular mechanisms and the key hub genes of pathog

关键词：

来源：评论

学校读者我要写书评

暂无评论

MXenes: MXenes: Synthesis, Optical Properties, and Applications in Ultrafast Photonics (Small 11/2021)

引用

Small 2021年第11期17卷

作者： Bo Fu Jingxuan Sun Cong Wang Ce Shang Lijun Xu Jiebo Li Han Zhang BUAA-CCMU Advanced Innovation Center for Big Data-Based Precision Medicine School of Medicine and Engineering Beihang University Beijing 100191 China Key Laboratory of Big Data-Based Precision Medicine Ministry of Industry and Information Technology Interdisciplinary Innovation Institute of Medicine and Engineering Beihang University Beijing 100191 China School of Instrumentation and Optoelectronic Engineering Beihang University Beijing 100191 China Shenzhen Engineering Laboratory of Phosphorene and Optoelectronics Collaborative Innovation Center for Optoelectronic Science and Technology College of Optoelectronic Engineering Shenzhen University Shenzhen 518060 China School of Biological Science and Medical Engineering Beihang University Beijing 100191 China Beijing Advanced Innovation Center for Biomedical Engineering Beihang University Beijing 100191 China

来源：评论

学校读者我要写书评

暂无评论

基于划分的集合相似连接

基于划分的集合相似连接

引用

第29届中国数据库学术会议

作者： Rong Chuitian 荣垂田 Xu Tianren 徐天任 Du Xiaoyong 杜小勇 Key Laboratory of Data Engineering and Knowledge Engineering(Renmin University of China) Ministry o 教育部数据工程与知识工程重点实验室(中国人民大学) 北京 100872 中国人民大学信息学院北京 100872 School of Information Renmin University of China Beijing 100872 Key Laboratory of Education Inform 中国人民大学信息学院北京 100872 民族教育信息化教育部重点实验室(云南师范大学) 昆明 650500

集合相似连接(set similarity join)是指在给定的数据集中，按照基于集合间覆盖关系的相似度计算方法来衡量数据之间的相似度、并找出所有相似度不小于给定阈值的数据对的操作。集合相似连接作为一种新的基本操作在很多领域中有重要应... 详细信息

集合相似连接(set similarity join)是指在给定的数据集中，按照基于集合间覆盖关系的相似度计算方法来衡量数据之间的相似度、并找出所有相似度不小于给定阈值的数据对的操作。集合相似连接作为一种新的基本操作在很多领域中有重要应用。随着社会网络、移动应用以及在线服务的发展，使得数据收集的效率和规模得到了很大的提高，同时给相似连接操作带来新的挑战。根据集合相似的必要条件，提出了相似集合之间的差异度。利用差异度和鸽巢原理，提出了一种新颖的基于数据划分的集合相似连接计算方法，该方法对集合进行自适应的均衡划分，并利用基于划分块的过滤方法来提高过滤的效率。为了进一步提高过滤的效果和相似连接的效率，利用划分块的位置信息提出了增强的过滤方法。针对提出的方法，在不同的环境下进行了实验，实验结果表明，该方法与已有的方法相比可以有效地提高相似连接的效率。

关键词：数据库集合相似连接均衡划分法阈值

来源：评论

学校读者我要写书评

暂无评论

FAST drift scan survey for Hi intensity mapping: I. preliminary data analysis

arXiv

引用

arXiv 2023年

作者： Li, Yichao Wang, Yougang Deng, Furen Yang, Wenxiu Hu, Wenkai Liu, Diyang Zhao, Xinyang Zuo, Shifan Shu, Shuanghao Li, Jixia Timbie, Peter Ansari, Réza Perdereau, Olivier Stebbins, Albert Wolz, Laura Wu, Fengquan Zhang, Xin Chen, Xuelei College of Sciences Northeastern University Shenyang110819 China National Astronomical Observatories Chinese Academy of Sciences Beijing100101 China School of Astronomy and Space Science University of Chinese Academy of Sciences Beijing100049 China Key Laboratory of Radio Astronomy and Technology Chinese Academy of Sciences A20 Datun Road Chaoyang District Beijing100101 China Aix Marseille Univ CNRS CNES LAM Marseille France Australia Department of Physics University of Wisconsin – Madison MadisonWI53706 United States Université Paris-Saclay Université Paris Cité CEA CNRS AIM Gif-sur-Yvette91191 France Université Paris-Saclay CNRS IN2P3 IJCLab Orsay91405 France Fermi National Accelerator Laboratory P.O. Box 500 BataviaIL60510 United States Jodrell Bank Centre for Astrophysics Department of Physics & Astronomy The University of Manchester ManchesterM13 9PL United Kingdom National Frontiers Science Center for Industrial Intelligence and Systems Optimization Northeastern University Shenyang110819 China Key Laboratory of Data Analytics and Optimization for Smart Industry Ministry of Education Northeastern University Shenyang110819 China

This work presents the initial results of the drift-scan observation for the neutral hydrogen (Hi) intensity mapping survey with the Five-hundred-meter Aperture Spherical radio Telescope (FAST). The data analyzed in this work were collected in night observations from 2019 through 2021. The primary findings are based on 28 hours of drift-scan observation carried out over seven nights in 2021, which covers 60 deg2 sky area. Our main findings are: (i) Our calibration strategy can successfully correct both the temporal and bandpass gain variation over the 4-hour drift-scan observation. (ii) The continuum maps of the surveyed region are made with frequency resolution of 28 kHz and pixel area of 2.95 arcmin2. The pixel noise levels of the continuum maps are slightly higher than the forecast assuming Tsys = 20 K, which are 36.0 mK (for 10.0 s integration time) at the 1050–1150 MHz band, and 25.9 mK (for 16.7 s integration time) at the 1323–1450 MHz band, respectively. (iii) The flux-weighted differential number count is consistent with the NRAO-VLA Sky Survey (NVSS) catalog down to the confusion limit ∼ 7 mJy/beam−1. (iv) The continuum flux measurements of the sources are consistent with that found in the literature. The difference in the flux measurement of 81 isolated NVSS sources is about 6.3%. Our research offers a systematic analysis for the FAST Hi intensity mapping drift-scan survey and serves as a helpful resource for further cosmology and associated galaxies sciences with the FAST drift-scan survey. Copyright © 2023, The Authors. All rights reserved.

关键词： data handling

来源：评论

学校读者我要写书评

暂无评论

Cover Feature: The Configuration Identification of Guanine Molecules Adsorbed on the Si(100) Surface by Using XPS Shake-up Satellites and NEXAFS (ChemPhysChem 20/2024)

引用

ChemPhysChem 2024年第20期25卷

作者： Shuyi Wang Jingdong Guo Hujun Shen Xiong Li Chao Cen Shaohong Cai Mingsen Deng College of Big Data and Information Engineering Guizhou University Guiyang 550025 China Guizhou Provincial Key Laboratory of Computational Nano-material Science Guizhou Education University Guiyang 550018 China School of Information Guizhou University of Finance and Economics Guiyang 550025 China Moutai Institute Renhuai 564507 China National Engineering Research Center for Compounding and Modification of Polymer Materials Guiyang 550014 China

来源：评论

学校读者我要写书评

暂无评论

Asymmetry in the number of L4 and L5 Jupiter Trojans driven by jumping Jupiter

arXiv

引用

arXiv 2022年

作者： Li, Jian Xia, Zhihong Jeff Yoshida, Fumi Georgakarakos, Nikolaos Li, Xin School of Astronomy and Space Science Nanjing University 163 Xianlin Avenue Nanjing210023 China Key Laboratory of Modern Astronomy and Astrophysics in Ministry of Education Nanjing University Nanjing210023 China Department of Mathematics Northwestern University 2033 Sheridan Road EvanstonIL60208 United States University of Occupational and Environmental Health 1-1 Iseigaoka Yahata Kitakyusyu807-8555 Japan Planetary Exploration Research Center Chiba Institute of Technology 2-17-1 Tsudanuma Chiba Narashino275-0016 Japan New York University Abu Dhabi PO Box 129188 Abu Dhabi United Arab Emirates New York University Abu Dhabi PO Box 129188 Abu Dhabi United Arab Emirates Department of Statistics and Data Science Southern University of Science and Technology of China No 1088 Xueyuan Rd. Xili Nanshan District Guangdong Shenzhen518055 China

Context. More than 10000 Jupiter Trojans have been detected so far. They are moving around the L4 and L5 triangular Lagrangian points of the Sun-Jupiter system and their distributions can provide important clues to the early evolution of the Solar System. Aims. The number asymmetry of the L4 and L5 Jupiter Trojans is a longstanding problem. We aim to test a new mechanism in order to explain this anomalous feature by invoking the jumping-Jupiter scenario. Methods. First, we introduce the orbital evolution of Jupiter caused by the giant planet instability in the early Solar System. In this scenario, Jupiter could undergo an outward migration at a very high speed. We then investigate how such a jump changes the numbers of the L4 (N4) and L5 (N5) Trojans. Results. The outward migration of Jupiter can distort the co-orbital orbits near the Lagrangian points, resulting in L4 Trojans being more stable than the L5 ones. We find that, this mechanism could potentially explain the unbiased number asymmetry of N4/N5 ∼ 1.6 for the known Jupiter Trojans. The uncertainties of the system parameters, e.g. Jupiter’s eccentricity and inclination, the inclination distribution of Jupiter Trojans, are also taken into account and our results about the L4/L5 asymmetry have been further validated. However, the resonant amplitudes of the simulated Trojans are excited to higher values compared to the current population. A possible solution is that collisions among the Trojans may reduce their resonant amplitudes. Copyright © 2022, The Authors. All rights reserved.

关键词： Orbits

来源：评论

学校读者我要写书评

暂无评论

Crystallization Regulation by Self-Assembling Liquid Crystal Template Enables Efficient and Stable Perovskite Solar Cells

引用

Angewandte Chemie 2023年第52期135卷

作者： Meizi Wu Hongyan Wang Yong Li Dr. Ran Chen Hui Zhou Shaomin Yang Dongfang Xu Kun Li Prof. Dr. Zhongwei An Shengzhong (Frank) Liu Prof. Dr. Zhike Liu Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education Shaanxi Key Laboratory for Advanced Energy Devices Shaanxi Engineering Lab for Advanced Energy Technology International Joint Research Center of Shaanxi Province for Photoelectric Materials Science School of Materials Science & Engineering Shaanxi Normal University Xi'an 710119 P. R. China Contribution: Data curation (lead) Formal analysis (lead) Investigation (lead) Writing - original draft (lead) Contribution: Data curation (equal) Formal analysis (equal) Contribution: Data curation (equal) Investigation (equal) School of Materials Science and Engineering Xi' an University of Science and Technology Xi'an 710054 P. R. China Contribution: Conceptualization (lead) Methodology (equal) Contribution: Formal analysis (equal) Investigation (equal) Contribution: Methodology (equal) Contribution: Data curation (equal) Contribution: Investigation (equal) Contribution: Conceptualization (equal) Methodology (equal) Contribution: Conceptualization (equal) Methodology (equal) Writing - review & editing (lead)

It is found that the disordered growth of bottom perovskite film deteriorates the buried interface of perovskite solar cells (PSCs), so developing a new material to modify the buried interface for regulating the crystal growth and defect passivation is an effective approach for improving the photovoltaic performance of PSCs. Here, we developed a new ionic liquid crystal (ILC, 1-Dodecyl-3-methylimidazolium tetrafluoroborate) as both crystal regulator and defect passivator to modify the buried interface of PSCs. The high lattice matching between this ILC and perovskite promotes preferential growth of perovskite film along [001] direction, while the oriented ILC with mesomorphic phase has a strong chemical interaction with perovskite to passivate the interface defect, as a result, the modified buried interface exhibits suppressed defects, improved band alignment, reduced nonradiative recombination losses, and enhanced charge extraction. The ILC-modified PSC delivers a power conversion efficiency of 24.92 % and maintains 94 % of the original value after storage in ambient for 3000 h.

关键词： Crystallization Regulation Ionic Liquid Crystals Perovskite Solar Cells Self-Assembling

来源：评论

学校读者我要写书评

暂无评论

Fluorine-Containing Passivation Layer via Surface Chelation for Inorganic Perovskite Solar Cells

引用

Angewandte Chemie 2022年第6期135卷

作者： Hao Zhang Prof. Wanchun Xiang Xuejiao Zuo Xiaojing Gu Shiang Zhang Yachao Du Zhiteng Wang Yali Liu Haifeng Wu Peijun Wang Qingyue Cui Hang Su Prof. Qingwen Tian Prof. Shengzhong (Frank) Liu Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education Shaanxi Key Laboratory for Advanced Energy Devices Shaanxi Engineering Lab for Advanced Energy Technology School of Materials Science and Engineering Shaanxi Normal University No. 620 West Chang'an Avenue Xi'an 710119 P. R. China Contribution: Data curation (lead) Formal analysis (lead) Investigation (lead) Writing - original draft (supporting) Contribution: Conceptualization (lead) Data curation (lead) Writing - original draft (lead) Contribution: Formal analysis (supporting) Investigation (supporting) Contribution: Data curation (supporting) Formal analysis (equal) Investigation (equal) Contribution: Data curation (supporting) Investigation (supporting) Contribution: Data curation (supporting) Formal analysis (supporting) State Key Laboratory of Organic-Inorganic Composites Key Lab of Biomedical Materials of Natural Macromolecules Ministry of Education Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology No. 15 East Road North Third Ring Chaoyang District Beijing 100029 P. R. China Contribution: Conceptualization (lead) Data curation (lead) Funding acquisition (lead) Project administration (lead) Supervision (lead) Validation (lead) Visualization (lead) Writing - review & editing (lead) Dalian National Laboratory for Clean Energy iChEM Dalian Institute of Chemical Physics Chinese Academy of Sciences No. 457 Zhongshan Road Dalian Liaoning 116023 P. R. China Contribution: Project administration (lead) Supervision (lead) Validation (lead) Writing - review & editing (equal)

Minimizing surface defect is vital to further improve power conversion efficiency (PCE) and stability of inorganic perovskite solar cells (PSCs). Herein, we designed a passivator trifluoroacetamidine (TFA) to suppress CsPbI 3− x Br x film defects. The amidine group of TFA can strongly chelate onto the perovskite surface to suppress the iodide vacancy, strengthened by additional hydrogen bonds. Moreover, three fluorine atoms allow strong intermolecular connection via intermolecular hydrogen bonds, thus constructing a robust shield against moisture. The TFA-treated PSCs exhibit remarkably suppressed recombination, yielding the record PCEs of 21.35 % and 17.21 % for 0.09 cm 2 and 1.0 cm 2 device areas, both of which are the highest for all-inorganic PSCs so far. The device also achieves a PCE of 39.78 % under indoor illumination, the highest for all-inorganic indoor photovoltaic devices. Furthermore, TFA greatly improves device ambient stability by preserving 93 % of the initial PCE after 960 h.

关键词： Chelation Defect Passivation Inorganic Perovskite Solar Cells

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：