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Virus Detection: Nanopore Targeted Sequencing for the Accurate and Comprehensive Detection of SARS-CoV-2 and Other Respiratory Viruses (Small 32/2020)

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Small 2020年第32期16卷

作者： Ming Wang Aisi Fu Ben Hu Yongqing Tong Ran Liu Zhen Liu Jiashuang Gu Bin Xiang Jianghao Liu Wen Jiang Gaigai Shen Wanxu Zhao Dong Men Zixin Deng Lilei Yu Wu Wei Yan Li Tiangang Liu Department of Clinical Laboratory Renmin Hospital of Wuhan University Wuhan 430060 China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education and Wuhan University School of Pharmaceutical Sciences Wuhan 430071 China CAS Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational Biology Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Sciences Shanghai 200031 China Wuhan Dgensee Clinical Laboratory Co. Ltd. Wuhan 430075 China Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China Department of Internal Medicine Renmin Hospital of Wuhan University Wuhan 430060 China Center for Biomedical Informatics Shanghai Engineering Research Center for Big Data in Pediatric Precision Medicine Shanghai Children's Hospital Shanghai Jiao Tong University Shanghai 200040 China

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Bidirectional Tandem Electrocatalysis Manipulated Sulfur Speciation Pathway for High-Capacity and Stable Na-S Battery

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Angewandte Chemie 2022年第6期135卷

作者： Hong Zhang Bin Song Weiwei Zhang Bowen An Lin Fu Songtao Lu Yingwen Cheng Qianwang Chen Ke Lu Institutes of Physical Science and Information Technology School of Materials Science and Engineering Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education Anhui University Hefei Anhui 230601 China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China Hefei Anhui 230026 China Contribution: Conceptualization (equal) Writing - original draft (equal) Institute of Functional Nano & Soft Materials (FUNSOM) Soochow University Suzhou Jiangsu 215123 China Contribution: Data curation (supporting) Formal analysis (supporting) Writing - original draft (supporting) School of Chemistry and Chemical Engineering Qufu Normal University Qufu Shandong 273165 China School of Chemistry and Chemical Engineering Harbin Institute of Technology Harbin Heilongjiang 150001 China Contribution: Data curation (supporting) Investigation (supporting) Department of Chemistry and Biochemistry Northern Illinois University DeKalb IL 60115 USA Contribution: Formal analysis (supporting) School of Chemistry and Chemical Engineering Guizhou University Guiyang Guizhou 550025 China Contribution: Formal analysis (supporting) Writing - review & editing (supporting) Contribution: Data curation (supporting) Investigation (supporting) Writing - review & editing (supporting) Contribution: Writing - review & editing (equal) Contribution: Conceptualization (lead) Formal analysis (lead) Writing - original draft (lead) Writing - review & editing (lead)

The sluggish polysulfide redox kinetics and the uncontrollable sulfur speciation pathway, leading to serious shuttling effect and high activation barrier associated with sulfur cathode. We describe here the use of core–shell structured composite matrixes containing abundant catalytic sites for nearly fully reversible cycling of sulfur cathodes for Na-S batteries. The bidirectional tandem electrocatalysis provide successive reversible conversion of both long- and short-chain polysulfides, whereas Fe 2 O 3 accelerates Na 2 S 8 /Na 2 S 6 to Na 2 S 4 conversion and the redox-active Fe(CN) 6 4− -doped polypyrrole shell catalyzes Na 2 S 4 reduction to Na 2 S. The electrochemically reactive Na 2 S can be readily charged back to sulfur with minimal overpotential. Simultaneously, stable cycling of Na-S pouch cell with a high reversible capacity of 696 mAh g −1 is also demonstrated. The bidirectional confined tandem catalysis renders the manipulation of sulfur redox electrochemistry for practical Na-S cells.

关键词： Bidirectional Catalysts Confined Catalysis Na-S Battery Polysulfide Manipulation

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Intramolecular Chloro–Sulfur Interaction and Asymmetric Side-Chain Isomerization to Balance Crystallinity and Miscibility in All-Small-Molecule Solar Cells

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Angewandte Chemie 2022年第33期134卷

作者： Dr. Wei Gao Mengyun Jiang Ziang Wu Dr. Baobing Fan Dr. Wenlin Jiang Prof. Ning Cai Prof. Hua Xie Dr. Francis R. Lin Prof. Jingdong Luo Prof. Qiaoshi An Prof. Han Young Woo Prof. Alex K.-Y. Jen Department of Materials Science and Engineering City University of Hong Kong Kowloon 999077 Hong Kong Hong Kong Hong Kong Institute for Clean Energy City University of Hong Kong Kowloon 999077 Hong Kong Hong Kong Contribution: Data curation (lead) Methodology (lead) Writing - original draft (lead) Key Laboratory of Cluster Science of Ministry of Education Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials School of Chemistry and Chemical Engineering Beijing Institute of Technology Beijing 100081 China Contribution: Investigation (supporting) Department of Chemistry College of Science Korea University Seoul 136-713 Republic of Korea School of Chemical Engineering and Light Industry Guangdong University of Technology Guangzhou 510006 China School of Water Resources and Hydropower Wuhan University Wuhan 430072 China Department of Chemistry City University of Hong Kong Kowloon 999077 Hong Kong Hong Kong Contribution: Writing - review & editing (supporting) Contribution: Investigation (supporting) Methodology (supporting) Department of Materials Science and Engineering University of Washington Seattle WA 98195-2120 USA Contribution: Funding acquisition (lead) Supervision (lead) Writing - review & editing (lead)

Intramolecular Cl−S non-covalent interaction is introduced to modify molecular backbone of a benzodithiophene terthiophene rhodamine (BTR) benchmark structure, helping planarize and rigidify the molecular framework for improving charge transport. Theoretical simulations and temperature-variable NMR experiments clearly validate the existence of Cl−S non-covalent interaction in two designed chlorinated donors and explain its important role in enhancing planarity and rigidity of the molecules for enhancing their crystallinity. The asymmetric isomerization of side-chains further optimizes the molecular orientation and surface energy to strike a balance between its crystallinity and miscibility. This carefully manipulated molecular design helps result in increased carrier mobility and suppressed charge recombination to obtain simultaneously enhanced short-circuit current ( J sc ) and fill factor (FF) and a very high efficiency of 15.73 % in binary all-small-molecule organic solar cells.

关键词： Crystallinity Intramolecular Interaction Miscibility Small Molecule Donors Solar Cells

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Monodisperse Adducts-Induced Homogeneous Nucleation Towards High-Quality Tin-Based Perovskite Film

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Angewandte Chemie 2023年第33期135卷

作者： Huan Rao Yang Su Gengling Liu Hongbo Zhou Jia Yang Wangping Sheng Yang Zhong Prof. Licheng Tan Prof. Yiwang Chen College of Chemistry and Chemical Engineering/Institute of Polymers and Energy Chemistry (IPEC)/Jiangxi Provincial Key Laboratory of New Energy Chemistry Nanchang University 999 Xuefu Avenue Nanchang 330031 China Contribution: Investigation (lead) Methodology (lead) Writing - original draft (lead) Contribution: Investigation (equal) Methodology (equal) Writing - original draft (equal) Key Laboratory of Bioinorganic and Synthetic Chemistry (MoE) Lehn Institute of Functional Materials School of Chemistry Sun Yat-sen University Guangzhou 510006 China Contribution: Data curation (equal) Contribution: Software (equal) Contribution: Writing - review & editing (equal) Contribution: Resources (equal) Contribution: Investigation (equal) Peking University Yangtze Delta Institute of Optoelectronics 60 Chongzhou Avenue Nantong 226010 China Contribution: Resources (equal) Writing - review & editing (equal) National Engineering Research Center for Carbohydrate Synthesis/Key Laboratory of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education Jiangxi Normal University 99 Ziyang Avenue Nanchang 330022 China Contribution: Funding acquisition (lead) Methodology (equal)

The classic solvent system can't sufficiently separate one-dimensional edge-sharing SnI 2 crystals in solution, which severely restricts the fabrication of high-quality tin-based perovskite film. Herein, a strong Lewis base (hexamethylphosphoramide, HMPA) has been introduced to coordinate Sn 2+ to modulate solvation behaviours on perovskite precursor and regulate crystallization kinetics. The large molecular volume of HMPA and stronger bind energy of SnI 2 ⋅ 2HMPA (−0.595 eV vs −0.118 eV for SnI 2 ⋅ 2DMSO) change the solvation structure of SnI 2 from edge-sharing cluster to monodisperse adduct, which contributes to uniform nucleation sites and prolongs crystal growth process. Delightfully, a fully-covered perovskite film is formed on the large-area substrate and tin-based perovskite solar cells processed with HMPA exhibit an excellent efficiency of 13.46 %. This research provides novel insights and directions for the solution preparation of smooth and uniform large-area tin-based perovskite film.

关键词： Monodisperse Adduct Uniform Nucleation Crystallization Tin-Based Perovskite Solar Cells

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A Molybdenum Disulfide Nanozyme with Charge-Enhanced Activity for Ultrasound-Mediated Cascade-Catalytic Tumor Ferroptosis

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Angewandte Chemie 2022年第11期135卷

作者： Longwei Wang Xiaodi Zhang Zhen You Zhongwei Yang Dr. Mengyu Guo Jiawei Guo He Liu Xiaoyu Zhang Zhuo Wang Prof. Aizhu Wang Prof. Yawei Lv Dr. Jian Zhang Prof. Xin Yu Prof. Jing Liu Prof. Chunying Chen CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China University of Chinese Academy of Science Beijing 100190 China Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of Education School of Medicine Northwest University Xi'an 710069 China Contribution: Data curation (lead) Formal analysis (lead) Investigation (lead) Methodology (lead) Institute for Advanced Interdisciplinary Research School of Chemistry and Chemical Engineering University of Jinan Jinan 250022 China Contribution: Data curation (equal) Contribution: Investigation (equal) Methodology (equal) Contribution: Formal analysis (supporting) Contribution: Methodology (supporting) Contribution: Investigation (supporting) Contribution: Formal analysis (supporting) Software (lead) School of Physics and Electronics Hunan University Changsha 410082 China Contribution: Software (lead) Department of Biology and Biological Engineering Chalmers University of Technology Kemivägen 10 41296 Göteborg Sweden Contribution: Data curation (lead) Formal analysis (lead) Writing - original draft (lead) Contribution: Data curation (lead) Formal analysis (lead) Funding acquisition (equal) Writing - original draft (equal) Writing - review & editing (lead) Contribution: Conceptualization (lead) Funding acquisition (lead) Writing - review & editing (lead)

The deficient catalytic activity of nanozymes and insufficient endogenous H 2 O 2 in the tumor microenvironment (TME) are major obstacles for nanozyme-mediated catalytic tumor therapy. Since electron transfer is the basic essence of catalysis-mediated redox reactions, we explored the contributing factors of enzymatic activity based on positive and negative charges, which are experimentally and theoretically demonstrated to enhance the peroxidase (POD)-like activity of a MoS 2 nanozyme. Hence, an acidic tumor microenvironment-responsive and ultrasound-mediated cascade nanocatalyst (BTO/MoS 2 @CA) is presented that is made from few-layer MoS 2 nanosheets grown on the surface of piezoelectric tetragonal barium titanate (T-BTO) and modified with pH-responsive cinnamaldehyde (CA). The integration of pH-responsive CA-mediated H 2 O 2 self-supply, ultrasound-mediated charge-enhanced enzymatic activity, and glutathione (GSH) depletion enables out-of-balance redox homeostasis, leading to effective tumor ferroptosis with minimal side effects.

关键词： Ferroptosis Nanozymes Reactive Oxygen Species Tumor Therapy

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Regularized logistic regression with network-based pairwise interaction for biomarker identification in breast cancer

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BMC bioinformatics 2016年第1期17卷 108页

作者： Meng-Yun Wu Xiao-Fei Zhang Dao-Qing Dai Le Ou-Yang Yuan Zhu Hong Yan School of Statistics and Management Shanghai University of Finance and Economics Guoding Road Shanghai 200433 China. wu.mengyun@***. Key Laboratory of Mathematical Economics SUFE Ministry of Education Guoding Road Shanghai 200433 China. wu.mengyun@***. School of Mathematics and Statistics & Hubei Key Laboratory of Mathematical Sciences Central China Normal University Luoyu Road Wuhan 430079 China. zhangxf@***. Intelligent Data Center and Department of Mathematics Sun Yat-Sen University Xingang West Road Guangzhou 510275 China. stsddq@***. College of Information Engineering Shenzhen University Nanhai Avenue Shenzhen 518060 China. ouyangle@***. School of Automation China University of Geosciences Lumo Road Wuhan 430074 China. zhuyuan7@***. Department of Electronic and Engineering City University of Hong Kong Tat Chee Avenue Hong Kong 999077 China. h.yan@cityu.edu.hk.

BACKGROUND:To facilitate advances in personalized medicine, it is important to detect predictive, stable and interpretable biomarkers related with different clinical characteristics. These clinical characteristics may be heterogeneous with respect to underlying interactions between genes. Usually, traditional methods just focus on detection of differentially expressed genes without taking the interactions between genes into account. Moreover, due to the typical low reproducibility of the selected biomarkers, it is difficult to give a clear biological interpretation for a specific disease. Therefore, it is necessary to design a robust biomarker identification method that can predict disease-associated interactions with high reproducibility. RESULTS:In this article, we propose a regularized logistic regression model. Different from previous methods which focus on individual genes or modules, our model takes gene pairs, which are connected in a protein-protein interaction network, into account. A line graph is constructed to represent the adjacencies between pairwise interactions. Based on this line graph, we incorporate the degree information in the model via an adaptive elastic net, which makes our model less dependent on the expression data. Experimental results on six publicly available breast cancer datasets show that our method can not only achieve competitive performance in classification, but also retain great stability in variable selection. Therefore, our model is able to identify the diagnostic and prognostic biomarkers in a more robust way. Moreover, most of the biomarkers discovered by our model have been verified in biochemical or biomedical researches. CONCLUSIONS:The proposed method shows promise in the diagnosis of disease pathogenesis with different clinical characteristics. These advances lead to more accurate and stable biomarker discovery, which can monitor the functional changes that are perturbed by diseases. Based on these predictions, researche

关键词： Protein-protein interaction network Edge-biomarker discovery Network-based pairwise interaction Node degree Adaptive elastic net

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Wide-Bandgap Perovskite Solar Cell Using a Fluoride-Assisted Surface Gradient Passivation Strategy

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Angewandte Chemie 2023年第11期135卷

作者： Nan Yan Yan Gao Junjie Yang Zhimin Fang Jiangshan Feng Prof. Xiaojun Wu Prof. Tao Chen Prof. Shengzhong (Frank) Liu Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education Shaanxi Key Laboratory for Advanced Energy Devices Shaanxi Engineering Lab for Advanced Energy Technology School of Materials Science and Engineering Shaanxi Normal University Xi'an 710119 China Contribution: Data curation (lead) Formal analysis (lead) Investigation (lead) Methodology (lead) Writing - original draft (lead) Writing - review & editing (lead) Hefei National Laboratory for Physical Sciences at Microscale Department of Materials Science and Engineering University of Science and Technology of China Hefei 230026 China Contribution: Software (lead) Contribution: Methodology (equal) Validation (supporting) Contribution: Formal analysis (equal) Funding acquisition (lead) Investigation (equal) Writing - original draft (equal) Writing - review & editing (equal) Contribution: Funding acquisition (supporting) Investigation (supporting) Writing - original draft (equal) Writing - review & editing (equal) Dalian National Laboratory for Clean Energy iChEM Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China Contribution: Formal analysis (supporting) Funding acquisition (lead) Investigation (equal) Project administration (lead) Resources (lead) Supervision (lead) Writing - original draft (supporting) Writing - review & editing (supporting)

Wide-band gap (1.68 eV) perovskite solar cells (PSCs) are important components of perovskite/Si tandem devices. However, the efficiency of wide band gap PSCs has been limited by their huge open-circuit voltage ( V oc ) deficit due to non-radiative recombination. Deep-level acceptor defects are identified as the major killers of V oc , and they can be effectively improved by passivation with ammonium salts. Theoretical calculation predicts that increasing the distance between F and −NH 3 + of fluorinated ammonium can dramatically enhance the electropositivity of −NH 3 + terminals, thus providing strong adsorption onto the negatively charged I A and I Pb anti-site defects. Characterizations further confirm that surface gradient passivation employing p -FPEAI demonstrates the most efficient passivation effect. Consequently, a record-efficiency of 21.63 % with the smallest V oc deficit of 441 mV is achieved for 1.68 eV-band gap inverted PSCs. Additionally, a flexible PSC and 1 cm 2 opaque device also deliver the highest PCEs of 21.02 % and 19.31 %, respectively.

关键词： Defects Fluoride Open-Circuit Voltage Deficit Perovskite Wide Band Gap

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A Hypothesis on the Function of High-Valent Fe in NiFe (Hydr)oxide in the Oxygen-Evolution Reaction

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Angewandte Chemie 2024年第6期137卷

作者： Nader Akbari Jafar Hussain Shah Cejun Hu Subhajit Nandy Pavlo Aleshkevych Rile Ge Sumbal Farid Changchang Dong Liang Zhang Keun Hwa Chae Wei Xie Taifeng Liu Junhu Wang Mohammad Mahdi Najafpour Department of Chemistry Institute for Advanced Studies in Basic Sciences (IASBS) Zanjan 45137-66731 Iran CAS Key Laboratory of Science and Technology on Applied Catalysis Mössbauer Effect Data Center Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China Key Lab of Advanced Energy Materials Chemistry (Ministry of Education) Renewable Energy Conversion and Storage Center College of Chemistry Nankai University Tianjin 300071 China Advanced Analysis Center Korea Institute of Science and Technology Seoul 02792 Republic of Korea Institute of Physics Polish Academy of Sciences Warsaw 02-668 Poland School of Environmental and Chemical Engineering Jiangsu University of Science and Technology Zhenjiang 212100 China National and Local Joint Engineering Research Center for Applied Technology of Hybrid Nanomaterials Henan University Kaifeng 475004 China Department of Chemistry Sharif University of Technology Tehran 11155-9516 Iran

This study investigated the dynamic changes in NiFe (hydr)oxide and identified the role of high-valent Fe in the oxygen-evolution reaction (OER) within alkaline media via in situ techniques. Several high-valent Fe ions were found to remain considerably stable in the absence of potential in NiFe (hydr)oxide, even 96 hours after the OER. For Ni 2+ hydroxide treated with 57 Fe ions, where Fe sites are introduced onto the surface of Ni 2+ hydroxide, no Fe 4+ species were detected at the rate-determining step (RDS). The findings of this study suggested that the oxidation of bulk Fe ions, similar to Ni ions, to high valent forms, is charge accumulation without a direct role in OER; these results offered a novel perspective on manipulating Fe states to optimize OER efficacy. The prevailing hypothesis suggested that trace amounts of high-valent Fe ions, notably those on the surface, directly participate in OER.

关键词： NiFe (hydr)oxide oxygen evolution reaction high-valent Fe4+ in situ techniques electrocatalysts alkaline conditions mechanism active sites

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Palladium Encapsulated by an Oxygen-Saturated TiO2Overlayer for Low-Temperature SO2-Tolerant Catalysis during CO Oxidation

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Angewandte Chemie 2023年第49期135卷

作者： Jingkun Chen Yuetan Su Qingjie Meng Hehe Qian Le Shi Prof. Jawwad A. Darr Prof. Zhongbiao Wu Prof. Xiaole Weng Key Laboratory of Environment Remediation and Ecological Health Ministry of Education College of Environmental and Resource Sciences Zhejiang University Hangzhou 310058 P. R. China Contribution: Data curation (lead) Writing - original draft (lead) Contribution: Data curation (equal) School of Civil & Environmental Engineering and Geography Science Ningbo University Ningbo 315211 P. R. China Contribution: Writing - review & editing (supporting) ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311200 P. R. China Contribution: Methodology (supporting) Christopher Ingold Laboratories Department of Chemistry University College London London WC1H 0AJ UK Zhejiang Provincial Engineering Research Centre of Industrial Boiler & Furnace Flue Gas Pollution Control Hangzhou 310058 P. R. China Contribution: Funding acquisition (lead) Resources (lead) Validation (lead) Writing - review & editing (lead)

The development of oxidation catalysts that are resistant to sulfur poisoning is crucial for extending the lifespan of catalysts in real-working conditions. Herein, we describe the design and synthesis of oxide-metal interaction (OMI) catalyst under oxidative atmospheres. By using organic coated TiO 2 , an oxide/metal inverse catalyst with non-classical oxygen-saturated TiO 2 overlayers were obtained at relatively low temperature. These catalysts were found to incorporate ultra-small Pd metal and support particles with exceptional reactivity and stability for CO oxidation (under 21 vol % O 2 and 10 vol % H 2 O). In particular, the core (Pd)-shell (TiO 2 ) structured OMI catalyst exhibited excellent resistance to SO 2 poisoning, yielding robust CO oxidation performance at 120 °C for 240 h (at 100 ppm SO 2 and 10 vol % H 2 O). The stability of this new OMI catalyst was explained through density functional theory (DFT) calculations that interfacial oxygen atoms at Pd−O−Ti sites (of oxygen-saturated overlayers) serve as non-metal active sites for low-temperature CO oxidation, and change the SO 2 adsorption from metal(d)-to-SO 2 (π*) back-bonding to much weaker σ(Ti−S) bonding.

关键词： CO Oxidation Non-Metal Active Site Oxide-Metal Interaction Stability Sulfur Tolerance

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H2O2-Responsive NIR-II AIE Nanobomb for Carbon Monoxide Boosting Low-Temperature Photothermal Therapy

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Angewandte Chemie 2022年第36期134卷

作者： Gongcheng Ma Zhongke Liu Chunguang Zhu Prof. Huajie Chen Prof. Ryan T. K. Kwok Prof. Pengfei Zhang Ben Zhong Tang Prof. Lintao Cai Prof. Ping Gong Guangdong Key Laboratory of Nanomedicine Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations CAS-HK Joint Lab for Biomaterials Research Laboratory for Biomedical Optics and Molecular Imaging Shenzhen Key Laboratory for Molecular Imaging CAS Key Lab for Health Informatics Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China University of Chinese Academy of Sciences Beijing 100049 China Contribution: Data curation (lead) Validation (lead) Writing - original draft (lead) Nano Science and Technology Institute University of Science & Technology of China Suzhou 215123 China Contribution: Data curation (equal) Investigation (equal) Key Laboratory of Environmentally Friendly Chemistry and Application of the Ministry of Education College of Chemistry Xiangtan University Xiangtan 411105 China Contribution: Data curation (supporting) Methodology (supporting) Contribution: Project administration (supporting) Resources (supporting) Supervision (supporting) Writing - review & editing (equal) Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Study The Hong Kong University of Science and Technology (HKUST) Clear Water Bay Kowloon Hong Kong China Contribution: Funding acquisition (equal) Supervision (equal) Writing - review & editing (equal) Contribution: Conceptualization (lead) Formal analysis (lead) Methodology (equal) Project administration (lead) Resources (equal) Supervision (equal) Writing - original draft (equal) Writing - review & editing (lead) School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong Shenzhen Guangdong 518172 China Contribution: Formal analysis (supporting) Funding acquisition (equal) Writing - review & editing (supporting) Contribution: Funding acquisition (lead) Project administration (lead) Supervision (lead) Writing - revi

Low-temperature photothermal therapy (PTT), which circumvents the limitations of conventional PTT (e.g., thermotolerance and adverse effects), is an emerging therapeutic strategy which shows great potential for future clinical applications. The expression of heat shock proteins (HSPs) can dramatically impair the therapeutic efficacy of PTT. Thus, inhibition of HSPs repair and reducing the damage of nearby normal cells is crucial for improving the efficiency of low-temperature PTT. Herein, we developed a nanobomb based on the self-assembly of NIRII AIE polymer PBPTV and carbon monoxide (CO) carrier polymer mPEG(CO). This smart nanobomb can be exploded in a tumor microenvironment in which hydrogen peroxide is overexpressed and release CO into cancer cells to significantly inhibit the expression of HSPs and hence improve the antitumor efficiency of the low-temperature PTT.

关键词： Aggregation Induced Emission Gas Therapy Heat Shock Protein NIR-II Photothermal Therapy

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