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arXiv 2017年

作者： Bauer, Franz E. Treister, Ezequiel Schawinski, Kevin Schulze, Steve Luo, Bin Alexander, David M. Brandt, William N. Comastri, Andrea Forster, Francisco Gilli, Roberto Kann, David Alexander Maeda, Keiichi Nomoto, Kenichi Paolillo, Maurizio Ranalli, Piero Schneider, Donald P. Shemmer, Ohad Tanaka, Masaomi Tolstov, Alexey Tominaga, Nozomu Tozzi, Paolo Vignali, Cristian Wang, Junxian Xue, Yongquan Yang, Guang Instituto de Astrofísica Facultad de Física Pontificia Universidad Católica de Chile 306 Santiago 22 Chile Nuncio Monseñor Sótero Sanz 100 Providencia Santiago Chile Space Science Institute 4750 Walnut Street Suite 205 BoulderCO80301 United States EMBIGGEN Anillo Concepción Chile Departamento de Astronomía Universidad de Concepción Casilla 160-C Concepción Chile Institute for Astronomy Department of Physics ETH Zurich Wolfgang-Pauli-Strasse 27 ZurichCH-8093 Switzerland School of Astronomy and Space Science Nanjing University Nanjing210093 China Ministry of Education Nanjing210093 China Department of Physics Durham University DurhamDH1 3LE United Kingdom Department of Astronomy and Astrophysics Pennsylvania State University 525 Davey Lab University ParkPA16802 United States Institute for Gravitation and the Cosmos Pennsylvania State University University ParkPA16802 United States Department of Physics 104 Davey Laboratory Pennsylvania State University University ParkPA16802 United States INAF-Osservatorio Astronomico di Bologna via Ranzani 1 Bologna40127 Italy Centro de Modelamiento Matemático Universidad de Chile Av. Blanco Encalada 2120 Piso 7 Santiago Chile Thüringer Landessternwarte Tautenburg Sternwarte 5 Tautenburg07778 Germany Department of Astronomy Kyoto University Kitashirakawa-Oiwake-cho Sakyo-ku Kyoto606-8502 Japan University of Tokyo KashiwaChiba277-8583 Japan Hamamatsu Department of Physics University Federico II via Cintia 9 Naples80126 Italy INFN - Sezione di Napoli via Cinthia 9 Naples80126 Italy Agenzia Spaziale Italiana Science Data Center via del Politecnico snc Roma00133 Italy Lund Observatory Department of Astronomy and Theoretical Physics Lund University Box 43 Lund22100 Sweden Department of Physics University of North Texas DentonTX76203 National Astronomical Observatory of Japan Mitaka Tokyo181-8588 Japan Department of Physics Faculty of Science and Engineering Konan University 8-

We report on the detection of a remarkable new fast high-energy transient found in the Chandra Deep Field-South, robustly associated with a faint (mR = 27.5 mag, zph∼2.2) host in the CANDELS survey. The X-ray event is comprised of 115+−1211 net 0.3–7.0 keV counts, with a light curve characterised by a ≈100 s rise time, a peak 0.3–10 keV flux of ≈5×10−12 erg s−1 cm−2, and a power-law decay time slope of −1.53 ± 0.27. The average spectral slope is Γ = 1.43+−00..2313, with no clear spectral variations. The X-ray and multi-wavelength properties effectively rule out the vast majority of previously observed high-energy transients. A few theoretical possibilities remain: an "orphan" X-ray afterglow from an off-axis short-duration Gamma-ray Burst (GRB) with weak optical emission;a low-luminosity GRB at high redshift with no prompt emission below ∼20 keV rest-frame;or a highly beamed Tidal Disruption Event (TDE) involving an intermediate-mass black hole and a white dwarf with little variability. However, none of the above scenarios can completely explain all observed properties. Although large uncertainties exist, the implied rate of such events is comparable to those of orphan and low-luminosity GRBs as well as rare TDEs, implying the discovery of an untapped regime for a known transient class, or a new type of variable phenomena whose nature remains to be determined. Copyright © 2017, The Authors. All rights reserved.

关键词： Luminance

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Single-cell RNA sequencing reveals distinct immune cell subsets in phalangeal and soft-tissue recurrence of giant cell tumor of bone

Medicine Advances

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Medicine Advances 2023年第1期1卷

作者： Meiling Yang Fen Wang Huishan Liang Genxin Ji Yating Lian Changye Zou Wei Zhao Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou China Medical Research Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China Contribution: Data curation (lead) Formal analysis (lead) Investigation (lead) Writing - original draft (equal) Writing - review & editing (equal) Department of Pathology The First Affiliated Hospital of Sun Yat-Sen University Guangzhou China Contribution: Investigation (lead) Validation (lead) Contribution: Investigation (supporting) Validation (supporting) The Second School of Clinical Medicine Southern Medical University Guangzhou China Contribution: Writing - review & editing (supporting) Contribution: Validation (supporting) Writing - review & editing (supporting) Musculoskeletal Oncology Department The First Affiliated Hospital of Sun Yat-Sen University Guangzhou China Wei Zhao Guangdong Provincial People's Hospital No.106 Zhongshan Road II Guangzhou 510080 China Contribution: Conceptualization (supporting) Funding acquisition (equal) Resources (lead) Supervision (supporting) Writing - original draft (supporting) Key Laboratory of Stem Cells and Tissue Engineering Ministry of Education Sun Yat-Sen University Guangzhou China Changye Zou Department of Musculoskeletal Oncology The First Affiliated Hospital of Sun Yat-Sen University No.58 Zhongshan Road II Guangzhou 510080 China. Contribution: Conceptualization (lead) Funding acquisition (equal) Supervision (lead) Writing - original draft (equal) Writing - review & editing (equal)

Background Giant cell tumor of the bone (GCTB), an intermediate locally aggressive neoplasm that frequently involves the epiphyseal region of the long bones. GCTB of the distal phalanx and soft-tissue recurrences are extremely rare. Little is known about the cellular and molecular differences between GCTB of the long bones and rare sites. Methods We employed single-cell RNA sequencing to elucidate the transcriptional profiles of 28,992 cells originating from patients afflicted with GCTB in the femur, distal phalanx, and soft-tissue relapse. To confirm the critical findings, we subjected the paraffin sections of GCTB to immunohistochemical staining. Results Our study revealed that GCTBs in rare sites display distinct immune subtypes and antigen presentation gene signatures. We observed minimal lymphocyte infiltration in GCTBs of the phalanx. Further analyses demonstrated that the transforming growth factor-β pathway and profibrotic proteins were significantly upregulated in phalanx lesions. In contrast, GCTB cells from soft-tissue recurrence exhibited discernible chondrocyte characteristics but presented lower antigen-presenting ability compared to those from femur lesions. Notably, we identified an immunosuppressive subset of mast cells in the soft-tissue recurrence. The secretion of proangiogenic and immunosuppressive factors from these mast cells suggests their potential role in the formation of vascular-rich and immunosuppressive niches in recurrent lesions. Conclusions Collectively, this study broadens our comprehension of the gene expression patterns observed in infrequent location GCTBs and furnishes a repository of information for illuminating promising therapeutic targets for rare GCTBs.

关键词： giant cell tumor of bone phalangeal GCTB rare site GCTB single-cell RNA sequencing soft-tissue recurrence of GCTB

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Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

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The Lancet 2020年第10258期396卷 1204-1222页

作者： Abbafati, Cristiana Abbas, Kaja M. Abbasi, Mohammad Abbasifard, Mitra Abbasi-Kangevari, Mohsen Abbastabar, Hedayat Abd-Allah, Foad Abdelalim, Ahmed Abdollahi, Mohammad Abdollahpour, Ibrahim Abedi, Aidin Abedi, Parisa Abegaz, Kedir Hussein Abolhassani, Hassan Abosetugn, Akine Eshete Aboyans, Victor Abrams, Elissa M. Abreu, Lucas Guimarães Abrigo, Michael R.M. Abu Haimed, Abdulaziz Khalid Abualhasan, Ahmed Abu-Gharbieh, Eman Abu-Raddad, Laith Jamal Abushouk, Abdelrahman I. Acebedo, Alyssa Ackerman, Ilana N. Adabi, Maryam Adair, Tim Adamu, Abdu A. Adebayo, Oladimeji M. Adedeji, Isaac Akinkunmi Adekanmbi, Victor Adelson, Jaimie D. Adeoye, Abiodun Moshood Adetokunboh, Olatunji O. Adham, Davoud Advani, Shailesh M. Afarideh, Mohsen Afshari, Mahdi Afshin, Ashkan Agardh, Emilie E. Agarwal, Gina Agasthi, Pradyumna Agesa, Kareha M. Aghaali, Mohammad Aghamir, Seyed Mohammad Kazem Agrawal, Anurag Ahmad, Tauseef Ahmadi, Alireza Ahmadi, Keivan Ahmadi, Mehdi Ahmadieh, Hamid Ahmadpour, Ehsan Ahmed, Muktar Beshir Aji, Budi Akalu, Temesgen Yihunie Akinyemi, Rufus Olusola Akinyemiju, Tomi Akombi, Blessing Akunna, Chisom Joyqueenet Alahdab, Fares Al-Aly, Ziyad Alam, Khurshid Alam, Noore Alam, Samiah Alam, Tahiya Alanezi, Fahad Mashhour Alanzi, Turki M. Albertson, Samuel B. Alcalde-Rabanal, Jacqueline Elizabeth Alema, Niguse Meles Alemu, Biresaw Wassihun Alemu, Yihun Mulugeta Alhabib, Khalid F. Alhassan, Robert Kaba Ali, Muhammad Ali, Saqib Alicandro, Gianfranco Alijanzadeh, Mehran Alinia, Cyrus Alipour, Vahid Alizade, Hesam Aljunid, Syed Mohamed Alla, François Allebeck, Peter Almadi, Majid Abdulrahman Hamad Almasi, Ali Almasi-Hashiani, Amir Almasri, Nihad A. Al-Mekhlafi, Hesham M. Almulhim, Abdulaziz M. Alonso, Jordi Al-Raddadi, Rajaa M. Altirkawi, Khalid A. Alumran, Arwa Khalid Alvis-Guzman, Nelson Alvis-Zakzuk, Nelson J. Amare, Azmeraw T. Amare, Bekalu Amini, Saeed Amini-Rarani, Mostafa Aminorroaya, Arya Amiri, Fatemeh Amit, Arianna Maever L. Amugsi, Dickson A. Amul, Gianna Gayle Herrera Anbesu, Etsay Woldu Ancuceanu, Robert Anderl Department of Juridical and Economic Studies La Sapienza University Rome Italy Department of Infectious Disease Epidemiology London School of Hygiene and Tropical Medicine London United Kingdom Social Determinants of Health Research Center Tehran Iran Department of Neurology Cairo University Cairo Egypt School of Pharmacy Tehran Iran The Institute of Pharmaceutical Sciences (TIPS) Tehran Iran Neuroscience Research Center Isfahan University of Medical Sciences Isfahan Iran Biostatistics Department Near East University Nicosia Cyprus Biostatistics and Health Informatics Madda Walabu University Bale Robe Ethiopia Research Center for Immunodeficiencies Tehran Iran Karolinska University Hospital Huddinge Sweden Department of Cardiology Dupuytren University Hospital Limoges France University of Limoges Limoges France Department of Pediatric Dentistry Federal University of Minas Gerais Belo Horizonte Brazil Department of Research Philippine Institute for Development Studies Quezon City Philippines Department of Healthcare Policy and Research Weill Cornell Medical College in Qatar Doha Qatar Harvard Medical School Boston MA United States Department of Medicine Ain Shams University Cairo Egypt Hamadan University of Medical Sciences Hamadan Iran School of Medicine Cardiff University Cardiff United Kingdom School of Laboratory Medicine and Science University College Hospital Ibadan Ibadan Nigeria Institute of Cardiovascular Diseases University of Ibadan Ibadan Nigeria Centre of Excellence for Epidemiological Modelling and Analysis Stellenbosch University Cape Town South Africa Department of Global Health Stellenbosch University Cape Town South Africa School of Health Ardabil University of Medical Science Ardabil Iran Social Behavioral Research Branch National Institute of Health Bethesda MD United States Department of Oncology Georgetown University Washington DC DC United States Department of Health Metrics Sciences School of Medicine Seattle WA

Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw value

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Author Correction: BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets

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Nature methods 2024年第10期21卷 1959页

作者： Linus Manubens-Gil Zhi Zhou Hanbo Chen Arvind Ramanathan Xiaoxiao Liu Yufeng Liu Alessandro Bria Todd Gillette Zongcai Ruan Jian Yang Miroslav Radojević Ting Zhao Li Cheng Lei Qu Siqi Liu Kristofer E Bouchard Lin Gu Weidong Cai Shuiwang Ji Badrinath Roysam Ching-Wei Wang Hongchuan Yu Amos Sironi Daniel Maxim Iascone Jie Zhou Erhan Bas Eduardo Conde-Sousa Paulo Aguiar Xiang Li Yujie Li Sumit Nanda Yuan Wang Leila Muresan Pascal Fua Bing Ye Hai-Yan He Jochen F Staiger Manuel Peter Daniel N Cox Michel Simonneau Marcel Oberlaender Gregory Jefferis Kei Ito Paloma Gonzalez-Bellido Jinhyun Kim Edwin Rubel Hollis T Cline Hongkui Zeng Aljoscha Nern Ann-Shyn Chiang Jianhua Yao Jane Roskams Rick Livesey Janine Stevens Tianming Liu Chinh Dang Yike Guo Ning Zhong Georgia Tourassi Sean Hill Michael Hawrylycz Christof Koch Erik Meijering Giorgio A Ascoli Hanchuan Peng Institute for Brain and Intelligence Southeast University Nanjing China. Microsoft Corporation Redmond WA USA. Tencent AI Lab Bellevue WA USA. Computing Environment and Life Sciences Directorate Argonne National Laboratory Lemont IL USA. Kaya Medical Seattle WA USA. University of Cassino and Southern Lazio Cassino Italy. Center for Neural Informatics Structures and Plasticity Krasnow Institute for Advanced Study George Mason University Fairfax VA USA. Faculty of Information Technology Beijing University of Technology Beijing China. Beijing International Collaboration Base on Brain Informatics and Wisdom Services Beijing China. Nuctech Netherlands Rotterdam the Netherlands. Janelia Research Campus Howard Hughes Medical Institute Ashburn VA USA. Department of Electrical and Computer Engineering University of Alberta Edmonton Alberta Canada. Ministry of Education Key Laboratory of Intelligent Computation and Signal Processing Anhui University Hefei China. Paige AI New York NY USA. Scientific Data Division and Biological Systems and Engineering Division Lawrence Berkeley National Lab Berkeley CA USA. Helen Wills Neuroscience Institute and Redwood Center for Theoretical Neuroscience UC Berkeley Berkeley CA USA. RIKEN AIP Tokyo Japan. Research Center for Advanced Science and Technology (RCAST) The University of Tokyo Tokyo Japan. School of Computer Science University of Sydney Sydney New South Wales Australia. Texas A&M University College Station TX USA. Cullen College of Engineering University of Houston Houston TX USA. Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei Taiwan. National Centre for Computer Animation Bournemouth University Poole UK. PROPHESEE Paris France. Department of Neuroscience Columbia University New York NY USA. Mortimer B. Zuckerman Mind Brain Behavior Institute Columbia University New York NY USA. Department of Computer Science Northern Illinois Universit

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Follow up of GW170817 and its electromagnetic counterpart by Australian-led observing programs

arXiv

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arXiv 2017年

作者： Andreoni, I. Ackley, K. Cooke, J. Acharyya, A. Allison, J.R. Anderson, G.E. Ashley, M.C.B. Baade, D. Bailes, M. Bannister, K. Beardsley, A. Bessell, M.S. Bian, F. Bland, P.A. Boer, M. Booler, T. Brandeker, A. Brown, I.S. Buckley, D.A.H. Chang, S.-W. Coward, D.M. Crawford, S. Crisp, H. Crosse, B. Cucchiara, A. Cupák, M. de Gois, J.S. Deller, A. Devillepoix, H.A.R. Dobie, D. Elmer, E. Emrich, D. Farah, W. Farrell, T.J. Franzen, T. Gaensler, B.M. Galloway, D.K. Gendre, B. Giblin, T. Goobar, A. Green, J. Hancock, P.J. Hartig, B.A.D. Howell, E.J. Horsley, L. Hotan, A. Howie, R.M. Hu, L. Hu, Y. James, C.W. Johnston, S. Johnston-Hollitt, M. Kaplan, D.L. Kasliwal, M. Keane, E.F. Kenney, D. Klotz, A. Lau, R. Laugier, R. Lenc, E. Li, X. Liang, E. Lidman, C. Luvaul, L.C. Lynch, C. Ma, B. Macpherson, D. Mao, J. McClelland, D.E. McCully, C. Möller, A. Morales, M.F. Morris, D. Murphy, T. Noysena, K. Onken, C.A. Orange, N.B. Oslowski, S. Pallot, D. Paxman, J. Potter, S.B. Pritchard, T. Raja, W. Ridden-Harper, R. Romero-Colmenero, E. Sadler, E.M. Sansom, E.K. Scalzo, R.A. Schmidt, B.P. Scott, S.M. Seghouani, N. Shang, Z. Shannon, R.M. Shao, L. Shara, M.M. Sharp, R. Sokolowski, M. Sollerman, J. Staff, J. Steele, K. Sun, T. Suntzeff, N.B. Tao, C. Tingay, S. Towner, M.C. Thierry, P. Trott, C. Tucker, B.E. Väisänen, P. Krishnan, V. Venkatraman Walker, M. Wang, L. Wang, X. Wayth, R. Whiting, M. Williams, A. Williams, T. Wolf, C. Wu, C. Wu, X. Yang, J. Yuan, X. Zhang, H. Zhou, J. Zovaro, H. Centre for Astrophysics and Supercomputing Swinburne University of Technology PO Box 218 H29 HawthornVIC3122 Australia Australian Astronomical Observatory 105 Delhi Rd North RydeNSW2113 Australia Monash Centre of Astrophysics Monash University VIC3800 Australia School of Physics & Astronomy Monash University VIC3800 Australia Research School of Astronomy and Astrophysics Australian National University CanberraACT2611 Australia Sydney Institute for Astronomy School of Physics University of Sydney NSW2006 Australia International Centre for Radio Astronomy Research Curtin University BentleyWA6102 Australia School of Physics University of New South Wales NSW2052 Australia Karl-Schwarzschild-Str. 2 Garching bei München85748 Germany ATNF CSIRO Astronomy and Space Science PO Box 76 EppingNSW1710 Australia School of Earth and Space Exploration Arizona State University TempeAZ85287 United States Department of Applied Geology Curtin University GPO Box U1987 PerthWA6845 Australia Artémis/Observatoire de la Cote d’Azur/ CNRS Boulevard de l’Observatoire CS 34229 NICE Cedex 4F 06304 France Department of Astronomy Stockholm University Albanova StockholmSE 10691 Sweden Department of Physics University of Wisconsin–Milwaukee MilwaukeeWI53201 United States South African Astronomical Observatory PO Box 9 Observatory7935 South Africa School of Physics University of Western Australia CrawleyWA6009 Australia University of the Virgin Islands 2 John Brewer’s Bay 00802 St ThomasUS Virgin Islands United States School of Physics and Astronomy University of Nottingham Nottingham United Kingdom ATNF CSIRO Astronomy and Space Science 26 Dick Perry Avenue KensingtonWA6152 Australia Dunlap Institute for Astronomy and Astrophysics University of Toronto ONM5S 3H4 Canada Department of Physics U.S. Air Force Academy 2354 Fairchild Drive CO 80840 United States The Oskar Klein Centre Department of Physics Stockholm University Albanova Stockh

The discovery of the first electromagnetic counterpart to a gravitational wave signal has generated follow-up observations by over 50 facilities world-wide, ushering in the new era of multi-messenger astronomy. In this paper, we present follow-up observations of the gravitational wave event GW170817 and its electromagnetic counterpart SSS17a/DLT17ck (IAU label AT2017gfo) by 14 Australian telescopes and partner observatories as part of Australian-based and Australian-led research programs. We report early- to late-time multi-wavelength observations, including optical imaging and spectroscopy, mid-infrared imaging, radio imaging, and searches for fast radio bursts. Our optical spectra reveal that the transient source afterglow cooled from approximately 6400K to 2100K over a 7-day period and produced no significant optical emission lines. The spectral profiles, cooling rate, and photometric light curves are consistent with the expected outburst and subsequent processes of a binary neutron star merger. Star formation in the host galaxy probably ceased at least a Gyr ago, although there is evidence for a galaxy merger. Binary pulsars with short (100 Myr) decay times are therefore unlikely progenitors, but pulsars like PSR B1534+12 with its 2.7 Gyr coalescence time could produce such a merger. The displacement (∼2.2 kpc) of the binary star system from the centre of the main galaxy is not unusual for stars in the host galaxy or stars originating in the merging galaxy, and therefore any constraints on the kick velocity imparted to the progenitor are poor. Copyright © 2017, The Authors. All rights reserved.

关键词： Gravity waves

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Spinning up a Daze: TESS Uncovers a Hot Jupiter orbiting the Rapid-Rotator TOI-778

arXiv

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arXiv 2022年

作者： Clark, Jake T. Addison, Brett C. Okumura, Jack Vach, Sydney Errico, Adriana Heitzmann, Alexis Rodriguez, Joseph E. Wright, Duncan J. Clerté, Mathieu Brown, Carolyn J. Fetherolf, Tara Wittenmyer, Robert A. Plavchan, Peter Kane, Stephen R. Horner, Jonathan Kielkopf, John F. Shporer, Avi Tinney, C.G. Hui-Gen, Liu Ballard, Sarah Bowler, Brendan P. Mengel, Matthew W. Zhou, George Lee, Annette S. David, Avelyn Heim, Jessica Lee, Michele E. Sevilla, Verónica Zafar, Naqsh E. Hinkel, Natalie R. Allen, Bridgette E. Bayliss, Daniel Berberyan, Arthur Berlind, Perry Bieryla, Allyson Bouchy, François Brahm, Rafael Bryant, Edward M. Christiansen, Jessie L. Ciardi, David R. Ciardi, Krys N. Collins, Karen A. Dallant, Jules Davis, Allen B. Díaz, Matías R. Dressing, Courtney D. Esquerdo, Gilbert A. Harre, Jan-Vincent Howell, Steve B. Jenkins, Jon M. Jensen, Eric L.N. Jones, Matías I. Jordán, Andrés Latham, David W. Lund, Michael B. McCormac, James Nielsen, Louise D. Otegi, Jon Quinn, Samuel N. Radford, Don J. Ricker, George R. Schwarz, Richard P. Seager, Sara Smith, Alexis M.S. Stockdale, Chris Tan, Thiam-Guan Udry, Stéphane Vanderspek, Roland Günther, Maximilian N. Wang, Songhu Wingham, Geof Winn, Joshua N. University of Southern Queensland Centre for Astrophysics USQ Toowoomba West Street QLD4350 Australia Swinburne University of Technology Centre for Astrophysics and Supercomputing John Street HawthornVIC3122 Australia Center for Astrophysics Harvard & Smithsonian 60 Garden St CambridgeMA02138 United States Astronomy Unit Queen Mary University of London Mile End Road LondonE1 4NS United Kingdom Department of Physics and Astronomy Michigan State University East LansingMI48824 United States Department of Earth and Planetary Sciences University of California Riverside 900 University Avenue RiversideCA92521 United States Department of Physics & Astronomy George Mason University 4400 University Drive MS 3F3 FairfaxVA22030 United States Department of Earth and Planetary Sciences University of California RiversideCA92521 United States Department of Physics and Astronomy University of Louisville LouisvilleKY40292 United States Department of Physics Kavli Institute for Astrophysics and Space Research Massachusetts Institute of Technology CambridgeMA02139 United States Exoplanetary Science UNSW School of Physics UNSW Sydney NSW2052 Australia School of Astronomy and Space Science Key Laboratory of Modern Astronomy and Astrophysics in Ministry of Education Nanjing University Jiangsu Nanjing210046 China Department of Astronomy University of Florida 211 Bryant Space Science Center GainesvilleFL32611 United States Department of Astronomy The University of Texas AustinTX78712 United States The Native Skywatchers Initiative MN United States Department of Physics and Astronomy St. Cloud University MN United States Department of Astronomy and Astrophysics University of California Santa CruzCA95064 United States Jeremiah Horrocks Institute University of Central Lancashire PrestonPR1 2HE United Kingdom Space Science and Engineering Division Southwest Research Institute San AntonioTX78238 United States NASA Exoplanet Science Institute - Ca

NASA’s Transiting Exoplanet Survey Satellite (TESS) mission, has been uncovering a growing number of exoplanets orbiting nearby, bright stars. Most exoplanets that have been discovered by TESS orbit narrow-line, slow-rotating stars, facilitating the confirmation and mass determination of these worlds. We present the discovery of a hot Jupiter orbiting a rapidly rotating (v sin (i) = 35.1 ± 1.0 km s−1) early F3V-dwarf, HD 115447 (TOI-778). The transit signal taken from Sectors 10 and 37 of TESS’s initial detection of the exoplanet is combined with follow-up ground-based photometry and velocity measurements taken from Minerva-Australis, TRES, CORALIE and CHIRON to confirm and characterise TOI-778 b. A joint analysis of the light curves and the radial velocity measurements yield a mass, radius, and orbital period for TOI-778 b of 2.76+0−0.2423 MJ, 1.370 ± 0.043 RJ, and ∼ 4.63 days, respectively. The planet orbits a bright (V = 9.1 mag) F3-dwarf with M = 1.40 ± 0.05 M, R = 1.70 ± 0.05 R, and log g = 4.05 ± 0.17. We observed a spectroscopic transit of TOI-778 b, which allowed us to derive a sky-projected spin-orbit angle of 18◦ ± 11◦, consistent with an aligned planetary system. This discovery demonstrates the capability of smaller aperture telescopes such as Minerva-Australis to detect the radial velocity signals produced by planets orbiting broad-line, rapidly rotating stars. © 2022, CC BY.

关键词： Satellites

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Publisher Correction: Global estimates on the number of people blind or visually impaired by cataract: a meta-analysis from 2000 to 2020

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Eye (London, England) 2024年第11期38卷 2229-2231页

作者： Konrad Pesudovs Hugh R. Taylor Tabassom Sedighi Rupert R. A. Bourne Shahina Pardhan Van Charles Lansingh John H. Kempen Ian Tapply Arthur G. Fernandes Maria Vittoria Cicinelli Alessandro Arrigo Nicolas Leveziel Serge Resnikoff Seth Flaxman Mukkharram M. Bikbov Tasanee Braithwaite Alain Bron Ching-Yu Cheng Monte A. Del Monte Joshua R. Ehrlich Leon B. Ellwein David Friedman João M. Furtado Gus Gazzard Ronnie George M. Elizabeth Hartnett Jost B. Jonas Rim Kahloun Moncef Khairallah Rohit C. Khanna Janet Leasher Julie-Anne Little Vinay Nangia Michal Nowak Tunde Peto Pradeep Ramulu Fotis Topouzis Mitiadis Tsilimbaris Ya Xing Wang Ningli Wang Paul Svitil Briant Theo Vos Katrin Burkart Kaleb Coberly Xiaochen Dai Stephen S. Lim Tomislav Mestrovic Ali H. Mokdad Christopher J. L. Murray Jaimie D. Steinmetz Awoke Misganaw Yohannes Habtegiorgis Abate Mohammad Abdollahi Mozhan Abdollahi Ayele Mamo Abebe Olumide Abiodun Richard Gyan Aboagye Woldu Aberhe Abrha Hasan Abualruz Hiwa Abubaker Ali Eman Abu-Gharbieh Salahdein Aburuz Tadele Girum Girum Adal Mesafint Molla Adane Isaac Yeboah Addo Qorinah Estiningtyas Sakilah Adnani Muhammad Sohail Afzal Muhammad Umair Shahin Aghamiri Bright Opoku Ahinkorah Aqeel Ahmad Sajjad Ahmad Ali Ahmadi Siamak Sabour Ayman Ahmed Haroon Ahmed Ahmad Samir Alfaar Abid Ali Syed Shujait Shujait Ali Awais Altaf Hubert Amu Emmanuel Manu Sofia Androudi Rodrigo Anguita Abhishek Anil Rimple Jeet Kaur Muhammad Aaqib Shamim Saeid Anvari Anayochukwu Edward Anyasodor Francis Appiah Jalal Arabloo Haleh Ayatollahi Mosab Arafat Damelash Areda Reza Arefnezhad Brhane Berhe Aregawi Akeza Awealom Asgedom Tahira Ashraf Seyyed Shamsadin Athari Bantalem Tilaye Tilaye Atinafu Birhan Tsegaw Taye Maha Moh’d Wahbi Atout Alok Atreya Ahmed Y. Azzam Hassan Babamohamadi Sara Bagherieh Yogesh Bahurupi Atif Amin Baig Shumaila Nargus Biswajit Banik Mainak Bardhan Saurav Basu Kavita Batra Nebiyou Simegnew Bayileyegn Fatemeh Bazvand Addisu Shunu Beyene Awoke Masrie Asrat Derese Devidas S. Bhagat Akshaya Srikanth Bhagavathula Pankaj Bh Medicine & Health University of New South Wales Sydney NSW Australia School of Optometry and Vision Science University of New South Wales Sydney NSW Australia School of Population and Global Health University of Melbourne Carlton VIC Australia Vision and Eye Research Institute Anglia Ruskin University Cambridge UK HelpMeSee Instituto Mexicano de Oftalmologia Santiago de Querétaro Mexico University of Miami Gables FL USA University of Utah Salt Lake City UT USA Chief Medical Office HelpMeSee New York NY USA Mexican Institute of Ophthalmology Queretaro Mexico Department of Ophthalmology Massachusetts Eye and Ear/Shepens Eye Research Institute/Harvard Medical School Boston MA USA Eye Unit MyungSung Christian Medical Center (MCM) Comprehensive Specialized Hospital and MyungSun Medical College Addis Ababa Ethiopia Department of Ophthalmology Addis Ababa University Addis Ababa Ethiopia Sight for Souls Bellevue WA USA Department of Ophthalmology Harvard University Boston MA USA Eye Unit MyungSung Medical College Addis Ababa Ethiopia Addenbrooke’s Hospital Cambridge UK Department of Ophthalmology Cambridge University Hospitals Cambridge UK Federal University of Sao Paolo Sao Paolo SP Brazil University of Calgary Calgary AB Canada Department of Ophthalmology and Visual Sciences Federal University of São Paulo Sao Paulo Brazil School of Medicine Vita-Salute San Raffaele University Milan Italy Department of Ophthalmology IRCCS San Raffaele Scientific Institute Milan Italy Department of Ophthalmology San Raffaele Scientific Institute Milano Italy IRCCS San Raffaele Scientific Institute Vita-Salute University Milan Italy Scientific Institute San Raffaele Hospital Vita-Salute University Milan Italy University of Poitiers Poitiers France CHU de Poitiers Poitiers France Ophthalmology Department CHU de Poitiers (Poitiers University Hospital) Poitiers France Unité 1084 National Institute of Health and Medical Research (INSERM) Poitiers France

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Global, regional, and national sex-specific burden and control of the HIV epidemic, 1990–2019, for 204 countries and territories: the Global Burden of Diseases Study 2019

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The Lancet HIV 2021年第10期8卷 e633-e651页

作者： Jahagirdar, Deepa Walters, Magdalene K. Novotney, Amanda Brewer, Edmond D. Frank, Tahvi D. Carter, Austin Biehl, Molly H. Abbastabar, Hedayat Abhilash, E.S. Abu-Gharbieh, Eman Abu-Raddad, Laith Jamal Adekanmbi, Victor Adeyinka, Daniel Adedayo Adnani, Qorinah Estiningtyas Sakilah Afzal, Saira Aghababaei, Soodabeh Ahinkorah, Bright Opoku Ahmad, Sajjad Ahmadi, Keivan Ahmadi, Sepideh Ahmadpour, Ehsan Ahmed, Muktar Beshir Rashid, Tarik Ahmed Salih, Yusra Ahmed Aklilu, Addis Akram, Tayyaba Akunna, Chisom Joyqueenet Al Hamad, Hanadi Alahdab, Fares Alanezi, Fahad Mashhour Aleksandrova, Ekaterina A. Alene, Kefyalew Addis Ali, Liaqat Alipour, Vahid Almustanyir, Sami Alvis-Guzman, Nelson Ameyaw, Edward Kwabena Amu, Hubert Andrei, Catalina Liliana Andrei, Tudorel Anvari, Davood Arabloo, Jalal Aremu, Olatunde Arulappan, Judie Atnafu, Desta Debalkie Quintanilla, Beatriz Paulina Ayala Ayza, Muluken Altaye Azari, Samad Darshan, B.B. Banach, Maciej Bärnighausen, Till Winfried Barra, Fabio Barrow, Amadou Basu, Sanjay Bazargan-Hejazi, Shahrzad Belay, Habtamu Gebrehana Berheto, Tezera Moshago Bezabhe, Woldesellassie Mequanint Bezabih, Yihienew Mequanint Bhagavathula, Akshaya Srikanth Bhardwaj, Nikha Bhardwaj, Pankaj Bhattacharyya, Krittika Bibi, Sadia Bijani, Ali Bisignano, Catherine Bolarinwa, Obasanjo Afolabi Boloor, Archith Boltaev, Azizbek A. Briko, Nikolay Ivanovich Buonsenso, Danilo Burkart, Katrin Butt, Zahid A. Cao, Chao Charan, Jaykaran Chatterjee, Souranshu Chattu, Soosanna Kumary Chattu, Vijay Kumar Choudhari, Sonali Gajanan Chu, Dinh-Toi Couto, Rosa A.S. Cowden, Richard G. Dachew, Berihun Assefa Dadras, Omid Dagnew, Amare Belachew Dahlawi, Saad M.A. Dai, Xiaochen Dandona, Lalit Dandona, Rakhi das Neves, José Degenhardt, Louisa Demeke, Feleke Mekonnen Desta, Abebaw Alemayehu Deuba, Keshab Dhamnetiya, Deepak Dhungana, Govinda Prasad Dianatinasab, Mostafa Diaz, Daniel Djalalinia, Shirin Doan, Linh Phuong Dorostkar, Fariba Edinur, Hisham Atan Effiong, Andem Eftekharzadeh, Sahar El Sayed Zaki, Maysaa Elayedath, Rajesh Elhadi, Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Division of Allergy and Infectious Diseases University of Washington Seattle WA United States Department of Global Health University of Washington Seattle WA United States School of Social Work University of Washington Seattle WA United States Department of Medicine University of Washington Seattle WA United States Vagelos College of Physicians and Surgeones Columbia University Medical Center New York NY United States Division of Data Analytics and Delivery for Impact WHO Geneva Switzerland Advanced Diagnostic and Interventional Radiology Research Centre Tehran University of Medical Sciences Tehran Iran Multiple Sclerosis Research Centre Tehran University of Medical Sciences Tehran Iran School of Public Health Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Paediatric Chronic Kidney Disease Research Centre Tehran University of Medical Sciences Tehran Iran Department of Psychiatry Tehran University of Medical Sciences Tehran Iran Metabolomics and Genomics Research Centre Tehran University of Medical Sciences Tehran Iran Sina Trauma and Surgery Research Centre Tehran University of Medical Sciences Tehran Iran Research Centre for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Non-Communicable Diseases Research Centre Tehran University of Medical Sciences Tehran Iran Department of Botany Sree Narayana Guru College Chelannur Kozhikode India Clinical Sciences Department University of Sharjah Sharjah United Arab Emirates Mass Communication Department University of Sharjah Sharjah United Arab Emirates Department of Health-Care Policy and Research Weill Cornell Medical College in Qatar Doha Qatar Department of Population Medicine Ca

Background: The sustainable development goals (SDGs) aim to end HIV/AIDS as a public health threat by 2030. Understanding the current state of the HIV epidemic and its change over time is essential to this effort. This study assesses the current sex-specific HIV burden in 204 countries and territories and measures progress in the control of the epidemic. Methods: To estimate age-specific and sex-specific trends in 48 of 204 countries, we extended the Estimation and Projection Package Age-Sex Model to also implement the spectrum paediatric model. We used this model in cases where age and sex specific HIV-seroprevalence surveys and antenatal care-clinic sentinel surveillance data were available. For the remaining 156 of 204 locations, we developed a cohort-incidence bias adjustment to derive incidence as a function of cause-of-death data from vital registration systems. The incidence was input to a custom Spectrum model. To assess progress, we measured the percentage change in incident cases and deaths between 2010 and 2019 (threshold >75% decline), the ratio of incident cases to number of people living with HIV (incidence-to-prevalence ratio threshold <0·03), and the ratio of incident cases to deaths (incidence-to-mortality ratio threshold <1·0). Findings: In 2019, there were 36·8 million (95% uncertainty interval [UI] 35·1–38·9) people living with HIV worldwide. There were 0·84 males (95% UI 0·78–0·91) per female living with HIV in 2019, 0·99 male infections (0·91–1·10) for every female infection, and 1·02 male deaths (0·95–1·10) per female death. Global progress in incident cases and deaths between 2010 and 2019 was driven by sub-Saharan Africa (with a 28·52% decrease in incident cases, 95% UI 19·58–35·43, and a 39·66% decrease in deaths, 36·49–42·36). Elsewhere, the incidence remained stable or increased, whereas deaths generally decreased. In 2019, the global incidence-to-prevalence ratio was 0·05 (95% UI 0·05–0·06) and the global incidence-to-mortality ratio was

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Global investments in pandemic preparedness and COVID-19: development assistance and domestic spending on health between 1990 and 2026

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The Lancet Global Health 2023年第3期11卷 e385-e413页

作者： Micah, Angela E. Bhangdia, Kayleigh Cogswell, Ian E. Lasher, Dylan Lidral-Porter, Brendan Maddison, Emilie R. Nguyen, Trang Nhu Ngoc Patel, Nishali Pedroza, Paola Solorio, Juan Stutzman, Hayley Tsakalos, Golsum Wang, Yifeng Warriner, Wesley Zhao, Yingxi Zlavog, Bianca S. Abbafati, Cristiana Abbas, Jaffar Abbasi-Kangevari, Mohsen Abbasi-Kangevari, Zeinab Abdelmasseh, Michael Abdulah, Deldar Morad Abedi, Aidin Abegaz, Kedir Hussein Abhilash, E.S. Aboagye, Richard Gyan Abolhassani, Hassan Abrigo, Michael R.M. Abubaker Ali, Hiwa Abu-Gharbieh, Eman Adem, Mohammed Hussien Afzal, Muhammad Sohail Ahmadi, Ali Ahmed, Haroon Ahmed Rashid, Tarik Aji, Budi Akbarialiabad, Hossein Akelew, Yibeltal Al Hamad, Hanadi Alam, Khurshid Alanezi, Fahad Mashhour Alanzi, Turki M. Al-Hanawi, Mohammed Khaled Alhassan, Robert Kaba Aljunid, Syed Mohamed Almustanyir, Sami Al-Raddadi, Rajaa M. Alvis-Guzman, Nelson Alvis-Zakzuk, Nelson J. Amare, Azmeraw T. Ameyaw, Edward Kwabena Amini-Rarani, Mostafa Amu, Hubert Ancuceanu, Robert Andrei, Tudorel Anwar, Sumadi Lukman Appiah, Francis Aqeel, Muhammad Arabloo, Jalal Arab-Zozani, Morteza Aravkin, Aleksandr Y. Aremu, Olatunde Aruleba, Raphael Taiwo Athari, Seyyed Shamsadin Avila-Burgos, Leticia Ayanore, Martin Amogre Azari, Samad Baig, Atif Amin Bantie, Abere Tilahun Barrow, Amadou Baskaran, Pritish Basu, Sanjay Batiha, Abdul-Monim Mohammad Baune, Bernhard T. Berezvai, Zombor Bhardwaj, Nikha Bhardwaj, Pankaj Bhaskar, Sonu Boachie, Micheal Kofi Bodolica, Virginia Botelho, João Silva Botelho Braithwaite, Dejana Breitborde, Nicholas J.K. Busse, Reinhard Cahuana-Hurtado, Lucero Catalá-López, Ferrán Chansa, Collins Charan, Jaykaran Chattu, Vijay Kumar Chen, Simiao Chukwu, Isaac Sunday Dadras, Omid Dandona, Lalit Dandona, Rakhi Dargahi, Abdollah Debela, Sisay Abebe Denova-Gutiérrez, Edgar Desye, Belay Dharmaratne, Samath Dhamminda Diao, Nancy Doan, Linh Phuong Dodangeh, Milad dos Santos, Wendel Mombaque Doshmangir, Leila Dube, John Eini, Ebrahim El Sayed Zaki, Maysaa El Tantawi, Maha Enyew, Daniel Berhanie Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Applied Mathematics University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Nuffield Department of Medicine University of Oxford Oxford United Kingdom Department of Juridical and Economic Studies La Sapienza University Rome Italy Antai College of Economics Shanghai Jiao Tong University Shanghai China Non-communicable Diseases Research Center Tehran University of Medical Sciences Tehran Iran Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Multiple Sclerosis Research Center Tehran University of Medical Sciences Tehran Iran Children’s Medical Center Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Tehran Heart Center Tehran University of Medical Sciences Tehran Iran Faculty of Medicine Tehran University of Medical Sciences Tehran Iran National Institute for Health Research Tehran University of Medical Sciences Tehran Iran Department of Pharmacology Tehran University of Medical Sciences Tehran Iran Department of Cardiology Tehran University of Medical Sciences Tehran Iran Sina Trauma and Surgery Research Center Tehran University of Medical Sciences Tehran Iran Digestive Diseases Research Institute Tehran University of Medical Sciences Tehran Iran Department of Neurology Tehran University of Medical Sciences Tehran Iran Social Determinants of Health Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Department of Epidemiology Shahid Beheshti University of Medical Sciences Tehran Iran Department of Health Economics and Statistics Shahid Beheshti University of Medical Sciences Tehran Iran Department of Neurosurgery Shahid Beheshti University of Medical Sciences Tehran Iran Ophthalmic R

Background: The COVID-19 pandemic highlighted gaps in health surveillance systems, disease prevention, and treatment globally. Among the many factors that might have led to these gaps is the issue of the financing of national health systems, especially in low-income and middle-income countries (LMICs), as well as a robust global system for pandemic preparedness. We aimed to provide a comparative assessment of global health spending at the onset of the pandemic;characterise the amount of development assistance for pandemic preparedness and response disbursed in the first 2 years of the COVID-19 pandemic;and examine expectations for future health spending and put into context the expected need for investment in pandemic preparedness. Methods: In this analysis of global health spending between 1990 and 2021, and prediction from 2021 to 2026, we estimated four sources of health spending: development assistance for health (DAH), government spending, out-of-pocket spending, and prepaid private spending across 204 countries and territories. We used the Organisation for Economic Co-operation and Development (OECD)'s Creditor Reporting System (CRS) and the WHO Global Health Expenditure database (GHED) to estimate spending. We estimated development assistance for general health, COVID-19 response, and pandemic preparedness and response using a keyword search. Health spending estimates were combined with estimates of resources needed for pandemic prevention and preparedness to analyse future health spending patterns, relative to need. Findings: In 2019, at the onset of the COVID-19 pandemic, US$9·2 trillion (95% uncertainty interval [UI] 9·1–9·3) was spent on health worldwide. We found great disparities in the amount of resources devoted to health, with high-income countries spending $7·3 trillion (95% UI 7·2–7·4) in 2019;293·7 times the $24·8 billion (95% UI 24·3–25·3) spent by low-income countries in 2019. That same year, $43·1 billion in development assistance was provided

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Author Correction: Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

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Nature communications 2021年第1期12卷 7260页

作者： Merel C Postema Daan van Rooij Evdokia Anagnostou Celso Arango Guillaume Auzias Marlene Behrmann Geraldo Busatto Filho Sara Calderoni Rosa Calvo Eileen Daly Christine Deruelle Adriana Di Martino Ilan Dinstein Fabio Luis S Duran Sarah Durston Christine Ecker Stefan Ehrlich Damien Fair Jennifer Fedor Xin Feng Jackie Fitzgerald Dorothea L Floris Christine M Freitag Louise Gallagher David C Glahn Ilaria Gori Shlomi Haar Liesbeth Hoekstra Neda Jahanshad Maria Jalbrzikowski Joost Janssen Joseph A King Xiang Zhen Kong Luisa Lazaro Jason P Lerch Beatriz Luna Mauricio M Martinho Jane McGrath Sarah E Medland Filippo Muratori Clodagh M Murphy Declan G M Murphy Kirsten O'Hearn Bob Oranje Mara Parellada Olga Puig Alessandra Retico Pedro Rosa Katya Rubia Devon Shook Margot J Taylor Michela Tosetti Gregory L Wallace Fengfeng Zhou Paul M Thompson Simon E Fisher Jan K Buitelaar Clyde Francks Department of Language & Genetics Max Planck Institute for Psycholinguistics Nijmegen The Netherlands. Department of Cognitive Neuroscience Donders Institute for Brain Cognition and Behaviour Donders Centre for Cognitive Neuroimaging Radboud University Medical Centre Nijmegen The Netherlands. Bloorview Research Institute Holland Bloorview Kids Rehabilitation Hospital and Department of Pediatrics University of Toronto Toronto ON USA. Child and Adolescent Psychiatry Department Gregorio Marañón General University Hospital School of Medicine Universidad Complutense IiSGM CIBERSAM Madrid Spain. Institut de Neurosciences de la Timone UMR 7289 Aix Marseille Université CNRS Marseille France. Department of Psychology Carnegie Mellon University Pittsburgh PA USA. Laboratory of Psychiatric Neuroimaging (LIM-21) Departamento e Instituto de Psiquiatria Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo Sao Paulo SP Brazil. IRCCS Stella Maris Foundation viale del Tirreno 331 56128 Pisa Italy. Department of Clinical and Experimental Medicine University of Pisa Pisa Italy. Department of Child and Adolescent Psychiatry and Psychology Hospital Clinic Psychiatry Unit Department of Medicine 2017SGR881 University of Barcelona IDIBAPS CIBERSAM Barcelona Spain. Department of Forensic and Neurodevelopmental Sciences Institute of Psychiatry Psychology & Neuroscience King's College London London UK. Institute for Pediatric Neuroscience NYU Child Study Center New York NY USA. Department of Psychology Ben-Gurion University of the Negev Beer Sheva Israel. Brain Center Rudolf Magnus Department of Psychiatry University Medical Center Utrecht Utrecht The Netherlands. Department of Child and Adolescent Psychiatry Psychosomatics and Psychotherapy University Hospital Goethe University Frankfurt am Main Frankfurt Germany. Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine of USC University o

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