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Non-invasive biopsy diagnosis of diabetic kidney disease via deep learning applied to retinal images: a population-based study

引用

The Lancet Digital Health 2025年第5期7卷 100868页

作者： Meng, Ziyao Guan, Zhouyu Yu, Shujie Wu, Yilan Zhao, Yaoning Shen, Jie Lim, Cynthia Ciwei Chen, Tingli Yang, Dawei Ran, An Ran He, Feng Hamzah, Haslina Singh, Sarkaaj Abd Raof, Anis Syazwani Lee-Boey, Jian Wen Samuel Lim, Soo-Kun Sun, Xufang Ge, Shuwang Xu, Gang Su, Hua Cheng, Yang Lu, Feng Liao, Xiaofei Jin, Hai Deng, Chenxin Ruan, Lei Zhang, Cuntai Wu, Chan Dai, Rongping Jin, Yixiao Wang, Wenxiao Li, Tingyao Liu, Ruhan Li, Jiajia Shu, Jia Lu, Yuwei Wang, Xiangning Wu, Qiang Qin, Yiming Tang, Jin Sheng, Xiaohua Jiao, Qiong Yang, Xiaokang Guo, Minyi McKay, Gareth J Hogg, Ruth E Liew, Gerald Chee, Evelyn Yi Lyn Hsu, Wynne Lee, Mong Li Szeto, Simon Luk, Andrea O Y Chan, Juliana C N Cheung, Carol Y Tan, Gavin Siew Wei Tham, Yih-Chung Cheng, Ching-Yu Sabanayagam, Charumathi Lim, Lee-Ling Jia, Weiping Li, Huating Sheng, Bin Wong, Tien Yin Shanghai Belt and Road International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases Department of Computer Science and Engineering School of Electronic Information and Electrical Engineering Institute for Proactive Healthcare Shanghai Jiao Tong University Department of Endocrinology and Metabolism Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Diabetes Institute Shanghai Clinical Centre for Diabetes Shanghai Key Laboratory of Diabetes Mellitus Shanghai China MOE Key Laboratory of AI School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai China Beijing Tsinghua Changgung Hospital Eye Center School of Clinical Medicine Tsinghua Medicine Tsinghua University Beijing China Medical Records and Statistics Office Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China Department of Renal Medicine Singapore General Hospital SingHealth-Duke Academic Medical Centre Singapore Singapore Department of Ophthalmology Shanghai Health and Medical Center Wuxi China Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong Hong Kong Special Administrative Region China Singapore Eye Research Institute Singapore National Eye Centre Singapore Department of Medicine Faculty of Medicine Universiti Malaya Kuala Lumpur Malaysia Department of Ophthalmology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Hubei Wuhan China Department of Nephrology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Nephrology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Ophthalmology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China National Engineering Research Centre for Big Dat

Background: Improving the accessibility of screening diabetic kidney disease (DKD) and differentiating isolated diabetic nephropathy from non-diabetic kidney disease (NDKD) are two major challenges in the field of diabetes care. We aimed to develop and validate an artificial intelligence (AI) deep learning system to detect DKD and isolated diabetic nephropathy from retinal fundus images. Methods: In this population-based study, we developed a retinal image-based AI-deep learning system, DeepDKD, pretrained using 734 084 retinal fundus images. First, for DKD detection, we used 486 312 retinal images from 121 578 participants in the Shanghai Integrated Diabetes Prevention and Care System for development and internal validation, and ten multi-ethnic datasets from China, Singapore, Malaysia, Australia, and the UK (65 406 participants) for external validation. Second, to differentiate isolated diabetic nephropathy from NDKD, we used 1068 retinal images from 267 participants for development and internal validation, and three multi-ethnic datasets from China, Malaysia, and the UK (244 participants) for external validation. Finally, we conducted two proof-of-concept studies: a prospective real-world study with 3 months' follow-up to evaluate the effectiveness of DeepDKD in screening DKD;and a longitudinal analysis of the effectiveness of DeepDKD in differentiating isolated diabetic nephropathy from NDKD on renal function changes with 4·6 years' follow-up. Findings: For detecting DKD, DeepDKD achieved an area under the receiver operating characteristic curve (AUC) of 0·842 (95% CI 0·838–0·846) on the internal validation dataset and AUCs of 0·791–0·826 across external validation datasets. For differentiating isolated diabetic nephropathy from NDKD, DeepDKD achieved an AUC of 0·906 (0·825–0·966) on the internal validation dataset and AUCs of 0·733–0·844 across external validation datasets. In the prospective study, compared with the metadata model, DeepDKD could detect DKD wit

关键词： Deep learning

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An MRC Framework for Semantic Role Labeling

arXiv

引用

arXiv 2021年

作者： Wang, Nan Li, Jiwei Meng, Yuxian Sun, Xiaofei Qiu, Han Wang, Ziyao Wang, Guoyin He, Jun Key Laboratory of Data Engineering and Knowledge Engineering of MOE School of Information Renmin University of China China Shannon.AI China Zhejiang University China Tsinghua University China University of Leeds United Kingdom Amazon Alexa AI United States

Semantic Role Labeling (SRL) aims at recognizing the predicate-argument structure of a sentence and can be decomposed into two subtasks: predicate disambiguation and argument labeling. Prior work deals with these two tasks independently, which ignores the semantic connection between the two tasks. In this paper, we propose to use the machine reading comprehension (MRC) framework to bridge this gap. We formalize predicate disambiguation as multiple-choice machine reading comprehension, where the descriptions of candidate senses of a given predicate are used as options to select the correct sense. The chosen predicate sense is then used to determine the semantic roles for that predicate, and these semantic roles are used to construct the query for another MRC model for argument labeling. In this way, we are able to leverage both the predicate semantics and the semantic role semantics for argument labeling. We also propose to select a subset of all the possible semantic roles for computational efficiency. Experiments show that the proposed framework achieves state-of-the-art or comparable results to previous work. Code is available at https://***/ShannonAI/MRC-SRL. © 2021, CC BY.

关键词： Semantics

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Penetration Effect of Informatization on Technological Progress in Logistics Industry: Empirical Evidence from Inter-provincial Panel data in China 9th

Penetration Effect of Informatization on Technological Progr...

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9th International Conference on Information Technology and Quantitative Management, ITQM 2022

作者： Gong, Yaling Tian, Xin Jiang, Zuoliang Jiao, Yamin School of Economics and Management Yuzhang Normal University Nanchang330103 China School of Economics and Management University of Chinese Academy of Sciences Beijing100190 China Research Center on Fictitious Economy and Data Science Chinese Academy of Sciences Beijing100190 China Key Laboratory of Big Data Mining and Knowledge Management Chinese Academy of Sciences Beijing100190 China Shanghai Heading Information Engineering Co. Ltd. Shanghai201112 China Shanghai Winjoin Information Technology Co. Ltd. Shanghai200126 China

This paper investigates pervasiveness effect of information technology on the technological progress of logistics in China. Using panel data of 30-regions in China during 2008 to 2020, we propose both static and dynamic panel data models, and find both resource level and spreading rate of information technology have negative influences on technological progress of logistics. The resource level of information technology has a short-term effect on technological progress of logistics, whereas the spreading rate of information technology has a long-term effect. Moreover, the result reveals that the discordant problem of information construction of logistics between resource level and spreading rate cause the negative influence of information technology. © 2022 The Authors. Published by Elsevier B.V.

关键词： Industry 4.0

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Static vulnerabilities detection method based on security state tracing and checking

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Jisuanji Xuebao/Chinese Journal of Computers 2009年第5期32卷 899-909页

作者： Liang, Bin Hou, Kan-Kan Shi, Wen-Chang Liang, Zhao-Hui School of Information Renming University of China Beijing 100872 China MOE Key Laboratory of Data Engineering and Knowledge Engineering Beijing 100872 China

The main problem of existing static vulnerability detection methods based source code analysis is their high false positive and false negative rates. One main reason is lack of accurate and effective identification and analysis of security-related program elements, e.g. data validation checking, tainted data source, etc. A static vulnerability detection method based on data security state tracing and checking is proposed. In this method, the state space of state machine model is extended;the security state of a variable is identified by a vector that may correspond to multiple security-related properties rather than by a single property;Fine-grained state transition is provided to support accurate recognition of program security-related behaviors;The recognition of validation checking is introduced in vulnerability state machine to reduce false positives;and a systematic discrimination mechanism for tainted data is constructed to prevent false negatives result from neglecting tainted data sources. The experimental results of a prototype system show that this method can effectively detect buffer overflow and other type's vulnerabilities in software systems, and with obviously lower false positive than existing mainstream static detection methods and avoid some serious false negatives of these methods.

关键词： Static analysis

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Enabling Efficient Random Access to Hierarchically-Compressed data

Enabling Efficient Random Access to Hierarchically-Compresse...

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International Conference on data engineering

作者： Feng Zhang Jidong Zhai Xipeng Shen Onur Mutlu Xiaoyong Du Key Laboratory of Data Engineering and Knowledge Engineering (MOE) and School of Information Renmin University of China Department of Computer Science and Technology Tsinghua University BNRist Computer Science Department North Carolina State University Department of Computer Science ETH Zürich

ISBN: (数字)9781728129037

ISBN: (纸本)9781728129044

Recent studies have shown the promise of direct data processing on hierarchically-compressed text documents. By removing the need for decompressing data, the direct data processing technique brings large savings in both time and space. However, its benefits have been limited to data traversal operations; for random accesses, direct data processing is several times slower than the state-of-the-art baselines. This paper presents a set of techniques that successfully eliminate the limitation, and for the first time, establishes the feasibility of effectively handling both data traversal operations and random data accesses on hierarchically-compressed data. The work yields a new library, which achieves 3.1× speedup over the state-of-the-art on random data accesses to compressed data, while preserving the capability of supporting traversal operations efficiently and providing large (3.9×) space savings.

关键词： Indexing data processing data structures Technological innovation Dictionaries Law data mining

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Generalized Category Discovery with Large Language Models in the Loop

arXiv

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arXiv 2023年

作者： An, Wenbin Shi, Wenkai Tian, Feng Lin, Haonan Wang, QianYing Wu, Yaqiang Cai, Mingxiang Wang, Luyan Chen, Yan Zhu, Haiping Chen, Ping School of Automation Science and Engineering Xi’an Jiaotong University China School of Computer Science and Technology Xi’an Jiaotong University China Ministry of Education Key Laboratory of Intelligent Networks and Network Security China Shaanxi Province Key Laboratory of Big Data Knowledge Engineering China Lenovo Research China University of Massachusetts Boston United States

Generalized Category Discovery (GCD) is a crucial task that aims to recognize both known and novel categories from a set of unlabeled data by utilizing a few labeled data with only known categories. Due to the lack of supervision and category information, current methods usually perform poorly on novel categories and struggle to reveal semantic meanings of the discovered clusters, which limits their applications in the real world. To mitigate the above issues, we propose Loop, an end-to-end active-learning framework that introduces Large Language Models (LLMs) 1 into the training loop, which can boost model performance and generate category names without relying on any human efforts. Specifically, we first propose Local Inconsistent Sampling (LIS) to select samples that have a higher probability of falling to wrong clusters, based on neighborhood prediction consistency and entropy of cluster assignment probabilities. Then we propose a Scalable Query strategy to allow LLMs to choose true neighbors of the selected samples from multiple candidate samples. Based on the feedback from LLMs, we perform Refined Neighborhood Contrastive Learning (RNCL) to pull samples and their neighbors closer to learn clustering-friendly representations. Finally, we select representative samples from clusters corresponding to novel categories to allow LLMs to generate category names for them. Extensive experiments on three benchmark datasets show that Loop outperforms SOTA models by a large margin and generates accurate category names for the discovered clusters. Code and data are available at https://***/Lackel/LOOP. Copyright © 2023, The Authors. All rights reserved.

关键词： Semantics

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The Spatiotemporal Traffic Accident Risk Analysis in Urban Traffic Network 9th

The Spatiotemporal Traffic Accident Risk Analysis in Urban T...

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9th International Conference on Mobile Wireless Middleware, Operating Systems and Applications, MOBILWARE 2020

作者： Zhang, Chijun jin, Jing Huang, Qiuyang Du, Zhanwei Yuan, Zhilu Tang, Shengjun Liu, Yang School of Management Science and Information Engineering Jilin University of Finance and Economics Changchun130117 China Jilin Province Key Laboratory of Fintech Jilin University of Finance and Economics Changchun130117 China College of Computer Science and Technology Jilin University Changchun130012 China Research Institute for Smart Cities and Shenzhen Key Laboratory of Spatial Information Smart Sensing and Services School of Architecture and Urban Planning Shenzhen University Shenzhen China Jilin Big Data Research Center for Business Jilin University of Finance and Economics Changchun130117 China

ISBN: (纸本)9783030622046

Traffic accidents seriously threaten people’s lives and property all over the world. Therefore, it is of great significance to human society to have a long-term traffic accidents data with detail temporal and geographic information in a specific space, which can be used for traffic accident hotspots identification to reduce the incidence of traffic accidents. Here, we obtain a one-year dataset of traffic accidents of the city center in Changchun, Northeast China, in 2017. In this paper, we analyze the risk of traffic accident in urban area, and then discover the characteristics of traffic accidents at the temporal and spatial aspect. We construct a traffic network, which takes crossings as nodes and road sections as edges and weighted by the total number of traffic accidents. In addition, we integrate road structure data and meteorological data to explore the characteristics of the traffic network. © 2020, ICST Institute for Computer Sciences, Social Informatics and Telecommunications engineering.

关键词： Risk analysis

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Stealthy Backdoor Attack Towards Federated Automatic Speaker Verification

Stealthy Backdoor Attack Towards Federated Automatic Speaker...

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International Conference on Acoustics, Speech, and Signal Processing (ICASSP)

作者： Longling Zhang Lyqi Liu Dan Meng Jun Wang Shengshan Hu School of Cyber Science and Engineering Huazhong University of Science and Technology China National Engineering Research Center for Big Data Technology and System Services Computing Technology and System Lab Hubei Key Laboratory of Distributed System Security Hubei Engineering Research Center on Big Data Security OPPO Research Institute China

Automatic speech verification (ASV) authenticates individuals based on distinct vocal patterns, playing a pivotal role in many applications such as voice-based unlocking systems for devices. The ASV system comprises three stages: training, registration, and validation. The model refines using voice data in training, extracts vocal features in registration, and contrasts these with speech patterns in validation. Modern ASV models, primarily grounded in DNN architectures, require extensive data for training. Federated learning (FL) fosters model-sharing across multiple clients while ensuring data privacy. Due to its open architecture, FL is vulnerable to backdoor attacks. However, training a stealthy backdoor attack in FL presents challenges, including diminished attack generalization owing to data heterogeneity, and conspicuous triggers that render them easily detectable. In this paper, we propose a Federated Stealthy Backdoor Attack method ($FedSBA$). FedSBA aims to improve the attack model’s generalization, enhance its persistence, and elude anomaly detection under the heterogeneous data distribution. FedSBA constructs an attack model based on a personalized transformer and encompasses a stealthy trigger. Moreover, we also propose a defensive strategy that utilizes an adaptive weight aggregation scheme. The stealthiness and effectiveness of FedSBA are demonstrated by exhibiting superior performance in comparison to previous works.

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Learning Group-Disentangled Representation for Interpretable Thoracic Pathologic Prediction

Learning Group-Disentangled Representation for Interpretable...

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IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

作者： Hao Li Yirui Wu Hexuan Hu Hu Lu Yong Lai Shaohua Wan Key Laboratory of Water Big Data Technology of Ministry of Water Resources Hohai University College of Computer and Information Hohai University Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University School of Computer Science and Communication Engineering Jiangsu University Shenzhen Institute for Advanced Study University of Electronic Science and Technology of China

ISBN: (数字)9781665468190

ISBN: (纸本)9781665468206

Deep learning methods have shown significant performance in medical image analysis tasks. However, they generally act like ”black box” without explanations in both feature extraction and decision processes, leading to lack of clinical insights and high risk assessments. To aid deep learning in envisioning diseases with visual clues, we propose Representation Group-Disentangling Network (RGD-Net), which can completely disentangle feature space of input X-ray images into several independent feature groups, each corresponding to a specific disease. Taking several semantically related and labeled X-ray images as input, RGD-Net firstly extracts completely group-disentangled representations of diseases through Group-Disentangle Module, which applies group-swap and linking operations to construct latent space by enforcing semantic consistency of attributes. To prevent learning degenerate representations defined as shortcut problem, we further introduce adversarial constricts on mapping from features to diseases, thus avoiding model collapse with former free-form disentanglement. Experiments on chestxray-14 and ChestXpert datasets demonstrate that RGD-Net are effective in predicting diseases with remarkable advantages, which leverage potential factors contributing to different diseases, thus enhancing interpretability in working patterns of deep learning methods.

关键词： Deep learning Training Visualization Image analysis Semantics Feature extraction Risk management

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Real-time Semantic Segmentation via Spatial-detail Guided Context Propagation

arXiv

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arXiv 2020年

作者： Hao, Shijie Zhou, Yuan Guo, Yanrong Hong, Richang Cheng, Jun Wang, Meng Key Laboratory of Knowledge Engineering with Big Data Hefei University of Technology Ministry of Education School of Computer Science and Information Engineering Hefei University of Technology Hefei230009 China CAS Key Laboratory of Human-Machine Intelligence-Synergy Systems Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Chinese University of Hong Kong Hong Kong

Nowadays, vision-based computing tasks play an important role in various real-world applications. However, many vision computing tasks, e.g. semantic segmentation, are usually computationally expensive, posing a challenge to the computing systems that are resource-constrained but require fast response speed. Therefore, it is valuable to develop accurate and real-time vision processing models that only require limited computational resources. To this end, we propose the Spatial-detail Guided Context Propagation Network (SGCPNet) for achieving real-time semantic segmentation. In SGCPNet, we propose the strategy of spatial-detail guided context propagation. It uses the spatial details of shallow layers to guide the propagation of the low-resolution global contexts, in which the lost spatial information can be effectively reconstructed. In this way, the need for maintaining high-resolution features along the network is freed, therefore largely improving the model efficiency. On the other hand, due to the effective reconstruction of spatial details, the segmentation accuracy can be still preserved. In the experiments, we validate the effectiveness and efficiency of the proposed SGCPNet model. On the Citysacpes dataset, for example, our SGCPNet achieves 69.5% mIoU segmentation accuracy, while its speed reaches 178.5 FPS on 768×1536 images on a GeForce GTX 1080 Ti GPU card. In addition, SGCPNet is very lightweight and only contains 0.61 M parameters. The code will be released at https://***/zhouyuan888888/SGCPNet. Copyright © 2020, The Authors. All rights reserved.

关键词： Semantic Segmentation

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