Multiparty dialogue question answering (QA) within machine reading comprehension (MRC) presents significant challenges due to the complex interplay of information across multiple speakers and the need for advanced log...
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Fuel cells are made from fuel and *** of its low pollution,high energy conversion efficiency and high reliability,fuel cell has become the future direction of new energy application,the technological development path ...
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Fuel cells are made from fuel and *** of its low pollution,high energy conversion efficiency and high reliability,fuel cell has become the future direction of new energy application,the technological development path in the field of fuel cell research has great significance to the development of technological and energy *** the patent analysis method,this paper analyses the patent data from Derwent Innovation Index quantitively to study the state of application for patents,core technologies,highly cited patents and the main *** shows that auxiliary device and related methods were a research hotspot in recent years;as the biggest patent holder of fuel cell technologies,Toyota,Honda motor *** Nissan motor *** an *** paper has discovered some potential problems behind the phenomena and some suggestions are put forward finally.
With the high mortality rate for the cases of malignant tumors, the discovery and early treatment of cancer is critical to improving the 5-year survival rate of cancer. The biggest challenge in control and prevention ...
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The understory terrain is an essential component of forest vertical structure and ecosystem health, providing crucial insights for resource assessment and forestry surveys. This letter proposes a novel method for extr...
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Synthetic lethality describes an interaction whereby the co-occurrence of two mutations leads to cell death but one mutation alone does not,which can be exploited for cancer therapeutics.1 Due to lacking effective non...
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Synthetic lethality describes an interaction whereby the co-occurrence of two mutations leads to cell death but one mutation alone does not,which can be exploited for cancer therapeutics.1 Due to lacking effective nonsurgical treatment and early clinical diagnosis markers,patients have high mortality and low overall survival rates in cholangiocarcinoma(CCA).
Novel coronavirus disease 2019(COVID-19)is an ongoing health *** studies are related to ***,its molecular mechanism remains *** rapid publication of COVID-19 provides a new way to elucidate its mechanism through compu...
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Novel coronavirus disease 2019(COVID-19)is an ongoing health *** studies are related to ***,its molecular mechanism remains *** rapid publication of COVID-19 provides a new way to elucidate its mechanism through computational *** paper proposes a prediction method for mining genotype information related to COVID-19 from the perspective of molecular mechanisms based on machine *** method obtains seed genes based on prior *** genes are mined from biomedical *** candidate genes are scored by machine learning based on the similarities measured between the seed and candidate ***,the results of the scores are used to perform functional enrichment analyses,including KEGG,interaction network,and Gene Ontology,for exploring the molecular mechanism of *** results show that the method is promising for mining genotype information to explore the molecular mechanism related to COVID-19.
Construction of network-based academic resources is undergoing rapid development in this big data era, displaying a trend to replace digital libraries. This challenge calls for the construction of digital libraries to...
Construction of network-based academic resources is undergoing rapid development in this big data era, displaying a trend to replace digital libraries. This challenge calls for the construction of digital libraries to have big data related considerations, i.e., from resource construction aspect, we should expand the resource scope, aggrandize the breadth of resource integration, and increase the depth of the resource organization and processing;from technology application aspect, we should attach great importance to the semantic technology, emphasize the application of clustering technology, widely adopt data analysis technology, and elevate the retrieval technology level;from service aspect, we need to enrich services and product categories of digital libraries, and convert the passive, and general service mode to the proactive and personalized mode. The construction of next generation digital libraries must differ from the traditional way. Comprehensive service ideas should be established;comprehensive resource services should be provided;the conventional service mode and transmission form also need to be expanded;even the librarians of digital libraries are required to become data analysts.
Long non-coding RNAs(lncRNAs)play an important role in many life activities such as epigenetic material regulation,cell cycle regulation,dosage compensation and cell differentiation regulation,and are associated with ...
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Long non-coding RNAs(lncRNAs)play an important role in many life activities such as epigenetic material regulation,cell cycle regulation,dosage compensation and cell differentiation regulation,and are associated with many human *** are many limitations in identifying and annotating lncRNAs using traditional biological experimental *** the development of high-throughput sequencing technology,it is of great practical significance to identify the lncRNAs from massive RNA sequence data using machine learning *** on the Bagging method and Decision Tree algorithm in ensemble learning,this paper proposes a method of lncRNAs gene sequence identification called *** identification results of this classification method are compared with the identification results of several models including Byes,Support Vector Machine,Logical Regression,Decision Tree and Random *** experimental results show that the lncRNAs identification method named BDLR proposed in this paper has an accuracy of 86.61%in the human test set and 90.34%in the mouse for lncRNAs,which is more than the identification results of the other ***,the proposed method offers a reference for researchers to identify lncRNAs using the ensemble learning.
The lifestyle transition of fungi,defined as switching from taking organic material as nutrients to pathogens,is a fundamental phenomenon in ***,the mechanisms of such transition remain largely *** we show microRNA-li...
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The lifestyle transition of fungi,defined as switching from taking organic material as nutrients to pathogens,is a fundamental phenomenon in ***,the mechanisms of such transition remain largely *** we show microRNA-like RNAs(milRNAs)play a key role in fungal lifestyle transition for the first *** identified milRNAs by small RNA sequencing in Arthrobotrys oligospora,a known nematode-trapping *** them,7 highly expressed milRNAs were confirmed by northern-blot *** out two milRNAs significantly decreased ***’s ability to switch *** further identified that two of these milRNAs were associated with argonaute protein QDE-2 by RNA-immunoprecipitation(RIP)*** of the predicted target genes of milRNAs were found in immunoprecipitation(IP)products of *** of argonaute gene qde-2 also led to serious defects in lifestyle ***,knocking out individual milRNAs or qde-2 lead to diverse responses under different conditions,and qde-2 itself may be targeted by the ***,it indicates the lifestyle transition of fungi is mediated by milRNAs through RNA interference(RNAi)machinery,revealing the wide existence of miRNAs in fungi kingdom and providing new insights into understanding the adaptation of fungi from scavengers to predators and the mechanisms underlying fungal infections.
With the high mortality rate for the cases of malignant tumors, the discovery and early treatment of cancer is critical to improving the 5-year survival rate of cancer. The biggest challenge in control and prevention ...
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ISBN:
(纸本)9781450372510
With the high mortality rate for the cases of malignant tumors, the discovery and early treatment of cancer is critical to improving the 5-year survival rate of cancer. The biggest challenge in control and prevention is how to detect tumors as early as possible, so that the most effective means can be used for treatment. With the help of the WOS database, researchers found that liquid biopsy, genetic material/protein expression and computer imaging play an important role in cancer detection. Through analysis of the history and current status of cancer detection technology development, this paper also aims to provide guidance for the clinical practice of current cancer screening and provide inspiration for future technological development.
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