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31st International Conference on Computational Linguistics, COLING 2025

作者： Zhou, Shu Zhao, Rui Zhou, Zhengda Yi, Haohan Zheng, Xuhui Wang, Hao Nanjing University China Key Laboratory of Data Engineering and Knowledge Services in Jiangsu Provincial Universities Nanjing University China University of Technology Sydney Australia

ISBN: (纸本)9798891761964

Multiparty dialogue question answering (QA) within machine reading comprehension (MRC) presents significant challenges due to the complex interplay of information across multiple speakers and the need for advanced logical reasoning. While existing models often focus on separating dialogue information based on speakers and utterances, they rarely address the crucial aspect of logical inference, leading to suboptimal performance in understanding and answering questions. To bridge this gap, we introduce the Logical Inference Memory Network (LIMN), a novel architecture designed for extractive QA in multiparty dialogues. LIMN incorporates a unique inference module pretrained on plain text QA datasets (like SQuAD 2.0), enabling it to transfer robust logical reasoning abilities to the dialogue domain. This module generates representations that are specifically attuned to logical inference, which are then integrated into the dialogue context. Furthermore, we propose a key-utterance-based interaction mechanism that dynamically focuses on the most relevant utterances within the dialogue, enhancing the model's ability to pinpoint answers. To ensure robust performance, LIMN employs a multitask learning strategy that jointly optimizes for answer extraction, answerability prediction, key-utterance identification, and masked speaker prediction. Extensive experiments on the Molweni and FriendsQA benchmarks, encompassing 25,000 and 10,000 questions respectively, demonstrate that LIMN achieves state-of-the-art results, affirming the effectiveness of incorporating logical inference in multiparty dialogue QA. © 2025 Association for Computational Linguistics.

关键词： Memory architecture

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Inhibition of ALDH2 by disulfiram leads to synthetic lethality via ROS strikes twice in ARID1A-deficient cholangiocarcinoma

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Genes & Diseases 2023年第1期10卷 69-71页

作者： Tingming Liang Lin Jia Rui Duan Lulu Shen Dekang Ren Yujie Ren Yuyang Dou Li Guo Jiangsu Key Laboratory for Molecular and Medical Biotechnology School of Life ScienceNanjing Normal UniversityNanjingJiangsu210023China Department of Bioinformatics Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu ProvinceSchool of Geographic and Biologic InformationNanjing University of Posts and TelecommunicationsNanjingJiangsu 210023China

Synthetic lethality describes an interaction whereby the co-occurrence of two mutations leads to cell death but one mutation alone does not,which can be exploited for cancer therapeutics.1 Due to lacking effective nonsurgical treatment and early clinical diagnosis markers,patients have high mortality and low overall survival rates in cholangiocarcinoma(CCA).

关键词： diagnosis mortality alone

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LRCu: A High-Performance Parallel Program for Identifying Hub Genes 17

LRCu: A High-Performance Parallel Program for Identifying Hu...

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17th International Congress on Image and Signal Processing, BioMedical engineering and Informatics, CISP-BMEI 2024

作者： Liu, Jiaxin Ji, Xinglai Nanjing University of Posts and Telecommunications Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province Nanjing210003 China Yunnan University State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunan Kunming650091 China

ISBN: (纸本)9798331507398

The LeaderRank algorithm identifies influential nodes using the idea of the random walk and performs well in the identification of hub genes in biological networks. The rapid development of biological technologies promotes the evolution of networks to be highly complex and increasing largely in size. In this study, we introduce LRCu, for computing LeaderRank using CUDA, to identify hub genes. The results show that the parallel implementation is highly effective and achieves a speedup of more than 42 times for a 13,000-gene network, thereby enhancing large-scale network computation. © 2024 IEEE.

关键词： CUDA gene co-expression network hub gene parallel computing

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BDLR:lncRNA identification using ensemble learning

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BIOCELL 2022年第4期46卷 951-960页

作者： LEJUN GONG SHEHAI ZHOU JINGMEI CHEN YONGMIN LI LI ZHANG ZHIHONG GAO Jiangsu Key Lab of Big Data Security&Intelligent Processing School of Computer Science Nanjing University of Posts and TelecommunicationsNanjing210046China Smart Health Big Data Analysis and Location Services Engineering Laboratory of Jiangsu Province Nanjing210046China Zhejiang Engineering Research Center of Intelligent Medicine Wenzhou325035China College of Computer Science and Technology Nanjing Forestry UniversityNanjing210037China

Long non-coding RNAs(lncRNAs)play an important role in many life activities such as epigenetic material regulation,cell cycle regulation,dosage compensation and cell differentiation regulation,and are associated with many human *** are many limitations in identifying and annotating lncRNAs using traditional biological experimental *** the development of high-throughput sequencing technology,it is of great practical significance to identify the lncRNAs from massive RNA sequence data using machine learning *** on the Bagging method and Decision Tree algorithm in ensemble learning,this paper proposes a method of lncRNAs gene sequence identification called *** identification results of this classification method are compared with the identification results of several models including Byes,Support Vector Machine,Logical Regression,Decision Tree and Random *** experimental results show that the lncRNAs identification method named BDLR proposed in this paper has an accuracy of 86.61%in the human test set and 90.34%in the mouse for lncRNAs,which is more than the identification results of the other ***,the proposed method offers a reference for researchers to identify lncRNAs using the ensemble learning.

关键词： lncRNAs High-throughput sequencing Ensemble learning Bagging Decision Tree

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The Master-Slave Encoder Model for Improving Patent Text Summarization: A New Approach to Combining Specifications and Claims

arXiv

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arXiv 2024年

作者： Zhou, Shu Wang, Xin Zhou, Zhengda Yi, Haohan Zheng, Xuhui Wang, Hao School of Information Management Nanjing University China Key Laboratory of Data Engineering and Knowledge Services in Jiangsu Provincial Universities Nanjing University China Baidu Inc. Beijing China

In order to solve the problem of insufficient generation quality caused by traditional patent text abstract generation models only originating from patent specifications, the problem of new terminology OOV caused by rapid patent updates, and the problem of information redundancy caused by insufficient consideration of the high professionalism, accuracy, and uniqueness of patent texts, we proposes a patent text abstract generation model (MSEA) based on a master-slave encoder architecture;Firstly, the MSEA model designs a master-slave encoder, which combines the instructions in the patent text with the claims as input, and fully explores the characteristics and details between the two through the master-slave encoder;Then, the model enhances the consideration of new technical terms in the input sequence based on the pointer network, and further enhances the correlation with the input text by re weighing the "remembered" and "for-gotten" parts of the input sequence from the encoder;Finally, an enhanced repetition suppression mechanism for patent text was introduced to ensure accurate and non redundant abstracts generated. On a publicly available patent text dataset, compared to the state-of-the-art model, Improved Multi-Head Attention Mechanism (IMHAM), the MSEA model achieves an improvement of 0.006, 0.005, and 0.005 in Rouge-1, Rouge-2, and Rouge-L scores, respectively. MSEA leverages the characteristics of patent texts to effectively enhance the quality of patent text generation, demonstrating its advancement and effectiveness in the experiments. Copyright © 2024, The Authors. All rights reserved.

关键词： Specifications

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Predicting Genotype Information Related to COVID-19 for Molecular Mechanism Based on Computational Methods

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Computer Modeling in engineering & Sciences 2021年第10期129卷 31-45页

作者： Lejun Gong Xingxing Zhang Li Zhang Zhihong Gao Jiangsu Key Laboratory of Big Data Security&Intelligent Processing School of Computer Science Nanjing University of Posts and TelecommunicationsNanjing210046China Smart Health Big Data Analysis and Location Services Engineering Laboratory of Jiangsu Province Nanjing210046China College of Computer Science and Technology Nanjing Forestry UniversityNanjing210037China Zhejiang Engineering Research Center of Intelligent Medicine Wenzhou325035China

Novel coronavirus disease 2019(COVID-19)is an ongoing health *** studies are related to ***,its molecular mechanism remains *** rapid publication of COVID-19 provides a new way to elucidate its mechanism through computational *** paper proposes a prediction method for mining genotype information related to COVID-19 from the perspective of molecular mechanisms based on machine *** method obtains seed genes based on prior *** genes are mined from biomedical *** candidate genes are scored by machine learning based on the similarities measured between the seed and candidate ***,the results of the scores are used to perform functional enrichment analyses,including KEGG,interaction network,and Gene Ontology,for exploring the molecular mechanism of *** results show that the method is promising for mining genotype information to explore the molecular mechanism related to COVID-19.

关键词： COVID-19 SARS-CoV-2 computational method bioinformatics genotype machine learning

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Salient Patch Based NAS for Grading of Colorectal Cancer Histology Images 13

Salient Patch Based NAS for Grading of Colorectal Cancer His...

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13th International Multi-Conference on Complexity, Informatics and Cybernetics, IMCIC 2022

作者： Meng, Hang Li, Fei Yang, Zhen Zhu, Qiang Fan, Chaogang Zhan, Shu Key Laboratory of Knowledge Engineering with Big Data Ministry of Education Hefei University of Technology Anhui Province Hefei230009 China The Second Affiliated Hospital of Anhui Medical University Anhui Province Hefei230601 China Tongcheng Teachers College Anhui Province Tongcheng231400 China Department of General Surgery The Affiliated BenQ Hospital of Nanjing Medical University Jiangsu Province Nanjing210021 China

ISBN: (纸本)9781950492619

Digital histopathological tissue images are gold material for cancer diagnosis and grades. Convolutional Neural Networks (CNNs) are state-of-the-art models in many image classification tasks. However, considering the limited computing resources, it is not practical to directly train CNNs on gigapixel resolution histopathological tissue images. Therefore, the entire histopathological image is commonly divided into a grid of patches and then fed each patch to CNNs, but not all patches are necessary for specific tasks. Besides, although CNNs are excellent image classifiers, many pre-trained models are based on natural images. Neural Architecture Search (NAS) can realize automatic search, construction, and training specific problemoriented networks. We present salient patch based NAS for grading colorectal cancer (CRC) histology images with these motivations. The proposed framework first applies the classic classification network to extract significant patches from the whole image, then use the network obtained by NAS to grade the patches, and finally aggregates the patch-level predictions to generate the entire CRC histological image label. Our experiments on microscopic colorectal tissue images demonstrate that the proposed method is sufficient to obtain more accurate classification results compared to its counterparts. We also conducted a comprehensive analysis of the different scenarios of the proposed method. © by the International Institute of Informatics and Systemics.

关键词： Grading

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LRCu: A High-Performance Parallel Program for Identifying Hub Genes

LRCu: A High-Performance Parallel Program for Identifying Hu...

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International Congress on Image and Signal Processing, BioMedical engineering and Informatics (CISP-BMEI)

作者： Jiaxin Liu Xinglai Ji Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province Nanjing University of Posts and Telecommunications Nanjing China State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunan Yunnan University Kunming China

ISBN: (数字)9798331507398

ISBN: (纸本)9798331507404

关键词： Evolution (biology) Signal processing algorithms Graphics processing units Signal processing Informatics Biomedical engineering

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Soft Film Plate Method Based Ultrafine Ag-Cu Nanosheets with Multi-Nanozyme Activities for Neurotransmitter Biosensing

SSRN

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SSRN 2023年

作者： Kong, Lijun Fan, Lin Liu, Hao Zhang, JiaWei Hu, Mengdi Fan, Li Zhu, Hongliang Yan, Shancheng School of Geographic and Biologic Information Smart Health Big Data Analysis and Location Services Engineering Research Center of Jiangsu Province Nanjing University of Posts and Telecommunications Nanjing210023 China State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and Devices Southeast University Nanjing210096 China Nanjing University Nanjing210093 China

Ag and Cu based nanostructures serve as advanced functional materials for biomedical applications, due to their unique properties. Here, we proposed a novel Neurotransmitter Biosensing method based on Ag-Cu composite nanozyme, synthesized through the soft film plate method. Supported by the soft film template, the Ag-Cu nanozymes were stably kept to an ultrafine 2D structure with high monodispersity, which provided a large specific surface area and sufficient binding sites, leading to controllable and improved multi-nanozyme activities over similar-sized mono-Ag and mono-Cu, and up to 4.95 times of natural enzyme-level. Beyond that, the multi-path enzymatic reaction processes catalyzed by Ag-Cu composite nanozymes were firstly theoretically discussed in detail, according to the theoretical redox potential of redox couples in the reaction systems. On this basis, the Ag-Cu nanosheets based Neurotransmitter Biosensing is successfully applied in rapid detection for glutathione and dopamine, possessing a linear range of 10~100 μM and 1~10 μM, and a detection limit of 5.066 μM and 0.288 μM, respectively, which exhibited superior performance for biomedical purposes over most commercially available products in speed and precision. © 2023, The Authors. All rights reserved.

关键词： Binary alloys

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Soft Film Plate Method Based Ultrafine Ag-Cu Nanosheets with Multi-Nanozyme Activities for Neurotransmitter Biosensing

SSRN

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SSRN 2023年

作者： Fan, Lin Kong, Lijun Liu, Hao Zhang, JiaWei Hu, Mengdi Fan, Li Zhu, Hongliang Yan, Shancheng School of Geographic and Biologic Information Smart Health Big Data Analysis and Location Services Engineering Research Center of Jiangsu Province Nanjing University of Posts and Telecommunications Nanjing210023 China Nanjing University Nanjing210093 China State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and Devices Southeast University Nanjing210096 China

Ag and Cu based nanostructures serve as advanced functional materials for biomedical applications, due to their unique properties. Here, we proposed a novel neurotransmitter biosensing method based on Ag-Cu composite nanozyme, synthesized through the soft film plate method. Supported by the soft film template, the Ag-Cu nanozymes were stably kept to an ultrafine 2D structure with high monodispersity, which provided a large specific surface area and sufficient binding sites, leading to controllable and improved multi-nanozyme activities over similar-sized mono-Ag and mono-Cu, and up to 4.95 times of natural enzyme-level. The multi-path enzymatic reaction processes catalyzed by Ag-Cu composite nanozymes were firstly theoretically discussed in detail, according to the theoretical redox potential of redox couples in the reaction systems. On this basis, the Ag-Cu nanosheets based neurotransmitter biosensing is successfully applied in rapid detection for glutathione and dopamine, possessing a linear range of 10~100 μM and 1~10 μM, and a detection limit of 3.01 μM and 0.29 μM, respectively, which exhibited superior performance for biomedical purposes over most commercially available products in speed and precision. © 2023, The Authors. All rights reserved.

关键词： Binary alloys

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