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arXiv 2023年

作者： Yao, Wenpo Yao, Wenli Wang, Jun School of Geographic and Biologic Information Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province Nanjing University of Posts and Telecommunications Nanjing210023 China Ministry of Education State Key Laboratory of Hydroscience and Engineering Tsinghua University Beijing100084 China

Objective. The distribution of equal states (DES) quantifies amplitude fluctuations in biomedical signals. However, under certain conditions, such as a high resolution of data collection or special signal processing techniques, equal states may be very rare, whereupon the DES fails to measure the amplitude fluctuations. Approach. To address this problem, we develop a novel threshold DES (tDES) that measures the distribution of differential states within a threshold. To evaluate the proposed tDES, we first analyze five sets of synthetic signals generated in different frequency bands. We then analyze sleep electroencephalography (EEG) datasets taken from the public PhysioNet. Main results. Synthetic signals and detrend-filtered sleep EEGs have no neighboring equal values;however, tDES can effectively measure the amplitude fluctuations within these data. The tDES of EEG data increases significantly as the sleep stage increases, even with datasets covering very short periods, indicating decreased amplitude fluctuations in sleep EEGs. Generally speaking, the presence of more low-frequency components in a physiological series reflects smaller amplitude fluctuations and larger DES. *** tDES provides a reliable computing method for quantifying amplitude fluctuations, exhibiting the characteristics of conceptual simplicity and computational robustness. Our findings broaden the application of quantitative amplitude fluctuations and contribute to the classification of sleep stages based on EEG data. © 2023, CC0.

关键词： Electroencephalography

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SAMPLING LOVÁSZ LOCAL LEMMA FOR GENERAL CONSTRAINT SATISFACTION SOLUTIONS IN NEAR-LINEAR TIME

arXiv

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arXiv 2022年

作者： He, Kun Wang, Chunyang Yin, Yitong The Key Lab of Data Engineering and Knowledge Engineering MOE Renmin University of China No. 59 Zhongguancun Street Haidian District Beijing China State Key Laboratory for Novel Software Technology Nanjing University 163 Xianlin Avenue Jiangsu Province Nanjing China

We give a fast algorithm for sampling uniform solutions of general constraint satisfaction problems (CSPs) in a local lemma regime. Suppose that the CSP has n variables with domain size at most q, each constraint contains at most k variables, shares variables with at most Δ constraints, and is violated with probability at most p by a uniform random assignment. The algorithm returns an almost uniform satisfying assignment in expected poly(q,k, Δ) ·(n) time, as long as a local lemma condition is satisfied: k · p · q2 · Δ5 ≤ C0 for a suitably small absolute constant C0. Previously, under similar local lemma conditions, sampling algorithms with running time polynomial in both nand Δ were only known for the almost atomic case, where each constraint is violated by a small number of forbidden local configurations. The key term Δ5 in our local lemma condition also improves the previously best known Δ7 for general CSPs [JPV21b] and Δ5.714 for atomic CSPs, including the special case of k-CNF [JPV21a, HSW21]. Our sampling approach departs from previous fast algorithms for sampling LLL, which were based on Markov chains. A crucial step of our algorithm is a recursive marginal sampler that is of independent interests. Within a local lemma regime, this marginal sampler can draw a random value for a variable according to its marginal distribution, at a cost independent of the size of the CSP. Copyright © 2022, The Authors. All rights reserved.

关键词： Constraint satisfaction problems

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The Development Trends of Fuel Cell Technologies Based on Patent Analysis

The Development Trends of Fuel Cell Technologies Based on Pa...

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2019 International Conference on Building Energy Conservation, Thermal Safety and Environmental Pollution Control, ICBTE 2019

作者： Tan Xinyu Zhang Yingxuan Deng Sanhong School of Information Management Nanjing university Key Laboratory of Data Engineering and Knowledge Services in Jiangsu Province

Fuel cells are made from fuel and *** of its low pollution,high energy conversion efficiency and high reliability,fuel cell has become the future direction of new energy application,the technological development path in the field of fuel cell research has great significance to the development of technological and energy *** the patent analysis method,this paper analyses the patent data from Derwent Innovation Index quantitively to study the state of application for patents,core technologies,highly cited patents and the main *** shows that auxiliary device and related methods were a research hotspot in recent years;as the biggest patent holder of fuel cell technologies,Toyota,Honda motor *** Nissan motor *** an *** paper has discovered some potential problems behind the phenomena and some suggestions are put forward finally.

关键词： Fuel cells

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Networked Information Interactions in Schizophrenia Magnetoencephalograms Based on Permutation Transfer Entropy

SSRN

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SSRN 2023年

作者： Wang, Qiong Yang, Xinran Yan, Wei Yu, Jiafeng Wang, Jun School of Telecommunications and Information Engineering Nanjing University of Posts and Telecommunications Jiangsu Nanjing210003 China School of Geographic and Biologic Information Smart Health Big Data Analysis and Location Services Engineering Research Center of Jiangsu Province Nanjing University of Posts and Telecommunications Jiangsu Nanjing210023 China School of Physics and Information Engineering Jiangsu Second Normal University Jiangsu Nanjing210013 China Department of Psychiatry Affiliated Nanjing Brain Hospital Nanjing Medical University Jiangsu Nanjing210029 China Shandong Key Laboratory of Biophysics Institute of Biophysics Dezhou University Dezhou253023 China

Brain network science plays an important role in the exploration of neurological and psychiatric diseases. To explore the information interactions in the magnetoencephalogram (MEG) data of schizophrenia, we construct resting-state brain networks based on permutation transfer entropy in 17 schizophrenia patients (SCZs) and 14 healthy controls (HCs). In this process, the effects of equal values on permutation and probability distribution are particularly considered. We quantify three network features, namely, weight, complexity and nonequilibrium, to characterize the schizophrenia MEG network. The results indicate that the level of information interactions between brain regions, the inward, outward and total information flows in brain regions of SCZs are generally smaller than those of HCs. In the complexity analysis, the Shannon entropy of the information inflows and outflows in the right parietal region of SCZs exhibits significant differences, and further the Shannon entropy of the information inflows (p=0.003) and outflows (p=0.034) of the whole brain of SCZs is significantly higher than that for HCs. Additionally, SCZs have lower values of local nonequilibrium than HCs in all brain regions except the middle central and middle frontal regions, with the right parietal region having the strongest significance (p=0.015), and the whole-brain nonequilibrium of SCZs is significantly lower than that of HCs (p=0.022). The MEG network constructed based on permutation transfer entropy can be used to effectively extract the characteristics of schizophrenia, and the comparative analysis of the complexity and nonequilibrium features can expand the exploration of the pathological and physiological mechanisms of schizophrenia. © 2023, The Authors. All rights reserved.

关键词： Probability distributions

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The lifestyle transition of Arthrobotrys oligospora is mediated by microRNA-like RNAs

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Science China(Life Sciences) 2020年第4期63卷 543-551页

作者： Xinglai Ji Heng Li Weihua Zhang Jiai Wang Lianming Liang Chenggang Zou Zefen Yu Shuqun Liu Ke-Qin Zhang State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Yunnan UniversityKunming 650091China Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province Nanjing University of Posts and TelecommunicationsNanjing 210023China Institute of Medical Biology Chinses Academy of Medical Sciences&Peking Union Medical CollegeKunming 650118China

The lifestyle transition of fungi,defined as switching from taking organic material as nutrients to pathogens,is a fundamental phenomenon in ***,the mechanisms of such transition remain largely *** we show microRNA-like RNAs(milRNAs)play a key role in fungal lifestyle transition for the first *** identified milRNAs by small RNA sequencing in Arthrobotrys oligospora,a known nematode-trapping *** them,7 highly expressed milRNAs were confirmed by northern-blot *** out two milRNAs significantly decreased ***’s ability to switch *** further identified that two of these milRNAs were associated with argonaute protein QDE-2 by RNA-immunoprecipitation(RIP)*** of the predicted target genes of milRNAs were found in immunoprecipitation(IP)products of *** of argonaute gene qde-2 also led to serious defects in lifestyle ***,knocking out individual milRNAs or qde-2 lead to diverse responses under different conditions,and qde-2 itself may be targeted by the ***,it indicates the lifestyle transition of fungi is mediated by milRNAs through RNA interference(RNAi)machinery,revealing the wide existence of miRNAs in fungi kingdom and providing new insights into understanding the adaptation of fungi from scavengers to predators and the mechanisms underlying fungal infections.

关键词： lifestyle transition Arthrobotrys oligospora,microRNA-like RNAs nematode-trapping fungi trap induction fungal adaptation

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Research progress of CDT 8

Research progress of CDT

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8th International Conference on Bioinformatics and Biomedical Science, ICBBS 2019

作者： Yuting, Gao Shutong, Shen Sanhong, Deng School of Information Management Nanjing University China Key Laboratory of Data Engineering and Knowledge Services in Jiangsu China

ISBN: (纸本)9781450372510

With the high mortality rate for the cases of malignant tumors, the discovery and early treatment of cancer is critical to improving the 5-year survival rate of cancer. The biggest challenge in control and prevention is how to detect tumors as early as possible, so that the most effective means can be used for treatment. With the help of the WOS database, researchers found that liquid biopsy, genetic material/protein expression and computer imaging play an important role in cancer detection. Through analysis of the history and current status of cancer detection technology development, this paper also aims to provide guidance for the clinical practice of current cancer screening and provide inspiration for future technological development. © 2019 Association for Computing Machinery.

关键词： Gene expression

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Research Progress of CDT 19

Research Progress of CDT

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Proceedings of the 2019 8th International Conference on Bioinformatics and Biomedical Science

作者： Gao Yuting Shen Shutong Deng Sanhong School of Information Management Nanjing University China School of Information Management Nanjing University China Key Laboratory of Data Engineering and Knowledge Services in Jiangsu Province

ISBN: (纸本)9781450372510

关键词： Biopharmaceutical engineering Tissue Biopsy Cancer Detection Imaging Technology Tumor Marker Gene Expression

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Rankings never really quantify contributions: A quantitative and qualitative study on universities and their libraries

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Journal of Library Science in China 2020年 117-126页

作者： Shelia X.WEI Ronda J.ZHANG Howell Y.WANG CAO Cong Fred Y.YE International Joint Informatics Laboratory & Jiangsu Key Laboratory of Data Engineering and Knowledge Services School of Information Management Nanjing University Nottingham University Business School University of Nottingham

By comparing quantitative ranking with qualitative contributions, we reveal that academic assessment has to put real contributions ahead of quantitative indicators and that rankings have nothing to do with universities’ and their libraries’ true values. The greatness of a university lies in its impacts on the progress for human knowledge and the promotion for social development. Although ranking of universities by way of quantitative indicators can reflect some information, we should pay more attention to qualitative contributions.

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Comparative analysis of time irreversibility and amplitude irreversibility based on joint permutation

arXiv

引用

arXiv 2022年

作者： Yao, Wenpo Yao, Wenli Xu, Rongshuang Wang, Jun School of Geographic and Biologic Information Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province Nanjing University of Posts and Telecommunications Nanjing210023 China Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan University Ministry of Education China Department of Hydraulic Engineering School of Civil Engineering Tsinghua University Beijing100084 China School of Applied Meteorology Nanjing University of Information Science & Technology Nanjing210044 China

Although time irreversibility (TIR) and amplitude irreversibility (AIR) are relevant concepts for nonequilibrium analysis, their association has received little attention. This paper conducts a systematic comparative analysis of the relationship between TIR and AIR based on statistical descriptions and numerical simulations. To simplify the quantification of TIR and AIR, the amplitude permutation and global information of the associated vector are combined to produce a joint probability estimation. Chaotic logistic, Henon, and Lorenz series are generated to evaluate TIR and AIR according to surrogate theory, and the distributions of joint permutations for these model series are measured to compare the degree of TIR and AIR. The joint permutation TIR and AIR are then used to investigate nonequilibrium pathological features in epileptic electroencephalography data. Test results suggest that epileptic brain electrical activities, particular those during the onset of seizure, manifest higher nonequilibrium characteristics. According to the statistical definitions and targeted pairs of joint permutations in the chaotic model data, TIR and AIR are fundamentally different nonequilibrium descriptors from time- and amplitude-reversibility, respectively, and thus require different forms of numerical analysis. At the same time, TIR and AIR both provide measures for fluctuation theorems associated with nonequilibrium processes, and have similar probabilistic differences in the pairs of joint permutations and consistent outcomes when used to analyze both the model series and real-world signals. Overall, comparative analysis of TIR and AIR contributes to our understanding of nonequilibrium features and broadens the scope of quantitative nonequilibrium measures. Additionally, the construction of joint permutations contributes to the development of symbolic time series analysis. Copyright © 2022, The Authors. All rights reserved.

关键词： Electroencephalography

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Local and global structure-aware entropy regularized mean teacher model for 3d left atrium segmentation 23rd

Local and global structure-aware entropy regularized mean te...

引用

23rd International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2020

作者： Hang, Wenlong Feng, Wei Liang, Shuang Yu, Lequan Wang, Qiong Choi, Kup-Sze Qin, Jing School of Computer Science and Technology Nanjing Tech University Nanjing China State Key Laboratory for Novel Software Technology Nanjing University Nanjing China Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province Nanjing University of Posts and Telecommunications Nanjing China Department of Radiation Oncology Stanford University StanfordCA94305 United States CAS Key Laboratory of Human-Machine Intelligence-Synergy Systems Shenzhen Institutes of Advanced Technology Shenzhen China School of Nursing Hong Kong Polytechnic University Hong Kong

ISBN: (纸本)9783030597092

Emerging self-ensembling methods have achieved promising semi-supervised segmentation performances on medical images through forcing consistent predictions of unannotated data under different perturbations. However, the consistency only penalizes on independent pixel-level predictions, making structure-level information of predictions not exploited in the learning procedure. In view of this, we propose a novel structure-aware entropy regularized mean teacher model to address the above limitation. Specifically, we firstly introduce the entropy minimization principle to the student network, thereby adjusting itself to produce high-confident predictions of unannotated images. Based on this, we design a local structural consistency loss to encourage the consistency of inter-voxel similarities within the same local region of predictions from teacher and student networks. To further capture local structural dependencies, we enforce the global structural consistency by matching the weighted self-information maps between two networks. In this way, our model can minimize the prediction uncertainty of unannotated images, and more importantly that it can capture local and global structural information and their complementarity. We evaluate the proposed method on a publicly available 3D left atrium MR image dataset. Experimental results demonstrate that our method achieves outstanding segmentation performances than the state-of-the-art approaches in scenes with limited annotated images. © Springer Nature Switzerland AG 2020.

关键词： Forecasting

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