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Non-invasive biopsy diagnosis of diabetic kidney disease via deep learning applied to retinal images: a population-based study

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The Lancet Digital Health 2025年第5期7卷 100868页

作者： Meng, Ziyao Guan, Zhouyu Yu, Shujie Wu, Yilan Zhao, Yaoning Shen, Jie Lim, Cynthia Ciwei Chen, Tingli Yang, Dawei Ran, An Ran He, Feng Hamzah, Haslina Singh, Sarkaaj Abd Raof, Anis Syazwani Lee-Boey, Jian Wen Samuel Lim, Soo-Kun Sun, Xufang Ge, Shuwang Xu, Gang Su, Hua Cheng, Yang Lu, Feng Liao, Xiaofei Jin, Hai Deng, Chenxin Ruan, Lei Zhang, Cuntai Wu, Chan Dai, Rongping Jin, Yixiao Wang, Wenxiao Li, Tingyao Liu, Ruhan Li, Jiajia Shu, Jia Lu, Yuwei Wang, Xiangning Wu, Qiang Qin, Yiming Tang, Jin Sheng, Xiaohua Jiao, Qiong Yang, Xiaokang Guo, Minyi McKay, Gareth J Hogg, Ruth E Liew, Gerald Chee, Evelyn Yi Lyn Hsu, Wynne Lee, Mong Li Szeto, Simon Luk, Andrea O Y Chan, Juliana C N Cheung, Carol Y Tan, Gavin Siew Wei Tham, Yih-Chung Cheng, Ching-Yu Sabanayagam, Charumathi Lim, Lee-Ling Jia, Weiping Li, Huating Sheng, Bin Wong, Tien Yin Shanghai Belt and Road International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases Department of Computer Science and Engineering School of Electronic Information and Electrical Engineering Institute for Proactive Healthcare Shanghai Jiao Tong University Department of Endocrinology and Metabolism Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Diabetes Institute Shanghai Clinical Centre for Diabetes Shanghai Key Laboratory of Diabetes Mellitus Shanghai China MOE Key Laboratory of AI School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai China Beijing Tsinghua Changgung Hospital Eye Center School of Clinical Medicine Tsinghua Medicine Tsinghua University Beijing China Medical Records and Statistics Office Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China Department of Renal Medicine Singapore General Hospital SingHealth-Duke Academic Medical Centre Singapore Singapore Department of Ophthalmology Shanghai Health and Medical Center Wuxi China Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong Hong Kong Special Administrative Region China Singapore Eye Research Institute Singapore National Eye Centre Singapore Department of Medicine Faculty of Medicine Universiti Malaya Kuala Lumpur Malaysia Department of Ophthalmology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Hubei Wuhan China Department of Nephrology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Nephrology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Ophthalmology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China National Engineering Research Centre for Big Dat

Background: Improving the accessibility of screening diabetic kidney disease (DKD) and differentiating isolated diabetic nephropathy from non-diabetic kidney disease (NDKD) are two major challenges in the field of diabetes care. We aimed to develop and validate an artificial intelligence (AI) deep learning system to detect DKD and isolated diabetic nephropathy from retinal fundus images. Methods: In this population-based study, we developed a retinal image-based AI-deep learning system, DeepDKD, pretrained using 734 084 retinal fundus images. First, for DKD detection, we used 486 312 retinal images from 121 578 participants in the Shanghai Integrated Diabetes Prevention and Care System for development and internal validation, and ten multi-ethnic datasets from China, Singapore, Malaysia, Australia, and the UK (65 406 participants) for external validation. Second, to differentiate isolated diabetic nephropathy from NDKD, we used 1068 retinal images from 267 participants for development and internal validation, and three multi-ethnic datasets from China, Malaysia, and the UK (244 participants) for external validation. Finally, we conducted two proof-of-concept studies: a prospective real-world study with 3 months' follow-up to evaluate the effectiveness of DeepDKD in screening DKD;and a longitudinal analysis of the effectiveness of DeepDKD in differentiating isolated diabetic nephropathy from NDKD on renal function changes with 4·6 years' follow-up. Findings: For detecting DKD, DeepDKD achieved an area under the receiver operating characteristic curve (AUC) of 0·842 (95% CI 0·838–0·846) on the internal validation dataset and AUCs of 0·791–0·826 across external validation datasets. For differentiating isolated diabetic nephropathy from NDKD, DeepDKD achieved an AUC of 0·906 (0·825–0·966) on the internal validation dataset and AUCs of 0·733–0·844 across external validation datasets. In the prospective study, compared with the metadata model, DeepDKD could detect DKD wit

关键词： Deep learning

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Group Signatures with Decentralized Tracing 15th

Group Signatures with Decentralized Tracing

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15th International Conference on Information Security and Cryptology, Inscrypt 2019

作者： Lu, Tingting Li, Jiangtao Zhang, Lei Lam, Kwok-Yan Shanghai Key Laboratory of Trustworthy Computing Software Engineering Institute East China Normal University Shanghai China State Key Laboratory of Cryptology P.O. Box 5159 Beijing China Shanghai Institute for Advanced Communication and Data Science Shanghai China School of Computer Engineering and Science Shanghai University Shanghai China Nanyang Technological University Singapore Singapore

ISBN: (纸本)9783030429201

Group signature is a useful cryptographic primitive that allows a message to be signed by a user on behalf of a group which is managed by some trusted authority, namely the group manager. However, group signature schemes typically place a disturbingly high level of trust on the group manager, which has become a major deployment issue in cyber applications where there is no centralized trust management. In this paper, we investigate mechanisms that aim to achieve a balance between anonymity and accountability in group signatures by decentralizing the operation of tracing the signer. We propose a practical group signature scheme with decentralized tracing. When comparing with a similar result by Benjumea et al. (FC 2008), our proposal has the advantage of a shorter signature size. © 2020, Springer Nature Switzerland AG.

关键词： Managers

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Non-structured Pruning for Deep-learning based Steganalytic Frameworks

Non-structured Pruning for Deep-learning based Steganalytic ...

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Asia-Pacific Signal and Information Processing Association Annual Summit and Conference (APSIPA)

作者： Qiushi Li Zilong Shao Shunquan Tan Jishen Zeng Bin Li Shenzhen Key Laboratory of Media Security Guangdong Key Laboratory of Intelligent Information Processing National Engineering Laboratory for Big Data System Computing Technology Shenzhen China

ISBN: (数字)9781728132488

ISBN: (纸本)9781728132495

Image steganalysis aims to discriminate innocent cover images and those suspected stego images embedded with secret message. Recently, increasing advanced deep neural networks have been proposed and used in image steganalysis. Though those deep learning models can gain superior performance, they also result in redundancy of computational resource and memory storage. In this paper, we apply a non-structured pruning method to prune XuNet2 and SRNet - the two state-of-the-art deep-learning framework in the field of JPEG image steganalysis. We obtain the priorities of the connections among neurons according to a certain criterion, then keep those significant weights and prune those nonsignificant ones in the meantime. We have conducted extensive experiments on BOSSBase and BOWS image dataset. The experimental results demonstrate that our proposed non-structured pruning method can significantly reduce the cost of computation and storage required by the original deep-learning frameworks without affecting their detection accuracy.

关键词： Transform coding Training Convolution Computer architecture Computational modeling Brain modeling Testing

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Research on Hardware-in-the-Loop Test System for the Main Control Unit of Unmanned Vehicles

Research on Hardware-in-the-Loop Test System for the Main Co...

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Chinese Intelligent Systems Conference, CISC 2020

作者： Ni, Haoyuan Yu, Guizhen Zhou, Bin Liu, Guoqiang School of Transportation Science and Engineering Beijing Advanced Innovation Center for Big Data and Brain Computing Beijing Key Laboratory for Cooperative Vehicle Infrastructure Systems and Safety Control Beihang University Beijing100191 China School of Electronic Information Engineering Beihang University Beijing100191 China

ISBN: (纸本)9789811584572

At present, there are more researches on the automatic driving technology of unmanned vehicles. It needs a main control unit, which enables the vehicle to automatically drive. The main control unit supports the access of various sensors and controllers. It can process data of each device and control the movement state of vehicles. Therefore, the main control unit needs to be tested repeatedly to ensure its functionality and stability. Based on Prescan simulation software and Matlab/Simulink software, this paper studies a hardware-in-the-loop (HIL) test system for testing the main control unit of unmanned vehicles according to the communication protocol and communication method of the real sensor and controller hardware devices. At the same time, this paper studies a simulation method of the main control unit, which can effectively verify the function of the test system and conduct the feasibility test of the communication protocol and communication method used. © 2021, The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

关键词： Simulink

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Unlearnable 3D Point Clouds: Class-wise Transformation Is All You Need 38

Unlearnable 3D Point Clouds: Class-wise Transformation Is Al...

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38th Conference on Neural Information Processing Systems, NeurIPS 2024

作者： Wang, Xianlong Li, Minghui Liu, Wei Zhang, Hangtao Hu, Shengshan Zhang, Yechao Zhou, Ziqi Jin, Hai National Engineering Research Center for Big Data Technology and System China Services Computing Technology and System Lab China Cluster and Grid Computing Lab China Hubei Engineering Research Center on Big Data Security China Hubei Key Laboratory of Distributed System Security China School of Cyber Science and Engineering Huazhong University of Science and Technology China School of Software Engineering Huazhong University of Science and Technology China School of Computer Science and Technology Huazhong University of Science and Technology China

Traditional unlearnable strategies have been proposed to prevent unauthorized users from training on the 2D image data. With more 3D point cloud data containing sensitivity information, unauthorized usage of this new type data has also become a serious concern. To address this, we propose the first integral unlearnable framework for 3D point clouds including two processes: (i) we propose an unlearnable data protection scheme, involving a class-wise setting established by a category-adaptive allocation strategy and multi-transformations assigned to samples;(ii) we propose a data restoration scheme that utilizes class-wise inverse matrix transformation, thus enabling authorized-only training for unlearnable data. This restoration process is a practical issue overlooked in most existing unlearnable literature, i.e., even authorized users struggle to gain knowledge from 3D unlearnable data. Both theoretical and empirical results (including 6 datasets, 16 models, and 2 tasks) demonstrate the effectiveness of our proposed unlearnable framework. Our code is available at https://***/CGCL-codes/UnlearnablePC. © 2024 Neural information processing systems foundation. All rights reserved.

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MS²-GNN: Exploring GNN-Based Multimodal Fusion Network for Depression Detection

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IEEE transactions on cybernetics 2023年第12期53卷 7749-7759页

作者： Tao Chen Richang Hong Yanrong Guo Shijie Hao Bin Hu Key Laboratory of Knowledge Engineering with Big Data Ministry of Education and the School of Computer Science and Information Engineering Hefei University of Technology Hefei China Gansu Provincial Key Laboratory of Wearable Computing School of Information Science and Engineering Lanzhou University Lanzhou China

Major depressive disorder (MDD) is one of the most common and severe mental illnesses, posing a huge burden on society and families. Recently, some multimodal methods have been proposed to learn a multimodal embedding for MDD detection and achieved promising performance. However, these methods ignore the heterogeneity/homogeneity among various modalities. Besides, earlier attempts ignore interclass separability and intraclass compactness. Inspired by the above observations, we propose a graph neural network (GNN)-based multimodal fusion strategy named modal-shared modal-specific GNN, which investigates the heterogeneity/homogeneity among various psychophysiological modalities as well as explores the potential relationship between subjects. Specifically, we develop a modal-shared and modal-specific GNN architecture to extract the inter/intramodal characteristics. Furthermore, a reconstruction network is employed to ensure fidelity within the individual modality. Moreover, we impose an attention mechanism on various embeddings to obtain a multimodal compact representation for the subsequent MDD detection task. We conduct extensive experiments on two public depression datasets and the favorable results demonstrate the effectiveness of the proposed algorithm.

关键词： Task analysis Feature extraction Semantics Depression Graph neural networks Electroencephalography data mining Mental disorders Multisensory integration

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LESaET: Low-Dimensional Embedding Method for Link Prediction Combining Self-Attention and Enhanced-TuckER

LESaET: Low-Dimensional Embedding Method for Link Prediction...

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2024 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2024

作者： Ding, Lichao Zhao, Jing Lu, Kai Hao, Zenghao Key Laboratory of Computing Power Network and Information Security Ministry of Education Shandong Computer Science Center Jinan China Shandong Engineering Research Center of Big Data Applied Technology Faculty of Computer Science and Technology Jinan China Shandong Provincial Key Laboratory of Computer Networks Shandong Fundamental Research Center for Computer Science Jinan China

ISBN: (纸本)9781665410205

Knowledge graphs (KGs) provide a structured representation of the real world through entity-relation triples. However, current KGs are often incomplete, typically containing only a small fraction of all possible facts. This involves inferring missing content from existing information, a task known as link prediction. Existing methods in the field of link prediction struggle with controlling the dimensionality of embedding vectors or suffer from overly complex models. In order to tackle these challenges, we introduce a method in this paper, named Low-Dimensional Embedding Method for Link Prediction Combining Self-Attention and Enhanced-TuckER (LESaET). LESaET leverages both self-attention mechanisms and tensor factorization to learn expressive contextual-enhanced representations of KGs. Specifically, LESaET employs the multi-head self-attention mechanism of Transformer as an encoder to capture the mutual information between entities and relationships, and utilizes Enhanced-TuckER as a decoder, ultimately achieving expressive low-dimensional embeddings for link prediction tasks. LESaET demonstrates competitive performance compared to advanced methods on standard datasets. © 2024 IEEE.

关键词： Prediction models

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Brain-inspired artificial intelligence research: A review

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Science China(Technological Sciences) 2024年第8期67卷 2282-2296页

作者： WANG GuoYin BAO HuaNan LIU Qun ZHOU TianGang WU Si HUANG TieJun YU ZhaoFei LU CeWu GONG YiHong ZHANG ZhaoXiang HE Sheng Chongqing Key Laboratory of Computational Intelligence Chongqing University of Posts and TelecommunicationsChongqing 400065China Key Laboratory of Cyberspace Big Data Intelligent Security Chongqing University of Posts and TelecommunicationsChongqing 400065China College of Computer and Information Science Chongqing Normal UniversityChongqing 401331China State Key Laboratory of Brain and Cognitive Science Institute of BiophysicsChinese Academy of SciencesBeijing 100101China School of Psychological and Cognitive Sciences Peking UniversityBeijing 100871China State Key Laboratory of Multimedia Information Processing School of Computer SciencePeking UniversityBeijing 100871China Department of Computer Science School of ElectronicsInformation and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Faculty of Electronic and Information Engineering Xi’an Jiaotong UniversityXi’an 710049China The Center for Research on Intelligent Perception and Computing Institute of AutomationChinese Academy of SciencesBeijing 100190China Institute of Biophysics Chinese Academy of SciencesBeijing 100101China

Artificial intelligence(AI) systems surpass certain human intelligence abilities in a statistical sense as a whole, but are not yet the true realization of these human intelligence abilities and behaviors. There are differences, and even contradictions, between the cognition and behavior of AI systems and humans. With the goal of achieving general AI, this study contains a review of the role of cognitive science in inspiring the development of the three mainstream academic branches of AI based on the three-layer framework proposed by David Marr, and the limitations of the current development of AI are explored and analyzed. The differences and inconsistencies between the cognition mechanisms of the human brain and the computation mechanisms of AI systems are analyzed. They are found to be the cause of the differences and contradictions between the cognition and behavior of AI systems and humans. Additionally, eight important research directions and their scientific issues that need to focus on braininspired AI research are proposed: highly imitated bionic information processing, a large-scale deep learning model that balances structure and function, multi-granularity joint problem solving bidirectionally driven by data and knowledge, AI models that simulate specific brain structures, a collaborative processing mechanism with the physical separation of perceptual processing and interpretive analysis, embodied intelligence that integrates the brain cognitive mechanism and AI computation mechanisms,intelligence simulation from individual intelligence to group intelligence(social intelligence), and AI-assisted brain cognitive intelligence.

关键词： artificial intelligence cognitive science brain science intelligence science large language model

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First-principles investigation of microscopic mechanisms underlying hole mobilities in diamond, silicon, and germanium

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Physical Review B 2024年第15期110卷 155203页

作者： Qiao-Lin Yang Fan-Chen Meng Wu Li Zhi Wang Hui-Xiong Deng Su-Huai Wei Fan-long Ning Jun-Wei Luo School of Physics and Zhejiang Key Laboratory of Micro-Nano Quantum Chips and Quantum Control State Key Laboratory of Superlattices and Microstructures Research Computing and Data Eastern Institute for Advanced Study Center of Materials Science and Optoelectronics Engineering State Key Laboratory of Silicon and Advanced Semiconductor Materials

Silicon (Si) dominates the semiconductor industry but currently suffers from significant hole mobility degradation in advanced transistors due to its abnormally low hole mobility (505cm2/Vs), compared to its group IV neighbors, diamond and germanium (Ge) (both ∼2000cm2/Vs). While Ge's high mobility is understandable by its lighter effective hole mass due to its narrower direct bandgap at Γ point, diamond's superior hole mobility remains difficult to understand since its bandgap is ultrawide. Conventional wisdom attributes diamond's high mobility to reduced phonon scattering due to high acoustic phonon group velocity and optical phonon frequency, overcoming its heaviest effective mass. However, our study reveals that this mechanism alone is insufficient to explain the observed mobility. We demonstrate that the diamond's abnormally light effective hole mass is a primary factor contributing to its high mobility; otherwise, its hole mobility would be approximately nine times lower than Si's. The unexpectedly light mass in diamond stems from larger transition matrix elements, resulting from substantial electronic wave-function overlap between valence and conduction bands, remarkably overcoming the effect of diamond's large bandgap. Furthermore, our investigation uncovers a unique feature in diamond's valence band structure: an inherent strain-enhanced mobility characteristic, where the top valence band manifests as a light-hole (lh) state along certain crystallographic directions (e.g., [100]), instead of the typical heavy-hole (hh) state. Contrary to prevailing assumptions, we observe a strong coupling between holes and transverse acoustic (TA) phonons, and even TA scattering dominates over longitudinal acoustic (LA) scattering in both diamond and Si, challenging the long-held belief that TA scattering is negligible. Our calculations yield a dilation deformation potential of 3.45 eV for diamond, significantly diverging from previously reported values, e.g., 7 or −35 eV.

关键词： Electrical conductivity Electron-phonon coupling Semiconductors Density functional calculations Wannier function methods

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Few-Shot Class-Incremental Semantic Segmentation via Pseudo-Labeling and Knowledge Distillation 4

Few-Shot Class-Incremental Semantic Segmentation via Pseudo-...

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4th International Conference on Information Science, Parallel and Distributed Systems, ISPDS 2023

作者： Jiang, Chengjia Wang, Tao Li, Sien Wang, Jinyang Wang, Shirui Antoniou, Antonios Minjiang University Fujian Provincial Key Laboratory of Information Processing and Intelligent Control Fuzhou China Fujian Education Institutions Wuyi University The Key Laboratory of Cognitive Computing and Intelligent Information Processing Wuyishan China College of Computer and Data Science Fuzhou University Fuzhou China European University Cyprus Department of Computer Science and Engineering Nicosia Cyprus

ISBN: (纸本)9798350337181

We address the problem of learning new classes for semantic segmentation models from few examples, which is challenging because of the following two reasons. Firstly, it is difficult to learn from limited novel data to capture the underlying class distribution. Secondly, it is challenging to retain knowledge for existing classes and to avoid catastrophic forgetting. For learning from limited data, we propose a pseudo-labeling strategy to augment the few-shot training annotations in order to learn novel classes more effectively. Given only one or a few images labeled with the novel classes and a much larger set of unlabeled images, we transfer the knowledge from labeled images to unlabeled images with a coarse-to-fine pseudo-labeling approach in two steps. Specifically, we first match each labeled image to its nearest neighbors in the unlabeled image set at the scene level, in order to obtain images with a similar scene layout. This is followed by obtaining pseudo-labels within this neighborhood by applying classifiers learned on the few-shot annotations. In addition, we use knowledge distillation on both labeled and unlabeled data to retain knowledge on existing classes. We integrate the above steps into a single convolutional neural network with a unified learning objective. Extensive experiments on the Cityscapes and KITTI datasets validate the efficacy of the proposed approach in the self-driving domain. Code is available from https://***/ChasonJiang/FSCILSS. © 2023 IEEE.

关键词： Distillation

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