The identification of drug-protein interactions(DTIs) is a critical step in drug development and ***,detecting these interactions using scientific methods presents a formidable *** models often struggle to extract rel...
The identification of drug-protein interactions(DTIs) is a critical step in drug development and ***,detecting these interactions using scientific methods presents a formidable *** models often struggle to extract relevant information from drug-protein sequences,and they fail to consider pre-existing interactions between ***,we introduce a deep learning model,DPAG,based on attention mechanisms and graph neural networks,which overcomes these *** leverages information from both the drug and protein sequences,as well as the association between drug-protein pairs,to predict *** conducted multiple experiments to evaluate the performance of the model in benchmark datasets,and the results showed that DPAG achieved excellent performance in terms of AUC,AUPR,precision,and *** findings suggest that DPAG holds significant potential as a promising tool for predicting DTIs in drug development and *** is available at https://***/veres se/DPAG.
Loss functions steer the optimization direction of recommendation models and are critical to model performance, but have received relatively little attention in recent recommendation research. Among various losses, we...
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With the development of intelligent agents pursuing humanisation,artificial intelligence must consider emotion,the most basic spiritual need in human *** emotional dialogue systems usually use an external emotional di...
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With the development of intelligent agents pursuing humanisation,artificial intelligence must consider emotion,the most basic spiritual need in human *** emotional dialogue systems usually use an external emotional dictionary to select appropriate emotional words to add to the response or concatenate emotional tags and semantic features in the decoding step to generate appropriate ***,selecting emotional words from a fixed emotional dictionary may result in loss of the diversity and consistency of the *** propose a semantic and emotion-based dual latent variable generation model(Dual-LVG)for dialogue systems,which is able to generate appropriate emotional responses without an emotional *** from previous work,the conditional variational autoencoder(CVAE)adopts the standard transformer ***,Dual-LVG regularises the CVAE latent space by introducing a dual latent space of semantics and *** content diversity and emotional accuracy of the generated responses are improved by learning emotion and semantic features ***,the average attention mechanism is adopted to better extract semantic features at the sequence level,and the semi-supervised attention mechanism is used in the decoding step to strengthen the fusion of emotional features of the *** results show that Dual-LVG can successfully achieve the effect of generating different content by controlling emotional factors.
Medical image registration is vital for disease diagnosis and treatment with its ability to merge diverse informa-tion of images,which may be captured under different times,angles,or *** several surveys have reviewed ...
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Medical image registration is vital for disease diagnosis and treatment with its ability to merge diverse informa-tion of images,which may be captured under different times,angles,or *** several surveys have reviewed the development of medical image registration,they have not systematically summarized the existing med-ical image registration *** this end,a comprehensive review of these methods is provided from traditional and deep-learning-based perspectives,aiming to help audiences quickly understand the development of medical image *** particular,we review recent advances in retinal image registration,which has not attracted much *** addition,current challenges in retinal image registration are discussed and insights and prospects for future research provided.
Due to its decentralized,tamper-proof,and trust-free characteristics,blockchain is used in the Internet of Things(IoT)to guarantee the reliability of ***,some technical flaws in blockchain itself prevent the developme...
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Due to its decentralized,tamper-proof,and trust-free characteristics,blockchain is used in the Internet of Things(IoT)to guarantee the reliability of ***,some technical flaws in blockchain itself prevent the development of these applications,such as the issue with linearly growing storage capacity of blockchain *** the other hand,there is a lack of storage resources for sensor devices in IoT,and numerous sensor devices will generate massive data at ultra-high speed,which makes the storage problem of the IoT enabled by blockchain more *** are various solutions to reduce the storage burden by modifying the blockchain’s storage policy,but most of them do not consider the willingness of *** attempt to make the blockchain more compatible with the IoT,this paper proposes a storage optimization scheme that revisits the system data storage problem from amore practically oriented *** will only store transactional data that they are directly involved *** addition,a transaction verification model is developed to enable peers to undertake transaction verification with the aid of cloud computing,and an incentive mechanism is premised on the storage optimization scheme to assure data *** results of the simulation experiments demonstrate the proposed scheme’s advantage in terms of storage and throughput.
Logistic distribution (LogDis) is frequently used in many different applications, such as logistic regression, logit models, classification, neural networks, physical sciences, sports modeling, finance and health and ...
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With the proliferation of cloud services and the continuous growth in enterprises' demand for dynamic multi-dimensional resources, the implementation of effective strategy for time-varying workload scheduling has ...
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作者:
Taisheng ZengXiaodong WuSchool of Mathematics and Computer Science
Quanzhou Normal University Fujian Provincial Key Laboratory of Data-Intensive Computing Key Laboratory of Intelligent Computing and Information Processing Fujian Province University Quanzhou China
Virtual machine placement (VMP) plays a crucial role in optimizing the efficiency and sustainability of data centers. By consolidating virtual machines (VMs) onto fewer physical machines (PMs), VMP can significantly r...
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ISBN:
(数字)9798350377033
ISBN:
(纸本)9798350377040
Virtual machine placement (VMP) plays a crucial role in optimizing the efficiency and sustainability of data centers. By consolidating virtual machines (VMs) onto fewer physical machines (PMs), VMP can significantly reduce power consumption and enhance resource utilization. This not only leads to cost savings but also contributes to environmental sustainability by minimizing energy waste. This paper focuses on addressing the energy-efficient VMP problem, which is critical for modern data centers aiming to balance performance and energy consumption. To tackle this challenge, we propose an improved group-based genetic algorithm (GGA). The GGA employs a novel grouping approach to encode chromosomes, allowing for more effective representation of VM-to-PM assignments. Additionally, optimized crossover and mutation operators are designed to improve the algorithm's performance, ensuring faster convergence and better solutions. Experimental results demonstrate that the proposed algorithm outperforms traditional algorithms in terms of energy-saving efficiency and convergence speed.
Drug repositioning is a vital area of biomedicine, where confirming interactions between drugs and specific targets is essential for establishing the efficacy of pharmaceutical agents. Traditional in vitro screening m...
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A sequent is a pair (Γ, Δ), which is true under an assignment if either some formula in Γ is false, or some formula in Δ is true. In L_(3)-valued propositional logic, a multisequent is a triple Δ∣Θ∣Γ, which i...
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A sequent is a pair (Γ, Δ), which is true under an assignment if either some formula in Γ is false, or some formula in Δ is true. In L_(3)-valued propositional logic, a multisequent is a triple Δ∣Θ∣Γ, which is true under an assignment if either some formula in Δ has truth-value t, or some formula in Θ has truth-value m, or some formula in Γ has truth-value f. There is a sound, complete and monotonic Gentzen deduction system G for sequents. Dually, there is a sound, complete and nonmonotonic Gentzen deduction system G′ for co-sequents Δ: Θ: Γ. By taking different quantifiers some or every, there are 8 kinds of definitions of validity of multisequent Δ∣Θ∣Γ and 8 kinds of definitions of validity of co-multisequent Δ: Θ: Γ, and correspondingly there are 8 sound and complete Gentzen deduction systems for sequents and 8 sound and complete Gentzen deduction systems for co-sequents. Correspondingly their monotonicity is discussed.
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