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IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

作者： Yichong Li Xiaojian Liu Fan Cheng Xiaoyong Pan Yang Yang Department of Computer Science and Engineering Shanghai Jiao Tong University Shanghai China Institute of Image Processing and Pattern Recognition Shanghai Jiao Tong University Shanghai China Key Laboratory of System Control and Information Processing Ministry of Education of China Shanghai China Key Laboratory of Shanghai Education Commission for Intelligent Interaction and Cognitive Engineering Shanghai China

ISBN: (数字)9798350386226

ISBN: (纸本)9798350386233

RNA-binding proteins (RBPs) are essential for gene expression, and the complex RNA-protein interaction mechanisms require analysis of global RNA information. Therefore, accurate prediction of RBP binding sites on full-length RNA transcripts is crucial for understanding these mechanisms and their roles in diseases. While machine learning methods can predict RBP binding to RNA fragments, extending this to full-length transcripts presents challenges due to sequence length and data imbalance. In this paper, we introduce RBP-Former, a binding site joint prediction model designed specifically for full-length RNA transcripts that can be used for multiple RBPs. This model processes information at both coarse and fine-grained levels to fully exploit sequence data and its interactions with multiple RBPs. We develop multi-level imbalance learning strategies, achieving favorable results on imbalanced data. Our method outperforms existing methods in predicting binding sites on full-length RNA transcripts for multiple RBPs, demonstrating its effectiveness in handling imbalanced label and sample distributions.

关键词： Proteins Protein engineering Accuracy RNA Machine learning Predictive models Data models Gene expression Bioinformatics Diseases

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Region stability analysis for switched discrete-time recurrent neural network with multiple equilibria

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Neurocomputing 2017年 249卷 182-190页

作者： Gang Bao Zhigang Zeng Hubei Key Laboratory of Cascaded Hydropower Stations Operation & Control China Three Gorges University Yichang 443002 China School of Automation Huazhong University of Science and Technology Wuhan 430074 China Key Laboratory of Image Information Processing and Intelligent Control of Education Ministry of China Wuhan 430074 China

This paper investigates a kind of switched discrete-time neural network. Such neural network is composed of multiple sub-networks and switched different sub-networks according to the states of neural network. There is no common equilibrium for all of sub-networks, i.e., multiple equilibria coexist. Firstly, a bounded condition is presented for the switched discrete-time neural network. And then sufficient conditions are derived to ensure region stability of the equilibrium points of such neural network by mathematical analysis and nonsingular M-matrix theory. Four examples are presented to verify the validity of our results.

关键词： Switched neural network Region stability Multiple equilibria

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Complete stability of delayed recurrent neural networks with Gaussian activation functions

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Neural networks : the official journal of the International Neural Network Society 2017年 85卷 21-32页

作者： Peng Liu Zhigang Zeng Jun Wang School of Automation Huazhong University of Science and Technology Wuhan 430074 China Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China Wuhan 430074 China. Electronic address: liupengjz@***. Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China Wuhan 430074 China. Electronic address: zgzeng@***. Department of Computer Science City University of Hong Kong Kowloon Tong Hong Kong. Electronic address: jwang.cs@cityu.edu.hk.

This paper addresses the complete stability of delayed recurrent neural networks with Gaussian activation functions. By means of the geometrical properties of Gaussian function and algebraic properties of nonsingular M-matrix, some sufficient conditions are obtained to ensure that for an n-neuron neural network, there are exactly 3 equilibrium points with 0≤k≤n, among which 2 and 3-2 equilibrium points are locally exponentially stable and unstable, respectively. Moreover, it concludes that all the states converge to one of the equilibrium points; i.e., the neural networks are completely stable. The derived conditions herein can be easily tested. Finally, a numerical example is given to illustrate the theoretical results.

关键词： Complete stability Gaussian functions Recurrent neural networks Time-varying delays

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Prognostic Prediction for Non-small-Cell Lung Cancer Based on Deep Neural Network and Multimodal Data 17th

Prognostic Prediction for Non-small-Cell Lung Cancer Based o...

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17th International Conference on intelligent Computing, ICIC 2021

作者： Zhang, Zhong-Si Xu, Fei Jiang, Han-Jing Chen, Zhan-Heng Key Laboratory of Image Information Processing and Intelligent Control of Education Ministry of China Institute of Artificial Intelligence School of Artificial Intelligence and Automation Huazhong University of Science and Technology Wuhan430074 China Institute of Machine Learning and Systems Biology School of Electronics and Information Engineering Tongji University No. 4800 Caoan Road Shanghai201804 China

ISBN: (纸本)9783030845315

Non-small-cell lung cancer (NSCLC) is the most common lung cancer with poor prognosis. Prognostic prediction is significant in improving the prognosis of NSCLC patients. Clinical information and multi-omics data including gene expression, miRNA, copy number variations, and DNA methylation are closely related to NSCLC prognosis. In this study, we propose a deep neural network to conduct prognostic prediction for NSCLC patients based on all five types of data. Given the high dimensional features of the omics data, past works reduce the feature dimension by regression analysis or correlation sorting algorithms. A shortcoming of these methods is that only a small number of features are considered. To overcome it, we propose a convolution neural network-based feature transformation method, which considers all features and extracts the abstract representations of the omics data. Based on the representations, we predict the five-year survival status of NSCLC patients. The results show that our method achieves a more precise prediction than previous work, with the areas under the curve improved from 0.8163 to 0.8508 and the accuracy improved from 0.7544 to 0.8096. © 2021, Springer Nature Switzerland AG.

关键词： Forecasting

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Research on the detection method of alignment beacon based on the spatial structure feature of train bogies

Research on the detection method of alignment beacon based o...

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2022 Chinese Automation Congress, CAC 2022

作者： Cao, Chong Wan, Shaowei Peng, Gang He, Dingxin Zhong, Sheng Deng, Zhang Guo, Wentao School of Artificial Intelligence and Automation Huazhong University of Science and Technology Key Laboratory of Image Processing and Intelligent Control Ministry of Education Wuhan430074 China Beijing Railway Institute of Mechanical & Electrical Engineering Group Co. Ltd. Beijing100071 China Wuhan Lisai Technology Co. Ltd. Wuhan430073 China

ISBN: (纸本)9781665465335

The high-speed train inspection robot needs to perform alignment parking and image acquisition at the position of the train bogie, and reliable alignment identification marks are the basis for the inspection robot to achieve highprecision alignment parking. The existing alignment method is mainly based on the way of artificial beacons, in the inspection workshop through manual laying of additional identification marks such as QR codes, magnetic stripes, RFID electronic tags, auxiliary robot alignment parking, but this type of method in beacon maintenance, laying costs and other aspects have certain limitations. Aiming at the problem, this paper proposes a vision-based bogie beacon detection method, which combines the target detection technology with the unique bogie spatial structure feature of the train, and provides reliable identification marks for the alignment and parking of the inspection robot. This method improves the alignment accuracy, reduces the cost of laying and maintaining artificial beacons, and has high application value. © 2022 IEEE.

关键词： Railroads

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Prediction of Drug-Disease Associations Based on Long Short-Term Memory Network and Gaussian Interaction Profile Kernel 15th

Prediction of Drug-Disease Associations Based on Long Short-...

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15th International Conference on Bio-Inspired Computing: Theories and Applications, BIC-TA 2020

作者： Jiang, Han-Jing Wang, Yan-Bin Huang, Yabing Key Laboratory of Image Information Processing and Intelligent Control of Education Ministry of China Institute of Artificial Intelligence School of Artificial Intelligence and Automation Huazhong University of Science and Technology Wuhan430074 China College of Computer Science and Technology Zhejiang University Hangzhou315000 China Department of Pathology Renmin Hospital of Wuhan University Wuhan430060 China

ISBN: (纸本)9789811613531

Drug-disease association depicts the accessibility landscape of the association at the molecular level, thereby revealing the intermolecular reaction in the process of drug reposition. However, the scarcity of drug-disease association data often complicates the drug reposition. In this work, we present a method for predicting drug-disease association, which is called drug-disease association prediction via Gaussian interaction profile kernel and long short-term memory network (G-LSTM). G-LSTM combines a recurrent network framework with a Gaussian interaction profile kernel to learn underlying features that accurately characterize drug-disease-association data. We have verified G-LSTM models on the two benchmark datasets Fdataset and Cdataset, respectively. The experimental results show that the predictive performance was significantly improved, with AUC of 0.9527 and 0.9705, respectively. © 2021, Springer Nature Singapore Pte Ltd.

关键词： Long short-term memory

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Modeling and simulation of temperature distribution for planar cross-flow solid oxide fuel cell

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Energy Procedia 2019年 158卷 1585-1590页

作者： Yuan-wu Xu Xiao-long Wu Hang You Tao Xue Dong-qi Zhao Jian-hua Jiang Zhong-hua Deng Xiao-wei Fu Li Xi School of Automation Key Laboratory of Education Ministry for Image Processing and Intelligent Control Huazhong University of Science and Technology Wuhan 430074 China Hubei Province Key Laboratory of Intelligent Information Processing and Real-time Industrial System Wuhan University of Science and Technology Wuhan 430065 China Research Institute of Huazhong University of Science & Technology in Shenzhen Shenzhen 518057 China

Solid oxide fuel cell is a device that can convert chemical energy directly into electricity. Its advantages, such as high efficiency, low emission, quiet operation, fuel flexibility, bring about the broad application prospect. However, it is difficult to obtain the temperature distribution in the existing planar cross flow solid oxide fuel cell through the experiment. In this paper, a control orient two-dimensional differential equation model is established for a planar cross flow solid oxide fuel cell based on the finite node method, and an iterative algorithm for calculating the real time voltage of the fuel cell is proposed for the model. Based on the model, the temperature distribution of the fuel cell in the test and system configuration is simulated. The simulation results show that the model can reflect the thermoelectric characteristics of the planar cross flow solid oxide fuel cell, especially the temperature distribution of the fuel cell. The SOFC temperature distribution modeling in this paper is helpful for the development of temperature distribution observers and design related control methods in later studies.

关键词： modeling simulation temperature distribution planar cross flow solid oxide fuel cell

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A Visual Kinematics Calibration Method for Manipulator Based on Nonlinear Optimization

A Visual Kinematics Calibration Method for Manipulator Based...

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2022 Chinese Automation Congress, CAC 2022

作者： Peng, Gang Wang, Zhihao Guan, Shangbin Deng, Zhang Guo, Wentao Key Laboratory of Image Processing and Intelligent Control Ministry of Education Wuhan China School of Artificial Intelligence and Automation Huazhong University of Science and Technology Wuhan China Beijing Railway Institute of Mechanical & Electrical Engineering Group Co. Ltd. Beijing China Wuhan Lisai Technology Co. Ltd. Wuhan China

ISBN: (纸本)9781665465335

The traditional kinematic calibration method for manipulators requires precise three-dimensional measuring instruments to measure the end pose, which is not only expensive due to the high cost of the measuring instruments but also not applicable to all manipulators. Another calibration method uses a camera, but the system error caused by the camera's parameters affects the calibration accuracy of the kinematics of the robot arm. In order to solve this problem, this paper reduces the dimensionality of the experimental data and redesigns the objective function to be optimized. That is, the three-dimensional positions of the feature points of the calibration plate under each manipulator attitude corresponding to the actual kinematic model and the classic D-H kinematic model are mapped into the pixel coordinate system, and the sum of Euclidean distance errors of the pixel coordinates of the two is used as the objective function to be optimized. And then, nonlinear optimization and parameter compensation are performed. The experimental results show that the pixel deviation of the end pose corresponding to the optimized D-H kinematic model proposed in this paper and the end pose corresponding to the actual kinematic model in the pixel coordinate system is 0.99 pixels. Compared with the 7.9 deviation pixels between the pixel coordinates calculated by the classic D-H kinematic model and the actual pixel coordinates, the deviation is reduced by nearly 7 pixels for an 87% reduction in error. Therefore, the proposed method can effectively avoid system errors caused by camera parameters in visual calibration, can improve the absolute positioning accuracy of the end of the robotic arm, and has good economy and universality. © 2022 IEEE.

关键词： Pixels

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Standby and Shutdown Cycles Modeling of SOFC Lifetime Prediction

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Energy Procedia 2019年 158卷 1573-1578页

作者： Wu Xiao-long Xu Yuanwu Xue Tao Zhao Dongqi Jiang Jianhua Deng Zhonghua Fu Xiaowei Li Xi School of Automation Key Laboratory of Education Ministry for Image Processing and Intelligent Control Huazhong University of Science and Technology Wuhan 430074 China Hubei Province Key Laboratory of Intelligent Information Processing and Real-time Industrial System Wuhan University of Science and Technology Wuhan 430065 China Shenzhen Huazhong University of Science and Technology Research Institute Shenzhen 518057 China

In order to more accurately predict the impact of solid oxide fuel cells to stack life on standby and shutdown, this paper proposes a modeling method based on experimental data. Which is based on Elman neural network(NN). At the same time, a main factor is considered in the modeling process which is the effect of cooling rate on the stack. In the process of modeling, the most obvious cooling rate is used to modeling. There are two different influencing factors on classify, the training set and the verification set respectively. After the reliability of the model, the Solid Oxide Fuel cell (SOFC) stack life prediction is carried out. From the predict results and the experimental results, it is found that the prediction results are good and the high precision.

关键词： Solid Oxide Fuel Cell(SOFC) Stack useful lifetime predict Cooling speed Gas composition Cycle standby shutdown

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A short-term power load forecasting model based on the generalized regression neural network with decreasing step fruit fly optimization algorithm

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Neurocomputing 2017年 221卷 24-31页

作者： Rui Hu Shiping Wen Zhigang Zeng Tingwen Huang School of Automation Huazhong University of Science and Technology Wuhan PR China Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China Wuhan PR China Texas A & M University at Qatar Doha 5825 Qatar

Short term power load forecasting plays an important role in the security of power system. In the past few years, application of artificial neural network (ANN) for short-term load forecasting (STLF) has become a research hotspots. Generalized regression neural network (GRNN) has been proved to be suitable for solving the non-linear problems. And according to the historical load curve, it can be known that STLF is a non-linear problem. Thus, the GRNN was used for STLF in this paper. However, the value of spread parameter σ determines the performance of the GRNN. The fruit fly optimization algorithm with decreasing step size (SFOA) is introduced to select an appropriate spread parameter σ . Combined with the weather factors and the periodicity of short-term load, an effective STLF model based on the GRNN with decreasing step FOA was proposed. Performance of the proposed SFOA-GRNN model is compared with other ANN on the basis of prediction error.

关键词： Short term power load forecasting Generalized regression neural network Fruit fly optimization algorithm Decreasing step size

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