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Nanomedicine sheds new light on cancer immunotherapy

Medical Review 2023年第2期3卷 188-192页

作者： Yingying Yu Liangzhu Feng Zhuang Liu Jiangsu Key Laboratory for Carbon-Based Functional Materials&Devices Institute of Functional Nano&Soft Materials(FUNSOM)Soochow UniversitySuzhouJiangsu ProvinceChina Jiangsu Key Laboratory for Carbon-Based Functional Materials&Devices Institute of Functional Nano&Soft Materials(FUNSOM)Soochow University199 Ren’ai RoadSuzhou 215123Jiangsu ProvinceChina

Cancer immunotherapy comprising of immune checkpoint blockade(ICB)therapy,immune cell therapies,cancer vaccines and many others represents a profound arsenal in the fight against different types of ***,their overall clinical objective response rates,particularly against most solid tumors,are still not sufficient owing to a variety of reasons including the heterogenous expression of tumor antigens,limited tumor infiltration of effector immune cells,acquired tumor immunosuppression and some other *** recent years,various nanomedicine strategies have been proposed to assist cancer immunotherapy via distinct mechanisms,presenting new promises in many published *** perspective will thus provide a brief overview regarding the development of nanomedicine platforms for improving cancer immunotherapy.

关键词： cancer immunotherapy in situ cancer vaccine nanomedicine nanovaccine tumor microenvironment

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Clamping effect driven design and fabrication of new infrared birefringent materials with large optical anisotropy

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Science China Chemistry 2023年第4期66卷 1086-1093页

作者： Linan Wang Chenchen Tu Hongbo Gao Jiazheng Zhou Hongshan Wang Zhihua Yang Shilie Pan Junjie Li Research Center for Crystal Materials CAS Key Laboratory of Functional Materials and Devices for Special EnvironmentsXinjiang Technical Institute of Physics&ChemistryChinese Academy of SciencesUrumqi 830011China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Infrared(IR)birefringent materials with large optical anisotropy and wide transparency range are important for efficient light manipulation in various IR optical ***,two new IR birefringent materials AMgGeSe_(3)(A=Li,Na)with large optical anisotropy were rationally designed by a rigid octahedron and flexible dimer combined strategy and fabricated in *** introduction of rigid[LiSe_(6)]/[NaSe_(6)]and[MgSe_(6)]octahedra effectively regulates the geometry and arrangement of the flexible[Ge2Se6]dimers,resulting in the birefringence as large as 0.334@1,064 nm in LiMgGeSe_(3) and 0.445@1,064 nm(the largest one in the reported[Ge_(2)Se_(6)]dimer-contained selenides)in NaMgGeSe_(3).Density functional theory(DFT)calculations and statistical analyses highlight the influence of polarizability anisotropy,density,arrangement of units,as well as layer distance on *** results indicate that AMgGeSe_(3)(A=Li,Na)crystals are the promising IR birefringent materials and it gives an insight into the exploration of new IR birefringent materials with large birefringence based on the clamping effect from rigid groups.

关键词： birefringence clamping effect AMgGeSe_(3) [Ge_(2)Se_(6)]dimer octahedra

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Polarization extension yielding ultrahigh piezoelectric response in xPb(Nb_(2/3)Ni_(1/3))O_(3)-(1-x)Pb(Zr_(0.3)Ti_(0.7))O_(3)ferroelectrics ceramics

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Journal of materials Science & Technology 2024年第22期189卷 37-43页

作者： Yongxing Wei Junlong Yan Siyuan Dong Changqing Jin Huawei Zhang Lin Hu Ruihua Nan Ling Gao Zhonghua Dai Zengzhe Xi Zengyun Jian Li Jin Shaanxi Key Laboratory of Optoelectronic Functional Materials and Devices School of Materials and Chemical EngineeringXi’an Technological UniversityXi’an 710021China Shaanxi Coal Chemical Industry Technology Research Institute Co.Ltd. Xi’an 710070China Shaanxi Province Key Laboratory of Thin Films Technology&Optical Test Xi’an Technological UniversityXi’an 710021China Electronic Materials Research Laboratory Key Laboratory of the Ministry of EducationSchool of Electronic Science and EngineeringFaculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China

The heightened piezoelectric performance observed in most explored perovskite systems is typically at-tributed to the electric-field-induced phase transition near the morphotropic phase boundary(MPB)or polymorphic phase boundary(PPB).This study,however,unveils a distinct piezoelectric enhancement mechanism in the xPb(Nb_(2/3)Ni_(1/3))O_(3)-(1-x)Pb(Zr_(0.3)Ti_(0.7))O_(3)(PNN-PZT)system,diverging from the MPB/PPB-centered piezoelectric ***,the composition with x=0.55,positioned close to the tetragonal-pseudocubic(T-PC)phase boundary,achieves an unprecedented piezoelectric coefficient(d_(33))of 1264 pC/N,while retaining a tetragonal local ***,on a local scale,electric fields do not in-cite phase transitions,suggesting that the exceptional piezoelectric performance in PNN-PZT stems from polarization extension near the T-PC *** from other mechanisms,the relative permittivity significantly increases post-poling due to this particular enhancement *** dielectric behavior in poled specimens does not exhibit a conspicuous change at the ferroelectric-relaxor transition ***,both the relative permittivity and planar electromechanical coupling coefficient experience a sharp rise in the temperature range of−25℃to 25℃.This investigation underscores the pivotal role of designing compositionally-driven T-PC phase boundaries,presenting a promising avenue for enhancing piezoelectric properties in ferroelectric ceramics.

关键词： Phase boundary Pseudocubic Polarization extension Local structure Piezoelectric effect

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Modulation of polymerization rate of N-carboxyanhydrides in a biphasic system

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Chinese Chemical Letters 2024年第1期35卷 326-331页

作者： Guonan Ji Xuetao Zheng Xiangdie Hou Xiao Sun Shijie Wang Xiaohong Li Jianjun Cheng Ziyuan Song Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123China Research Center for Industries of the Future Westlake UniversityHangzhou 310030China School of Engineering Westlake UniversityHangzhou 310030China The Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

The recent advances in accelerated polymerization of N-carboxyanhydrides (NCAs) offer an effective strategy to simplify the preparation of polypeptide materials. However, the fine-tuning of polymerization kinetics, which is critical to differentiate the main polymerization and the side reactions, remains largely unexplored. Herein we report the modulation of polymerization rate of NCA in a water/oil biphasic system. By altering the aqueous pH, the initial location of the initiators, and the pK_(a) of initiating amines, we observed the change in polymerization time from several minutes to a few hours. Due to the high interfacial activity and low pKa value, controlled polymerization was observed from multi-amine initiators even if they were initially located in the aqueous phase. This work not only improves our understanding on the biphasic polymerization mechanism, but also facilitates preparation of versatile polypeptide materials.

关键词： N-Carboxyanhydrides Polypeptides Biphasic system Cooperative covalent polymerization Polymerization kinetics

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Diffusion behavior along Nd-Fe-B grain boundaries in different directions and mechanism of coercivity strengthening

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Journal of Rare Earths 2025年第4期43卷 766-773,I0005页

作者： Shengwu Shen Munan Yang Shuwei Zhong Hang Wang Sangen Luo Jiajie Li Xi Yu Sajjad Ur Rehman Ihor Bulyk Haijiao Xie Jiangxi Key Laboratory for Rare Earth Magnetic Materials and Devices&Institute for Rare Earth Magnetic Materials and Devices(IREMMD) College of Rare EarthsJiangxi University of Science and TechnologyGanzhou341000China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou341000China National Rare Earth Functional Material Innovation Center&Guorui Scientific Innovation Rare Earth Functional Materials Co. Ltd.Ganzhou341000China Hangzhou Yanqu Information Technology Co. Ltd.Hangzhou310000China

In this study,DyF_(3)powder was sprayed onto the polar and side surfaces of the magnets to determine the anisotropic diffusion mechanism of Dy in the sintered Nd-Fe-B *** coercivity and squareness of the magnet in which the diffusion of Dy is perpendicular to the c-axis(a-magnet)are lower than those of the magnet with the diffusion of Dy parallel to the c-axis(c-magnet).Compared with the c-magnet,the a-magnet has a longer Dy-enrichment region from the diffusion surface,where Dy is enriched in the 2:14:1 *** contrast,the Dy concentration in the grain boundaries beyond the Dy enrichment region is lower in the ***,the Dy shells beyond the Dy enrichment region in the a-magnet are distributed on the side surfaces of the 2:14:1 grains but not on the polar *** on the micromagnetic simulation,the Dy shells on the polar surfaces of the grains are more effective in enhancing *** to first-principle calculations,Dy migrating through 001 into the Nd vacancy in the Nd_(2)Fe_(14)B crystal has a higher diffusion barrier,thus indicating that the lattice diffusion of Dy parallel to the c-axis is more difficult.

关键词： Nd-Fe-B Grain boundary diffusion Anisotropic diffusion Micromagnetic simulation First-principle calculations Rare earths

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Observation of Ice-Like Two-Dimensional Flakes on Self-Assembled Protein Monolayer without Nanoconfinement under Ambient Conditions

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Nano-Micro Letters 2025年第8期 245-258页

作者： Wuxian Peng Linbo Li Xiyue Bai Ping Yi Yu Xie Lejia Wang Wei Du Tao Wang Jian-Qiang Zhong Yuan Li Key Laboratory of Organic Optoelectronics and Molecular Engineering Department of ChemistryTsinghua University School of Physics Hangzhou Normal University School of Materials and Chemical Engineering Ningbo University of Technology Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & DevicesSoochow University

Directly correlating the morphology and composition of interfacial water is vital not only for studying water icing under critical conditions but also for understanding the role of protein–water interactions in bio-relevant systems. In this study, we present a model system to study two-dimensional(2D) water layers under ambient conditions by using self-assembled monolayers(SAMs) supporting the physisorption of the Cytochrome C(Cyt C) protein layer. We observed that the 2D island-like water layers were uniformly distributed on the SAMs as characterized by atomic force microscopy, and their composition was confirmed by nano-atomic force microscopy-infrared spectroscopy and Raman spectroscopy. In addition, these 2D flakes could grow under high-humidity conditions or melt upon the introduction of a heat source. The formation of these flakes is attributed to the activation energy for water desorption from the Cyt C being nearly twofold high than that from the SAMs. Our results provide a new and effective method for further understanding the water–protein interactions.

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Mn single-atoms decorated CNT electrodes for high-performance supercapacitors

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Nano Research 2024年第5期17卷 4039-4046页

作者： Qian Rong Chao Yuwen Yingkai Liu Yuanrong Liu Chunyang Wang Yang Wang Ding Zhang Zhen Wen Yunnan Key Laboratory of Opto-Electronic Information Technology Institute of Physics and Electronic InformationYunnan Normal UniversityKunming 650500China Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093China Department of Physics and Astronomy University of CaliforniaIrvineCA 92697USA School of Materials Science and Engineering National Institute for Advanced MaterialsSmart Sensing Interdisciplinary Science CenterNankai UniversityTianjin 300350China Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Institute of Functional Nano and Soft Materials(FUNSOM)Soochow UniversitySuzhou 215123China

Developing highly robust and efficient electrode materials is of critical importance to promoting the energy density of current supercapacitors for ***,we report an efficient catalyst with monodispersed Mn single-atoms embedded in carbon nanotubes(Mn-CNTs)for enhancing the electrode performance of supercapacitors.A high specific capacitance(1523.6 F·g^(-1) at 1.0 A·g^(-1))can be achieved,which is about twice as high as the specific capacitance of the electrode material without the introduction of Mn ***,the asymmetric electrochemical capacitor created with Mn-CNT and activated carbon exhibits a high energy density of 180.8 Wh·kg^(-1) at a power density of 1.4 kW·kg^(-1),much higher than most reported *** study shows that the integration of Mn atoms into the CNT can enhance the charge transport capacity and the number of polar active sites of Mn-CNT and then facilitate chemical interactions between Mn-CNT and OH-.This work provides a novel strategy to enable high-energy storage in supercapacitors by introducing single-atoms into carbon nanotubes to improve electrodes’energy density and cycle life.

关键词： carbon nanotube(CNT) supercapacitor single-atoms power density energy density

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Interface terminal group regulated organic phototransistors with tunable persistent and switchable photoconductivity

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Science China Chemistry 2022年第12期65卷 2567-2575页

作者： Di Xue Yingying Zhang Weijie Gong Yao Yin Zi Wang Lizhen Huang Lifeng Chi Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou215123China Gusu Laboratory of Materials Suzhou215123China Macao Institute of Materials Science and Engineering(MIMSE) MUST-SUDA Joint Research Center for Advanced Functional MaterialsMacao University of Science and TechnologyTaipaMacao999078China

With both light detection and intrinsic amplification functions,organic phototransistors have demonstrated promising applications,including photodetection and *** achieve excellent photoresponse and superior photogain,a common and effective strategy is to modulate the trapping effect with the purpose of reducing recombination or prolonging the lifetime of the photogenerated charge ***,introducing trapping sites delicately is challenging and might sacrifice the response rate together with a typical persistent ***,we demonstrate a facile strategy for achieving high photo-responsive organic phototransistors with both persistent and switchable photoconductivity features via interface terminal group *** varying the terminate groups of self-assembled monolayer(SAMs)from the strong electron withdrawing group-F,neutral−CH_(3) to electron donating−NH_(2) on the dielectric surface,we realize both minority carrier trapping and majority carrier trapping in the organic phototransistor based on the C8-BTBT active *** electron withdrawing effect of F significantly enhances the minority carrier trapping process and yields a high photoresponsivity with a long-lasting persistent *** contrast,the electron donating group−NH_(2) with a distinct majority carrier trapping ability causes switchable photoconductivity so that the photocurrent can rise pronouncedly and fully decay along with light on/***,both cases can deliver high performance with photoresponsivities higher than 104 A W^(−1) together with a photosensitivity in the level of 107 and a detectivity of approximately 10^(15)–10^(16) *** a tunable,excellent photoresponse property enables the convenient exploration of organic phototransistors to satisfy different application requirements.

关键词： organic phototransistor surface modification trapping persistent photoconductivity

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Organic white-light sources:Multiscale construction of organic luminescent materials from molecular to macroscopic level

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Science China Chemistry 2022年第4期65卷 740-745页

作者： Song Chen Xue-Dong Wang Ming-Peng Zhuo Qiang Lv Jing-Feng Liu Liang-Sheng Liao Jiangsu Key Laboratory for Carbon-Based Functional Materials&Devices Institute of Functional Nano&Soft Materials(FUNSOM)Soochow UniversitySuzhou 215123China Macao Institute of Materials Science and Engineering Macao University of Science and TechnologyTaipa 999078China

Organic luminescent materials play an integral role in the optoelectronic applications of displays and solid-state ***, high-performance organic luminescent materials require the efficient combination of two or more kinds of materials, which is extremely difficult owing to the completely different self-assembly behaviors of multicomponent ***, based on a broad scale from the molecular, micro-/nano-scale, and macroscopic levels, we successfully demonstrate the multiscale construction of organic luminescent microwires of cocrystals, solid solutions, and core-shell microstructures. Through the wide selection of electron donor/acceptor pairs, a series of color-tunable charge-transfer(CT) cocrystals are formed via the intermolecular cooperative self-assembly process. On this basis, the high structural compatibility and perfect lattice mismatching(~1.1%) of cocrystals are critical factors that facilitate the combination of dissimilar materials to form solid solutions and core/shell microwires. Significantly, because of the full-spectrum light transport from 400 to 800 nm, the nano-micro-scaled solid solution microwires act as microscale white-light sources [CIE(0.32, 0.36)]. Meanwhile, the macroscopic-scale core/shell organic-microwires demonstrate tunable white-light emission with a high color-rendering index(CRI) of 83, whose CIE coordinates span from(0.37, 0.39) to(0.40, 0.31). Therefore, our work provides a feasible approach to the multiscale synthesis of novel luminescent organic semiconductor materials, which could lay a solid foundation for organic optoelectronics.

关键词： noncovalent interaction multiscale self-assembly core/shell solid solution white-light emission

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From n-alkane to polyacetylene on Cu(110):Linkage modulation in chain growth

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Science China Chemistry 2022年第4期65卷 733-739页

作者： Zhengming Hao Junjie Zhang Miao Xie Xuechao Li Lina Wang Ye Liu Kaifeng Niu Junbo Wang Luying Song Tao Cheng Haiming Zhang Lifeng Chi Institute of Functional Nano and Soft Materials(FUNSOM)and Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Soochow UniversitySuzhou 215123China Department of Physics Chemistry and BiologyLinköping UniversityLinköping 58183Sweden

Direct coupling or transformation of inert alkanes based on the selective C-H activation is of great importance for both chemistry and chemical ***,we report the coupling of polyenes that are transformed from n-dotriacontane(n-C_(22)H_(66))through on-surface cascade dehydrogenation on Cu(110)surface,leading to the formation of polyacetylene(PA).Three distinct linkages have been resolved by scanning tunneling microscope(STM)and noncontact atomic force microscope(nc-AFM).Apart from the α-type linkage which is the stemless coupling of the terminal C-C double bond in trans-configuration,β-and γ-type linkages appear as knots or defects which are,in fact,the C-C couplings in ***,the“defects”can be effectively suppressed by adjusting the surface coverage,thus making it of general interest for uniform structure modulation.

关键词： on-surface chemistry scanning tunneling microscope all-trans polyacetylene linkage chain growth

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