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Applications of artificial intelligence to lipid nanoparticle delivery

Particuology 2024年第7期90卷 88-97页

作者： Ye Yuan Yuqi Wu Jiabei Cheng Kaiyuan Yang Yilin Xia Hongguang Wu Xiaoyong Pan Institute of Image Processing and Pattern Recognition Shanghai Jiao Tong UniversityKey Laboratory of System Control and Information ProcessingMinistry of Education of ChinaChina Songjiang Research Institute Songjiang District Central HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Lipid nanoparticles(LNPs)are nanocarriers composed of four lipid components and can be used for gene therapy,protein replacement,and vaccine ***,LNPs also face several challenges,such as toxicity,immune activation,and low delivery *** overcome these challenges,artificial intelligence can be used to optimize the design and formulation of LNPs,as well as to predict their properties and ***,antibody-targeted conjugation can be used to enhance the specificity and selectivity of LNPs by attaching an antibody that recognizes a specific antigen on the cell surface to LNPs.

关键词： Artificial intelligence Lipid nanoparticles Antibody Targeted conjugation

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Sufficient and necessary conditions for Lyapunov stability of Lorenz system and their application

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Science China(Information Sciences) 2010年第8期53卷 1574-1583页

作者： LUO Qi 1 , LIAO XiaoXin 2 & ZENG ZhiGang 2 1 College of Information and control, Nanjing University of Information Science and Technology, Nanjing 210044, China 2 Department of control Science and Engineering, Huazhong University of Science and Technology, image processing and intelligent control key laboratory of education ministry of China, Wuhan 430074, China 1. College of Information and Control Nanjing University of Information Science and Technology Nanjing 210044 China2. Department of Control Science and Engineering Huazhong University of Science and Technology Image Processing and Intelligent Control Key Laboratory of Education Ministry of China Wuhan 430074 China

The sufficient and necessary conditions for Lyapunov stability of the zero equilibrium point of Lorenz system are discussed, and some brief criteria are presented for globally exponential stability, globally asymptotical stability and instability. Furthermore, the behavior of the non-zero equilibrium point of Lorenz system is also investigated, and several sufficient and necessary conditions are provided for locally exponential stability and instability. The established theorems in this paper develop and extend the existing achievements on Lyapunov stability of Lorenz system. In conclusion, by applying the obtained results, some less conservative feedback-control laws are derived to guarantee the globally exponential stability of the chaos control of Chen system, Lu¨ system, Yang-Chen system and Yu-Xia Li system.

关键词： Lorenz system Lyapunov stability sufficient and necessary condition bifurcation values globally exponential synchronization

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Cross-user Gesture Recognition Based on Deep Domain Adaptation Networks 43

Cross-user Gesture Recognition Based on Deep Domain Adaptati...

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43rd Chinese control Conference, CCC 2024

作者： Fu, Zhongzheng He, Xinrun Wang, Haoyuan Chen, Xingjian Li, Yixuan Huang, Jian Huazhong University of Science and Technology Ministry of Education Key Laboratory of Image Processing and Intelligent Control Hubei Key Laboratory of Brain-inspired Intelligent Systems School of Artificial Intelligence and Automation Wuhan430074 China

ISBN: (纸本)9789887581581

This study introduces an innovative approach for gesture recognition in smart wearable devices using a deep domain adaptation model, focusing on the challenges posed by heterogeneous user environments and the need for precise, adaptable, and personalized gesture recognition systems. Traditional methods based on machine learning and deep learning techniques, while effective, struggle with the variance in data distribution among different users, leading to accuracy challenges. To address this, the study proposes the Domain Kernel-Alignment Adaptation Network (DKAN) model, utilizing a new Kernel-Aligned Multi-kernel Maximum Mean Discrepancy (KAMMD) method within deep networks. By calculating kernel alignments between source and target domains and adjusting weights of Gaussian kernels accordingly, DKAN emphasizes features conducive to transfer learning, enabling more accurate cross-user gesture recognition. The model achieves a significant average accuracy of 97.3% across 21 gestures, highlighting its potential in practical applications. This advancement addresses challenges in traditional gesture recognition methods and sets a new direction for future research in smart wearable technology. © 2024 Technical Committee on control Theory, Chinese Association of Automation.

关键词： Adversarial machine learning

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Research on fuzzy enhancement in the diagnosis of liver tumor from B-mode ultrasound images

Research on fuzzy enhancement in the diagnosis of liver tumo...

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2011 IEEE International conference on intelligent Computation and Bio-Medical Instrumentation, ICBMI 2011

作者： Qiu, Wu Wang, Rui Xiao, Feng Ding, Mingyue School of Life Science and Technololgy Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China Huazhong University of Science and Technology Wuhan Hubei China

ISBN: (纸本)9780769546230

Fuzzy enhancement is applied in computer aided diagnosis of liver cancer from B mode ultrasound images as a pre-processing procedure in this paper. It was evaluated with three classifiers including K means, back propagation neural network and support vector machine using 25 features from first order statistic (FOS), gray-level co-occurrence matrix (GLCM), gray-level run-length matrix (GLRLM), Grey level dependant matrix (GLDM) and LAWS. In the analysis of 166 normal liver tissue, 30 hemangioma and 60 malignant tumor, our method improved the classification accuracy of three classifiers (K means, BP neural network and support machine vector) in distinguishing liver cancer, hemangioma and normal liver cancer from B mode ultrasound images. It is proved that fuzzy enhancement as an efficient preprocessing procedure could be used in the computer aided diagnosis system of liver cancer. © 2011 IEEE.

关键词： Support vector machines

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Semisupervised Transfer Boosting (SS-TrBoosting)

IEEE Transactions on Artificial Intelligence

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IEEE Transactions on Artificial Intelligence 2024年第7期5卷 3431-3444页

作者： Deng, Lingfei Zhao, Changming Du, Zhenbang Xia, Kun Wu, Dongrui Key Laboratory of Image Processing and Intelligent Control Ministry of Education School of Artificial Intelligence and Automation Huazhong University of Science and Technology Wuhan 430074 China and also with Shenzhen Huazhong University of Science and Technology Research Institute Shenzhen 518063 China

Semisupervised domain adaptation (SSDA) aims at training a high-performance model for a target domain using few labeled target data, many unlabeled target data, and plenty of auxiliary data from a source domain. Previous works in SSDA mainly focused on learning transferable representations across domains. However, it is difficult to find a feature space where the source and target domains share the same conditional probability distribution. Additionally, there is no flexible and effective strategy extending existing unsupervised domain adaptation (UDA) approaches to SSDA settings. In order to solve the above two challenges, we propose a novel fine-tuning framework, semisupervised transfer boosting (SS-TrBoosting). Given a well-trained deep learning-based UDA or SSDA model, we use it as the initial model, generate additional base learners by boosting, and then use all of them as an ensemble. More specifically, half of the base learners are generated by supervised domain adaptation, and half by semisupervised learning. Furthermore, for more efficient data transmission and better data privacy protection, we propose a source data generation approach to extend SS-TrBoosting to semisupervised source-free domain adaptation (SS-SFDA). Extensive experiments showed that SS-TrBoosting can be applied to a variety of existing UDA, SSDA, and SFDA approaches to further improve their performance. © 2020 IEEE.

关键词： Supervised learning

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A novel estimation strategy for the eye-in-hand depth-independent visual servoing

A novel estimation strategy for the eye-in-hand depth-indepe...

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2011 International Conference on Consumer Electronics, Communications and Networks, CECNet 2011

作者： Liang, Xinwu Huang, Xinhan Wang, Min Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China Dept. of Control Science and Engineering Huazhong University of Science and Technology Wuhan 430074 Hubei China

ISBN: (纸本)9781612844572

As we know, a novel adaptive visual servoing strategy has been proposed for the control of robot manipulators with an eye-in-hand configuration, where an adaptive law is used to estimate the unknown parameters determined by the products of the unknown 3D coordinates and the unknown camera parameters. From a practical point of view, in this paper, we propose a novel strategy for the estimation of these two types of unknown parameters. The new strategy is very useful in that it can reduce the number of the unknown parameters to be estimated. To demonstrate the feasibility of the proposed method, preliminary simulation results based on a two-link planar robot manipulator are presented in this paper. © 2011 IEEE.

关键词： Parameter estimation

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Solving 0-1 planning problem based on self-assembly of dna tiles

Solving 0-1 planning problem based on self-assembly of dna t...

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作者： Huang, Yufang Cheng, Zhen Xu, Jin Shi, Xiaolong Zhou, Kang Key Laboratory of Image Processing and Intelligent Control Department of Control Science and Engineering Huazhong University of Science and Technology 430074 Wuhan China Ministry of Education 10087 Beijing China

DNA tile self-assembly has been proved to enable programmable manipulation of biological systems as a tool of molecular computation. It is mainly based on the property that is the spontaneous self-ordering of substructure into superstructure driven by annealing of Watson-Crick base-pairing DNA sequences. We take full advantage of the superiority of DNA tile self-assembly to construct a molecular computing system that implements a solution for the 0-1 planning problem. This algorithm can independently and simultaneously yield the data pool, containing all possible solutions when all basic operation tiles are designed beforehand. Then we can use some advanced bio-chemistry techniques to select the optimization solutions of the 0-1 planning problem. Our work has shown that it is possible to work with an exponential number of components to solve NP-complete problems. The method proposed here also can reduce the number of laboratory steps required for computation so that it can improve the computation speed. Copyright © 2010 American Scientific Publishers. All rights reserved.

关键词： Self assembly

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Solving Nonlinear Equations Systems with a Two-Phase Root-Finder Based on Niching Differential Evolution 15th

Solving Nonlinear Equations Systems with a Two-Phase Root-Fi...

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15th International Conference on Bio-Inspired Computing: Theories and Applications, BIC-TA 2020

作者： Duan, Lianlang Xu, Fei Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China School of Artificial Intelligence and Automation Huazhong University of Science and Technology Wuhan430074 China

ISBN: (纸本)9789811613531

Solving nonlinear equation systems (NESs) is a challenging problems in numerical computation. Two goals should be considered for solving NESs. One is to locate as many roots as possible and the other is to improve the solving precision. In this work, in order to achieve these two goals, a two-phase niching differential evolution (TPNDE) is proposed. The innovation of TPNDE is mainly reflected in the following three aspects. First, a probabilistic mutation mechanism is designed to increase the diversity of the population. Second, a novel reinitialization procedure is proposed to detect converged individuals and explore more new regions that may contain global optima. Third, distribution adjustment local search (DALS) is proposed to deal with the isolated solution and enhance the convergence of the algorithm. To evaluate the performance of TPNDE, we test our TPNDE and 5 state-of-the-art algorithms on 20 NESs with diverse features. The experimental results show that the proposed TPNDE algorithm is better than the other methods. © 2021, Springer Nature Singapore Pte Ltd.

关键词： Nonlinear equations

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A New Scrambling Method Based on Semi-frequency Domain and Chaotic System

A New Scrambling Method Based on Semi-frequency Domain and C...

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2005 International Conference on Neural Networks and Brain(ICNN&B’05)

作者： Tao Li Shaowu Zhou Zhaofu Zeng Qingli Ou School of Information and Electrical Engineering Hunan University of Science and Technology Key Laboratory of Education Ministry for Image Processing and Intelligent Control Huazhong University of Science & Technology

ISBN: (纸本)0780394224

A new digital image scrambling method based on DCT and chaos maps is presented in this *** the chaotic system in semi-frequency domain,all the pixels of the original image are rearranged and *** procedure of the algorithm is roughly divided into three steps:first,an original image is decomposed for its first variable by 1-D DCT, then modulated by chaos system,a primary scrambling result is achieved,at last,after by inverse 1-D DCT for the scrambling result,repeating the same procedure for the second variable,a final scrambling result is obtained for the original *** confirm the robustness of the novel method,some robustness testing experiments are carried out on the scrambling *** experimental results shows that the method succeeds in enduring several kinds of common image attacks,such as cropping,noise and rotation.

关键词： image security image scrambling chaotic sequences DCT(the discrete cosine transform)

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Unsupervised polarimetric SAR image classification using fisher linear discriminant

Unsupervised polarimetric SAR image classification using fis...

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2009 Asia-Pacific Conference on Synthetic Aperture Radar, APSAR 2009

作者： Chen, Bo Wang, Shuang Jiao, Licheng Zhang, Shuang Key Laboratory of Intelligent Perception and Image Understanding of Ministry of Education of China Institute of Intelligent Information Processing Xidian University Xi'an 710071 China

ISBN: (纸本)9781424427314

How to use the POLSAR data to classify and interpret the conditions of the earth is a very important research field of POLSAR. In this paper, we propose an improved algorithm on the basis of studying and analyzing some common algorithms. This technique introduces the fisher criterion in the feature selection and the hierarchical method in the classification of POLSAR image, which can improve Lee's combination method of the unsupervised classification based on polarimetric target decomposition and the maximum likelihood classifier based on the complex Wishart distribution. The effectiveness of this algorithm is demonstrated using a polerimetric SAR image. ©2009 IEEE.

关键词： Synthetic aperture radar

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