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Oral Administration of Fucosylated Chondroitin Sulfate Oligomers in Gastro-Resistant Microcapsules Exhibits a Safe Antithrombotic Activity

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Thrombosis and Haemostasis 2020年第1期121卷 015-026页

作者： Lufeng Yan Mengshan Zhu Danli Wang Wenyang Tao Donghong Liu Fuming Zhang Robert J. Linhardt Xingqian Ye Shiguo Chen College of Biosystems Engineering and Food Science National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment Zhejiang Key Laboratory for Agro-Food Processing Integrated Research Base of Southern Fruit and Vegetable Preservation Technology Zhejiang International Scientific and Technological Cooperation Base of Health Food Manufacturing and Quality Control Zhejiang University Hangzhou China Center for Biotechnology and Interdisciplinary Studies Department of Chemistry and Chemical Biology Rensselaer Polytechnic Institute Troy New York United States Division of Applied Life Sciences Graduate School of Agriculture Kyoto University Uji Japan

Fucosylated chondroitin sulfate (FCS) polysaccharide isolated from sea cucumber has potent anticoagulant activity. Based on its resistance to the enzymes present in vertebrates, it may serve as an anticoagulant and shows antithrombotic effects when delivered through gastro-resistant (GR) tablets. However, due to the multiple plasma targets of FCS polysaccharide in the coagulation pathway, bleeding can occur after its oral administration. In the current study, we used FCS oligomers, in particular a mixture of oligosaccharides having 6 to 18 saccharide units, as the active ingredient in GR microcapsules for oral anticoagulation. In a Caco-2 model, the FCS oligomers showed higher absorption than native FCS polysaccharides. Oral administration of FCS oligomer-GR microcapsules provided a dose-dependent, prolonged anticoagulant effect with a selective inhibition of the intrinsic coagulation pathway when compared with

关键词： fucosylated chondroitin sulfate oligomers gastro resistant microcapsules oral administration anticoagulant and antithrombotic activities bleeding tendency

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Manipulability and Robustness Optimization of the Cable-Driven Redundant Soft Manipulator

Manipulability and Robustness Optimization of the Cable-Driv...

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IEEE International Conference on Robotics and Biomimetics

作者： Yi Shen Yang Hong Wei Zhou Ruochen Tai Ye Yuan Han Ding School of Artificial Intelligence and Automation Key Laboratory of Image Processing and Intelligent Control Huazhong University of Science and Technology Wuhan People’s Republic of China School of Electrical and Electronic Engineering Nanyang Technological University Singapore Singapore School of Mechanical Science and Engineering Huazhong University of Science and Technology Wuhan People’s Republic of China State Key Lab of Digital Manufacturing Equipment and Technology Huazhong University of Science and Technology Wuhan People’s Republic of China

ISBN: (纸本)9781665405362

Redundancy makes soft manipulators manage to complete a variety of tasks in complex environments. However, a pseudo-inverse kinematics controller for redundant soft manipulators simply maximizes the manipulability while ignoring some material constraints, e.g., actuation saturation and control noise. As manipulability is the indicator for the dexterity of motion in all directions of the redundant soft manipulators, this work proposes an optimization based controller, where the manipulability and robustness are optimized for a cable-driven redundant soft manipulator to adapt actuation saturation and control noise. Experiments are conducted to demonstrate the effectiveness of the proposed controller.

关键词： Conferences Biomimetics Redundancy Kinematics Manipulators Robustness Trajectory

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LinK3D: Linear keypoints Representation for 3D LiDAR Point Cloud

arXiv

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arXiv 2022年

作者： Cui, Yunge Zhang, Yinlong Dong, Jiahua Sun, Haibo Chen, Xieyuanli Zhu, Feng The Key Laboratory of Opto-Electronic Information Processing Shenyang Institute of Automation Chinese Academy of Sciences Shenyang China The Key Laboratory of Networked Control Systems Shenyang Institute of Automation Chinese Academy of Sciences Shenyang China The State Key Laboratory of Robotics Shenyang Institute of Automation Chinese Academy of Science Shenyang China The Institutes for Robotics and Intelligent Manufacturing Chinese Academy of Sciences Shenyang110016 China The University of Chinese Academy of Sciences Beijing101408 China The Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai China The College of Intelligence Science and Technology National University of Defense Technology Changsha China

Feature extraction and matching are the basic parts of many robotic vision tasks, such as 2D or 3D object detection, recognition, and registration. As is known, 2D feature extraction and matching have already achieved great success. Unfortunately, in the field of 3D, the current methods may fail to support the extensive application of 3D LiDAR sensors in robotic vision tasks due to their poor descriptiveness and inefficiency. To address this limitation, we propose a novel 3D feature representation method: Linear keypoints representation for 3D LiDAR point cloud, called LinK3D. The novelty of LinK3D lies in that it fully considers the characteristics (such as the sparsity and complexity) of LiDAR point clouds and represents the keypoint with its robust neighbor keypoints, which provide strong constraints in the description of the keypoint. The proposed LinK3D has been evaluated on three public datasets, and the experimental results show that our method achieves great matching performance. More importantly, LinK3D also shows excellent real-time performance, faster than the sensor frame rate at 10 Hz of a typical rotating LiDAR sensor. LinK3D only takes an average of 30 milliseconds to extract features from the point cloud collected by a 64-beam LiDAR and takes merely about 20 milliseconds to match two LiDAR scans when executed on a computer with an Intel Core i7 processor. Moreover, our method can be extended to LiDAR odometry task, and shows good scalability. We release the implementation of our method at https://***/YungeCui/LinK3D. Copyright © 2022, The Authors. All rights reserved.

关键词： Object detection

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Advancing Embodied Intelligence in Robotic-Assisted Endovascular Procedures: A Systematic Review of AI Solutions

arXiv

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arXiv 2025年

作者： Yao, Tianliang Lu, Bo Kowarschik, Markus Yuan, Yixuan Zhao, Hubin Ourselin, Sebastien Althoefer, Kaspar Ge, Junbo Qi, Peng Department of Control Science and Engineering College of Electronic and Information Engineering Shanghai Institute of Intelligent Science and Technology Tongji University Shanghai200092 China Department of Electronic Engineering Faculty of Engineering The Chinese University of Hong Kong 999077 Hong Kong Robotics and Microsystems Center School of Mechanical and Electrical Engineering Soochow University Suzhou215131 China Bavaria Forchheim91301 Germany CREATe Division of Surgery & Interventional Science UCL LondonHA7 4LP United Kingdom School of Biomedical Engineering & Imaging Sciences King’s College London LondonSE1 7EH United Kingdom Centre for Advanced Robotics @ Queen Mary School of Engineering and Materials Science Queen Mary University of London LondonE1 4NS United Kingdom Department of Cardiology Zhongshan Hospital Fudan University Shanghai Institute of Cardiovascular Diseases Shanghai200032 China State Key Laboratory of Cardiovascular Diseases Medical Innovation Center Shanghai East Hospital School of Medicine Tongji University Shanghai200092 China

Endovascular procedures have revolutionized the treatment of vascular diseases thanks to minimally invasive solutions that significantly reduce patient recovery time and enhance clinical outcomes. However, the precision and dexterity required during these procedures poses considerable challenges for interventionists. Robotic systems have emerged offering transformative solutions, addressing issues such as operator fatigue, radiation exposure, and the inherent limitations of human precision. The integration of Embodied Intelligence (EI) into these systems signifies a paradigm shift, enabling robots to navigate complex vascular networks and adapt to dynamic physiological conditions. Data-driven approaches, advanced computer vision, medical image analysis, and machine learning techniques, are at the forefront of this evolution. These methods augment procedural intelligence by facilitating real-time vessel segmentation, device tracking, and anatomical landmark detection. Reinforcement learning and imitation learning further refine navigation strategies and replicate experts’ techniques. This review systematically examines the integration of EI principles into robotic technologies, in relation to endovascular procedures. We discuss recent advancements in intelligent perception and data-driven control, and their practical applications in robot-assisted endovascular procedures. By critically evaluating current limitations and emerging opportunities, this review establishes a framework for future developments, emphasizing the potential for greater autonomy and improved clinical outcomes. Emerging trends and specific areas of research, such as federated learning for medical data sharing, explainable AI for clinical decision support, and advanced human-robot collaboration paradigms, are also explored, offering insights into the future direction of this rapidly evolving field. © 2025, CC BY.

关键词： Medical robotics

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Analysis of smart glucose meter stability from the economic perspective

Boletin Tecnico/Technical Bulletin

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Boletin Tecnico/Technical Bulletin 2017年第9期55卷 457-462页

作者： Lin, Zhongyan Song, Libin Zheng, Dachuan Li, Zuoyong Internet Innovation Research Center College's Research Base of Humanities and Social Science in Fujian Province Minjiang University Fuzhou Fujian350108 China Fuzhou Digital Health Industry Technology Innovation Center Minjiang University Fuzhou Fujian350108 China Fuzhou Comvee Network Technology Co. Ltd. Fuzhou Fujian350001 China Fujian Provincial Key Laboratory of Information Processing and Intelligent Control Minjiang University Fuzhou Fujian350108 China

Objective: to explore and interpret the model of diabetes mobile online management from the perspective of web model. Methods: from the interdisciplinary perspective, combined with economics, management science and computer science, with the only dynamic model in microeconomics—the cobweb model, from chronic disease management, Internet + medical application, analyze the application of Internet technology in diabetes management. Results: through mobile Internet technology, optimized the unit of diabetes management and realized the "monitoring - assessment - intervention" closed-loop management. Conclusion: explore the digital medical health industry in periodic production commodity price fluctuations and other activities, can establish early warning system and mechanism, to improve patients and their families to the cognitive level of diabetes, according to the medical behavior and self management ability.

关键词： Medical applications

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Size-Invariance Matters: Rethinking Metrics and Losses for Imbalanced Multi-object Salient Object Detection

arXiv

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arXiv 2024年

作者： Li, Feiran Xu, Qianqian Bao, Shilong Yang, Zhiyong Cong, Runmin Cao, Xiaochun Huang, Qingming Institute of Information Engineering Chinese Academy of Sciences Beijing China School of Cyber Security University of Chinese Academy of Sciences Beijing China Key Laboratory of Intelligent Information Processing Institute of Computing Technology Chinese Academy of Sciences Beijing China School of Computer Science and Technology University of Chinese Academy of Sciences Beijing China Institute of Information Science Beijing Jiaotong University Beijing China School of Control Science and Engineering Shandong University Jinan China Key Laboratory of Machine Intelligence and System Control Ministry of Education Jinan China School of Cyber Science and Tech. Sun Yat-Sen University Shenzhen Campus China Key Laboratory of Big Data Mining and Knowledge Management Chinese Academy of Sciences Beijing China

This paper explores the size-invariance of evaluation metrics in Salient Object Detection (SOD), especially when multiple targets of diverse sizes co-exist in the same image. We observe that current metrics are size-sensitive, where larger objects are focused, and smaller ones tend to be ignored. We argue that the evaluation should be size-invariant because bias based on size is unjustified without additional semantic information. In pursuit of this, we propose a generic approach that evaluates each salient object separately and then combines the results, effectively alleviating the imbalance. We further develop an optimization framework tailored to this goal, achieving considerable improvements in detecting objects of different sizes. Theoretically, we provide evidence supporting the validity of our new metrics and present the generalization analysis of SOD. Extensive experiments demonstrate the effectiveness of our method. The code is available at https://***/Ferry-Li/SI-SOD. Copyright © 2024, The Authors. All rights reserved.

关键词： Object detection

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Channel Reflection: Knowledge-Driven Data Augmentation for Eeg-Based Bcis

SSRN

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SSRN 2024年

作者： Wang, Ziwei Li, Siyang Luo, Jingwei Liu, Jiajing Wu, Dongrui Key Laboratory of the Ministry of Education for Image Processing and Intelligent Control School of Artificial Intelligence and Automation Huazhong University of Science and Technology Wuhan430074 China Shenzhen Huazhong University of Science and Technology Research Institute Shenzhen518063 China China Electronic System Technology Co. Ltd. Beijing100089 China School of Civil and Hydraulic Engineering Huazhong University of Science and Technology Wuhan430074 China

A brain-computer interface (BCI) enables direct communication between the human brain and external devices. Electroencephalography (EEG) based BCIs are currently the most popular for able-bodied users. To increase user-friendliness, usually a small amount of user-specific EEG data are used for calibration, which may not be enough to develop a pure data-driven decoding model. To cope with this typical calibration data shortage challenge in EEG-based BCIs, this paper proposes a parameter-free channel reflection (CR) data augmentation approach that incorporates prior knowledge on the channel distributions of different BCI paradigms in data augmentation. Experiments on eight public EEG datasets across four different BCI paradigms (motor imagery, steady-state visual evoked potential, P300, and seizure classifications) using different decoding algorithms demonstrated that: 1) CR is effective, i.e., it can noticeably improve the classification accuracy;2) CR is robust, i.e., it consistently outperforms other data augmentation approaches in the literature;and, 3) CR is flexible, i.e., it can be combined with other data augmentation approaches to further increase the performance. We suggest that data augmentation approaches like CR should be an essential step in EEG-based BCIs. Our code is available online. © 2024, The Authors. All rights reserved.

关键词： Electroencephalography

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Named Entity Recognition Based on Anchor Span for Manufacturing Text Knowledge Extraction

SSRN

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SSRN 2024年

作者： Li, Yahui Sun, Qi Zhou, Chunjie Liu, Lu Tian, Yu-Chu School of Artificial Intelligence and Automation Huazhong University of Science and Technology Hubei Wuhan430074 China Key Laboratory of Image Processing and Intelligent Control Ministry of Education Huazhong University of Science and Technology Hubei Wuhan430074 China School of Cyber Science and Engineering Huazhong University of Science and Technology Hubei Wuhan430074 China School of Computer Science Queensland University of Technology BrisbaneQLD4001 Australia

intelligent industrial manufacturing heavily relies on structured knowledge. Named Entity Recognition (NER), an essential technique for extracting structured knowledge from text, has garnered significant research interest. However, current NER approaches face difficulties in handling multiple levels of entity nesting in knowledge extraction, especially within the manufacturing context. To address this issue, we present an Anchor Span-based NER (ASNER) approach for accurately and efficiently extracting manufacturing text knowledge. This method combines token and span classification. Initially, the head and tail features of the entity are extracted, with the corresponding anchor span of potential entities generated based on a boundary match neural network to localize the entities. Subsequently, token spatial contextual features are extracted using biaffine attention and convolutional neural networks, and classification categories are assigned to the anchor span-filtered entity features. Experimental studies demonstrate the effectiveness of the proposed ASNER approach. © 2024, The Authors. All rights reserved.

关键词： Character recognition

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A Learning Convolutional Neural Network Approach for Network Robustness Prediction

arXiv

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arXiv 2022年

作者： Lou, Yang Wu, Ruizi Li, Junli Wang, Lin Li, Xiang Chen, Guanrong The Department of Computing and Decision Sciences Lingnan University Hong Kong The Key Laboratory of System Control and Information Processing Ministry of Education of China Shanghai200240 China The College of Computer Science Sichuan Normal University Chengdu610066 China The Department of Automation Shanghai Jiao Tong University Shanghai200240 China The Institute of Complex Networks and Intelligent Systems Shanghai Research Institute for Intelligent Autonomous Systems Tongji University Shanghai201210 China The Department of Control Science and Engineering Tongji University Shanghai200240 China The Department of Electrical Engineering City University of Hong Kong Hong Kong

Network robustness is critical for various societal and industrial networks again malicious attacks. In particular, connectivity robustness and controllability robustness reflect how well a networked system can maintain its connectedness and controllability against destructive attacks, which can be quantified by a sequence of values that record the remaining connectivity and controllability of the network after a sequence of node- or edge-removal attacks. Traditionally, robustness is determined by attack simulations, which are computationally very time-consuming or even practically infeasible. In this paper, an improved method for network robustness prediction is developed based on learning feature representation using convolutional neural network (LFR-CNN). In this scheme, higher-dimensional network data are compressed to lower-dimensional representations, and then passed to a CNN to perform robustness prediction. Extensive experimental studies on both synthetic and real-world networks, both directed and undirected, demonstrate that 1) the proposed LFR-CNN performs better than other two state-of-the-art prediction methods, with significantly lower prediction errors;2) LFR-CNN is insensitive to the variation of the network size, which significantly extends its applicability;3) although LFR-CNN needs more time to perform feature learning, it can achieve accurate prediction faster than attack simulations;4) LFR-CNN not only can accurately predict network robustness, but also provides a good indicator for connectivity robustness, better than the classical spectral measures. © 2022, CC BY.

关键词： Complex networks

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A deep learning-based remaining useful life prediction approach for bearings

arXiv

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arXiv 2018年

作者： Cheng, Cheng Ma, Guijun Zhang, Yong Sun, Mingyang Teng, Fei Ding, Han Yuan, Ye The Key Laboratory of Image Processing and Intelligent Control School of Artificial Intelligence and Automation Huazhong University of Science and Technology Wuhan430074 China The State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and Technology Wuhan430074 China The School of Mechanical Science and Engineering Huazhong University of Science and Technology Wuhan430074 China School of Information Science and Engineering Wuhan University of Science and Technology Wuhan430081 China The College of Control Science and Engineering Zhejiang University Hangzhou310007 China The Department of Electrical & Electronic Engineering Imperial College London LondonSW7 2AZ United Kingdom

In industrial applications, nearly half the failures of motors are caused by the degradation of rolling element bearings (REBs). Therefore, accurately estimating the remaining useful life (RUL) for REBs is of crucial importance to ensure the reliability and safety of mechanical systems. To tackle this challenge, model-based approaches are limited by the complexity of mathematical modeling. Conventional data-driven approaches, on the other hand, require massive efforts to extract the degradation features and construct the health index. In this paper, a novel data-driven framework is proposed to exploit the adoption of deep convolutional neural networks (CNN) in predicting the RULs of bearings. More concretely, raw vibrations of training bearings are first processed using the Hilbert-Huang transform to construct a novel nonlinear degradation energy indicator which can be used as the training label. The CNN is then employed to identify the hidden pattern between the extracted degradation energy indicator and the raw vibrations of training bearings, which makes it possible to estimate the degradation of the test bearings automatically. Finally, testing bearings’ RULs are predicted through using a ǫ-support vector regression model. The superior performance of the proposed RUL estimation framework, compared with the state-of-the-art approaches, is demonstrated through the experimental results. The generality of the proposed CNN model is also validated by performance test on other bearings undergoing different operating conditions. Copyright © 2018, The Authors. All rights reserved.

关键词： Hilbert-Huang transform

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