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Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia

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Nano Research 2024年第7期17卷 6411-6419页

作者： Hao Chen Xianzhe Tang Yueye Huang Chen Chen Yuheng Yang Chaojie Hao Wenqi Xie Tingjing Huang Xiaofeng Cheng Qingnan Xu Shicong Huang Zhi Ye Xucong Lin Zhaowei Chen Zhitong Chen MOE Key Laboratory for Analytical Science of Food Safety and Biology and New Cornerstone Science LaboratoryCollege of ChemistryFuzhou UniversityFuzhou 350108China Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Advanced Therapeutic Center National Innovation Center for Advanced Medical DevicesShenzhen 518000China Department of Chemistry University College LondonLondon WC1H 0AJUK Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province College of ChemistryFuzhou UniversityFuzhou 350108China Key Laboratory of Biomedical Imaging Science and System Chinese Academy of SciencesShenzhen 518055China

Androgenetic alopecia(AGA)is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment,leading to cell apoptosis and eventual loss of hair follicles(HFs).Traditional therapeutic formulations,such as Minoxidil(MXD)tincture,have limitations in reshaping the perifollicular microenvironment and exhibit limited ***,we report a multi-synergistic therapeutic platform for high-performance hair regeneration *** platform combines microneedle(MN)patches loaded with MXD-encapsulated nanostructured lipid carriers(MXD-NLC-MNs)and cold atmospheric plasma(CAP).The MNs’mechanical strength enables efficient transdermal delivery of MXD to the targeted dermal papilla cells,promoting cell ***,in collaboration with MXD,the mechanical stimulation exerted by MN application synergistically upregulates the expression of vascular endothelial growth factor,leading to ***,the transient microchannels in the skin created by MNs facilitate the transdermal delivery of CAPgenerated nitric oxide(NO)to the sites of HF lesions,whereby the synergistic interaction between MXD and NO boosts perifollicular ***,the perifollicular microenvironment can be effectively reshaped to accelerate hair regeneration in AGA murine *** multi-synergistic combination therapy strategy would hold great promise for effectively treating AGA and promoting hair regrowth.

关键词： nanomedicine androgenetic alopecia microneedle cold atmospheric plasma drug delivery

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A Low Complexity Lossless Compression Based on General Code Table for infrared Images

SSRN

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SSRN 2024年

作者： Zhu, Yaohua Zhang, Yong Huang, Mingsheng Zhu, Yanghang Key Laboratory of Infrared System Detection and Imaging Technology Chinese Academy of Sciences Shanghai200083 China Shanghai Institute of Technical Phvsics Chinese Academy of Sciences Shanghai200083 China University of Chinese Academy of Sciences Beijing100049 China

In order to improve the storage and transmission of 14-bit image data acquired by line scanning infrared detectors, this paper proposes a novel method to realize real-time and efficient compression for infrared images. The proposed method utilizes the features of infrared images to reduce image redundancy, then a novel and improved Huffman coding is employed to achieve compression. This paper proposes a method for obtaining a general Huffman code table to increase compression speed and a trimming Huffman tree algorithm to reduce complexity caused by long codes of 14-bit images with low-loss compression ratios. The compression based on general code table avoids counting pixels and uses a simple rule to lookup code table that significantly improves the compression speed. The longest code in the general code table is employed to replace all the long codes in the 14-bit image, enabling low-complexity lossless compression. The proposed method outperforms other commonly used algorithms, which is very suitable for the compression of line scanning panoramic infrared images. The algorithmic idea can be applied not only to 14-bit images, but also to more-bit images. © 2024, The Authors. All rights reserved.

关键词： Trees (mathematics)

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SWIR Fluorescenceimaging In Vivo Monitoring and Evaluating Implanted M2 Macrophages in Skeletal Muscle Regeneration

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Engineering 2024年第2期33卷 283-294页

作者： Mo Chen Yuzhou Chen Sijia Feng Shixian Dong Luyi Sun Huizhu Li Fuchun Chen Nguyen Thi Kim Thanh Yunxia Li Shiyi Chen You Wang Jun Chen Sports Medicine Institute of Fudan University Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200127China Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Key Laboratory of Infrared System Detection&Imaging Technology Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK Healthcare Biomagnetic and Nanomaterials Laboratories University College LondonLondon W1S 4BSUK

Skeletal muscle has a robust regeneration ability that is impaired by severe injury,disease,and *** in a decline in skeletal muscle ***,improving skeletal muscle regeneration is a key challenge in treating skeletal muscle-related *** to their significant role in tissue regeneration,implantation of M2 macrophages(M2MФ)has great potential for improving skeletal muscle ***,we present a short-wave infrared(SWIR)fluorescence imaging technique to obtain more in vivo information for an in-depth evaluation of the skeletal muscle regeneration effect after M2MФ*** fluorescence imaging was employed to track implanted M2MФin the injured skeletal muscle of mouse *** is found that the implanted M2MФaccumulated at the injury site for two ***,SWIR fluorescence imaging of blood vessels showed that M2MФimplantation could improve the relative perfusion ratio on day 5(1.09±0.09 vs 0.85±0.05;p=0.01)and day 9(1.38±0.16 vs 0.95±0.03;p=0.01)post-injury,as well as augment the degree of skeletal muscle regencration on day 13 ***,multiple linear regression analyses determined that post-injury time and relative perfusion ratio could be used as predictive indicators to evaluate skeletal muscle *** results provide more in vivo details about M2MФin skeletal muscle regeneration and confirm that M2MФcould promote angiogenesis and improve the degree of skeletal muscle repair,which will guide the research and development of M2MФimplantation to improve skeletal muscle regeneration.

关键词： In vivo Short-wave infrared Skeletal muscle Macrophage Regeneration

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Accurate vehicle detection and counting algorithm for traffic data collection

Accurate vehicle detection and counting algorithm for traffi...

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International Conference on Connected Vehicles and Expo (ICCVE)

作者： Ye Tian Yangli Wang Rui Song Huansheng Song State Key Laboratory of Integrated Service Networks Xidian University Xi'an P.R. China Key Laboratory of Infrared System Detection and Imaging Technology Chinese Academy of Sciences Shanghai P.R. China Department of Electronic and Information Engineering Chang'an University Xi'an P.R. China

ISBN: (纸本)9781509002658

Number of vehicles on road is very important traffic data and is essential for transportation safety and management. In this paper, an approach for vehicle detection is presented. In this approach, virtual line based sensors which are just straight detection lines are first set on road lanes. Then two features, namely gradient and range feature, are proposed for vehicle detection. This is carried out by extracting and analyzing the two features on detection lines. Meanwhile, the solution for vehicle occlusion have also been proposed. Our proposed method has an outstanding advantage that it performs excellent in traffic jams as well as under various conditions, such as sunny, cloudy, and rainy days, or night time, or even tunnels with complex illumination. The high accuracy rate of our method is verified with the experiment results.

关键词： Vehicles Feature extraction Vehicle detection Roads Delays Video sequences Connected vehicles

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An improvement method of a lossless compression scheme for the datacube from Geostationary Interferometric infrared Sounder (GIIRS) and its FPGA implementation

An improvement method of a lossless compression scheme for t...

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IEEE Joint International Information technology and Artificial Intelligence Conference (ITAIC)

作者： Minzhu Yang Raúl Guerra Hernández Changpei Han José Francisco López Feliciano Key Laboratory of Electromagnetic Wave Information Technology and Metrology of Zhejiang Province College of Information Engineering China Jiliang University Hangzhou China Key Laboratory of Infrared System Detection and Imaging Technology Chinese Academy of Science Shanghai China Instituto Universitario de Microelectrónica Aplicada Universidad de Las Palmas de Gran Ganaria Las Palmas Spain

ISBN: (数字)9781728152448

ISBN: (纸本)9781728152455

This paper briefly described an improved method for the original proposed scheme based on Vector Quantization and Linear Prediction to further enhance the compression ratio while reduce the time cost. Given the fact that the interferograms belong to the same datacube are similar to each other, there are two obvious modifications in this paper: predict only once to get the general predicted coefficients for the same datacube; along with treat datacube rather than sequence as the encoded unit. The time consumption spent by Linear Prediction part will shrink about 35.55% by predicting just once. Moreover, the change of the encoded object makes the final compression ratio get a further rise range from 2.62% to 3.711%.

关键词： Vector quantization Conferences Information technology Artificial intelligence Field programmable gate arrays

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Study on the geometric characteristics of micro-seam stitching detectors

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Zhongguo Jiguang/Chinese Journal of Lasers 2014年第s1期41卷

作者： Gong, Xueyi Chen, Fansheng Su, Xiaofeng Huang, Sijie Liu, Qiang Key Laboratory of Infrared System Detection and Imaging Technology Shanghai Institute of Technical Physics Chinese Academy of Sciences Shanghai200083 China Key Laboratories of Infrared Imaging Materials and Detectors Shanghai Institute of Technical Physics Chinese Academy of Sciences Shanghai200083 China

The geometric parameters acquisition of splice detector is the most important thing to validate and evaluate the success of splice, but there is no systematic approach to solve it. For the rotation between the two detectors, the translation of the vertical slit, the slit width and other geometric parameters, the method based on imaging can give very accurate results. On the other hand, the smart-scope can give us the actual mean width of detector splicing, and the results are similar to the above. It proves that the method based on imaging can complete various geometric parameters tests with a very high precision. It just meets the needs of easy and high precision of the aerospace application, and it can provide powerful technical support for the detector slit splicing.

关键词： Aerospace applications

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Patch-based Object Tracking via Locality-constrained Linear Coding

Patch-based Object Tracking via Locality-constrained Linear ...

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第35届中国控制会议

作者： Kunqi Gu Mingna Liu Tao Zhou Fanghui Liu Xiangjian He Jie Yang Yu Qiao Institute of Image Processing and Pattern Recognition Shanghai Jiao Tong University Shanghai Institute of Spaceflight Control Technology Infrared Detection Technology Research and Development Center China Aerospace Science and Technology Corporation School of Computing and Communications University of Technology The Key Laboratory of Ministry of Education for System Control and Information Processing

ISBN: (纸本)9781509009107

In this paper,the Locality-constrained Linear Coding(LLC) algorithm is incorporated into the object tracking ***,we extract local patches within a candidate and then utilize the LLC algorithm to encode these *** on these codes,we exploit pyramid max pooling strategy to generate a richer feature *** feature histogram which integrates holistic and part-based features can be more discriminative and ***,an occlusion handling strategy is utilized to make our tracker more ***,an efficient graph-based manifold ranking algorithm is exploited to capture the relevance between target templates and *** tracking,target templates are taken as labeled nodes while target candidates are taken as unlabeled nodes,and the goal of tracking is to search for the candidate that is the most relevant to existing labeled nodes by manifold ranking *** on challenging video sequences have demonstrated the superior accuracy and robustness of the proposed method in comparison to other state-of-the-art baselines.

关键词： object tracking LLC pyramid max-pooling local appearance model manifold ranking

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AHSI: the Hyperspectral Imager on China's GaoFen-5 Satellite

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IOP Conference Series: Earth and Environmental Science 2020年第1期509卷

作者： Yin-Nian Liu De-Xin Sun Xiao-Ning Hu Shu-Feng Liu Kai-Qin Cao Key Laboratory of Infrared System Detection and Imaging Technologies Shanghai Institute of Technical Physics Chinese Academy of Sciences Shanghai 200083 China

The Advanced Hyperspectral Imager (AHSI) is a visible/short-wave infrared hyperspectral imager on China's GaoFen-5 satellite, which was launched on May 9th, 2018. The AHSI is the first spaceborne hyperspectral sensor that utilizes both the convex grating spectrophotometry and an improved three concentric-mirror (Offner) configuration. It has 60 km swath width, 30 m spatial resolution, 5-10 nm spectral resolution, and 330 spectral bands. Instrument performance was evaluated and validated through well-designed experiments on orbit. Results show that the performance of AHSI has met or exceeded predictions. The AHSI has outstanding capability of detecting and identifying different ground objects and in ecological environment monitoring and natural resource exploration.

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Application of transcutaneous diffuse reflectance spectroscopy in the measurement of blood glucose concentration

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Chinese Optics Letters 2004年第7期2卷 411-413页

作者：陈文亮刘蓉崔厚欣徐可欣吕丽娜 State Key Laboratory of Precision Measuring Technology and Instruments Tianjin UniversityTianjin 300072 State Key Laboratory of Precision Measuring Technology and Instruments Tianjin UniversityTianjin 300072n this paper the propagation characteristics of near-infrared (NIR) light in the palm tissue are analyzed and the principle and feasibility of using transcutaneous diffuse reflectance spectroscopy for non-invasive blood glucose detection are presented. An optical probe suitable for measuring the diffuse reflectance spectrum of human palm and a non-invasive blood glucose detection system using NIR spectroscopy are designed. Based on this system oral glucose tolerance tests are performed to measure the blood glucose concentrations of two young healthy volunteers. The partial least square calibration model is then constructed by all individual experimental data. The final result shows that correlation coefficients of the two experiments between the predicted blood glucose concentrations and the reference blood glucose concentrations are 0.9870 and 0.9854 respectively. The root mean square errors of prediction of full cross validation are 0.54 and 0.52 mmol/1 respectively.

In this paper, the propagation characteristics of near-infrared (NIR) light in the palm tissue are analyzed, and the principle and feasibility of using transcutaneous diffuse reflectance spectroscopy for non-invasive blood glucose detection are presented. An optical probe suitable for measuring the diffuse reflectance spectrum of human palm and a non-invasive blood glucose detection system using NIR spectroscopy are designed. Based on this system, oral glucose tolerance tests are performed to measure the blood glucose concentrations of two young healthy volunteers. The partial least square calibration model is then constructed by all individual experimental data. The final result shows that correlation coefficients of the two experiments between the predicted blood glucose concentrations and the reference blood glucose concentrations are 0.9870 and 0.9854, respectively. The root mean square errors of prediction of full cross validation are 0.54 and 0.52 mmol/1, respectively.

关键词： Application of transcutaneous diffuse reflectance spectroscopy in the measurement of blood glucose concentration NIR OGTT

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Acceleration of infrared Target detection via Efficient Channel Pruning

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Journal of Physics: Conference Series 2022年第1期2203卷

作者： Zhuang Miao Yong Zhang Weihua Li Ruimin Chen Key Laboratory of Infrared System Detection and Imaging Technology Shanghai Institute of Technical Physics Chinese Academy of Sciences Shanghai 200083 China School of Electronic Electrical and Communication Engineering University of Chinese Academy of Sciences Beijing 100049 China

Deployment of modern detection models is difficult for infrared target detection used in robot vision systems due to their heavy computational burden. To alleviate this situation, a simple but efficient channel pruning method is proposed for model acceleration. Specifically, a soft-gated module combined with batch normalization (SGBN) is designed as a standalone layer to substitute the standard batch normalization (BN) layer during training. The conversion between SGBN and BN is easy, and the training overhead introduced is almost negligible after replacement. By controlling the sparsity of the scaling factor in SGBN, unimportant channels with small output are blocked automatically and globally, which is simultaneous with model training. Removing these redundant channels no longer requires fine-tuning, thus significantly speeding up the pruning process. Experiments of pruning different detection models on the infrared dataset show the effectiveness of our method. For example, the parameters and FLOPs of pruned CetnerNet are reduced by 72.70% and 40.20%, respectively, without accuracy loss. The inference speed on the CPU is 12.01ms faster. Extended studies on the classification task also demonstrate its great potential when transferring to other applications.

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