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16th Annual Conference and 5th International Conference on Chinese Society of Micro-Nano technology, CSMNT 2014

作者： Zhang, Zhang Cheng, Zhengxi Zhuang, Yiwei Key Laboratory of Infrared Imaging Materials and Detectors Shanghai Institute of Technical Physics Chinese Academy of Sciences Shanghai China State Key Laboratory of ASIC and System Fudan University Shanghai China School of Electronic Science and Applied Physics Hefei University of Technology Hefei Anhui China

ISBN: (纸本)9783038354628

A low power low noise CMOS amplifier with integrated filter for neural signal recording is designed and fabricated with CSMC 0.5 μm CMOS process. DC offsets introduced by electrode-tissue interface are rejected through a feedback low-pass filter. The bandwidth of the amplifier is in 3.5Hz-5.5KHz range, and the gain is about 48dB in the midband. AC input differential mode voltage range is 10mV, and DC input differential mode voltage range is 180mV. The amplifier can accommodate 180mV DC offsets drift and 10mV neural spikes. The neural probe array is integrated directly on the surface of the amplifier array chip, and is tested in saline solution, and also is implanted in rats in vivo, the results of the experiments show that the amplifier is suitable for neural signal recording. The power dissipation is about 14μW while consuming 0.16 mm2 of chip area, which satisfies implantable devices requirements. © (2015) Trans Tech Publications, Switzerland.

关键词： Signal processing

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detection Algorithm of infrared Dim Small Target Based on FPGA

Detection Algorithm of Infrared Dim Small Target Based on FP...

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Chinese Automation Congress (CAC)

作者： Yingyue Wu Huaicheng Yan Mengling Wang Key Laboratory of Infrared System Detection and Imaging Technology Shanghai Institute of Technical Physics Chinese Academy of Sciences Shanghai China School of Information Science and Engineering East China University of Science and Technology Shanghai China

ISBN: (数字)9781728176871

ISBN: (纸本)9781728176888

The traditional infrared dim and small target detection algorithm is generally implemented by DSP (Digital Signal Processing) processor, which is complex and has poor real-time performance. In this paper, a FAST (Features from Accelerated Segment Test) algorithm of adaptive threshold based on FPGA (Field Programmable Gate Array) is proposed to detect infrared dim and small target. Based on the characteristics of FPGA parallel processing, the hardware acceleration of algorithm is realized by pipeline design. The improved adaptive threshold method can generate appropriate thresholds according to different environments, and avoid the loss or redundancy of dim and small infrared targets due to improper threshold selection. At last, two different groups of infrared images are used for experiment, the results show that the algorithm can detect the dim and small targets in the infrared image in real time, and can achieve high detection rate and low false alarm rate, which meets the requirements of real-time and effectiveness.

关键词： Signal processing algorithms Real-time systems Information science Field programmable gate arrays Digital signal processing Redundancy Pipelines

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Optical Waveguide Manufactured in Photo-Thermo-Refractive Glass Substrate by Ion Exchange 2

Optical Waveguide Manufactured in Photo-Thermo-Refractive Gl...

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Advanced Optical Manufacturing Technologies and Applications 2022, AOMTA 2022 and 2nd International Forum of Young Scientists on Advanced Optical Manufacturing, YSAOM 2022

作者： Hao, Yinlei Wu, Haoze Guo, Xiao Peng, Xiao Wang, Shiyong Meng, Haoran Liu, Xinyue Chen, Xinyang College of Information Science & Electronic Engineering Zhejiang University Hangzhou310027 China Key Laboratory of Infrared System Detection and Imaging Technology Chinese Academy of Sciences Shanghai200083 China Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences Changchun130033 China Shenzhen Institute Zhejiang University Shenzhen518057 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai200030 China

ISBN: (纸本)9781510661264

Photo-thermo-refractive (PTR) glasses exhibit promising characteristics for volume Bragg grating fabrication, one of key devices for construction of high performance lasers, among other optical device and systems. Aiming at employing this type of glass materials in the field of integrated photonics, buried optical channel waveguide is manufactured in PTR glass substrate by Ag+/Na+ thermal ion exchange and subsequent field assisted ion migration. The Ag+ doped zone in glass substrate, which is also the waveguide core, can be driven to several micrometers under the glass substrate surface, which decreases the propagation loss to a value as low as 0.12dB/cm, by eliminate scattering loss at glass substrate defects. Cross section of the waveguide core can be also engineered to match the core of single mode fiber, ensures a low coupling loss to single mode fiber. Analysis demonstrated that the buried optical waveguide fabrication proves can be expected to be applied in functional integrated optical device implementation. © 2023 SPIE.

关键词： Ion exchange

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Optical Waveguide in Thermally Developed Photo-Thermo-Refractive Glass Substrate 9

Optical Waveguide in Thermally Developed Photo-Thermo-Refrac...

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9th Symposium on Novel Photoelectronic detection technology and Applications

作者： Hao, Yinlei Guo, Xiao Peng, Xiao Wu, Haoze Wang, Shiyong Meng, Haoran Liu, Xinyue Chen, Xinyang College of Information Science & Electronic Engineering Zhejiang University Hangzhou310027 China Key Laboratory of Infrared System Detection and Imaging Technology Chinese Academy of Sciences Shanghai200083 China Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences Changchun130033 China Shenzhen Institute of Zhejiang University Shenzhen518057 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai200030 China

ISBN: (纸本)9781510664432

Photo-thermo-refractive (PTR) glasses are a new category of materials that possess special characteristics of refractive index decrement induced by UV exposure and subsequent thermal development. PTR glasses have been extensively utilized for the fabrication of various volume Bragg grating, and are expected to play an important role in the construction of high-performance guided-wave devices. Investigations on the optical waveguide fabrication process in thermally developed PTR glass Substrate are demonstrated. Optical grade PTR glass of the SiO2-Al2O3-Na2O-ZnO-NaFKBr system and doped with Ce, Ag, Sb, and Sn, is firstly melted, and then glass wafers made of the homemade PTR glass are UV exposed and thermal developed, during which nanometer-sized NaF crystalline is formed in these PTR glass wafers. The thermally developed PTR glass wafers are finally subjected to conventional glass-based optical waveguide melt salt thermal Ag+/Na+ ion exchange and subsequently field-assisted ion diffusion for waveguide fabrication. Results exhibited that buried channel optical waveguide, with Ag+ doped waveguide core dimension of approximately 9.5μm×8.6μm buried 5.2μm under the substrate surface can be obtained by the current procedure. In the current paper, the feasibility of implementing buried waveguide fabrication in thermally developed PTR glass materials is experimentally demonstrated. Since the shape and dimension of the waveguide core is well matched to that of single-mode fiber, and the buried waveguide eliminates scattering loss at the glass substrate surface, the buried optical waveguide is expected to find applications in guided-wave device fabrication. © 2023 SPIE.

关键词： Ion exchange

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Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia

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Nano Research 2024年第7期17卷 6411-6419页

作者： Hao Chen Xianzhe Tang Yueye Huang Chen Chen Yuheng Yang Chaojie Hao Wenqi Xie Tingjing Huang Xiaofeng Cheng Qingnan Xu Shicong Huang Zhi Ye Xucong Lin Zhaowei Chen Zhitong Chen MOE Key Laboratory for Analytical Science of Food Safety and Biology and New Cornerstone Science LaboratoryCollege of ChemistryFuzhou UniversityFuzhou 350108China Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Advanced Therapeutic Center National Innovation Center for Advanced Medical DevicesShenzhen 518000China Department of Chemistry University College LondonLondon WC1H 0AJUK Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province College of ChemistryFuzhou UniversityFuzhou 350108China Key Laboratory of Biomedical Imaging Science and System Chinese Academy of SciencesShenzhen 518055China

Androgenetic alopecia(AGA)is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment,leading to cell apoptosis and eventual loss of hair follicles(HFs).Traditional therapeutic formulations,such as Minoxidil(MXD)tincture,have limitations in reshaping the perifollicular microenvironment and exhibit limited ***,we report a multi-synergistic therapeutic platform for high-performance hair regeneration *** platform combines microneedle(MN)patches loaded with MXD-encapsulated nanostructured lipid carriers(MXD-NLC-MNs)and cold atmospheric plasma(CAP).The MNs’mechanical strength enables efficient transdermal delivery of MXD to the targeted dermal papilla cells,promoting cell ***,in collaboration with MXD,the mechanical stimulation exerted by MN application synergistically upregulates the expression of vascular endothelial growth factor,leading to ***,the transient microchannels in the skin created by MNs facilitate the transdermal delivery of CAPgenerated nitric oxide(NO)to the sites of HF lesions,whereby the synergistic interaction between MXD and NO boosts perifollicular ***,the perifollicular microenvironment can be effectively reshaped to accelerate hair regeneration in AGA murine *** multi-synergistic combination therapy strategy would hold great promise for effectively treating AGA and promoting hair regrowth.

关键词： nanomedicine androgenetic alopecia microneedle cold atmospheric plasma drug delivery

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A Low Complexity Lossless Compression Based on General Code Table for infrared Images

SSRN

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SSRN 2024年

作者： Zhu, Yaohua Zhang, Yong Huang, Mingsheng Zhu, Yanghang Key Laboratory of Infrared System Detection and Imaging Technology Chinese Academy of Sciences Shanghai200083 China Shanghai Institute of Technical Phvsics Chinese Academy of Sciences Shanghai200083 China University of Chinese Academy of Sciences Beijing100049 China

In order to improve the storage and transmission of 14-bit image data acquired by line scanning infrared detectors, this paper proposes a novel method to realize real-time and efficient compression for infrared images. The proposed method utilizes the features of infrared images to reduce image redundancy, then a novel and improved Huffman coding is employed to achieve compression. This paper proposes a method for obtaining a general Huffman code table to increase compression speed and a trimming Huffman tree algorithm to reduce complexity caused by long codes of 14-bit images with low-loss compression ratios. The compression based on general code table avoids counting pixels and uses a simple rule to lookup code table that significantly improves the compression speed. The longest code in the general code table is employed to replace all the long codes in the 14-bit image, enabling low-complexity lossless compression. The proposed method outperforms other commonly used algorithms, which is very suitable for the compression of line scanning panoramic infrared images. The algorithmic idea can be applied not only to 14-bit images, but also to more-bit images. © 2024, The Authors. All rights reserved.

关键词： Trees (mathematics)

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SWIR Fluorescenceimaging In Vivo Monitoring and Evaluating Implanted M2 Macrophages in Skeletal Muscle Regeneration

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Engineering 2024年第2期33卷 283-294页

作者： Mo Chen Yuzhou Chen Sijia Feng Shixian Dong Luyi Sun Huizhu Li Fuchun Chen Nguyen Thi Kim Thanh Yunxia Li Shiyi Chen You Wang Jun Chen Sports Medicine Institute of Fudan University Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200127China Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Key Laboratory of Infrared System Detection&Imaging Technology Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK Healthcare Biomagnetic and Nanomaterials Laboratories University College LondonLondon W1S 4BSUK

Skeletal muscle has a robust regeneration ability that is impaired by severe injury,disease,and *** in a decline in skeletal muscle ***,improving skeletal muscle regeneration is a key challenge in treating skeletal muscle-related *** to their significant role in tissue regeneration,implantation of M2 macrophages(M2MФ)has great potential for improving skeletal muscle ***,we present a short-wave infrared(SWIR)fluorescence imaging technique to obtain more in vivo information for an in-depth evaluation of the skeletal muscle regeneration effect after M2MФ*** fluorescence imaging was employed to track implanted M2MФin the injured skeletal muscle of mouse *** is found that the implanted M2MФaccumulated at the injury site for two ***,SWIR fluorescence imaging of blood vessels showed that M2MФimplantation could improve the relative perfusion ratio on day 5(1.09±0.09 vs 0.85±0.05;p=0.01)and day 9(1.38±0.16 vs 0.95±0.03;p=0.01)post-injury,as well as augment the degree of skeletal muscle regencration on day 13 ***,multiple linear regression analyses determined that post-injury time and relative perfusion ratio could be used as predictive indicators to evaluate skeletal muscle *** results provide more in vivo details about M2MФin skeletal muscle regeneration and confirm that M2MФcould promote angiogenesis and improve the degree of skeletal muscle repair,which will guide the research and development of M2MФimplantation to improve skeletal muscle regeneration.

关键词： In vivo Short-wave infrared Skeletal muscle Macrophage Regeneration

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Accurate vehicle detection and counting algorithm for traffic data collection

Accurate vehicle detection and counting algorithm for traffi...

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International Conference on Connected Vehicles and Expo (ICCVE)

作者： Ye Tian Yangli Wang Rui Song Huansheng Song State Key Laboratory of Integrated Service Networks Xidian University Xi'an P.R. China Key Laboratory of Infrared System Detection and Imaging Technology Chinese Academy of Sciences Shanghai P.R. China Department of Electronic and Information Engineering Chang'an University Xi'an P.R. China

ISBN: (纸本)9781509002658

Number of vehicles on road is very important traffic data and is essential for transportation safety and management. In this paper, an approach for vehicle detection is presented. In this approach, virtual line based sensors which are just straight detection lines are first set on road lanes. Then two features, namely gradient and range feature, are proposed for vehicle detection. This is carried out by extracting and analyzing the two features on detection lines. Meanwhile, the solution for vehicle occlusion have also been proposed. Our proposed method has an outstanding advantage that it performs excellent in traffic jams as well as under various conditions, such as sunny, cloudy, and rainy days, or night time, or even tunnels with complex illumination. The high accuracy rate of our method is verified with the experiment results.

关键词： Vehicles Feature extraction Vehicle detection Roads Delays Video sequences Connected vehicles

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An improvement method of a lossless compression scheme for the datacube from Geostationary Interferometric infrared Sounder (GIIRS) and its FPGA implementation

An improvement method of a lossless compression scheme for t...

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IEEE Joint International Information technology and Artificial Intelligence Conference (ITAIC)

作者： Minzhu Yang Raúl Guerra Hernández Changpei Han José Francisco López Feliciano Key Laboratory of Electromagnetic Wave Information Technology and Metrology of Zhejiang Province College of Information Engineering China Jiliang University Hangzhou China Key Laboratory of Infrared System Detection and Imaging Technology Chinese Academy of Science Shanghai China Instituto Universitario de Microelectrónica Aplicada Universidad de Las Palmas de Gran Ganaria Las Palmas Spain

ISBN: (数字)9781728152448

ISBN: (纸本)9781728152455

This paper briefly described an improved method for the original proposed scheme based on Vector Quantization and Linear Prediction to further enhance the compression ratio while reduce the time cost. Given the fact that the interferograms belong to the same datacube are similar to each other, there are two obvious modifications in this paper: predict only once to get the general predicted coefficients for the same datacube; along with treat datacube rather than sequence as the encoded unit. The time consumption spent by Linear Prediction part will shrink about 35.55% by predicting just once. Moreover, the change of the encoded object makes the final compression ratio get a further rise range from 2.62% to 3.711%.

关键词： Vector quantization Conferences Information technology Artificial intelligence Field programmable gate arrays

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Study on the geometric characteristics of micro-seam stitching detectors

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Zhongguo Jiguang/Chinese Journal of Lasers 2014年第S1期41卷

作者： Gong, Xueyi Chen, Fansheng Su, Xiaofeng Huang, Sijie Liu, Qiang Key Laboratory of Infrared System Detection and Imaging Technology Shanghai Institute of Technical Physics Chinese Academy of Sciences Shanghai200083 China Key Laboratories of Infrared Imaging Materials and Detectors Shanghai Institute of Technical Physics Chinese Academy of Sciences Shanghai200083 China

The geometric parameters acquisition of splice detector is the most important thing to validate and evaluate the success of splice, but there is no systematic approach to solve it. For the rotation between the two detectors, the translation of the vertical slit, the slit width and other geometric parameters, the method based on imaging can give very accurate results. On the other hand, the smart-scope can give us the actual mean width of detector splicing, and the results are similar to the above. It proves that the method based on imaging can complete various geometric parameters tests with a very high precision. It just meets the needs of easy and high precision of the aerospace application, and it can provide powerful technical support for the detector slit splicing.

关键词： Aerospace applications

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