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ToPoFM: Topology-Guided Pathology Foundation Model for High-Resolution Pathology image Synthesis with Cellular-Level Control

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IEEE Transactions on Medical Imaging 2025年 PP卷 PP页

作者： Li, Jingxiong Zhu, Chenglu Zheng, Sunyi Chen, Pingyi Sun, Yuxuan Li, Honglin Yang, Lin Zhejiang University College of Computer Science and Technology Hangzhou310027 China Westlake University School of Engineering Hangzhou310024 China Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine Tianjin Key Laboratory of Digestive Cancer Key Laboratory of Cancer Prevention and Therapy Department of Radiology Tianjin China Westlake University Artificial Intelligence and Biomedical Image Analysis Lab School of Engineering Hangzhou310024 China Westlake Institute for Advanced Study Institute of Advanced Technology Hangzhou310024 China Muyuan Laboratory Center for Interdisciplinary Research and Innovation Henan Zhengzhou450016 China

Synthetic data generation emerges as a strategy to mitigate data scarcity in digital pathology, where complicated tissue and cellular features are correlated with cancer diagnosis. The synthesis of such visuals, however, suffers from limited inter class diversity and scarcity of cellular annotations. Current methodologies struggle with capturing the broad spectrum of pathology features, causing unpredictable objects and defected fidelity. Moreover, discrepancies in image resolution across developmental and operational phases can amplify the distribution shifts, undermining the precision of diagnosis. To address these challenges, we introduce TOpology guided PathOlogy Foundation Model (ToPoFM), a visual foundation model designed for the synthesis of high-resolution pathology images with cellular-level control. Our approach integrates a topology-informed cell arrangement generator to steer large language models for crafting synthetic cell arrangements. We correlate cell arrangement guidance with diffusion model for pathology content generation, then further implement a random sliding inference strategy, merging discrete low-resolution samplings into single high-resolution representation. Our model requires only small patches for training. The efficacy of ToPoFM is demonstrated through extensive experiments, complemented by expert validations, showing high fidelity on data synthesis. Additionally, we underscore the utility of our generated imagery as an augmentation tool, enhancing the performance of downstream tasks, including cancer subtype classification and segmentation. © 2025 IEEE.

关键词： image segmentation

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Neural-Network-Based Nonlinear Model Predictive Tracking Control of a Pneumatic Muscle Actuator-Driven Exoskeleton

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IEEE/CAA Journal of Automatica Sinica 2020年第6期7卷 1478-1488页

作者： Yu Cao Jian Huang IEEE Key Laboratory of Image Processing and Intelligent Control School of Artificial Intelligence and AutomationHuazhong University of Science and TechnologyWuhan 430074China

Pneumatic muscle actuators(PMAs)are compliant and suitable for robotic devices that have been shown to be effective in assisting patients with neurologic injuries,such as strokes,spinal cord injuries,etc.,to accomplish rehabilitation ***,because PMAs have nonlinearities,hysteresis,and uncertainties,etc.,complex mechanisms are rarely involved in the study of PMA-driven robotic *** this paper,we use nonlinear model predictive control(NMPC)and an extension of the echo state network called an echo state Gaussian process(ESGP)to design a tracking controller for a PMA-driven lower limb *** dynamics of the system include the PMA actuation and mechanism of the leg orthoses;thus,the system is represented by two nonlinear uncertain *** facilitate the design of the controller,joint angles of leg orthoses are forecasted based on the universal approximation ability of the ESGP.A gradient descent algorithm is employed to solve the optimization problem and generate the control *** stability of the closed-loop system is guaranteed when the ESGP is capable of approximating system *** and experiments are conducted to verify the approximation ability of the ESGP and achieve gait pattern training with four healthy subjects.

关键词： Echo state Gaussian process model predictive control neural network pneumatic muscle actuators-driven exoskeleton

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Domain generalization for mammographic image analysis with contrastive learning

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Computers in Biology and Medicine 2025年 185卷 109455-109455页

作者： Li, Zheren Cui, Zhiming Zhang, Lichi Wang, Sheng Lei, Chenjin Ouyang, Xi Chen, Dongdong Zhao, Xiangyu Liu, Chunling Liu, Zaiyi Gu, Yajia Shen, Dinggang Cheng, Jie-Zhi Shanghai United Imaging Intelligence Co. Ltd. Shanghai200030 China The School of Biomedical Engineering Shanghai Jiao Tong University Shanghai200240 China The School of Biomedical Engineering ShanghaiTech University Shanghai201210 China The Department of Radiology Guangdong Provincial People's Hospital Southern Medical University Guangzhou510080 China Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application Guangzhou510080 China The Department of Radiology Fudan University Shanghai Cancer Center 270 Dongan Road Shanghai200032 China

The deep learning technique has been shown to be effectively addressed several image analysis tasks in the computer-aided diagnosis scheme for mammography. The training of an efficacious deep learning model requires large data with diverse styles and qualities. The diversity of data often comes from the use of various scanners of vendors. But, in practice, it is impractical to collect a sufficient amount of diverse data for training. To this end, a novel contrastive learning, MSVCL+, is developed to equip the deep learning models with better style generalizability. Specifically, the multi-style and multi-view unsupervised self-learning scheme is carried out to seek robust feature embedding against style diversity as a pretrained model. Afterward, the pretrained network is further fine-tuned to the downstream tasks, e.g., mass detection, matching, BI-RADS rating, and breast density classification. The proposed method has been evaluated extensively and rigorously with mammograms from various vendor style domains and several public datasets. The experimental results suggest that the proposed domain generalization method can effectively improve performance of four mammographic image tasks on the data from both seen and unseen domains, and outperform many state-of-the-art (SOTA) generalization methods. © 2024

关键词： Contrastive Learning

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image matching navigation based on fuzzy information

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Journal of Harbin Institute of Technology(New Series) 2003年第4期10卷 447-449页

作者：田玉龙吴伟仁田金文柳健 State Key Laboratory for Image Processing and Intelligence Control Institute for Pattern Recognition and Artificial Intelligence Huazhong University of Science and Technology

In conventional image matching methods, the image matching process is mostly based on image statistic information. One aspect neglected by all these methods is that there is much fuzzy information contained in these images. A new fuzzy matching algorithm based on fuzzy similarity for navigation is presented in this paper. Because the fuzzy theory is of the ability of making good description of the fuzzy information contained in images, the image matching method based on fuzzy similarity would look forward to producing good performance results. Experimental results using matching algorithm based on fuzzy information also demonstrate its reliability and practicability.

关键词： image matching fuzzy information similarity

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MP-MAT: A 3D-AND-INSTANCE-AWARE HUMAN MATTING AND EDITING FRAMEWORK WITH MULTIPLANE REPRESENTATION

arXiv

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arXiv 2025年

作者： Jiao, Siyi Zeng, Wenzheng Li, Yerong Zhang, Huayu Gao, Changxin Sang, Nong Shou, Mike Zheng Key Laboratory of Image Processing and Intelligent Control School of Artificial Intelligence and Automation Huazhong University of Science and Technology China Show Lab National University of Singapore Singapore

Human instance matting aims to estimate an alpha matte for each human instance in an image, which is challenging as it easily fails in complex cases requiring disentangling mingled pixels belonging to multiple instances along hairy and thin boundary structures. In this work, we address this by introducing MP-Mat, a novel 3D-and-instance-aware matting framework with multiplane representation, where the multiplane concept is designed from two different perspectives: scene geometry level and instance level. Specifically, we first build feature-level multiplane representations to split the scene into multiple planes based on depth differences. This approach makes the scene representation 3D-aware, and can serve as an effective clue for splitting instances in different 3D positions, thereby improving interpretability and boundary handling ability especially in occlusion areas. Then, we introduce another multiplane representation that splits the scene in an instance-level perspective, and represents each instance with both matte and color. We also treat background as a special instance, which is often overlooked by existing methods. Such an instance-level representation facilitates both foreground and background content awareness, and is useful for other down-stream tasks like image editing. Once built, the representation can be reused to realize controllable instance-level image editing with high efficiency. Extensive experiments validate the clear advantage of MP-Mat in matting task. We also demonstrate its superiority in image editing tasks, an area under-explored by existing matting-focused methods, where our approach under zero-shot inference even outperforms trained specialized image editing techniques by large margins. Code is open-sourced at https://***/JiaoSiyi/***. Copyright © 2025, The Authors. All rights reserved.

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Cone-Beam Computed Tomography Limited-Angle image Reconstruction Using Planning CT-Guided Deep Diffusion Model

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IEEE Transactions on Instrumentation and Measurement 2025年

作者： Wu, Zhan Yang, Yang Hu, Dianlin Lyu, Tianling Li, Yinsheng Tang, Hao Shu, Huazhong Xi, Yan Zhang, Yi Chen, Yang Southeast University Laboratory of Image Science and Technology Nanjing210096 China Southeast University Ministry of Education Key Laboratory of Computer Network and Information Integration Nanjing210096 China Zhejiang University of Technology Academy for Advanced Interdisciplinary Science and Technology Hangzhou China Chinese Academy of Sciences Key Laboratory of Biomedical Imaging Science and System China Capital Medical University Beijing Jishuitan Hospital China First-Imaging Tech Shanghai China Sichuan University School of Cyber Science and Engineering Chengdu China Laboratory of New Generation Artificial Intelligence Technology and Its Interdisciplinary Applications Southeast University Ministry of Education Jiangsu Provincial Joint International Research Laboratory of Medical Information Processing Laboratory of Image Science and Technology the School of Computer Science and Engineering Nanjing210096 China

For existing image-guided radiation therapy systems (IGRT), the limited angular range of the cone-beam computed tomography (CBCT) scanning improves the compactness of the system and compatibility between CBCT and linear accelerator configurations. However, the limited-angle CBCT reconstruction under incomplete projection data causes severe artifacts in the reconstructed images, further having a negative impact on the registration accuracy in IGRT. In this paper, we propose a planning CT-guided deep diffusion model, termed LARGE-DiffNet, to improve imaging quality and registration accuracy for limited-angle CBCT image reconstruction. In stark contrast to existing approaches leveraging hand-crafted regularization, such as local smoothness and/or sparsity of the image, LARGE-DiffNet learns the distribution-level prior knowledge to describe the features of ideal CBCT images via a planning CT-guided diffusion model. The proposed LARGE-DiffNet is evaluated on the clinical CBCT dataset, and extensive experimental results demonstrate that the proposed method outperforms the state-of-the-art methods. The proposed LARGE-DiffNet technique has great potential in IGRT. © 1963-2012 IEEE.

关键词： cone-beam computed tomography deep learning diffusion model image registration image-guided radiation therapy limited-angle

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Taming Consistency Distillation for Accelerated Human image Animation

arXiv

引用

arXiv 2025年

作者： Wang, Xiang Zhang, Shiwei Yuan, Hangjie Wei, Yujie Zhang, Yingya Gao, Changxin Wang, Yuehuan Sang, Nong Key Laboratory of Image Processing and Intelligent Control School of Artificial Intelligence and Automation Huazhong University of Science and Technology China Alibaba Group China Fudan University China

Recent advancements in human image animation have been propelled by video diffusion models, yet their reliance on numerous iterative denoising steps results in high inference costs and slow speeds. An intuitive solution involves adopting consistency models, which serve as an effective acceleration paradigm through consistency distillation. However, simply employing this strategy in human image animation often leads to quality decline, including visual blurring, motion degradation, and facial distortion, particularly in dynamic regions. In this paper, we propose the DanceLCM approach complemented by several enhancements to improve visual quality and motion continuity at low-step regime: (1) segmented consistency distillation with an auxiliary light-weight head to incorporate supervision from real video latents, mitigating cumulative errors resulting from single full-trajectory generation;(2) a motion-focused loss to centre on motion regions, and explicit injection of facial fidelity features to improve face authenticity. Extensive qualitative and quantitative experiments demonstrate that DanceLCM achieves results comparable to state-of-the-art video diffusion models with a mere 2-4 inference steps, significantly reducing the inference burden without compromising video quality. The code and models will be made publicly available. Copyright © 2025, The Authors. All rights reserved.

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A Game Theory-Reinforcement Learning Approach to Cooperation for UAVs

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IEEE Transactions on Vehicular Technology 2025年

作者： Tang, Changbing Pan, Linchao Chen, Jie Liu, Yang Lai, Jingang The College of Physics and Electronic Information Engineering Zhejiang Normal University Jinhua321004 China The School of Mathematical Sciences Zhejiang Normal University Jinhua321004 China The Hangzhou School of Automation Zhejiang Normal University Hangzhou311231 China The College of Electronic Engineering National University of Defense Technology Hefei230037 China The School of Artificial Intelligence and Automation the Key Laboratory of Image Processing and Intelligent Control Education Ministry of China China Huazhong University of Science and Technology Wuhan430074 China

To execute a variety of collaborative tasks, the cooperation for unmanned aerial vehicles (UAVs) with complicated interactions under dynamic environments is a challenging and critical issue. This paper studies the cooperation issue for UAVs under dynamic environments through an approach of game theory-reinforcement learning (GT-RL) approach, which combines the advantages of both game theory and reinforcement learning. First, to cope with the complicated interactions of UAVs, the cluster of UAVs is modeled as a public goods game with asymmetrical environmental feedback. Then, reinforcement learning is adopted to optimize decision-making of UAVs under unknown and dynamic environments through comparing the dynamic behaviors of UAVs, where a novel dynamics system offers a more comprehensive understanding on cooperative behavior among UAVs. Finally, the simulation results show that the GT-RL approach can effectively promote cooperation among UAVs in completing the collaborative tasks. © 1967-2012 IEEE.

关键词： Adversarial machine learning

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Recursive Least Squares Identification With Variable-Direction Forgetting via Oblique Projection Decomposition

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IEEE/CAA Journal of Automatica Sinica 2022年第3期9卷 547-555页

作者： Kun Zhu Chengpu Yu Yiming Wan Key Laboratory of Image Processing and Intelligent Control School of Artificial Intelligence and AutomationHuazhong University of Science and Technology Beijing Institute of Technology Chongqing Innovation Center

In this paper,a new recursive least squares(RLS)identification algorithm with variable-direction forgetting(VDF)is proposed for multi-output *** objective is to enhance parameter estimation performance under non-persistent *** proposed algorithm performs oblique projection decomposition of the information matrix,such that forgetting is applied only to directions where new information is *** proofs show that even without persistent excitation,the information matrix remains lower and upper bounded,and the estimation error variance converges to be within a finite ***,detailed analysis is made to compare with a recently reported VDF algorithm that exploits eigenvalue decomposition(VDF-ED).It is revealed that under non-persistent excitation,part of the forgotten subspace in the VDF-ED algorithm could discount old information without receiving new data,which could produce a more ill-conditioned information matrix than our proposed *** simulation results demonstrate the efficacy and advantage of our proposed algorithm over this recent VDF-ED algorithm.

关键词： Non-persistent excitation oblique projection recursive least squares(RLS) variable-direction forgetting(VDF)

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Adaptive Synchronization between Two Different Complex Networks with Time-Varying Delay Coupling

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中国物理快报（英文版） 2009年第6期26卷 59-62页

作者： CHEN Jian-Rui JIAO Li-Cheng WU Jian-She WANG Xiao-Hua Key Laboratory of Intelligent Perception and Image Understanding of Ministry of Education of China Institute of Intelligence Information ProcessingXidian UniversityXi'an 710071 College of Science Inner Mongolia University of TechnologyInner Mongolia 01 Key Laboratory of Intelligent Perception and Image Understanding of Ministry of Education of China Institute of Intelligence Information ProcessingXidian UniversityXi'an 710071

A new general network model for two complex networks with time-varying delay coupling is *** we investigate its synchronization *** two complex networks of the model differ in dynamic nodes,the number of nodes and the coupling *** using adaptive controllers,a synchronization criterion is *** examples are given to demonstrate the effectiveness of the obtained synchronization *** study may widen the application range of synchronization,such as in chaotic secure communication.

关键词： No English keywords

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