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IEEE International Conference on Bioinformatics and Biomedicine

作者： Peng Cao Jinzhu Yang Shanshan Tang Dazhe Zhao Osmar Zaiane Min Huang Amine Trabelsi College of Computer Science and Engineering Key Laboratory of Intelligent Computing in Medical Image Ministry of Education Northeastern University College of Computer Science and Engineering Northeastern University College of Information Science and Engineering Northeastern University Department of Computing Science University of Alberta Department of Computing Science University of Alberta

ISBN: (纸本)9781728118680

Machine learning algorithms and multivariate data analysis methods have been widely utilized in the field of Alzheimer's disease (AD) research in recent years. Predicting cognitive performance of subjects from neuroimage measures and identifying relevant imaging biomarkers are important research topics in the study of Alzheimer's disease. Multi-task based feature learning (MTFL) have been widely studied to select a discriminative feature subset from MRI features, and improve the performance by incorporating inherent correlations among multiple clinical cognitive measures. It is known that the brain imaging measures are often correlated with each other, and AD is closely related to the inter-correlation among different brain regions. However, the multitask based feature learning (MTFL) method neglects the inherent correlation among brain imaging measures. We present a novel regularized multi-task learning approach via a joint sparsity-inducing regularization to effectively incorporate both a relatedness among multiple cognitive score prediction tasks and a useful inherent correlation between brain imaging measures by exploiting correlations among features. It allows the simultaneous selection of a common set of biomarkers for all tasks and the preservation of the inherent structure of imaging measures. The reported experiments on the ADNI dataset show that the proposed method is effective and promising.

关键词： Alzheimer's disease Regression model Multi-task learning Magnetic resonance imaging Biomarkers discovery Alzheimer Disease simple regression (model) Magnetic Resonance Imaging PARALLEL PROCESSING (COMPUTERS) Learning Machine learning algorithms Diencephalon

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Dermoscopic image Classification Using Attention Mechanism and Ensemble Learning Approaches

Dermoscopic Image Classification Using Attention Mechanism a...

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IEEE International Conference on Big Data

作者： Shanchuan Huang Hongwei Lei Liuhan Jin Jinzhu Yang Tao Jiang Yudong Yao Marcin Grzegorzek Chen Li Microscopic Image and Medical Image Analysis Group College of Medicine and Biological Information Engineering Northeastern University China Key Laboratory of Intelligent Computing in Medical Image Ministry of Education Northeastern University Shenyang Liaoning China School of Intelligent Medicine Chengdu University of Traditional Chinese Medicine Chengdu China Department of Electrical and Computer Engineering Stevens Institute of Technology USA Institute of Medical Informatics University of Luebeck Luebeck Germany

Background and purpose: Skin tumours have become one of the most common diseases worldwide. While benign ones are not usually a threat to human health, malignant ones can develop into skin cancer and become life-threatening if left untreated. Early detection of the disease is important for the treatment of patients with skin tumours and dermoscopy is the most effective means of diagnosing skin tumours. However, the complexity of skin tumour cells makes the diagnosis somewhat erroneous for doctors. Therefore, a dermoscopic classification network based on deep learning and computer-aided diagnostic techniques is needed to obtain a high diagnostic accuracy rate for skin tumours. Methods: In this paper, Deep-skin, a model for dermoscopic image classification is proposed, which is based on both attention mechanism and ensemble learning. Considering the characteristics of dermoscopic images, embedding different attention mechanisms on top of Inception-V3 has been suggested to obtain more potential features. We then improve the classification performance by late fusion of the different models. To demonstrate the effectiveness of Deep-skin, experiments and evaluations are performed on the publicly available dataset Skin Cancer: Malignant vs. Benign and compare the performance of Deep-skin with other classification models. Results: The experimental results indicate that Deep-skin performs well on the dataset in comparison to other models, achieving a maximum accuracy of 87.8%.Conclusion: In this paper, the Deep-skin model is proposed for the classification of dermoscopic images and has shown better performance. In the future, we intend to investigate better classification models for automatic diagnosis of skin tumours. Such models can potentially assist physicians and patients in clinical settings.

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Availability analysis and optimization in CoMP and CA-enabled HetNets

Availability analysis and optimization in CoMP and CA-enable...

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作者： Jia, Jie Deng, Yansha Chen, Jian Aghvami, Abdol-Hamid Nallanathan, Arumugam Key Laboratory of Medical Image Computing Northeastern University Ministry of Education Shenyang110819 China School of Computer Science and Engineering Northeastern University Shenyang110819 China Department of Informatics King's College London LondonWC2R 2LS United Kingdom

Traditional cellular networks are moving toward heterogeneous cellular networks (HetNets) to satisfy the stringent demand for data rates and capacity. To enable the new applications in 5G, such as haptic communications, we face new challenges of achieving high availability with low latency in Het- Nets. In this paper, we introduce coordinated multi-point (CoMP) and carrier aggregation (CA) techniques in HetNets to guarantee the availability of all user equipment (UE), where the CoMP improves the single-path availability, and the CA enhances availability via multi-carrier gain combining. To characterize the availability, we first derive an exact closed-form expression for the availability of a random UE in a CoMP and CA-enabled HetNets. To achieve the maximum UE availability, we formulate a max- min optimization problem. To solve it, we then propose a two-step optimization algorithm (TSOA) and a joint (JTOA). The TSOA is based on heuristic algorithm for the optimal subcarrier assignment and UE association, and based on the Lagrangian dual method for the power allocation. The JTOA is based on genetic algorithm to achieve the interaction between the first step and the second step. Our results showcase the effective of our proposed JTOA, and the effective of the CoMP in availability improvement in HetNets. © 2017 IEEE.

关键词： Genetic algorithms

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dense feature aggregation and pruning for RGBT tracking

arXiv

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arXiv 2019年

作者： Zhu, Yabin Li, Chenglong Luo, Bin Tang, Jin Wang, Xiao Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education School of Computer Science and Technology Anhui University Hefei Anhui China Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education School of Computer Science and Technology Anhui University Institute of Physical Science and Information Technology Anhui University Hefei Anhui China Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education School of Computer Science and Technology Anhui University Key Laboratory of Industrial Image Processing and Analysis of Anhui Province Hefei Anhui China

How to perform effective information fusion of different modalities is a core factor in boosting the performance of RGBT tracking. This paper presents a novel deep fusion algorithm based on the representations from an end-to-end trained convolutional neural network. To deploy the complementarity of features of all layers, we propose a recursive strategy to densely aggregate these features that yield robust representations of target objects in each modality. In different modalities, we propose to prune the densely aggregated features of all modalities in a collaborative way. In a specific, we employ the operations of global average pooling and weighted random selection to perform channel scoring and selection, which could remove redundant and noisy features to achieve more robust feature representation. Experimental results on two RGBT tracking benchmark datasets suggest that our tracker achieves clear state-of-the-art against other RGB and RGBT tracking methods. Copyright © 2019, The Authors. All rights reserved.

关键词： Machine learning

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Boosting Point-BERT by Multi-choice Tokens

arXiv

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arXiv 2022年

作者： Fu, Kexue Yuan, Mingzhi Wang, Manning Digital Medical Research Center School of Basic Medical Science Fudan University Shanghai China Shanghai Key Laboratory of Medical Image Computing and Computer Assisted Intervention Shanghai China

Masked language modeling (MLM) has become one of the most successful self-supervised pre-training task. Inspired by its success, Point-BERT, as a pioneer work in point cloud, proposed masked point modeling (MPM) to pre-train point transformer on large scale unanotated dataset. Despite its great performance, we find the inherent difference between language and point cloud tends to cause ambiguous tokenization for point cloud. For point cloud, there doesn’t exist a gold standard for point cloud tokenization. Point-BERT use a discrete Variational AutoEncoder (dVAE) as tokenizer, but it might generate different token ids for semantically-similar patches and generate the same token ids for semantically-dissimilar patches. To tackle above problem, we propose our McP-BERT, a pre-training framework with multi-choice tokens. Specifically, we ease the previous single-choice constraint on patch token ids in Point-BERT, and provide multi-choice token ids for each patch as supervision. Moreover, we utilitze the high-level semantics learned by transformer to further refine our supervision signals. Extensive experiments on point cloud classification, few-shot classification and part segmentation tasks demonstrate the superiority of our method, e.g., the pre-trained transformer achieves 94.1% accuracy on ModelNet40, 84.28% accuracy on the hardest setting of ScanObjectNN and new state-of-the-art performance on few-shot learning. We also demonstrate that our method not only improves the performance of Point-BERT on all downstream tasks, but also incurs almost no extra computational overhead. The code will be released in https://***/fukexue/McP-BERT. Copyright © 2022, The Authors. All rights reserved.

关键词： Large dataset

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An Auto-Encoding Generative Adversarial Networks for Generating Brain Network 2020

An Auto-Encoding Generative Adversarial Networks for Generat...

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The Fourth International Symposium on image computing and Digital Medicine

作者： Shan Zhang Peng Cao Lili Dou Jinzhu Yang Dazhe Zhao Computer Science and Engineering Northeastern University Shenyang China and Key Laboratory of Intelligent Computing in Medical Image of Ministry of Education Northeastern University Shenyang China China Artificial Intelligence and Clinical Innovation Research Neusoft of Medical Systems Shenyang China China

ISBN: (纸本)9781450389686

Generative adversarial networks (GANs) are powerful generative models that have led to breakthroughs in image generation. The aim of our work is to adapt the idea of GANs to the graph data based on fMRI, which can solve the issue of limited data and improve the classification performance in the domain of the Autism spectrum disorder (ASD) diagnosis. In this work, we present a data augmentation method that generates synthetic graph data with the proposed graph generation model named α-GCNGAN, which is able to handle the intrinsic challenge of generating brain network with considering flexible context-structure. Extensive experiments on Autism Brain Imaging Data Exchange (ABIDE) dataset demonstrate the effectiveness and generalizability of α-GCNGAN.

关键词： Generative adversarial network Autism Spectrum Disorders fMRI Data Augmentation

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GCN-RNN: An Unified Framework for Modeling the multi-label diagnosis of chest X-ray disease 2020

GCN-RNN: An Unified Framework for Modeling the multi-label d...

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The Fourth International Symposium on image computing and Digital Medicine

作者： Chunyu Jiang Peng Cao Lili Dou Jinzhu Yang Dazhe Zhao Computer Science and Engineering Northeastern University Shenyang China and Key Laboratory of Intelligent Computing in Medical Image of Ministry of Education Northeastern University Shenyang China China Northeastern University China Neusoft Corporation Shenyang China China

ISBN: (纸本)9781450389686

Chest X-ray is one of the most common radiology exams used for screening of lung diseases. A typical chest X-ray image might contain multiple thoracic diseases, which is a multi-label learning problem. Multi-label learning is a supervised classification framework in which multiple target labels can be assigned to one instance. How to effectively capture the correlations between object labels and explore these label correlations to improve the classification performance are both important for multi-label image recognition. In this paper, we presented a combination of GCN and RNN(LSTM) to exploit label dependencies from global and local perspective. Experimental results on public CheXpert dataset demonstrate that the proposed architecture achieves better performance than the state-of-the-art classification models.

关键词： Chest X-ray disease RNN GCN Multi-label learning

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Crawling Result Pages for Data Extraction Based on URL Classification

Crawling Result Pages for Data Extraction Based on URL Class...

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Web Information Systems and Applications Conference (WISA)

作者： Tiezheng Nie Zhenhua Wang Yue Kou Rui Zhang Key Laboratory of Medical Image Computing Ministry of Education Northeastern University Shenyang China College of Information Science and Engineering Northeastern University Shenyang China

In Web database integration, crawling data pages is important for data extraction. The fact that data are contained by multiple result pages increases the difficulty of accessing data for integration. Thus, it is necessary to accurately and automatically crawl query result pages from Web database. To address this problem, we propose a novel approach based on URL classification to effectively identify result pages. In our approach, we compute the similarity between URLs of hyperlinks in result pages and classify them into four categories. Each category maps to a set of similar web pages, which separate result pages from others. Then, we use the page probing method to verify the correctness of classification and improve the accuracy of crawled result pages. The experimental result demonstrates that our approach is effective for identifying the collection of result pages in Web database, and can improve the quality and efficiency of data extraction.

关键词： Classification algorithms Databases Web pages Data mining Accuracy Clustering algorithms

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Protein-coding genes combined with long noncoding RNA as a novel transcriptome molecular staging model to predict the survival of patients with esophageal squamous cell carcinoma

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Cancer Communications 2018年第1期38卷 50-62页

作者： Jin-Cheng Guo Yang Wu Yang Chen Feng Pan Zhi-Yong Wu Jia-Sheng Zhang Jian-Yi Wu Xiu-E Xu Jian-Mei Zhao En-Min Li Yi Zhao Li-Yan Xu Key Laboratory of Molecular Biology in High Cancer Incidence Coastal Chaoshan Area of Guangdong Higher Education Institutes Shantou University Medical CollegeShantouGuangdong 515041P.R.China Department of Biochemistry and Molecular Biology Shantou University Medical CollegeShantouGuangdong 515041P.R.China Departments of Oncology Surgery Shantou Central HospitalAffiliated Shantou Hospital of Sun Yat-Sen UniversityShantouGuangdong 515041P.R.China Institute of Oncologic Pathology Shantou University Medical CollegeShantouGuangdong 515041P.R.China Key Laboratory of Intelligent Information Processing Advanced Computer Research CenterState Key Laboratory of Computer ArchitectureInstitute of Computing TechnologyChinese Academy of SciencesBeijing 100190P.R.China

Background:Esophageal squamous cell carcinoma(ESCC)is the predominant subtype of esophageal carcinoma in *** study was to develop a staging model to predict outcomes of patients with ***:Using Cox regression analysis,principal component analysis(PCA),partitioning clustering,Kaplan-Meier analysis,receiver operating characteristic(ROC)curve analysis,and classification and regression tree(CART)analysis,we mined the Gene Expression Omnibus database to determine the expression profiles of genes in 179 patients with ESCC from GSE63624 and GSE63622 ***:Univariate cox regression analysis of the GSE63624 dataset revealed that 2404 protein-coding genes(PCGs)and 635 long non-coding RNAs(lncRNAs)were associated with the survival of patients with *** categorized these PCGs and lncRNAs into three principal components(PCs),which were used to cluster the patients into three *** analysis demonstrated that the predictive ability of PCG-lncRNA PCs when applied to new patients was better than that of the tumor-node-metastasis staging(area under ROC curve[AUC]:0.69 vs.0.65,P<0.05).Accord-ingly,we constructed a molecular disaggregated model comprising one lncRNA and two PCGs,which we desig-nated as the LSB staging model using CART analysis in the GSE63624 *** LSB staging model classified the GSE63622 dataset of patients into three different groups,and its effectiveness was validated by analysis of another cohort of 105 ***:The LSB staging model has clinical significance for the prognosis prediction of patients with ESCC and may serve as a three-gene staging microarray.

关键词： Long non-coding RNA Protein-coding gene Esophageal squamous cell carcinoma Overall survival Staging model Transcriptome

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Space Engage: Collaborative Space Supervision for Contrastive-based Semi-Supervised Semantic Segmentation

arXiv

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arXiv 2023年

作者： Wang, Changqi Xie, Haoyu Yuan, Yuhui Fu, Chong Yue, Xiangyu School of Computer Science and Engineering Northeastern University Shenyang China The Chinese University of Hong Kong Hong Kong Microsoft Research Asia China Key Laboratory of Intelligent Computing in Medical Image Ministry of Education NEU China

Semi-Supervised Semantic Segmentation (S4) aims to train a segmentation model with limited labeled images and a substantial volume of unlabeled images. To improve the robustness of representations, powerful methods introduce a pixel-wise contrastive learning approach in latent space (i.e., representation space) that aggregates the representations to their prototypes in a fully supervised manner. However, previous contrastive-based S4 methods merely rely on the supervision from the model's output (logits) in logit space during unlabeled training. In contrast, we utilize the outputs in both logit space and representation space to obtain supervision in a collaborative way. The supervision from two spaces plays two roles: 1) reduces the risk of over-fitting to incorrect semantic information in logits with the help of representations;2) enhances the knowledge exchange between the two spaces. Furthermore, unlike previous approaches, we use the similarity between representations and prototypes as a new indicator to tilt training those under-performing representations and achieve a more efficient contrastive learning process. Results on two public benchmarks demonstrate the competitive performance of our method compared with state-of-the-art methods. Copyright © 2023, The Authors. All rights reserved.

关键词： Semantic Segmentation

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