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arXiv 2025年

作者： Hou, Qingshan Wang, Meng Cao, Peng Ke, Zou Liu, Xiaoli Fu, Huazhu Zaiane, Osmar R. Computer Science and Engineering Northeastern University Shenyang China Key Laboratory of Intelligent Computing in Medical Image of Ministry of Education Northeastern University Shenyang China Alberta Machine Intelligence Institute University of Alberta Edmonton Canada Ophthalmology Yong Loo Lin School of Medicine National University of Singapore Singapore Institute of High Performance Computing Agency for Science Technology and Research Singapore

Recent advancements in ophthalmology foundation models such as RetFound have demonstrated remarkable diagnostic capabilities but require massive datasets for effective pre-training, creating significant barriers for development and deployment. To address this critical challenge, we propose FundusGAN, a novel hierarchical feature-aware generative framework specifically designed for high-fidelity fundus image synthesis. Our approach leverages a Feature Pyramid Network within its encoder to comprehensively extract multi-scale information, capturing both large anatomical structures and subtle pathological features. The framework incorporates a modified StyleGAN-based generator with dilated convolutions and strategic upsampling adjustments to preserve critical retinal structures while enhancing pathological detail representation. Comprehensive evaluations on the DDR, DRIVE, and IDRiD datasets demonstrate that FundusGAN consistently outperforms state-of-the-art methods across multiple metrics (SSIM: 0.8863, FID: 54.2, KID: 0.0436 on DDR). Furthermore, disease classification experiments reveal that augmenting training data with FundusGAN-generated images significantly improves diagnostic accuracy across multiple CNN architectures (up to 6.49% improvement with ResNet50). These results establish FundusGAN as a valuable foundation model component that effectively addresses data scarcity challenges in ophthalmological AI research, enabling more robust and generalizable diagnostic systems while reducing dependency on large-scale clinical data collection. Copyright © 2025, The Authors. All rights reserved.

关键词： Ophthalmology

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Asymptotically Optimal Sequence Sets With Low/Zero Ambiguity Zone Properties

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IEEE Transactions on Information Theory 2025年

作者： Tian, Liying Song, Xiaoshi Liu, Zilong Li, Yubo Northeastern University School of Computer Science and Engineering Shenyang110819 China Northeastern University Key Laboratory of Intelligent Computing in Medical Image Ministry of Education Shenyang110189 China University of Essex School of Computer Science and Electronics Engineering ColchesterCO4 3SQ United Kingdom Yanshan University School of Information Science and Engineering Qinhuangdao066004 China Hebei Key Laboratory of Information Transmission and Signal Processing Qinhuangdao066004 China

Sequences with low/zero ambiguity zone (LAZ/ZAZ) properties are useful in modern communication and radar systems operating over mobile environments. This paper first presents a new family of ZAZ sequence sets motivated by the "modulating" zero correlation zone (ZCZ) sequences which were first proposed by Popovic and Mauritz. We then introduce a second family of ZAZ sequence sets with comb-like spectrum, whereby the local Doppler resilience is guaranteed by their inherent spectral nulls in the frequency domain. Finally, LAZ sequence sets are obtained by exploiting their connection with a novel class of mapping functions. These proposed unimodular ZAZ and LAZ sequence sets are cyclically distinct and asymptotically optimal with respect to the existing theoretical bounds on ambiguity functions. © 1963-2012 IEEE.

关键词： Frequency domain analysis

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Replace2Self: Self-Supervised Denoising based on Voxel Replacing and image Mixing for Diffusion MRI

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IEEE Transactions on medical Imaging 2025年 PP卷 PP页

作者： Wu, Linhai Wang, Lihui Deng, Zeyu Zhu, Yuemin Wei, Hongjiang Guizhou University Key Laboratory of Advanced Medical Imaging and Intelligent Computing of Guizhou Province Engineering Research Center of Text Computing & Cognitive Intelligence Ministry of Education State Key Laboratory of Public Big Data College of Computer Science and Technology 550025 China Univ Lyon INSA Lyon CNRS Inserm CREATIS UMR 5220 LyonF-69621 France Shanghai Jiao Tong University School of Biomedical Engineering Shanghai200030 China

Low signal to noise ratio (SNR) remains one of the limitations of diffusion weighted (DW) imaging. How to suppress the influence of noise on the subsequent analysis about the tissue microstructure is still challenging. This work proposed a novel self-supervised learning model, Replace2Self, to effectively reduce spatial correlated noise in DW images. Specifically, a voxel replacement strategy based on similar block matching in Q-space was proposed to destroy the correlations of noise in DW image along one diffusion gradient direction. To alleviate the signal gap caused by the voxel replacement, an image mixing strategy based on complementary mask was designed to generate two different noisy DW images. After that, these two noisy DW images were taken as input, and the non-correlated noisy DWimage after voxel replacement was taken as learning target, a denoising network was trained for denoising. To promote the denoising performance, a complementary mask mixing consistency loss and an inverse replacement regularization loss were also proposed. Through the comparisons against several existing DW image denoising methods on extensive simulation data with different noise distributions, noise levels and b-values, as well as the acquisition datasets and the ablation experiments, we verified the effectiveness of the proposed method. Regardless of the noise distribution and noise level, the proposed method achieved the highest PSNR, which was at least 1.9% higher than the suboptimal method when the noise level reaches 10%. Furthermore, our method has superior generalization ability due to the use of the proposed strategies. © 2025 IEEE. All rights reserved.

关键词： Signal to noise ratio

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Air Pollution Monitoring By Integrating Local and Global Information in Self-Adaptive Multiscale Transform Domain

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IEEE Transactions on Multimedia 2025年

作者： Gu, Ke Liu, Yuchen Liu, Hongyan Liu, Bo Qiao, Junfei Lin, Weisi Zhang, Wenjun Beijing University of Technology School of Information Science and Technology Engineering Research Center of Intelligent Perception and Autonomous Control of Ministry of Education Beijing Laboratory of Smart Environmental Protection Beijing Key Laboratory of Computational Intelligence and Intelligent System Beijing Artificial Intelligence Institute Beijing100124 China Massey University School of Mathematical and Computational Sciences New Zealand Nanyang Technological University College of Computing and Data Science Singapore Shanghai Jiao Tong University Institute of Image Communication and Information Processing Shanghai China

As the deadliest form of pollution, air pollution had a prolonged severe damage to the human health and life safety of nearly 99% of the world's population. Facing to the problem that billions of tons of pollutants discharged into the air per year by industrial activities, this paper proposed a novel image-based air pollution monitor (IAPM) by incorporating local and global information in the self-adaptive multiscale transform domain, so as to achieve the timely and effective leakage detection of typical air pollutants from a single image. To be specific, this paper first developed a screen-shaped module according to two significant findings in visual neuroscience, which include the high sensitivity of human eyes to horizontal and vertical stimuli and the center-surround inhibition, by designing and fusing the square module, horizontal strip module and vertical strip module parallelly for simulating the behaviour of human eyes to extract local features. Second, the learnable weights and proportional mapping were applied to incorporate the screen-shaped module and lightweight vision transformer as backbone, towards more richly exploiting and fusing local and global information just as the way a brain perceives external stimuli. Third, a new self-adaptive multiscale transform domain method was devised based on two motivations from the visual characteristics of multiscale perception and the brain characteristics of self-adaptive domain transform to modify the backbone by using the operations of pooling and pointwise convolution. Extensive experiments implemented on the datasets of carbon particulate matters and ethylene leakage confirmed the superior monitoring performance of the proposed IAPM model beyond the state-of-the-art (SOTA) peers by an accuracy gain of about 4%. Furthermore, the proposed IAPM model only required 0.089 GFLOPs and 0.15 million model parameters, remarkably outperforming SOTA competitors in computational efficiency and storage resources. © 1999-2

关键词： Information leakage

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Single-cell technologies: current and near future

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Science China(Life Sciences) 2025年第1期68卷 1-4页

作者： Chenfei Wang Qi Liu Xiaohui Fan Tieliu Shi KeyLaboratory of Spine and Spinal CordInjury Repairand Regeneration Ministry of EducationOrthopedics DepartmentTongji HospitalBioinformatics DepartmentSchoolofLifeSciencesandTechnologyTongji UniversityShanghai 200082China Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji UniversityShanghai 200092China Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji UniversityShanghai 200082China Research Institute of Intelligent Computing Zhejiang LabHangzhou 311121China Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314103China Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Key Laboratory of Advanced Theory and Application in Statistics and Data Science(MOE) School of StatisticsEast China Normal UniversityShanghai 200062China

Single-cell technologies enable the indepth exploration of multiple biological hierarchies at the scale of individual cells,which have deepened our knowledge of cellular diversity,tissue organization,and overall organism function(Sun et al.,2024).In 2009,single-cell RNA sequencing(scRNA-seq)was first developed as a powerful tool to dissect gene expression and uncover transcriptional *** the rapid advancement of technology,single-cell approaches have expanded to encompass other omics,such as genomics,epigenomics,proteomics,and ***,multimodal technologies including spatially resolved transcriptomics and clustered regularly interspaced short palindromic repeats(CRISPR)screening at the single-cell level further advanced our ability to comprehensively understand cellular ***-cell methods provide deeper insights into disease mechanisms across various conditions,including cancer,developmental disorders,and aging-associated *** this issue,we focus on topics related to single-cell methods,covering the following four aspects:(i)single-cell multi-omic sequencing technology;(ii)single-cell spatial technology;(iii)singlecell CRISPR screening technology;(iv)applications of single-cell technology.

关键词： expanded enable insight

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OH-DRL: An AoI-Guaranteed Energy-Efficient Approach for UAV-Assisted IoT Data Collection

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IEEE Transactions on Wireless Communications 2025年

作者： Yang, Bowen Yu, Yao Hao, Xin Yeoh, Phee Lep Zhang, Junxiong Guo, Lei Li, Yonghui Northeastern University School of Computer Science and Engineering Ministry of Education Northeastern University and Key Laboratory of Intelligent Computing in Medical Image Shenyang110819 China Deakin University School of Information Technology VIC3216 Australia University of the Sunshine Coast School of Science Technology and Engineering Australia Chongqing University of Posts and Telecommunications School of Communication and Information Engineering Chongqing400065 China University of Sydney School of Electrical and Computer Engineering SydneyNSW2006 Australia

In this paper, we propose a hierarchical optimization approach that guarantees the maximum age of information (AoI) for unmanned aerial vehicle (UAV) assisted Internet-of-Things (IoT) data collection. Our model is based on an energy-efficient simultaneously transmitting and reflecting reconfigurable intelligent surface (STAR-RIS) beamforming model. We formulate the optimization to minimize the UAV flight energy consumption subject to a maximum average AoI threshold by optimizing the UAV trajectory, IoT device scheduling, and STAR-RIS beamforming. To solve this, we develop an optimization-based hierarchical deep reinforcement learning (OH-DRL) algorithm that decomposes the formulated problem into an inter-cluster UAV visiting policy and STAR-RIS-based intra-cluster IoT scheduling policy. In OH-DRL, we jointly optimize the two policies in a high-level loop and a low-level loop, respectively. In the high-level loop, we design an AoI-guided DRL algorithm to determine the AoI-guaranteed UAV hovering position with minimal flight distance. In the low-level loop, a semidefinite relaxation (SDR)-based optimization algorithm further reduces the UAV’s flying time by minimizing the average AoI. Simulation results validate that OH-DRL achieves better convergence performance and energy-saving efficiency across different network scales. Compared to the state-of-the-art DRL algorithm, OH-DRL reduces the UAV flight energy consumption by 14.4% and decreases the number of training episodes required for convergence by 66%. © 2025 IEEE. All rights reserved.

关键词： Unmanned aerial vehicles (UAV)

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Phase synchronization on small-world networks with community structure

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Chinese Physics B 2010年第2期19卷 92-100页

作者：王晓华焦李成吴建设 Key Laboratory of Intelligent Perception and Image Understanding of Ministry of Education of China Xidian University Aeronautical Computing Technique Research Institute

In this paper, we propose a simple model that can generate small-world network with community structure. The network is introduced as a tunable community organization with parameter r, which is directly measured by the ratio of inter- to intra-community connectivity, and a smaller r corresponds to a stronger community structure. The structure properties, including the degree distribution, clustering, the communication efficiency and modularity are also analysed for the network. In addition, by using the Kuramoto model, we investigated the phase synchronization on this network, and found that increasing the fuzziness of community structure will markedly enhance the network synchronizability; however, in an abnormal region （r ≤ 0.001）, the network has even worse synchronizability than the case of isolated communities （r = 0）. Furthermore, this network exhibits a remarkable synchronization behaviour in topological scales： the oscillators of high densely interconnected communities synchronize more easily, and more rapidly than the whole network.

关键词： complex networks small-world community structure phase synchronization

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Single-cell omics: experimental workflow, data analyses and applications

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Science China(Life Sciences) 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University(The Second People’s Hospital of Wuhu City)Wuhu 241000China Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration(Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji UniversityShanghai 200082China Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji UniversityShanghai 200092China Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji UniversityShanghai 200082China Research Institute of Intelligent Computing Zhejiang LabHangzhou 311121China Shanghai Research Institute for Intelligent Autonomous Systems Shanghai 201210China Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of MedicineShanghai 200025China National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314103China Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Beijing Institutes of Life Science Chinese Academy of SciencesBeijing 100101China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology(CQB)Peking UniversityBeijing 100871China Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women’s HospitalZhejiang University School of MedicineHangzhou 310006China Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal U

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular *** exploration of how the genomes orchestrate the formation and maintenance of each cell,and control the cellular phenotypes of various organismsis,is both captivating and *** the inception of the first single-cell RNA technology,technologies related to single-cell sequencing have experienced rapid advancements in recent *** technologies have expanded horizontally to include single-cell genome,epigenome,proteome,and metabolome,while vertically,they have progressed to integrate multiple omics data and incorporate additional information such as spatial scRNA-seq and CRISPR ***-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases,including ***,we comprehensively summarize recent advances in single-cell omics technologies,with a specific focus on the methodology *** overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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Network evolution driven by dynamics applied to graph coloring

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Chinese Physics B 2013年第6期22卷 262-267页

作者：吴建设李力光王晓华于昕焦李成 Key Laboratory of Intelligent Perception and Image Understanding of Ministry of Education of China 224# Xidian University Aeronautical Computing Technique Research Institute

An evolutionary network driven by dynamics is studied and applied to the graph coloring problem. From an initial structure, both the topology and the coupling weights evolve according to the dynamics. On the other hand, the dynamics of the network are determined by the topology and the coupling weights, so an interesting structure-dynamics co-evolutionary scheme appears. By providing two evolutionary strategies, a network described by the complement of a graph will evolve into several clusters of nodes according to their dynamics. The nodes in each cluster can be assigned the same color and nodes in different clusters assigned different colors. In this way, a co-evolution phenomenon is applied to the graph coloring problem. The proposed scheme is tested on several benchmark graphs for graph coloring.

关键词： network dynamics evolution of network evolutionary strategies graph coloring problem

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Outlier Detection over Sliding Windows for Probabilistic Data Streams

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Journal of Computer Science & Technology 2010年第3期25卷 389-400页

作者：王斌杨晓春王国仁于戈 School of Information Science and Engineering Northeastern University(Shenyang) Key Laboratory of Medical Image Computing (Northeastern University) Ministry of Education

Outlier detection is a very useful technique in many applications, where data is generally uncertain and could be described using probability. While having been studied intensively in the field of deterministic data, outlier detection is still novel in the emerging uncertain data field. In this paper, we study the semantic of outlier detection on probabilistic data stream and present a new definition of distance-based outlier over sliding window. We then show the problem of detecting an outlier over a set of possible world instances is equivalent to the problem of finding the k-th element in its neighborhood. Based on this observation, a dynamic programming algorithm （DPA） is proposed to reduce the detection cost from 0（2IR（~＇d）l） to O（Ik.R（e, d）l）, where R（e, d） is the d-neighborhood of e. Furthermore, we propose a pruning-based approach （PBA） to effectively and efficiently filter non-outliers on single window, and dynamically detect recent m elements incrementally. Finally, detailed analysis and thorough experimental results demonstrate the efficiency and scalability of our approach.

关键词： outlier detection uncertain data probabilistic data stream sliding window

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