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arXiv 2023年

作者： Yang, Xing Zhang, Jian Chen, Qijian Wang, Li Wang, Lihui Engineering Research Center of Text Computing & Cognitive Intelligence Ministry of Education Key Laboratory of Intelligent Medical Image Analysis and Precise Diagnosis of Guizhou Province State Key Laboratory of Public Big Data College of Computer Science and Technology Guizhou University Guiyang550025 China

Automatic segmentation of breast tumors from the ultrasound images is essential for the subsequent clinical diagnosis and treatment plan. Although the existing deep learning-based methods have achieved significant progress in automatic segmentation of breast tumor, their performance on tumors with similar intensity to the normal tissues is still not pleasant, especially for the tumor boundaries. To address this issue, we propose a PBNet composed by a multilevel global perception module (MGPM) and a boundary guided module (BGM) to segment breast tumors from ultrasound images. Specifically, in MGPM, the long-range spatial dependence between the voxels in a single level feature maps are modeled, and then the multilevel semantic information is fused to promote the recognition ability of the model for non-enhanced tumors. In BGM, the tumor boundaries are extracted from the high-level semantic maps using the dilation and erosion effects of max pooling, such boundaries are then used to guide the fusion of low and high-level features. Moreover, to improve the segmentation performance for tumor boundaries, a multi-level boundary-enhanced segmentation (BS) loss is proposed. The extensive comparison experiments on both publicly available dataset and in-house dataset demonstrate that the proposed PBNet outperforms the state-of-the-art methods in terms of both qualitative visualization results and quantitative evaluation metrics, with the Dice score, Jaccard coefficient, Specificity and HD95 improved by 0.70%, 1.1%, 0.1% and 2.5% respectively. In addition, the ablation experiments validate that the proposed MGPM is indeed beneficial for distinguishing the non-enhanced tumors and the BGM as well as the BS loss are also helpful for refining the segmentation contours of the tumor. Copyright © 2023, The Authors. All rights reserved.

关键词： Tumors

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GESH-NET: GRAPH-ENHANCED SPHERICAL HARMONIC CONVOLUTIONAL NETWORKS FOR CORTICAL SURFACE REGISTRATION

arXiv

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arXiv 2024年

作者： Zhang, Ruoyu Wang, Lihui Tang, Kun Xu, Jingwen Wei, Hongjiang Engineering Research Center of Text Computing & Cognitive Intelligence Ministry of Education Key Laboratory of Intelligent Medical Image Analysis and Precise Diagnosis of Guizhou Province State Key Laboratory of Public Big Data College of Computer Science and Technology Guizhou University Guiyang550025 China School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China

Cortical surface registration plays a crucial role in coordinating individual cortical functions and anatomical features, serving as a fundamental step in cortical surface analysis. Its aim is to align the anatomical or functional regions of different individuals, which is of great importance for neuroimaging studies across different populations. Currently, cortical surface registration techniques based on classical methods have been well developed. However, a key issue with classical registration methods is that for each pair of images to be registered, it is necessary to search for the optimal transformation in the deformation space according to a specific optimization algorithm until the similarity measure function converges, which cannot meet the requirements of real-time and high-precision in medical image registration. With the spectacular success of deep learning in the field of computer vision, researching cortical surface image registration techniques based on deep learning models has become a new direction. But so far, there are still only a few studies on cortical surface image registration based on deep learning. Moreover, although deep learning methods theoretically have stronger representation capabilities, surpassing the most advanced classical methods in registration accuracy and distortion control remains a challenge. Therefore, to address this challenge, this paper constructs a deep learning model to study the technology of cortical surface image registration. The specific work is as follows: (1) An unsupervised cortical surface registration network based on a multi-scale cascaded structure is designed, and a convolution method based on spherical harmonic transformation is introduced to register cortical surface data. This solves the problem of scale-inflexibility of spherical feature transformation and optimizes the multi-scale registration process. The results show that the proposed network outperforms the other deep learning-based registration m

关键词： Spheres

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Self-supervised fast reconstruction method for diffusion MRI based on multi-directional assistance

Self-supervised fast reconstruction method for diffusion MRI...

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International Conference on Signal Processing Proceedings (ICSP)

作者： Yuxin Wu Jian Zhang Lihui Wang Ying Cao Linhai Wu Yunjia Wu Chen Ye Yuemin Zhu State Key Laboratory of Public Big Data College of Computer Science and Technology Key Laboratory of Intelligent Medical Image Analysis and Precise Diagnosis of Guizhou Province Engineering Research Center of Text Computing & Cognitive Intelligence Ministry of Education Guizhou University Guiyang China INSA Lyon CNRS Inserm CREATIS UMR 5220 U1206 Univ Lyon France

ISBN: (数字)9798350387384

ISBN: (纸本)9798350387391

Diffusion MRI (dMRI) is widely used for the detection and diagnosis of various pathologies due to its non-invasive nature. However, its signal acquisition process is relatively slow and susceptible to motions. In order to accelerate reconstruction process, many deep learning-based methods have been developed in recent years to achieve promising results, while most of them are supervised based methods and require fully sampled data which are difficult to obtain in practical applications to train the network. Self-supervised based methods were proposed to deal with this problem to a certain extent, however, they are devoted only to conventional MRI data, ignoring the correlation between the directions of dMRI data. To address this issue, we propose a self-supervised fast reconstruction method for dMRI based on multi-directional assistance. The method better utilizes the information between dMRI data directions by Partition-Replace operation, cleverly constructing data pairs and designing effective self-supervised strategy for bi-directional prediction, which can overcome the problem of data incompleteness and guide the model to reconstruct unsampled signals in spite of the difficulty of acquiring fully sampled data. Experimental results show that our method achieves better reconstruction in the absence of fully sampled data, even with an 8-fold acceleration factor.

关键词： Learning systems Pathology Correlation Magnetic resonance imaging Bidirectional control Reconstruction algorithms Signal processing Predictive models Data models

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Penta-Encoder with medical Transformer for Incomplete Multimodal Learning of Brain Tumor Segmentation

Penta-Encoder with Medical Transformer for Incomplete Multim...

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International Conference on Signal Processing Proceedings (ICSP)

作者： Guohui Yu Lihui Wang Qijian Chen Li Wang Kun Tang Xinyu Cheng Yuemin Zhu State Key Laboratory of Public Big Data College of Computer Science and Technology Key Laboratory of Intelligent Medical Image Analysis and Precise Diagnosis of Guizhou Province Engineering Research Center of Text Computing & Cognitive Intelligence Ministry of Education Guizhou University Guiyang China INSA Lyon CNRS Inserm CREATIS UMR 5220 U1206 Univ Lyon Lyon France

ISBN: (数字)9798350387384

ISBN: (纸本)9798350387391

Accurate brain tumor segmentation of magnetic resonance imaging (MRI) images requires the integration of multimodal data in effective collaborative learning. However, clinical scenarios often face missing modalities, significantly impacting segmentation performance. In this paper, we propose the penta-encoder with medical transformer (Penta-MedTrans) for incomplete multimodal learning, which consists of four main components: a modality-specific encoder (MSE), a modality-dynamic encoder (MDE), a multimodal fusion module (MMFM) and a convolutional decoder. The MSE extracts unique features for each modality, while the MDE captures inter-modal semantics to address missing modalities. The MMFM establishes and aligns long-range correlations between modal-invariant features and global semantics of tumor regions. The convolutional decoder generates robust segmentation results by progressively upsampling and fusing modality-invariant features. We extensively validated our method on the BraTS 2020 and BraTS 2021 datasets for brain tumor segmentation. Results showed that our method outperforms SOTA for incomplete multimodal brain tumor segmentation across most subsets.

关键词： image segmentation Correlation Convolution Magnetic resonance imaging Semantics Brain tumors Transformers Feature extraction Decoding Biomedical imaging

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Tumor State-Space Network for High and Low Grade Glioma Classification

Tumor State-Space Network for High and Low Grade Glioma Clas...

引用

International Conference on Signal Processing Proceedings (ICSP)

作者： Qijian Chen Lihui Wang Zeyu Deng Li Wang Chen Ye YueMin Zhu Engineering Research Center of Text Computing Ministry of Education Key Laboratory of Intelligent Medical Image Analysis and Precise Diagnosis of Guizhou Province State Key Laboratory of Public Big Data College of Computer Science and Technology Guizhou University Guiyang China INSA Lyon CNRS Inserm IRP Metislab CREATIS UMR5220 U1206 University Lyon Lyon France

ISBN: (数字)9798350387384

ISBN: (纸本)9798350387391

Accurately predicting the grade of gliomas is crucial for choosing right treatment plans. While current methods using radiomics and deep learning can predict glioma grades effectively using magnetic resonance imaging (MRI), they overlook dynamic changes in the tumor and its neighboring areas. To address this issue, we propose a tumor state-space network (TSSNet), which fully exploits changes in the tumor region and its surroundings through dynamical updating strategy. The experimental results demonstrated that TSSNet achieves 90.32% accuracy and 93.55% area under the curve (AUC) for the prediction of high-grade and low-grade gliomas, respectively, which are 2.4% and 2.5% higher than the best state-of-the-art deep learning models. Moreover, the proposed state-space module can effectively enhance prediction performance, which is advantageous for personalized glioma treatment.

关键词： Deep learning Accuracy Magnetic resonance imaging Signal processing Predictive models Tumors Radiomics

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Deformable registration framework for glioma images with absent correspondence based on auxiliary-image-aided intensity-consistency constraint

Deformable registration framework for glioma images with abs...

引用

IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

作者： Kun Tang Lihui Wang Menglong Yang Jingwen Xu Xinyu Cheng Jian Zhang Yuemin Zhu Hongjiang Wei Key Laboratory of Intelligent Medical Image Analysis and Precise Diagnosis of Guizhou Province Engineering Research Center of Text Computing & Cognitive Intelligence Ministry of Education State Key Laboratory of Public Big Data College of Computer Science and Technology Guiyang China INSA Lyon CNRS Inserm Univ Lyon Lyon France School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China

ISBN: (数字)9798350386226

ISBN: (纸本)9798350386233

Considering the tumor aggressive nature and the significant changes in anatomical structure, aligning the preoperative and follow up scans of glioma patients remains a challenge due to the presence of regions with absent correspondence. To address this challenge, this work proposed a novel bidirectional unsupervised deformable image registration framework for image pairs with missing correspondence based on an auxiliary-image-aided intensity-consistency constraint (ICC) strategy. Specifically, for any fixed and moving image pairs, we introduced an auxiliary image and warped it directly to fixed/moving image or warped it twice through a transition of moving/fixed image. By comparing the difference between these warped images, the weighting maps to identify and exclude regions with absent correspondence between fixed and moving image pairs can be generated. To verify the effectiveness of the proposed framework, we combined it with several deep learning-based registration models and tested it on BraTS-Reg challenge dataset, the results demonstrated that the proposed ICC strategy can improve the registration performance for all the models, with the improvement of average target registration error (TRE) and success rate (SR) being up to 44.9% and 66.7%, respectively. Comparing against the best existing forward-backward consistency strategy for dealing with missing correspondence registration, our auxiliary-image-aided ICC strategy can also decrease average TRE by 2.9%, demonstrating the superiority of the proposed framework. The present work is not limited to the glioma images, it can be used to address the registration problems for any image pairs with absent correspondence or inconsistent intensity.

关键词： image registration Pathology Deformation Magnetic resonance imaging Anatomical structure Bioinformatics Tumors Biomedical imaging

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GEM: Context-Aware Gaze EstiMation with Visual Search Behavior Matching for Chest Radiograph

arXiv

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arXiv 2024年

作者： Liu, Shaonan Chen, Wenting Liu, Jie Luo, Xiaoling Shen, Linlin Computer Vision Institute College of Computer Science and Software Engineering Shenzhen University China Department of Electrical Engineering City University of Hong Kong Hong Kong AI Research Center for Medical Image Analysis and Diagnosis Shenzhen University China Guangdong Provincial Key Laboratory of Intelligent Information Processing China

Gaze estimation is pivotal in human scene comprehension tasks, particularly in medical diagnostic analysis. Eye-tracking technology facilitates the recording of physicians’ ocular movements during image interpretation, thereby elucidating their visual attention patterns and information-processing strategies. In this paper, we initially define the context-aware gaze estimation problem in medical radiology report settings. To understand the attention allocation and cognitive behavior of radiologists during the medical image interpretation process, we propose a context-aware Gaze EstiMation (GEM) network that utilizes eye gaze data collected from radiologists to simulate their visual search behavior patterns throughout the image interpretation process. It consists of a context-awareness module, visual behavior graph construction, and visual behavior matching. Within the context-awareness module, we achieve intricate multimodal registration by establishing connections between medical reports and images. Subsequently, for a more accurate simulation of genuine visual search behavior patterns, we introduce a visual behavior graph structure, capturing such behavior through high-order relationships (edges) between gaze points (nodes). To maintain the authenticity of visual behavior, we devise a visual behavior-matching approach, adjusting the high-order relationships between them by matching the graph constructed from real and estimated gaze points. Extensive experiments on four publicly available datasets demonstrate the superiority of GEM over existing methods and its strong generalizability, which also provides a new direction for the effective utilization of diverse modalities in medical image interpretation and enhances the interpretability of models in the field of medical imaging. https://***/Tiger-SN/GEM. Copyright © 2024, The Authors. All rights reserved.

关键词： Eye movements

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AdaFuse: Adaptive medical image Fusion Based on Spatial-Frequential Cross Attention

arXiv

引用

arXiv 2023年

作者： Gu, Xianming Wang, Lihui Deng, Zeyu Cao, Ying Huang, Xingyu Zhu, Yue-Min Engineering Research Center of Text Computing & Cognitive Intelligence Ministry of Education Key Laboratory of Intelligent Medical Image Analysis and Precise Diagnosis of Guizhou Province State Key Laboratory of Public Big Data College of Computer Science and Technology Guizhou University Guiyang550025 China University Lyon INSA Lyon CNRS Inserm IRP Metislab CREATIS UMR5220 U1206 Lyon69621 France

Multi-modal medical image fusion is essential for the precise clinical diagnosis and surgical navigation since it can merge the complementary information in multi-modalities into a single image. The quality of the fused image depends on the extracted single modality features as well as the fusion rules for multi-modal information. Existing deep learning-based fusion methods can fully exploit the semantic features of each modality, they cannot distinguish the effective low and high frequency information of each modality and fuse them adaptively. To address this issue, we propose AdaFuse, in which multimodal image information is fused adaptively through frequency-guided attention mechanism based on Fourier transform. Specifically, we propose the cross-attention fusion (CAF) block, which adaptively fuses features of two modalities in the spatial and frequency domains by exchanging key and query values, and then calculates the cross-attention scores between the spatial and frequency features to further guide the spatial-frequential information fusion. The CAF block enhances the high-frequency features of the different modalities so that the details in the fused images can be retained. Moreover, we design a novel loss function composed of structure loss and content loss to preserve both low and high frequency information. Extensive comparison experiments on several datasets demonstrate that the proposed method outperforms state-of-the-art methods in terms of both visual quality and quantitative metrics. The ablation experiments also validate the effectiveness of the proposed loss and fusion strategy. © 2023, CC BY.

关键词： Deep learning

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Application of machine learning on the modelling of diffusion magnetic resonance imaging signal

Application of machine learning on the modelling of diffusio...

引用

2020 International Seminar on Artificial Intelligence, Networking and Information Technology, AINIT 2020

作者： Ye, Chen Xu, Daoyun Wang, Lihui Zhu, Yuemin Key Laboratory of Intelligent Medical Image Analysis and Precise Diagnosis of Guizhou Province School of Computer Science and Technology Guizhou University Guiyang China CNRS INSERM CREATIS UMR 5220 U1206 F-69621 Univ Lyon INSA Lyon Lyon France

The modelling of diffusion Magnetic Resonance Imaging (dMRI) signals is very important for medical clinical application. However, the traditional method is to use a fixed mathematical model to make assumptions about the diffusion-weighted (DW) signals of all regions of human organ, which is unreasonable. In this paper, Convolutional Neural Network (CNN), a machine learning based method is used for learning the different characteristics of the signals, and finally intelligently give multi-model predictions for different regions of human livers. The performance of the proposed method is verified on both simulation and real liver data. The results show that the multi-model predicted by CNN method has high performance in distinguishing normal liver from diseased liver, and has great clinical application prospects © Published under licence by IOP Publishing Ltd.

关键词： Diffusion

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Systematic Study of Joint Influence of Angular Resolution and Noise in Cardiac Diffusion Tensor Imaging 11th

Systematic Study of Joint Influence of Angular Resolution an...

引用

11th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2021

作者： He, Yunlong Wang, Lihui Yang, Feng Xia, Yong Clarysse, Patrick Zhu, Yuemin Univ Lyon INSA Lyon Université Claude Bernard Lyon 1 CNRS Inserm CREATIS UMR 5220 U1294 Lyon69621 France Key Laboratory of Intelligent Medical Image Analysis and Precise Diagnosis of Guizhou Province School of Computer Science and Technology Guizhou University Guiyang China National Library of Medicine National Institute of Health 8600 Rockvill Pike BethesdaMD20894 United States School of Computer Science NPU Xian China

ISBN: (纸本)9783030787097

Diffusion tensor imaging (DTI) is a promising imaging technique to non-invasively study diffusion properties and fiber structures of myocardial tissues. Previous studies have investigated the influence of noise or angular resolution independently on the estimation of diffusion tensors in DTI. However, the joint influence of these two factors in DTI remains unclear. In this paper, we propose to systematically study the joint influence of angular resolutions and noise levels on the estimation of diffusion tensors and tensor-derived fractional anisotropy (FA) and mean diffusivity (MD). The results showed that, as expected, given a certain noise level and sufficient acquisition time, the accuracy of diffusion tensor, FA and MD all increase as the angular resolution. Moreover, when the angular resolution reached a certain value, further increasing the number of angular resolutions has little effect on the estimation of diffusion tensor, FA and MD. Also, both the mean and variance of FA or MD decrease as the angular resolution increases. For an imposed acquisition time, increasing the angular resolution reduces SNR of DW images. When fixing SNR, higher angular resolution can be obtained at the expense of longer acquisition time. These findings suggest the necessity of an optimized trade-off when designing DTI protocols. © 2021, Springer Nature Switzerland AG.

关键词： Diffusion tensor imaging

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