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A Smart Photosensitizer–Manganese Dioxide Nanosystem for Enhanced Photodynamic Therapy by Reducing Glutathione Levels in Cancer Cells

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Angewandte Chemie 2016年第18期128卷

作者： Huanhuan Fan Guobei Yan Zilong Zhao Xiaoxiao Hu Wenhan Zhang Hui Liu Xiaoyi Fu Ting Fu Xiao‐Bing Zhang Weihong Tan Molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical Engineering College of Biology Collaborative Innovation Center for Chemistry and Molecular Medicine Hunan University Changsha 410082 China Department of Chemistry and Physiology and Functional Genomics Center for Research at the Bio/Nano Interface Shands Cancer Center UF Genetics Institute McKnight Brain Institute University of Florida Gainesville FL 32611-7200 USA

Photodynamic therapy (PDT) has been applied in cancer treatment by utilizing reactive oxygen species to kill cancer cells. However, a high concentration of glutathione (GSH) is present in cancer cells and can consume reactive oxygen species. To address this problem, we report the development of a photosensitizer–MnO 2 nanosystem for highly efficient PDT. In our design, MnO 2 nanosheets adsorb photosensitizer chlorin e6 (Ce6), protect it from self‐destruction upon light irradiation, and efficiently deliver it into cells. The nanosystem also inhibits extracellular singlet oxygen generation by Ce6, leading to fewer side effects. Once endocytosed, the MnO 2 nanosheets are reduced by intracellular GSH. As a result, the nanosystem is disintegrated, simultaneously releasing Ce6 and decreasing the level of GSH for highly efficient PDT. Moreover, fluorescence recovery, accompanied by the dissolution of MnO 2 nanosheets, can provide a fluorescence signal for monitoring the efficacy of delivery.

关键词： Glutathion Krebszellen MnO2-Nanoblätter Photodynamische Therapie Singulett-Sauerstoff

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Inside Back Cover: A Smart Photosensitizer–Manganese Dioxide Nanosystem for Enhanced Photodynamic Therapy by Reducing Glutathione Levels in Cancer Cells (Angew. Chem. Int. Ed. 18/2016)

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Angewandte Chemie International Edition 2016年第18期55卷

作者： Huanhuan Fan Guobei Yan Dr. Zilong Zhao Dr. Xiaoxiao Hu Wenhan Zhang Hui Liu Xiaoyi Fu Ting Fu Prof. Xiao-Bing Zhang Prof. Weihong Tan Molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical Engineering College of Biology Collaborative Innovation Center for Chemistry and Molecular Medicine Hunan University Changsha 410082 China Department of Chemistry and Physiology and Functional Genomics Center for Research at the Bio/Nano Interface Shands Cancer Center UF Genetics Institute McKnight Brain Institute University of Florida Gainesville FL 32611-7200 USA

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Strengthening mechanisms of indirect-extruded Mg-Sn based alloys at room temperature

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Journal of Magnesium and Alloys 2014年第4期2卷 299-304页

作者： Wei Li Cheng Quan Wei Tian Hui Yu Hua Zhang Bong Sun You Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of EducationTaiyuan University of TechnologyTaiyuan 030024China School of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Korea Institute of Materials Science Changwon 642-831Republic of Korea

The strength of a material is dependent on how dislocations in its crystal lattice can be easily *** dislocations create stress fields within the material depending on their intrinsic ***,the following strengthening mechanisms are relevant in wrought magnesium materials tested at room temperature:fine-grain strengthening,precipitate strengthening and solid solution strengthening as well as texture *** indirect-extruded Mg-8Sn(T8)and Mg-8Sn-1Al-1Zn(TAZ811)alloys present superior tensile properties compared to the commercial AZ31 alloy extruded in the same *** contributions to the strengthen of Mg-Sn based alloys made by four strengthening mechanisms were calculated quantitatively based on the microstructure characteristics,physical characteristics,thermomechanical analysis and interactions of alloying elements using AZ31 alloy as benchmark.

关键词： Mg alloys Microstructure Mechanical properties Strengthening mechanism

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Preparation of polypyrrole-coated CuFe_2O_4 and their improved electrochemical performance as lithium-ion anodes

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Journal of Energy Chemistry 2014年第3期23卷 354-357页

作者： Huayun Xu Yunpo Wang Long Zheng Xinhui Duan Lihui Wang Jian Yang Yitai Qian Key Laboratory of Colloid and Interface Chemistry Ministry of Education School of Chemistry and Chemical EngineeringShandong University Hefei National Laboratory for Physical Science at Microscale Department of ChemistryUniversity of Science and Technology of China

CuFe2O4 network,prepared via the electrostatic spray deposition technique,with high reversible capacity and long cycle lifetime for lithium ion battery anode material has been *** reversible capacity can be further enhanced by coating high electronic conductive polypyrrole（PPy）.At the current density of 100mA·***/CuFe2O4 electrode delivers a reversible capacity of 842.9 mAh·g-1 while the reversible capacity of Li/PPy-coated CuFe2O4 electrode increases up to 1106.7 mAh-g’.A high capacity of 640.7 mAhg＂1 for the Li/PPy-coated CuFe2O4electrode is maintained in contrast of 398.9 mAh·g-1 for CuFe2O4 electrode after 60 cycles,which demonstrates good electrochemical performance of the composite due to the increase of electronic *** electrochemical impedance spectroscopy（EIS） further reveals that the Li/PPy-coated CuFe2O4 electrode has a lower charge transfer resistance than the Li/CuFe2C〉4 electrode.

关键词： CuFe2O4 polypyrrole-coated electrostatic spray deposition lithium ion batteries

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Study of conductivity optimization and electro-active response of ion-exchange polymer

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Gongneng Cailiao/Journal of Functional Materials 2015年第22期46卷 22103-22107and22112页

作者： Guo, Dongjie Li, Yake Liu, Rui Chen, Yaqing Fang, Shaoming Henan Province Key Laboratory of Surface & Interface Science Zhengzhou China College of Material and Chemical Engineering Zhengzhou University of Light Industry Zhengzhou China College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics Nanjing China

In this paper, we firstly prepared graphene monolayer carrying Ag nano particles (GO/Ag NPs);then, widely dispersed GO/Ag NPs into the commercial the Nafion solution, thus obtained the GO/Ag NPs hybrid ion-exchange membrane;finally, sandwiched the ion-exchange membrane by two layers of Pt nanosheets, thus obtained hybrid ion-exchange polymer metal composite (IPMC) actuator. Detections of electrochemical impedance spectroscopy (EIS) and electromechanical properties of IPMC show that, after hybrid of GO/Ag NPs, conductivity of the ion-exchange membrane increases, both the swing angle and force output increase;electromechanical property of IPMC has a close relationship with the conductivity, which can act as a valuable parameter to evaluate the electromechanical properties. © 2015, Chongqing Functional Materials Periodical Press Co. Ltd. All right reserved.

关键词： Electrochemical impedance spectroscopy

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Role of Achiral Nucleobases in Multicomponent Chiral Self‐Assembly: Purine‐Triggered Helix and Chirality Transfer

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Angewandte Chemie 2016年第48期128卷

作者： Ming Deng Li Zhang Yuqian Jiang Minghua Liu Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Colloid Interface and Chemical Thermodynamics Institute of Chemistry Chinese Academy of Sciences Beijing 100190 P.R. China University of Chinese Academy of Sciences Beijing 1 00049 P.R. China Laboratory for Nanosystem and Hierarchy Fabrication CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 P.R. China Collaborative Innovation Center of Chemical Science and Engineering Tianjin 300072 P.R. China

Chiral self‐assembly is a basic process in biological systems, where many chiral biomolecules such as amino acids and sugars play important roles. Achiral nucleobases usually covalently bond to saccharides and play a significant role in the formation of the double helix structure. However, it remains unclear how the achiral nucleobases can function in chiral self‐assembly without the sugar modification. Herein, we have clarified that purine nucleobases could trigger N ‐(9‐fluorenylmethox‐ycarbonyl) (Fmoc)‐protected glutamic acid to self‐assemble into helical nanostructures. Moreover, the helical nanostructure could serve as a matrix and transfer the chirality to an achiral fluorescence probe, thioflavin T (ThT). Upon chirality transfer, the ThT showed not only supramolecular chirality but also circular polarized fluorescence (CPL). Without the nucleobase, the self‐assembly processes cannot happen, thus providing an example where achiral molecules played an essential role in the expression and transfer of the chirality.

关键词： Chiralitätstransfer Helikale Strukturen Nucleobasen Purine Zirkular polarisierte Fluoreszenz

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Intercellular Connections Related to Cell–Cell Crosstalk Specifically Recognized by an Aptamer

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Angewandte Chemie 2016年第12期128卷

作者： Nan Zhang Tao Bing Luyao Shen Rusheng Song Linlin Wang Xiangjun Liu Meirong Liu Juan Li Weihong Tan Dihua Shangguan Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry Chinese Academy of Sciences Beijing 100190 P.R. China University of the Chinese Academy of Sciences Beijing 100049 P.R. China Department of Chemistry Center for Research at the Bio/Nano Interface Health Cancer Center UF Genetics Institute McKnight Brain Institute University of Florida Gainesville FL 32611-7200 USA Molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Biology and College of Chemistry and Chemical Engineering Hunan University Changsha 410082 P.R. China

Intercellular connections are an important pathway for cell–cell crosstalk. However, their formation mechanism and functions are far from being understood. The lack of molecular probes hampers the research in this area. Herein, we report a kind of intercellular connection that is specifically recognized by aptamer M17A2 generated by cell‐SELEX against MCF‐7R cells. These connections have different morphologies, but have the same skeleton composed of F‐actin. The long filamentous connections were identified to be tunneling nanotubes (TNTs), a recently discovered cell–cell communication route. These connections could be built not only between MCF‐7R cells, but also from MCF‐7R to other cells after co‐culture. Proteins could be transported between cells through these connections, suggesting their cell communication function. Aptamer M17A2 shows the potential to act as a new probe for investigating this kind of intercellular connection, as well as for studying cell–cell communication.

关键词： Aptamere Fluoreszenzsonden Interzelluläre Anschlüsse Tunnelfähige Nanoröhren Zellkommunikation

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Microstructure and properties of TiC-Ni(Cr) cermet composite coating prepared by self-propagating high-temperature synthesis

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Gongneng Cailiao/Journal of Functional Materials 2015年第21期46卷 21045-21049页

作者： Zhang, Xiaoyu Tan, Jun Ren, Wei Dong, Meiling Su, Hongyi Lan, Long Science and Technology on Remanufacturing Laboratory Academy of Armored Force Engineering Beijing China Key Laboratory for Surface Engineering Academy of Armored Force Engineering Beijing China Central Iron and Steel Research Institute Beijing China Institute of Surface/Interface Science and Technology Harbin Engineering University Harbin China Xi'an Satellite Control Center Sanya Station Xi'an China

The TiC-Ni(Cr) cermet composite coating was prepared on 7A52 aluminum alloy by Self-propagating High-temperature Synthesis(SHS). The microstructure and properties of coating was investigated by means of SEM, EDS, XRD, micro-hardness measure and thermal shock resistance test. The results showed that: the coating was consisting of TiC ceramic phase and Ni metal phase. Each phase of coating combined very well. The surface of coating was the high strength metallurgical bonding. The micro-hardness of the coating was about 10 times of the substrate. The result of thermal shock test further validated the binding strength between the coating and the substrate was good. Experimental results showed that adding the metallic Cr and Ni, which had a good dissolvability in Al, to transition area of samples, and improved bonding strength of the coating and the substrate preferably. © 2015, Journal of Functional Materials. All right reserved.

关键词： Titanium carbide

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Effect of polyethylene glycol modification on the morphology and optical property of P3HT/ZnO composite film

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Gongneng Cailiao/Journal of Functional Materials 2015年第20期46卷 20057-20062页

作者： Hao, Yamin Yang, Weijia Yan, Lingpeng Yang, Yongzhen Liu, Xuguang Xu, Bingshe Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of Education Taiyuan University of Technology Taiyuan China Research Center of Advanced Materials Science and Technology Taiyuan University of Technology Taiyuan China College of Chemistry and Chemical Engineering Taiyuan University of Technology Taiyuan China

ZnO nanoparticles with average size about 200 nm synthesized by one-step hydrothermal method were firstly modified by surfactant polyethylene glycol (PEG). The effects of PEG molecular weight and dosage on the surface morphology and optical properties of ZnO film were discussed. The energy level structure of PEG was researched. Then poly(3-hexylthiophene) (P3HT) was adopted to prepare the composite films with pure ZnO and ZnO modified by PEG, respectively. The effects of PEG passivation on the morphology and optical property of the composite films were characterized by atomic force microscope, ultraviolet-visible spectrophotometer and photoluminescence spectra. The results showed that ZnO film modified by PEG with molecular weight 6000 and dosage of 5wt% had regular morphology;the energy level of P3HT matched well with that of ZnO modified by PEG;compared with P3HT/ZnO composite film, P3HT/PEG/ZnO composite film would have more regular surface, less surface defects, better absorptivity and higher fluorescence quenching, which indicated that PEG modification increased the contact area between ZnO and P3HT as well as promoted the charge transfer between their interface. © 2015, Chongqing Functional Materials Periodical Press Co. Ltd. All right reserved.

关键词： Polyethylene glycols

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Gold nanorod-photosensitizer conjugate with extracellular pH-driven tumor targeting ability for photothermal/photodynamic therapy

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Nano Research 2014年第9期7卷 1291-1301页

作者： Nannan Wang Zilong Zhao Yifan Lv Huanhuan Fan Huarong Bai Hongmin Meng Yuqian Long Ting Fu Xiaobing Zhang Weihong Tan Molecular Science and Biomedicine Laboratory State Key Laboratory for Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical Engineering College of Biology and Collaborative Research Center of Molecular Engineering for Theranostics Hunan University Changsha 410082 China Department of Chemistry and Department of Physiology and Functional Genomics Center for Research at Bio/nano Interface Shands Cancer Center UF Genetics Institute and McKnight Brain Institute University of Florida Gainesville Florida 32611-7200 USA

Chlorin e6-pHLIPss-AuNRs, a gold nanorod-photosensitizer conjugate containing a pH （low） insertion peptide （pHLIP） with a disulfide bond which imparts extracellular pH （pHe）-driven tumor targeting ability, has been successfully developed for bimodal photodynamic and photothermal therapy. In this bimodal therapy, chlorin e6 （Ce6）, a second-generation photosensitizer （PS）, is used for photodynamic therapy （PDT）. Gold nanorods （AuNRs） are used as a hyperthermia agent for photothermal therapy （PTT） and also as a nanocarrier and quencher of Ce6. pHLIPss is designed as a pile-driven targeting probe to enhance accumulation of Ce6 and AuNRs in cancer cells at low pH. In Ce6- pHLIPss-AuNRs, Ce6 is close to and quenched by AuNRs, causing little PDT effect. When exposed to normal physiological pH 7.4, Ce6-pHLIPs^-AuNRs loosely associate with the cell membrane. However, once exposed to acidic pH 6.2, pHLIP actively inserts into the cell membrane, and the conjugates are translocated into cells. When this occurs, Ce6 separates from the AuNRs as a result of disulfide bond cleavage caused by intracellular glutathione （GSH）, and singlet oxygen is produced for PDT upon light irradiation. In addition, as individual PTT agent, AuNRs can enhance the accumulation of PSs in the tumor by the enhanced permeation and retention （EPR） effect. Therefore, as indicated by our data, when exposed to acidic pH, Ce6-pHLIPss-AuNRs can achieve synergistic PTT/PDT bimodality for cancer treatment.

关键词： photodynamic therapy photothermal therapy gold nanorods targeting acidity peptide

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