The interaction between ncRNA and protein is a kind of crucial molecular activities in a cell. Developing computational methods to predict ncRNA-protein interactions has attracted increasing attentions in recent years...
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ISBN:
(数字)9781728162157
ISBN:
(纸本)9781728162164
The interaction between ncRNA and protein is a kind of crucial molecular activities in a cell. Developing computational methods to predict ncRNA-protein interactions has attracted increasing attentions in recent years. In this work, a novel stacked ensemble learning framework is presented for predicting ncRNA-protein interaction based on heterogeneous feature combinations, named HFC-RPI. Firstly, the compositional features of k-mer with different orders were extracted from the primary sequence and secondary structure of RNA and protein respectively. Secondly, we trained a set of base learners using a variety of heterogeneous combinations of the extracted features respectively. Thirdly, the prediction results of these base learners were employed to train the stacked learner, which output the final prediction result at the higher layer in HFC-RPI. Moreover, in order to improve the generalization of HFC-RPI, when training the base learners, a cross-validation based method was applied. Extensive experimental results showed that the proposed learning framework HFC-RPI was effective and feasible for predicting the interaction of ncRNA and protein. By comparing with state-of-the-art methods, HFC-RPI was superior to them on most performance evaluation metrics.
In this paper, we consider predicting travel time for aircraft operated in multi-airport systems by modeling and simulating a multiclass queuing network, which can systematically capture the complicated coupling relat...
ISBN:
(数字)9781728172705
ISBN:
(纸本)9781728172712
In this paper, we consider predicting travel time for aircraft operated in multi-airport systems by modeling and simulating a multiclass queuing network, which can systematically capture the complicated coupling relationship among multiple airports and terminal airspace and the complex nature of flight trajectories following different traffic flow patterns. In this multiclass queuing network model, each class of queuing network, named a class of customers, is modeled with the data of a traffic flow pattern, which is identified for a cluster of flight trajectories. Airports and airspace sectors are correspondingly modeled as networked servers with nonhomogeneous and time-varying arrival rate, service rate and server capacity to serve those classes of customers following their specific routing probabilities. Then, all of the parameters for setting up the multiclass queuing network model can be properly estimated using historical 4D flight trajectory data. To illustrate the superiority of this model, both average travel time for each class of customers, i.e., aircraft following a particular flow pattern, and the arrival time for an individual flight are predicted via simulations of a multiclass queuing network, and furthermore, compared with the real travel time. A typical example of a multi-airport system, the Guangdong-Hong Kong-Macau Greater Bay Area in China, is utilized to showcase the prediction performance of the proposed multiclass queuing network simulation model. The simulation experiments of the case study demonstrate that the proposed model well fits this multi-airports system. For most of the time periods, the percentage error (PE) of simulated average travel time and real average travel time is less than 5%. The travel time prediction for a random individual flight can achieve around 1% of the percentage error in terms of point estimation.
In 1990, Hendry conjectured that all Hamiltonian chordal graphs are cycle extendable. After a series of papers confirming the conjecture for a number of graph classes, the conjecture is yet refuted by Lafond and Seamo...
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In the research on the prevention of external damage to power transmission lines, it is a difficult problem to prevent large machinery vehicles from damaging the overhead transmission lines. After the emergence of vid...
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Forest dynamics monitoring is an important basis for assessing the stability of regional ecosystems and formulating sustainable management strategies, and forest evolution patterns under the interaction of frequent hu...
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Forest dynamics monitoring is an important basis for assessing the stability of regional ecosystems and formulating sustainable management strategies, and forest evolution patterns under the interaction of frequent human activities and natural disturbances in subtropical regions have not been fully revealed. This study uses Google Earth Engine and Landsat data (2001–2024) with the LandTrendr algorithm to detect spatiotemporal forest disturbances and recovery in Hunan Province, applying a random forest classifier to identify disturbance types. The results showed that from 2001 to 2024, the forest disturbance area in the study region was 4,723.46 km 2 , accounting for 3.48 % of the total forest area; the recovery area was 4,380.33 km 2 , accounting for 3.23 %; and the net loss was 343.13 km 2 , representing only 0.25 %. Among the disturbance types, weak disturbances accounted for 53.35 % of the total disturbed area, while low-level recovery accounted for 70.4 % of the total recovery area. Fire was the primary disturbance factor, accounting for 40.7 %, followed by land use conversion, which accounted for 27.3 %. This study provides a scientific basis for adaptive management, supporting targeted restoration and policy-making to enhance forest resilience and promote sustainable forest use in subtropical regions.
LiDAR-based 3D object detection is an important task for autonomous driving and current approaches suffer from sparse and partial point clouds of distant and occluded objects. In this paper, we propose a novel two-sta...
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Since the authentic Fritillaria Cirrhosa D. Don resources are scarce due to its high price and valuable medical uses, it is difficult to meet the clinical needs. Therefore, the problem of adulteration in the market is...
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The indigenous microorganisms might have great potential to influence coal flotation, however, have never been emphasized. This study focused on the relationship between indigenous microorganisms, flotation efficiency...
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