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Reduced clinical severity during 2022 Shanghai Spring epidemic of SARS-CoV-2 omicron BA.2 variant infection——an integrated account of virus pathogenicity and vaccination effectiveness

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National Science Review 2024年第4期11卷 24-27页

作者： Xingyue Wu Yao Chen Kangli Cao Yao Shen Xueling Wu Yilin Yang Zhongshu Kuang Qingrun Li Zhenzhen Lu Yichen Jia Mian Shao Guorong Gu Xiangwei Wang Ye Yao Ying Wang Shaodie Chen Zhigao Yu Wei Wei Longfei Ding Lulu Lan Tianwen Gu Xiangyu Long Jian Sun Lingyu Xing Jiayuan Shen Yi Han Yue Luo Sucheng Mu Mengna Lin Xiaoyan Zhang Rong Zeng Jianqing Xu Guoping Zhao Lihong Huang Zhenju Song Department of Emergency Medicine Clinical Center for Bio-Therapy Department of Biostatistics and Department of UrologyShanghai Key Laboratory of Lung Inflammation and Injury Zhongshan Hospital Fudan University Department of Respiratory and Critical Care Medicine Shanghai Pudong Hospital Fudan University Department of Pulmonology Renji Hospital Shanghai Jiao Tong University School of Medicine Key Laboratory of Systems Biology Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Shanghai Public Health Clinical Center Fudan University Department of Biostatistics School of Public Health Key Laboratory of Public Health Safety of Ministry of Education and Shanghai Institute of Infectious Disease and Biosecurity School of Public Health Fudan University Shanghai Institute of Immunology Department of Immunology and Microbiology Shanghai Institute of Virology Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationSchool of Medicine Shanghai Jiao Tong University State Key Laboratory of Genetic Engineering Fudan Microbiome CenterSchool of Life Sciences Fudan University Bio-Med Big Data Center Shanghai Institute of Nutrition and Health Chinese Academy of Sciences

The emergence of SARS-Co V-2 variant of concern omicron BA.2 led to high infection incidence rates as well as reduced severity of COVID-19 during the Shanghai Spring epidemic of 2022 [1]. We assessed the role of viral pathogenicity and the effectiveness of inactivated vaccines in a retrospective observational study including 10 258 confirmed COVID-19cases identified between April and June of 2022, from four COVID-19 designated hospitals located in two areas of Shanghai, namely the West Bund and the East Bund, where the populations’ demographic characteristics varied significantly (Table S1, Fig. S1).

关键词： sars-cov-2 effectiveness epidemic shanghai integrated spring clinical variant virus account

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Multi-Label classification with Missing Labels by Preserving Feature-Label Space Consistency

Multi-Label classification with Missing Labels by Preserving...

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IEEE International Conference on big knowledge (ICBK)

作者： Zan Zhang Depeng Zhang Gongqing Wu Key Laboratory of Knowledge Engineering with Big Data (the Ministry of Education of China) Hefei University of Technology Hefei China School of Computer Science and Information Engineering Hefei University of Technology Hefei China

Multi-label classification deals with the problem where an instance is associated with multiple labels simultaneously. Most existing multi-label classification algorithms assume that the labels of the training data are complete. However, we can obtain only a partial label set of each instance in some real applications since labelling data is difficult or costly. Some existing works on multi-label classification with missing labels focus on exploiting label correlations to complete the original label space and simultaneously build a multi-label learning model using label specific features. However, these methods may be suboptimal since they do not preserve feature-label space consistency. In this paper, we propose a Space Consistency-based Multi-Label classification algorithm named SCML to address this issue. First, label correlation in label space is learned to augment the incomplete original label matrix to a new supplementary label matrix, and the multi-label classifier is constructed simultaneously based on the new supplementary label matrix. Then, correlation information in feature space is learned based on the probabilistic neighborhood similarities to preserve feature-label space consistency. Moreover, the proposed algorithm has an effective mechanism for learning label-specific features to improve the multi-label classification with missing labels. Extensive experiments on twelve benchmark data sets validate the effectiveness of the proposed approach for improving the generalization performance of state-of-the-art algorithms of multi-label learning with missing labels.

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MEFA-Net: A mask enhanced feature aggregation network for polyp segmentation

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Computers in Biology and Medicine 2025年 186卷 109601-109601页

作者： Ke, Xiao Chen, Guanhong Liu, Hao Guo, Wenzhong Fujian Provincial Key Laboratory of Networking Computing and Intelligent Information Processing College of Computer and Data Science Fuzhou University Fuzhou350116 China Engineering Research Center of Big Data Intelligence Ministry of Education Fuzhou350116 China

Accurate polyp segmentation is crucial for early diagnosis and treatment of colorectal cancer. This is a challenging task for three main reasons: (i) the problem of model overfitting and weak generalization due to the multi-center distribution of data;(ii) the problem of interclass ambiguity caused by motion blur and overexposure to endoscopic light;and (iii) the problem of intraclass inconsistency caused by the variety of morphologies and sizes of the same type of polyps. To address these challenges, we propose a new high-precision polyp segmentation framework, MEFA-Net, which consists of three modules, including the plug-and-play Mask Enhancement Module (MEG), Separable Path Attention Enhancement Module (SPAE), and Dynamic Global Attention Pool Module (DGAP). Specifically, firstly, the MEG module regionally masks the high-energy regions of the environment and polyps through a mask, which guides the model to rely on only a small amount of information to distinguish between polyps and background features, avoiding the model from overfitting the environmental information, and improving the robustness of the model. At the same time, this module can effectively counteract the "dark corner phenomenon" in the dataset and further improve the generalization performance of the model. Next, the SPAE module can effectively alleviate the inter-class fuzzy problem by strengthening the feature expression. Then, the DGAP module solves the intra-class inconsistency problem by extracting the invariance of scale, shape and position. Finally, we propose a new evaluation metric, MultiColoScore, for comprehensively evaluating the segmentation performance of the model on five datasets with different domains. We evaluated the new method quantitatively and qualitatively on five datasets using four metrics. Experimental results show that MEFA-Net significantly improves the accuracy of polyp segmentation and outperforms current state-of-the-art algorithms. Code posted on https://***/

关键词： Endoscopy

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Learning Group-Disentangled Representation for Interpretable Thoracic Pathologic Prediction

Learning Group-Disentangled Representation for Interpretable...

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2022 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2022

作者： Li, Hao Wu, Yirui Hu, Hexuan Lu, Hu Lai, Yong Wan, Shaohua Hohai University Key Laboratory of Water Big Data Technology of Ministry of Water Resources China College of Computer and Information Hohai University China Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University China School of Computer Science and Communication Engineering Jiangsu University China Shenzhen Institute for Advanced Study University of Electronic Science and Technology of China China

ISBN: (纸本)9781665468190

Deep learning methods have shown significant performance in medical image analysis tasks. However, they generally act like 'black box' without explanations in both feature extraction and decision processes, leading to lack of clinical insights and high risk assessments. To aid deep learning in envisioning diseases with visual clues, we propose Representation Group-Disentangling Network (RGD-Net), which can completely disentangle feature space of input X-ray images into several independent feature groups, each corresponding to a specific disease. Taking several semantically related and labeled X-ray images as input, RGD-Net firstly extracts completely group-disentangled representations of diseases through Group-Disentangle Module, which applies group-swap and linking operations to construct latent space by enforcing semantic consistency of attributes. To prevent learning degenerate representations defined as shortcut problem, we further introduce adversarial constricts on mapping from features to diseases, thus avoiding model collapse with former free-form disentanglement. Experiments on chestxray-14 and ChestXpert datasets demonstrate that RGD-Net are effective in predicting diseases with remarkable advantages, which leverage potential factors contributing to different diseases, thus enhancing interpretability in working patterns of deep learning methods. © 2022 IEEE.

关键词： Forecasting

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TFGDA: Exploring Topology and Feature Alignment in Semi-supervised Graph Domain Adaptation through Robust Clustering 38

TFGDA: Exploring Topology and Feature Alignment in Semi-supe...

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38th Conference on Neural Information Processing Systems, NeurIPS 2024

作者： Dan, Jun Liu, Weiming Xie, Chunfeng Yu, Hua Dong, Shunjie Tan, Yanchao Zhejiang University China Queen Mary University of London United Kingdom Dalian University of Technology China Shanghai Jiao Tong University China Fuzhou University China Engineering Research Center of Big Data Intelligence Ministry of Education China Fujian Key Laboratory of Network Computing and Intelligent Information Processing China

Semi-supervised graph domain adaptation, as a branch of graph transfer learning, aims to annotate unlabeled target graph nodes by utilizing transferable knowledge learned from a label-scarce source graph. However, most existing studies primarily concentrate on aligning feature distributions directly to extract domain-invariant features, while ignoring the utilization of the intrinsic structure information in graphs. Inspired by the significance of data structure information in enhancing models' generalization performance, this paper aims to investigate how to leverage the structure information to assist graph transfer learning. To this end, we propose an innovative framework called TFGDA. Specially, TFGDA employs a structure alignment strategy named STSA to encode graphs' topological structure information into the latent space, greatly facilitating the learning of transferable features. To achieve a stable alignment of feature distributions, we also introduce a SDA strategy to mitigate domain discrepancy on the sphere. Moreover, to address the overfitting issue caused by label scarcity, a simple but effective RNC strategy is devised to guide the discriminative clustering of unlabeled nodes. Experiments on various benchmarks demonstrate the superiority of TFGDA over SOTA methods. © 2024 Neural information processing systems foundation. All rights reserved.

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Learning Concept Prerequisite Relation via Global knowledge Relation Optimization 39

Learning Concept Prerequisite Relation via Global Knowledge ...

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39th Annual AAAI Conference on Artificial Intelligence, AAAI 2025

作者： Zhang, Miao Wang, Jiawei Xiao, Kui Wang, Shihui Zhang, Yan Chen, Hao Li, Zhifei School of Computer Science and Information Engineering Hubei University China Hubei Key Laboratory of Big Data Intelligent Analysis and Application China Key Laboratory of Intelligent Sensing System and Security Ministry of Education China

ISBN: (纸本)157735897X

Learning concept prerequisite relations helps better master and build a logically coherent knowledge structure. Many studies use graph neural networks to create heterogeneous knowledge networks that enhance concept representations. However, different types of relations in these networks can influence each other. Existing research often focuses solely on concept relations, neglecting other types of knowledge connections. To address this issue, this paper proposes a novel concept prerequisite relation learning model, named the Global knowledge Relation Optimization Model(GKROM). Specifically, we capture the impact of different knowledge relation types on document and concept semantic representations separately, integrating the document and concept semantic representations. Then, we introduce multi-objective learning to optimize the knowledge relation network from a global perspective. Through the above optimization, GKROM learns richer semantic representations for concepts and documents, improving the accuracy of concept prerequisite relation learning. Extensive experiments on public datasets demonstrate the effectiveness of our GKROM, achieving state-of-the-art performance in concept prerequisite relation learning. Copyright © 2025, Association for the Advancement of Artificial Intelligence (***). All rights reserved.

关键词： Graph neural networks

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Tumor State-Space Network for High and Low Grade Glioma Classification 17

Tumor State-Space Network for High and Low Grade Glioma Clas...

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17th IEEE International Conference on Signal Processing, ICSP 2024

作者： Chen, Qijian Wang, Lihui Deng, Zeyu Wang, Li Ye, Chen Zhu, YueMin Guizhou University Engineering Research Center of Text Computing Ministry of Education Key Laboratory of Intelligent Medical Image Analysis and Precise Diagnosis of Guizhou Province State Key Laboratory of Public Big Data College of Computer Science and Technology Guiyang China University Lyon Insa Lyon Cnrs Inserm Irp Metislab Creatis UMR5220 U1206 Lyon69621 France

ISBN: (纸本)9798350387384

Accurately predicting the grade of gliomas is crucial for choosing right treatment plans. While current methods using radiomics and deep learning can predict glioma grades effectively using magnetic resonance imaging (MRI), they overlook dynamic changes in the tumor and its neighboring areas. To address this issue, we propose a tumor state-space network (TSSNet), which fully exploits changes in the tumor region and its surroundings through dynamical updating strategy. The experimental results demonstrated that TSSNet achieves 90.32% accuracy and 93.55% area under the curve (AUC) for the prediction of high-grade and low-grade gliomas, respectively, which are 2.4% and 2.5% higher than the best state-of-the-art deep learning models. Moreover, the proposed state-space module can effectively enhance prediction performance, which is advantageous for personalized glioma treatment. © 2024 IEEE.

关键词： Image enhancement

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Computational Intelligence in Remote Sensing Image Registration:A survey

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International Journal of Automation and computing 2021年第1期18卷 1-17页

作者： Yue Wu Jun-Wei Liu Chen-Zhuo Zhu Zhuang-Fei Bai Qi-Guang Miao Wen-Ping Ma Mao-Guo Gong Key Laboratory of Big Data and Intelligent Vision School of Computer Science and TechnologyXidian UniversityXi′an 710071China Key Laboratory of Intelligent Perception and Image Understanding of Ministry of Education School of Artificial IntelligenceXidian UniversityXi′an 710071China Key Laboratory of Intelligent Perception and Image Understanding of Ministry of Education School of Electronic EngineeringXidian UniversityXi′an 710071China

In recent years,computational intelligence has been widely used in many fields and achieved remarkable *** computing and deep learning are important branches of computational *** methods based on evolutionary computation and deep learning have achieved good performance in remote sensing image *** paper introduces the application of computational intelligence in remote sensing image registration from the two directions of evolutionary computing and deep *** the part of remote sensing image registration based on evolutionary calculation,the principles of evolutionary algorithms and swarm intelligence algorithms are elaborated and their application in remote sensing image registration is *** application of deep learning in remote sensing image registration is also *** the same time,the development status and future of remote sensing image registration are summarized and their prospects are examined.

关键词： Computational intelligence evolutionary computation neural network deep learning remote sensing image registration

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Attributes-based person re-identification via CNNs with coupled clusters loss

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Journal of Systems engineering and Electronics 2020年第1期31卷 45-55页

作者： SUN Rui HUANG Qiheng FANGWei ZHANG Xudong Key Laboratory of Knowledge Engineering with Big Data(Ministry of Education) Hefei University of TechnologyHefei 230601China School of Computer and Information Hefei University of TechnologyHefei 230601China

Person re-identification(re-id)involves matching a person across nonoverlapping views,with different poses,illuminations and *** attributes are understandable semantic information to help improve the issues including illumination changes,viewpoint variations and *** paper proposes an end-to-end framework of deep learning for attribute-based person *** the feature representation stage of framework,the improved convolutional neural network(CNN)model is designed to leverage the information contained in automatically detected attributes and learned low-dimensional CNN ***,an attribute classifier is trained on separate data and includes its responses into the training process of our person re-id *** coupled clusters loss function is used in the training stage of the framework,which enhances the discriminability of both types of *** combined features are mapped into the Euclidean *** L2 distance can be used to calculate the distance between any two pedestrians to determine whether they are the *** experiments validate the superiority and advantages of our proposed framework over state-of-the-art competitors on contemporary challenging person re-id datasets.

关键词： person re-identification(re-id) convolutions neural network(CNN) attributes coupled clusters loss(CCL)

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Electronic Medical Record Sharing System Based on Hyperledger Fabric and InterPlanetary File System 2021

Electronic Medical Record Sharing System Based on Hyperledge...

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5th International Conference on Compute and data Analysis, ICCDA 2021

作者： Li, Lei Yue, Zhengxiang Wu, Gongqing Key Laboratory of Knowledge Engineering with Big Data Hefei University of Technology Ministry of Education Hefei China School of Computer Science and Information Engineering Hefei University of Technology Hefei China

ISBN: (纸本)9781450389112

Electronic Medical Records (EMR) and other medical data contain important and sensitive privacy information of patients, which provide important basis and reference for their doctors to diagnose and treat them. With the continuous development of data sharing, big data applications and other technologies, new requirements are proposed for the storage of medical privacy data. At present, medical data have the characteristics of obstructed sharing and exchange, difficult data tracing and data sensitivity, which increases the cost and difficulty of each diagnosis. Moreover, patients lack the right to know and control their own medical data, which is easy to cause data fraud or data leakage. As a decentralized, tamper proof and traceable distributed ledger system, blockchain brings new solutions to these problems. This paper designs a medical data fusion and distributed privacy management system based on the Hyperledger Fabric blockchain development platform and InterPlanetary File System. It can not only solve the problem of mutual distrust in the traditional system, but also realize the safe data storage and the safe sharing of medical record data between medical organizations which is a beneficial attempt to overcome the disadvantages of traditional hospital data separation. At the same time, according to the requirements of different levels and types of medical users or groups for data security and personal privacy protection, the access control technology of users is studied to ensure personal privacy data. © 2021 ACM.

关键词： Blockchain

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