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SSRN 2023年

作者： Liu, Yuhang Zhao, Yuanjiang Zhou, Zhuxian Shen, Youqing Jiang, Liming MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou310027 China Key Laboratory of Biomass Chemical Engineering Ministry of Education and Zhejiang Key Laboratory of Smart Biomaterials College of Chemical and Biological Engineering Zhejiang University Hangzhou310027 China

In this work the sorption properties of three isoreticular Zr-based MOFs, viz., UiO-66, UiO-67, and UiO-68 as adsorbents of active organics were examined and especially the pore size effects are discussed using d-limonene, myrcene, α-terpinene, and α-pinene as probe molecules. Results indicated that the terpene uptake and release behavior are highly dependent on both the MOF pore size and the geometric feature of guest molecules themselves. The shape selective property of UiO-66 holds for the tested terpenes, where the adsorption capacity of d-limonene, myrcene, and α-terpinene in equilibrium with the liquid phase (0.43−0.46 g g¯1) was approximately 5-times larger than that of α-pinene with 0.56 nm kinetic diameter (0.09 g g¯1). The narrow triangular apertures of UiO-66 act as the permeation-limiting barrier for guest molecules with the dimension close to the pore size. Except for α-pinene, the loading fraction for other terpenes decreased with an increase in the MOF pore diameter. For example, the uptake of UiO-66, UiO-67, and UiO-68 for myrcene reached 90%, 81%, and 76% of their theoretical maximum loading, respectively. Differential scanning calorimetry revealed that the melting point of both d-limonene and α-terpinene confined in the 0.71 nm pores of UiO-67 shifts to a higher temperature relative to that in the bulk phase. Contrary to this, no significant sign of phase transitions was observed for terpene composites with either UiO-66 or UiO-68 (0.94 nm pore size) under identical conditions. In accord with the thermal analysis results, the monoterpenes constrained by UiO-67 showed a much lower release rate than their counterparts in the other two frameworks. © 2023, The Authors. All rights reserved.

关键词： Pore size

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Recent advances of bioresponsive polymeric nanomedicine for cancer therapy

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Nano Research 2023年第2期16卷 2660-2671页

作者： Tu Hong Xinyuan Shen Madiha Zahra Syeda Yang Zhang Haonan Sheng Yipeng Zhou JinMing Xu Chaojie Zhu Hongjun Li Zhen Gu Longguang Tang International institutes of Medicine The Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwu 322000China Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Shanghai Jiaotong University School of Medicine Shanghai 200025China Department of Thoracic Surgery The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310006China Liangzhu Laboratory Zhejiang University Medical CenterHangzhou 311121China Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated Hospital School of MedicineZhejiang UniversityHangzhou 310009China Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Jinhua Institute of Zhejiang University Jinhua 321299China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

A bioresponsive polymeric nanocarrier for drug delivery is able to alter its physical and physicochemical properties in response to a variety of biological signals and pathological changes,and can exert its therapeutic efficacy within a confined *** nanosystems can optimize the biodistribution and subcellular location of therapeutics by exploiting the differences in biochemical properties between tumors and normal ***,bioresponsive polymer-based nanosystems could be rationally designed as precision therapeutic platforms by optimizing the combination of responsive elements and therapeutic components according to the patient-specific disease type and *** this review,recent advances in smart bioresponsive polymeric nanosystems for cancer chemotherapy and immunotherapy will be *** mainly discuss three categories,including acidity-sensitive,redox-responsive,and enzyme-triggered polymeric *** important issues regarding clinical translation such as reproducibility,manufacture,and probable toxicity,are also commented.

关键词： drug delivery polymer bioresponsive immunotherapy cancer therapy

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Highly Thermally Conductive and Structurally Ultra‑Stable Graphitic Films with Seamless Heterointerfaces for Extreme Thermal Management

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Nano-Micro Letters 2024年第3期16卷 383-397页

作者： Peijuan Zhang Yuanyuan Hao Hang Shi Jiahao Lu Yingjun Liu Xin Ming Ya Wang Wenzhang Fang Yuxing Xia Yance Chen Peng Li Ziqiu Wang Qingyun Su Weidong Lv Ji Zhou Ying Zhang Haiwen Lai Weiwei Gao Zhen Xu Chao Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringKey Laboratory of Adsorption and Separation Materials and Technologies of Zhejiang ProvinceZhejiang University38 Zheda RoadHangzhou 310027People’s Republic of China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032People’s Republic of China Beijing Spacecrafts Manufacturing Co. LtdBeijing Friendship Road 104Haidian DistrictBeijing 100094People’s Republic of China Beijing Institute of Space Mechanics and Electricity Beijing Friendship Road 104Haidian DistrictBeijing 100094People’s Republic of China China Academy of Aerospace Aerodynamics Beijing 100074People’s Republic of China Hangzhou Gaoxi Technol Co. LtdHangzhou 311113People’s Republic of China International Research Center for X Polymers International CampusZhejiang UniversityHaining 314400People’s Republic of China

Highly thermally conductive graphitic film(GF)materials have become a competitive solution for the thermal management of high-power electronic ***,their catastrophic structural failure under extreme alternating thermal/cold shock poses a significant challenge to reliability and ***,we present the first investigation into the structural failure mechanism of GF during cyclic liquid nitrogen shocks(LNS),which reveals a bubbling process characterized by“permeation-diffusion-deformation”*** overcome this long-standing structural weakness,a novel metal-nanoarmor strategy is proposed to construct a Cu-modified graphitic film(GF@Cu)with seamless *** well-designed interface ensures superior structural stability for GF@Cu after hundreds of LNS cycles from 77 to 300 ***,GF@Cu maintains high thermal conductivity up to 1088 W m^(−1)K^(−1)with degradation of less than 5%even after 150 LNS cycles,superior to that of pure GF(50%degradation).Our work not only offers an opportunity to improve the robustness of graphitic films by the rational structural design but also facilitates the applications of thermally conductive carbon-based materials for future extreme thermal management in complex aerospace electronics.

关键词： Highly thermally conductive Structurally ultra-stable Graphitic film Extreme thermal management Liquid nitrogen bubbling

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miR-22 eluting cardiovascular stent based on a self-healable spongy coating inhibits in-stent restenosis

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Bioactive Materials 2021年第12期6卷 4686-4696页

作者： Jing Wang Hong-Lin Qian Sheng-Yu Chen Wei-Pin Huang Dan-Ni Huang Hong-Ye Hao Ke-Feng Ren Yun-Bing Wang Guo-Sheng Fu Jian Ji MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of CardiologySir Run Run Shaw HospitalZhejiang UniversityHangzhou310016China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu610064China

The in-stent restenosis(IRS)after the percutaneous coronary intervention contributes to the major treatment failure of stent *** have been revealed as powerful gene medicine to regulate endothelial cells(EC)and smooth muscle cells(SMC)in response to vascular injury,providing a promising therapeutic candidate to inhibit ***,the controllable loading and eluting of hydrophilic bioactive microRNAs pose a challenge to current lipophilic stent ***,we developed a microRNA eluting cardiovascular stent via the self-healing encapsulation process based on an amphipathic poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone)(PCL-PEG-PCL,PCEC)triblock copolymer spongy *** miR-22 was used as a model microRNA to regulate *** dynamic porous coating realized the uniform and controllable loading of miR-22,reaching the highest dosage of 133 pmol cm^(-2).We demonstrated that the sustained release of miR-22 dramatically enhanced the contractile phenotype of SMC without interfering with the proliferation of EC,thus leading to the EC dominating growth at an EC/SMC ratio of *** importantly,the PCEC@miR-22 coated stents showed reduced inflammation,low switching of SMC phenotype,and low secretion of extracellular matrix,which significantly inhibited *** work provides a simple and robust coating platform for the delivery of microRNAs on cardiovascular stent,which may extend to other combination medical devices,and facilitate practical application of bioactive agents in clinics.

关键词： microRNA Spongy coating Biodegradable stent Contractile phenotype Restenosis

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Oxygen and sulfur-based pure n-electron dendrimeric systems:generation-dependent clusteroluminescence towards multicolor cell imaging and molecular ruler

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Science China Chemistry 2021年第11期64卷 1990-1998页

作者： Zhijun Zhang Haoke Zhang Miaomiao Kang Na Li Dong Wang Ben Zhong Tang Center for AIE Research Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Material Science and EngineeringShenzhen UniversityShenzhen518060China Key Laboratory of Macromolecular Synthesis and Functionalization(Ministry of Education) Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China Shenzhen Institute of Molecular Aggregate Science and Engineering School of Science and EngineeringThe Chinese University of Hong KongShenzhen518172China

Dendrimers,as the latest generation of artificial macromolecules,have aroused great attention in the field of clusteroluminescence owing to their unique structural and photophysical ***,previously reported dendrimers with clusteroluminescenence property usually containπelectrons-involved carbonyl groups and/or environment-sensitive aliphatic amine moieties in their structures,thus complicating the interpretation of the emission *** the other hand,a systematic investigation on the luminescence performance of dendrimers with diverse generations is significantly important for the researchers to gain further mechanistic insights into the clusteroluminescence,but has still been scarcely *** this contribution,we reported a series of oxygen and sulfur-based pure n-electron dendrimers with different generations from G1 to *** from the highly-branched three-dimensional crowded molecular structures,all these dendrimers exhibited bright fluorescence emission in visible light region due to their prominent clusteroluminescence ***,the fluorescence intensity and emission wavelength were simultaneously boosted as their generation increased due to the more crowded molecular architectures,as well as the formation of tighter and larger clusters at higher ***,these dendrimers also showed concentration-and aggregation-enhanced luminescence behaviors,presenting typical aggregation-induced emission(AIE)*** with remarkable water solubility and biocompatibility as well as the excellent photostability,the G3 dendrimer selected as a representative was successfully applied in the multicolor cell *** addition,the G3 dendrimer was also proved to be capable of acting as a molecular ruler to detect specific-sized molecule in aqueous *** work not only validated the rationality of the clusteroluminescence mechanism but also offered high-performance clusteroluminogens for practical application.

关键词： clusteroluminescence aggregation-induced emission dendrimer cell imaging molecular ruler

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Substrate stiffness differentially impacts autophagy of endothelial cells and smooth muscle cells

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Bioactive Materials 2021年第5期6卷 1413-1422页

作者： Mi Hu Fan Jia Wei-Pin Huang Xu Li Deng-Feng Hu Jing Wang Ke-Feng Ren Guo-Sheng Fu Yun-Bing Wang Jian Ji MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of CardiologySir Run Run Shaw HospitalZhejiang UniversityHangzhou310016China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu610064China

Stiffening of blood vessels is one of the most important characteristics in the process of many cardiovascular pathologies such as atherosclerosis,angiosteosis,and vascular *** stiffness of the vascular extracellular matrix drives artery pathology and alters phenotypes of vascular *** how substrate stiffness impacts vascular cell behaviors is of great importance to the biomaterial design in tissue engineering,regenerative medicine,and medical *** we report that changing substrate stiffness has a significant impact on the autophagy of vascular endothelial cells(VECs)and smooth muscle cells(VSMCs).Interestingly,our findings demonstrate that,with the increase of substrate stiffness,the autophagy level of VECs and VSMCs showed differential changes:endothelial autophagy levels reduced,leading to the reductions in a range of gene expression associated with endothelial function;while,autophagy levels of VSMCs increased,showing a transition from contractile to the synthetic *** further demonstrate that,by inhibiting cell autophagy,the expressions of endothelial functional gene were further reduced and the expression of VSMC calponin increased,suggesting an important role of autophagy in response of the cells to the challenge of microenvironment stiffness *** the underlying mechanism requires further study,this work highlights the relationship of substrate stiffness,autophagy,and vascular cell behaviors,and enlightening the design principles of surface stiffness of biomaterials in cardiovascular practical applications.

关键词： Substrate stiffness Autophagy Endothelial cells Smooth muscle cells Polyelectrolyte film

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Manipulating the film morphology evolution toward green solvent-processed perovskite solar cells

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SusMat 2021年第4期1卷 537-544页

作者： Shiqi Shan Yaokai Li Haotian Wu Tianyi Chen Benfang Niu Yingzhu Zhang Di Wang Chenxia Kan Xuegong Yu Lijian Zuo Hongzheng Chen State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhouP.R.China State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhouP.R.China Zhejiang University-Hangzhou Global Scientific and Technological Innovation Center HangzhouP.R.China

High-performance perovskite solar cells(PVSCs)with low energy consumption and green processing are highly desired,but constrained by the difficulty in morphology control and the poor understanding on morphology evolution *** address this issue,here we studied the effect of antisolvents on the perovskite film *** found that both the antisolvents and the perovskite composition affect the perovskite film morphology greatly via influencing the intermediate phase,and different perovskite compositions require different antisolvents to reach the optimal *** provides the opportunity to achieve high-performance PVSCs with green antisolvent,that is,isopropanol(iPA)by changing the perovskite compositions,and leads to a powerconversionefficiency(PCE)of 21.50% for PVSCs based on MA_(0.6)FA_(0.4)PbI_(3).Further,we fabricated“fully green”PVSCs with all layers prepared by green sol-vents,and the optimal PCE can reach 19%,which represents the highest among PVSCs with full-green *** work provides insight into the perovskite morphology evolution and paves the way toward“green”processing PVSCs.

关键词： green antisolvent morphology evolution perovskite solar cells

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Effective Interlaminar Toughening of Cfrp Composite Laminates by Monolayer Graphene Oxide Nanosheets at Quite Low Volume Fractions

SSRN

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SSRN 2024年

作者： Gao, Chongyang Mu, Binghong Cheng, Shucan Xu, Zhen InstituteofAerospaceManufacturingEngineering CollegeofMechanicalEngineering Zhejiang University Hangzhou310027 China State Key Lab of Fluid Power and Mechatronic Systems College of Mechanical Engineering Zhejiang University Hangzhou310027 China Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Department of Polymer Science and Engineering Zhejiang University Hangzhou310027 China

An interlaminar ultrafine spraying method was proposed for monolayer GO modified CFRP laminates. The well-dispersed monolayer GO nano-solutions were prepared by multi-level dispersion and then sprayed on prepreg by the ultrafine atomizing technique. A series of GO/CFRP laminate specimens with different GO loadings were fabricated for our fracture toughness tests and SEM characterization. The test results indicated that the Mode I fracture toughness ( ) was enhanced by 140% with only 0.01vol% monolayer GO nanosheets. The distinct toughening effect at such a low nano-fraction was attributed to the sufficient number of monolayer GO nanosheets with uniform distribution, which was found to be more important than their volume or weight fraction. Thus, the proposed approach owns simplicity, effectiveness and especially low cost owing to the largely reduced nano-fraction, showing a promising potential of industrial scale-up. © 2024, The Authors. All rights reserved.

关键词： Nanosheets

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受自体材料启发的药物递送系统

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Science China Materials 2024年第8期67卷 2427-2446页

作者：冯慧珩程伊安柳扶摇顾臻李洪军 State Key Laboratory of Advanced Drug Delivery and Release Systems and Liangzhu LaboratoryCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China

随着个性化医疗理念的深入研究,基于自体来源材料的药物递送系统受到越来越多的关注并快速发展.自体来源材料具有保留其体内天然生理学特性和优良的生物相容性等特点,这为其在材料功能化和药物递送方面开辟了广泛的研究空间,也为疾病治... 详细信息

随着个性化医疗理念的深入研究,基于自体来源材料的药物递送系统受到越来越多的关注并快速发展.自体来源材料具有保留其体内天然生理学特性和优良的生物相容性等特点,这为其在材料功能化和药物递送方面开辟了广泛的研究空间,也为疾病治疗提供了坚实的基础.借助这些优势,受自体来源材料启发的药物递送系统有望在疾病治疗方面实现减毒增效.本文对基于人源蛋白、细胞材料及细胞外基质支架的药物递送系统的最新研究进行了全面回顾,重点关注了这类药物递送系统的载药策略和应用场景,深入分析了它们在疾病治疗中的优势和限制.此外,本文还探讨了受自体来源材料启发的药物递送系统在临床转化过程中面临的潜在机遇和挑战.

关键词：生理学特性药物递送疾病治疗减毒增效个性化医疗生物相容性功能化

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Rheological Behaviors of Reinforced Poly(Methylvinylsiloxane) by Silica Particles with Different Morphology

SSRN

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SSRN 2024年

作者： Liu, Fu-Yong He, Hong-Wei Wang, Pi Yu, Wen-Wen Zheng, Qiang Liu, Lu School of Materials Science and Engineering Taiyuan University of Technology Taiyuan030024 China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan030032 China Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou310058 China

The hydrodynamic effect and reinforcement effect of porous aerogel silica (SAG) with a fractal network structure and smooth regular spherical silica particle (SS) in Poly-methylvinylsiloxane (PMVS) were investigated. It was found that SAG tended to form aggregates with high aspect ratio (shape factor f values between 16-20) and highly branched backbone structures (x = 1.95). Consequently, these aggregates are more loosely packed (df = 1.7) and easily break into smaller flocs under the influence of shear forces. The load-bearing mechanism of the spatial network formed by these aggregates as nodes was akin to physical gels controlled by bond-bending forces (BBF), with a scaling exponent of G*r with φe-φc of ν = 3.84, close to the theoretical value of the BBFs model. In contrast, the SS particles formed more compact aggregates (f value approximately 1.6) in PMVS, with load-bearing characteristics of the spatial network formed by them closer to chemical gels controlled by central forces (CF). The scaling exponent of G*r with φe-φc for SS/PMVS was found to be ν = 2.15, close to the theoretical value of the CFs model. © 2024, The Authors. All rights reserved.

关键词： Aggregates

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