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Tough Polyion Complex Hydrogel Films of Natural Polysaccharides

Chinese Journal of Polymer Science 2017年第10期35卷 1276-1285页

作者： Feng-bo Zhu Hai-chao Yu Wen-xi Lei Ke-feng Ren Jin Qian 吴子良 Qiang Zheng Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Department of Engineering Mechanics Zhejiang University Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University

The developments of tough hydrogels in recent years have greatly expanded the applications of hydrogels as structural materials. However, most of the tough hydrogels are made of synthetic polymers. To develop biopolymer-based tough hydrogels has both fundamental and practical significances. Here we report a series of polysaccharides-based tough hydrogel films prepared by polyion complexation and solvent evaporation of chondroitin sulfate（CS） and protonated chitosan（CHT） solutions with different weight ratios. The obtained CS/CHT gel films with thickness of 40-80 μm and water content of 66 wt%-81 wt% possess excellent mechanical properties, with tensile breaking stress and breaking strain being 0.4-3 MPa and 160%-320%, respectively. We found that in the mixture solutions there are large amounts of excess CHT in terms of charges; after swelling the films in water, the acetic acid, which is used to protonate the amino groups of CHT, diffuses out of the gel matrix, enhancing the intermolecular interactions between CHT molecules and thus improving the mechanical properties of gel films, besides the ionic bonds between CS and CHT. Antimicrobial tests also showed that the gel films with low weight ratio of CS to CHT, corresponding to the case with excess CHT, have evident antimicrobial effect. These CS/CHT gel films with good mechanical properties and antimicrobial effect should extend the applications of hydrogels in biomedical fields.

关键词： responsive polymerization methacrylate acrylamide hydrophilic reversible dissipation AMPS toughness swelling

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BIODEGRADABLE ALIPHATIC/AROMATIC COPOLYESTERS BASED ON TEREPHTHALIC ACID AND POLY(L-LACTIC ACID):synthesis,CHARACTERIZATION AND HYDROLYTIC DEGRADATION

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Chinese Journal of Polymer Science 2010年第3期28卷 405-415页

作者：方征平 Institute of Polymer Composites Zhejiang UniversityKey Laboratory of Macromolecular Synthesis and Functionalization Ministry of Education Lab of Polymer Materials and Engineering Ningbo Institute of TechnologyZhejiang University

Biodegradable aliphatic/aromatic copolyesters, poly（butylene terephthalate-co-lactate）（PBTL） were prepared via direct melt polycondensation of terephthalic acid （TPA）, 1,4-butanediol （BDO） and poly（L-lactic acid） oligomer （OLLA）. The effects of polymerization time and temperature, as well as aliphatic/aromatic moiety ratio on the physical and thermal properties were investigated. The largest molecular weight of the copolyesters was up to 64100 with molecular weight distribution index of 2.09 when the polycondensation was carried out at 230℃ for 6 h. DSC, XRD, DMA and TGA analysis clearly indicated that the degree of crystallinity, glass-transition temperature, melting point, decomposition temperature, tensile strength, elongation and Young＇s modulus were influenced by the ratio between TPA and OLLA in the final copolyesters. Hydrolytic degradation results demonstrated that the incorporation of biodegradable lactate moieties into the aromatic polyester could efficiently improve hydrolytic degradability of the copolymer even though it still had many aromatic units in the main chains.

关键词： Aliphatic/aromatic copolyesters Direct melt polycondensation Biodegradable

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Preparation and cellular uptake of PLGA particles loaded with lamivudine

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Chinese Science Bulletin 2012年第31期57卷 3985-3993页

作者： WANG Bing CHEN GuanQun MAO ZhengWei ZHANG YuYing YU DaHai GAO ChangYou Key Laboratory of Macromolecular Synthesis and Functionalization(Ministry of Education) Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Poly (D， L-lactide-co-glycolide )(PLGA ) nanoparticles 与 lamivudine 装载了并且与牛的浆液白朊(BSA ) 涂经由一个双乳剂方法被准备。象内部水的阶段，器官的阶段的集中和粒子尺寸和药陷阱效率上的 ultrasonication 时间的体积那... 详细信息

Poly (D， L-lactide-co-glycolide )(PLGA ) nanoparticles 与 lamivudine 装载了并且与牛的浆液白朊(BSA ) 涂经由一个双乳剂方法被准备。象内部水的阶段，器官的阶段的集中和粒子尺寸和药陷阱效率上的 ultrasonication 时间的体积那样的实验参数的影响被调查，获得有 260 nm 的一条直径和 35% 的药陷阱效率的 PLGA 粒子。粒子被扫描电子显微镜学和发射度电子显微镜学观察，显示出核心壳结构。发现那 58 mg BSA 的 BCA 试金在 1 个 g LPB 粒子上 / 在是在场的。装载 lamivudine 在开始显示出一个爆炸版本并且处于生理的条件支撑了版本直到 24 h。低 pH 能从 PLGA 粒子加速 lamivudine 的版本，使 PLGA 粒子成为潜在的聪明的细胞内部的药搬运人。PLGA 粒子乐意地在一短时间以内被使内在化进人的肝房间并且不管装载 lamivudine 与孵化时间的延伸逐渐地增加了。粒子任何一个在 lysosomes 以内住了或转了到细胞质，但是不能进入房间原子核。房间生存能力显著地没不管 lamivudine 封装面对粒子被影响，建议这种粒子可以是细胞内部的反肝炎 B 药交货的一个好候选人。

关键词：拉米夫定 PLGA 纳米颗粒加载细胞摄取制备透射电子显微镜扫描电子显微镜

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The Moonlighting Function of Glutaminase 2 Promotes Immune Evasion of Pancreatic Ductal Adenocarcinoma by Tubulin Tyrosine Ligase-like 1-Mediated Yes1 Associated Transcriptional Regulator Glutamylation

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Gastroenterology 2025年第6期168卷 1137-1152页

作者： Chen, Xiao Fu, Haotian Zhu, Shimao Xiang, Zheng Fu, Hong Sun, Zhongquan Zhang, Sitong Zheng, Xiaofeng Hu, Xun Chao, Ming Mao, Zhengwei Bi, Yanli Wang, Weilin Ding, Yuan Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated Hospital Zhejiang University School of Medicine Zhejiang Hangzhou China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Zhejiang Hangzhou China Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province Zhejiang Hangzhou China Center for Medical Research and Innovation in Digestive System Tumors Ministry of Education China Cancer Center Zhejiang University Zhejiang Hangzhou China ZJU-Pujian Research & Development Center of Medical Artificial Intelligence for Hepatobiliary and Pancreatic Disease Zhejiang Hangzhou China Department of Gastroenterology and Hepatology The First Affiliated Hospital of Wenzhou Medical University Wenzhou China Department of Pathology & Pathophysiology Department of Breast Surgery of the Second Affiliated Hospital Zhejiang University School of Medicine Zhejiang Hangzhou China Cancer Institute (Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education) The Second Affiliated Hospital Zhejiang University School of Medicine Zhejiang Hangzhou China Interventional Radiology Department of Radiology The Second Affiliated Hospital Zhejiang University School of Medicine Zhejiang Hangzhou China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Zhejiang Hangzhou China

Background & Aims: Elevated programmed cell death-ligand 1 (PD-L1) expression in tumor cells facilitates immune evasion. However, the mechanism via which PD-L1 expression is regulated in pancreatic ductal adenocarcinoma (PDAC) cells remains inadequately elucidated. Methods: Immunoprecipitation, pull-down assays, and mass spectrometry were used to identify glutaminase 2 (GLS2) and yes1 associated transcriptional regulator (YAP1) binding proteins and modification sites. Immunoblotting, immunofluorescence, chromatin immunoprecipitation, and luciferase reporter assays were used to analyze YAP1 activation. Protein expression levels were assessed using immunoblotting, immunoprecipitation, immunofluorescence, and immunohistochemistry. RNA expression levels were analyzed using real-time quantitative polymerase chain reaction. Results: Hypoxia-induced general control nondepressible 5 (GCN5)–mediated acetylation of GLS2 at K151, which enhanced GLS2 interaction with YAP1. Subsequently, tubulin tyrosine ligase-like 1 mediated YAP1 glutamylation at E100 and promoted its nuclear translocation and the activation-dependent transcriptional up-regulation of PD-L1 expression. The expression of GLS2-K151R or YAP1-E100A mutants in PDAC cells blocked hypoxia-induced PD-L1 expression and enhanced CD4⁺ and CD8⁺ T-cell activation and tumor infiltration, thereby suppressing PDAC tumor growth. Simultaneous administration of MB-3, a GCN5 inhibitor, and an anti–programmed cell death 1 (PD-1) antibody abolished tumor immune evasion, boosting the anti-tumor efficacy of immune checkpoint blockade. Furthermore, GLS2-K151 acetylation and YAP1 E100 glutamylation levels correlated positively with PD-L1 expression and poor prognosis in PDAC patients. Conclusions: The present study revealed a novel mechanism by which hypoxia up-regulates PD-L1 expression and highlighted the involvement of GLS2 in noncanonical metabolic pathways involved in tumor immune evasion, with implications fo

关键词： GLS2 Glutamylation PD-L1 YAP1

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Poly(N,N-dimethylaminoethyl methacrylate) Grafted Poly(vinyl chloride)s Synthesized via ATRP Process and Their Membranes for Dye Separation

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Chinese Journal of Polymer Science 2015年第11期33卷 1491-1491,1492-1502页

作者： Li-feng Fang Na-chuan Wang Ming-yong Zhou 朱宝库 Li-ping Zhu Angelin Ebanezar John Key Laboratory of Macromolecular Synthesis and Functionalization (Ministry of Education) Engineering Research Center of Membrane and Water Treatment (Ministry of Education) Department of Polymer Science and Engineering Zhejiang University

To functionalize poly（vinyl chloride）（PVC） for various applications, monomers containing tertiary amine group are incorporated into PVC via atom transfer radical polymerization（ATRP） initiated by the labile chlorines in their backbones. The kinetics of synthesis was carefully investigated, and it is proven that the grafting polymerization process can be effectively controlled by regulating the reaction time. The membranes are fabricated using PVC and copolymers by non-solvent induced phase separation（NIPS） process. The hydrophilicity and pore structure of copolymer membranes were enhanced as well, these membranes are endowed with positive charge. When PDMA%（i.e., the PDMA weight percentage in copolymer） is 31.1%, the flux and Victoria blue B rejection are 26.0 L·m·^-2·h^-1（0.5 MPa） and 91.2%, respectively. Thus, the newly synthesized polymer is proven to be a promising material for dye separation with positive charges.

关键词： Poly（vinyl chloride） Poly（N N-dimethylaminoethyl methacrylate） Non-solvent induced phase separation Dye separation

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Label-free Fluorescent Sensor for Probing Heparin-Protein Interaction Based on Supramolecular Assemblies

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Chinese Journal of Chemistry 2014年第1期32卷 85-90页

作者： Lan Jia Lingyun Xu Zhaohui Wang Jianping Xu Jian Ji[*] MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou Zhejiang 310027 China Email: Jian Ji (jijian@***)[*]MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou Zhejiang 310027 China Tel./Fax: 0086-0571-87953729

In this paper a label-free fluorescent sensor for probing the interaction between heparin and protein was ***,the bioactive polyanions,formed supramolecular assemblies with cationic surfactant cetyltrimethyl ammonium bromide (CTAB).The environment-dependent dye pyrene,encapsulated in hydrophobic interiors of the supramolecular assemblies worked as the fluorescence *** the heparin-binding protein was added,competing interactions of protein with heparin would weaken the interaction between CTAB and *** a result,the noncovalently sequestered pyrene would be released upon disassembly and the fluorescence of the released pyrene was subsequently *** binding events were exemplified by protamine and Tat peptide,these processes were also verified by DLS and *** a strategy is appealing as organic synthesis was traded off against supramolecular *** label-free fluorescent system is simple,selective,convenient,and can serve as a good complement to other existing methods,also this method has the potential for preprimary drug screening.

关键词： supramolecular assemblies fluorescent sensor heparin protein interaction

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Poly(vinylidene fluoride)Separators with Dual-asymmetric Structure for High-performance Lithium Ion Batteries

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Chinese Journal of Polymer Science 2016年第12期34卷 1423-1435页

作者： Hong-qing Liang Ling-shu Wan 徐志康 MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Key Laboratory of Adsorption and Separation Materials & Technologies of Zhejiang Province Department of Polymer Science and Engineering Zhejiang University

Dual-asymmetric poly（vinylidene fluoride）（PVDF） separators have been fabricated by thermally induced phase separation with dimethyl sulfone （DMSO2） and glycerol as mixed diluents. The separators have a porous bulk with large interconnected pores （-1.0 μm） and two surfaces with small pores （-30 nm）. This dual-asymmetric porous structure endows the separators with higher electrolyte uptake amount and rapider uptake rate, as well as better electrolyte retention ability than the commercialized Celgard 2400. The separators even maintain their dimensional stability up to 160 ℃, at which temperature the surface pores close up, leading to a dramatic decrease of air permeability. The electrolyte filled separators also show high ion conductivity （1.72 ***-1） at room temperature. Lithium iron phosphate （LiFePO4）/lithium （Li） cells using these separators display superior discharge capacity and better rate performance as compared with those from the commercialized ones. The results provide new insight into the design and development of separators for high-performance lithium ion batteries with enhanced safety.

关键词： Polymer separator Lithium ion battery Dual-asymmetric structure Porous membrane Thermally induced phaseseparation.

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PREFERENTIAL INTERCALATION BEHAVIOR OF CLAY AND ITS EFFECT ON THE THERMAL DEGRADATION IN IMMISCIBLE PP/PS BLENDS

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Chinese Journal of Polymer Science 2008年第6期26卷 783-792页

作者：方征平 Institute of Polymer Composites Zhejiang UniversityKey Laboratory of Macromolecular Synthesis and FunctionalizationMinistry of Education Department of Biochemical and Chemical Engineering Ningbo Institute of TechnologyZhejiang University

The typical immiscible PP/PS blend based clay nanocomposites were prepared via melt *** dispersion of clay was determined by X-ray diffraction (XRD) and transmission electron microscopy (TEM).Thermal stability and dynamic mechanical properties were measured by thermogravimetrical analysis (TGA) and dynamic mechanical analysis (DMA),*** intercalation behavior of clay in PP/PS blends was *** dispersion of clay is significantly influenced by the polarity of PP and PS,meanwh...

关键词： Clay Nanocomposites Poly（propylene） Polystyrene.

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RHEOLOGICAL PROPERTIES OF POLY(VINYLIDENE FLUORIDE) IN MOLTEN STATE

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Chinese Journal of Polymer Science 2008年第5期26卷 639-644页

作者：沈烈 Department of Polymer Science and Engineering Zhejiang Universityand Key Laboratory of Macromolecular Synthesis and FunctionalizationMinistry of EducationHangzhou 310027China

The theological behavior of poly(vinylidene fluoride)(PVDF)samples of different molecular weights was investigated by means of high pressure capillary rheometer and rotational *** on the rheological properties of such materials above melt temperatures is of interest as this can lead to an improved understanding of polymer behavior in processing and fabrication *** factors derived from time-temperature superposition showed good fit to the Arrhenius equation with a flow activa...

关键词： Poly（vinylidene fluoride） Rheological properties Flow activation energy Plateau modulus.

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Understanding the Reinforcement and Dissipation of Natural Rubber Compounds Filled with Hybrid Filler Composed of Carbon Black and Silica

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Chinese Journal of Polymer Science 2017年第11期35卷 1436-1446页

作者：宋义虎 Ling-bin Zeng Qiang Zheng Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Key Laboratory of Adsorption and Separation Materials & Technologies of Zhejiang ProvinceZhejiang University Shanghai Aerospace System Engineering Institute

The performance of reinforced rubber compounds depends on the filler composition while the reinforcement and dissipation mechanisms still remain unclear. Herein linear and nonlinear dynamic rheological responses of carbon black/silica hybrid filler filling nature rubber compounds are investigated. The rheological contributions of dynamically retarded bulk phase and filler network are revealed to be crucial at high and low frequencies, respectively, and the bulk phase is shown to be of vital importance for the occurrence of nonlinear Payne effect at mediate frequencies. A framework for simultaneously solving reinforcement and dissipation varying with filler composition and content is suggested, providing a new perspective in understanding the filling effect for manufacturing high-performance rubber materials.

关键词： Filling Reinforcement Dissipation Rubber compounds Time-concentration superpositioning principle

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