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Wet-spun poly(ionic liquid)-graphene hybrid fibers for high performance all-solid-state flexible supercapacitors

Journal of Energy Chemistry 2019年第7期28卷 104-110页

作者： Karthikeyan Gopalsamy Qiuyan Yang Shengying Cai Tieqi Huang Zhengguo Gao Chao Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Key Laboratory of Adsorption and Separation Materials and Technologies of Zhejiang Province Zhejiang University

It is crucial to develop flexible and wearable electronic devices that have attracted tremendous interest due to their merits on compactness,flexibility and high capacitive *** we report the continuously ordered macroscopic poly(ionic liquid)-graphene fibers by wet spinning method via liquid crystal assembly for supercapacitor *** fabricated all-solid-state supercapacitors exhibited a high areal capacitance(268.2 mF cm 2)and volumetric capacitance(204.6 F cm 3)with an outstanding areal energy density(9.31μWh cm-2)and volumetric energy density(8.28 mWh cm-3).The fiber supercapacitors demonstrated exceptional cycle life for straight electrodes of about 10,000 cycles(94.2%capacitance retention)and flexibility at different angles(0°,45°,90°,180°)along with a good flexible cycling stability after 6000 cycles(92.7%capacitance retention).To date,such a novel poly(ionic liquid)-graphene fiber supercapacitors would be a new platform in real-time flexible electronics.

关键词： Graphene fiber Poly(ionic liquid) Wet spinning Supercapacitors Flexibility

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Capacitive charge storage enables an ultrahigh cathode capacity in aluminum-graphene battery

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Journal of Energy Chemistry 2020年第6期29卷 40-44,I0002页

作者： Hanyan Xu Hao Chen Haiwen Lai Zheng Li Xiaozhong Dong Shengying Cai Xingyuan Chu Chao Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringKey Laboratory of Adsorption and Separation Materials and Technologies of Zhejiang ProvinceZhejiang University38 Zheda RoadHangzhou 310027ZhejiangChina Hangzhou Gaoxi Technology Co. Ltd.LiangzhuHangzhou 310000ZhejiangChina

Aluminum^-graphene battery is promising for its abundant raw materials,high power density,ultralong cycle life and superior ***,the development of aluminum^-graphene battery is currently restricted by its insufficient cathode capacity,calling for a newly developed working *** addition,an irregular constant increase of the cathode capacity was always observed during cycling,but cannot be explained based on the current ***,we observed an increase of specific capacity by 60%with stable Coulombic efficiency of 98%during 7000 cycles life of Al-graphene batteries employing AlCl3/ET3NHCl *** demonstrated this growing cathode capacity is attributed to an increasing contribution of capacitive charge storage during cycling,because a gradually enlarged surface area as capacitive active sites is enabled by the exfoliation of graphitic cathode during the periodic intercalation ***,the graphene cathode was exfoliated more significantly in AlCl3/ET3NHCl than 1-ethyl-3-methylimidazolium chloride-based electrolyte,which results from the heavier stress on the graphene layers caused by the larger intercalants in AlCl3/*** common intercalation of cations with AlCl4-clusters was therefore supposed to occur during *** new proposed mechanism can offer the new thought for future design on high-capacity cathode of Al-ion battery.

关键词： Al-graphene battery Intercalated graphene Capacitive charge storage Increasing capacity Exfoliation

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Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression (27 Mar, 10.1038/s41589-024-01597-2, 2024)

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NATURE CHEMICAL BIOLOGY 2024年第11期20卷 1547-1547页

作者： Li, Min Wang, Zheng Tao, Jingjing Jiang, Hongfei Yang, Huang Guo, Dong Zhao, Hong He, Xuxiao Luo, Shudi Jiang, Xiaoming Yuan, Li Xiao, Liwei He, Haiyan Yu, Rilei Fang, Jing Liang, Tingbo Mao, Zhengwei Xu, Daqian Lu, Zhimin The First Affiliated Hospital and Institute of Translational Medicine Zhejiang University School of Medicine Zhejiang University Zhejiang Provincial Key Laboratory of Pancreatic Disease Hangzhou China (GRID:grid.13402.34) (ISNI:0000 0004 1759 700X) Cancer Center Zhejiang University Hangzhou China (GRID:grid.13402.34) (ISNI:0000 0004 1759 700X) The Affiliated Hospital of Qingdao University and Qingdao Cancer Institute Qingdao China (GRID:grid.412521.1) (ISNI:0000 0004 1769 1119) Zhejiang University MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Hangzhou China (GRID:grid.13402.34) (ISNI:0000 0004 1759 700X) The First Affiliated Hospital and Institute of Translational Medicine Zhejiang University School of Medicine Zhejiang University Zhejiang Provincial Key Laboratory of Pancreatic Disease Hangzhou China (GRID:grid.13402.34) (ISNI:0000 0004 1759 700X) Chinese Ministry of Education School of Medicine and Pharmacy Ocean University of China Key Laboratory of Marine Drugs Qingdao China (GRID:grid.4422.0) (ISNI:0000 0001 2152 3263)

Telomere dysfunction is intricately linked to the aging process and stands out as a prominent cancer hallmark. Here we demonstrate that telomerase activity is differentially regulated in cancer and normal cells depending on the expression status of fructose-1,6-bisphosphatase 1 (FBP1). In FBP1-expressing cells, FBP1 directly interacts with and dephosphorylates telomerase reverse transcriptase (TERT) at Ser227. Dephosphorylated TERT fails to translocate into the nucleus, leading to the inhibition of telomerase activity, reduction in telomere lengths, enhanced senescence and suppressed tumor cell proliferation and growth in mice. Lipid nanoparticle-mediated delivery of FBP1 mRNA inhibits liver tumor growth. Additionally, FBP1 expression levels inversely correlate with TERT pSer227 levels in renal and hepatocellular carcinoma specimens and with poor prognosis of the patients. These findings demonstrate that FBP1 governs cell immortality through its protein phosphatase activity and uncover a unique telomerase regulation in tumor cells attributed to the downregulation or deficiency of FBP1 *** was dephosphorylated by the protein phosphatase activity of the gluconeogenic enzyme FBP1, leading to inhibition of TERT nuclear translocation and telomere function. Lipid nanoparticle-delivered FBP1 mRNA blunts tumor growth in mice.

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Cryo-EM structures of human m6A writer complexes

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细胞研究（英文版） 2022年第11期32卷 982-994页

作者： Shichen Su Shanshan Li Ting Deng Minsong Gao Yue Yin Baixing Wu Chao Peng Jianzhao Liu Jinbiao Ma Kaiming Zhang State Key Laboratory of Genetic Engineering Collaborative Innovation Center of Genetics and DevelopmentMultiscale Research Institute of Complex SystemsDepartment of Biochemistry and BiophysicsSchool of Life SciencesFudan UniversityShanghaiChina MOE Key Laboratory for Cellular Dynamics and Division of Life Sciences and Medicine University of Science and Technology of ChinaHefeiAnhuiChina MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhouZhejiangChina National Facility for Protein Science in Shanghai Zhangjiang LaboratoryShanghai Advanced Research InstituteChinese Academy of ScienceShanghaiChina State Key Laboratory of Genetic Engineering Collaborative Innovation Center of Genetics and DevelopmentMultiscale Research Institute of Complex SystemsDepartment of Biochemistry and BiophysicsSchool of Life SciencesFudan UniversityShanghaiChina Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineRNA Biomedical InstituteMedical Research CenterSun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouGuangdongChina

N6-methyladenosine(m6A)is the most abundant ribonucleotide modification among eukaryotic messenger *** m6A"writer"consists of the catalytic subunit m6A-METTL complex(MAC)and the regulatory subunit m6A-METTL-associated complex(MACOM),the latter being essential for enzymatic ***,we report the cryo-electron microscopy(cryo-EM)structures of MACOM at a 3.0-A resolution,uncovering that WTAP and VIRMA form the core structure of MACOM and that ZC3H13 stretches the conformation by binding ***,the 4.4-? resolution cryo-EM map of the MACOM-MAC complex,combined with crosslinking mass spectrometry and GST pull-down analysis,elucidates a plausible model of the m6A writer complex,in which MACOM binds to MAC mainly through WTAP and METTL3 *** combination with in vitro RNA substrate binding and m6A methyltransferase activity assays,our results illustrate the molecular basis of how MACOM assembles and interacts with MAC to form an active m6A writer complex.

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Enhance efferocytosis capacity of dendritic cells for diabetic wound healing by nanozyme-loaded nanofiber dressings

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Nano Today 2025年 64卷

作者： Jian, Danfeng Ye, Kai Wang, Limo Jin, Lulu Yang, Huang Ma, Lie Yi, Chenggang Mao, Zhengwei Wu, Jindan MOE Key Laboratory of Advanced Textile Materials & Manufacturing Technology Zhejiang Sci-Tech University Hangzhou310018 China Department of Plastic Surgery The Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou310003 China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou310003 China Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou310003 China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Zhejiang Hangzhou310009 China

Improving efferocytosis of dendritic cells (DCs) by inhibiting membrane transporter protein SLC7A11 has been explored for healing diabetes wounds. However, the administration of SLC7A11 inhibitors has been linked to the generation of reactive oxygen species (ROS), which may compromise the viability and functionality of DCs. To mitigate this adverse effect, a nanozyme-loaded nanofiber dressing, termed GIPH, was developed. This dressing encapsulates a specific SLC7A11 inhibitor (HG106) in the core layer and incorporates an efficient nanozyme, Ir NPs-PVP, in the shell layer. The Ir NPs-PVP nanozyme effectively neutralizes ROS produced by HG106, thereby enhancing the viability of DCs and further promoting their efferocytosis. Our in vitro experiment results demonstrated that GIPH-treated Bone Marrow-Derived Dendritic Cells (BMDCs) exhibited a 1.68-fold increase in survival and a 1.52-fold enhancement in efferocytosis rate compared to those treated with HG106 alone. Furthermore, in a diabetic mouse wound model, the GIPH group showed superior healing outcomes, with wound nearly achieving complete recovery by day 12 (97.5 %). This research highlights the therapeutic potential of nanozyme-loaded nanofiber dressings while providing valuable insights for future investigations into the DCs-mediated wound healing process. © 2025 Elsevier Ltd

关键词： Nanofibers

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Correction to"Mediating the Migration of Mesenchymal Stem Cells by Dynamically Changing the Density of Cell-selective Peptides Immobilized on β-Cyclodextrin-modified Cell-resisting Polymer Brushes"

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Chinese Journal of Polymer Science 2020年第9期38卷 1045-1046,I0009页

作者： Wang Du De-Teng Zhang Xue-Mei Wang Tan-Chen Ren Chang-You Gao Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

The authors regret that Fig.4(c)was misplaced by the first author *** corrected version of Fig.4 is provided *** quantitative analysis shown in Fig.4(b)is not changed,and thus the conclusions related to Fig.4 and repo... 详细信息

关键词： correction originally placed

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An Unprecedented Efficiency with Approaching 21%Enabled by Additive‑Assisted Layer‑by‑Layer Processing in Organic Solar Cells

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Nano-Micro Letters 2025年第2期17卷 372-375页

作者： Shuai Xu Youdi Zhang Yanna Sun Pei Cheng Zhaoyang Yao Ning Li Long Ye Lijian Zuo Ke Gao Key Laboratory of Advanced Green Functional Materials College of ChemistryChangchun Normal UniversityChangchun 130032People’s Republic of China Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237People’s Republic of China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China State Key Laboratory and Institute of Elemento‑Organic Chemistry Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsRenewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071People’s Republic of China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Tianjin Key Laboratory of Molecular Optoelectronic Sciences School of Materials Science and EngineeringTianjin UniversityTianjin 300350People’s Republic of China State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Recently published in Joule,Feng Liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8%power conversion efficiency in organic solar cells(OSCs)with an interpenetrating fibril network active layer morphology,featuring a bulk p-in structure and proper vertical segregation achieved through additive-assisted layer-by-layer *** optimized hierarchical gradient fibrillar morphology and optical management synergistically facilitates exciton diffusion,reduces recombination losses,and enhances light capture *** approach not only offers a solution to achieving high-efficiency devices but also demonstrates the potential for commercial applications of OSCs.

关键词： Organic solar cells Additive-assisted layer-by-layer processing Three-dimensional fibril morphology Bulk p-i-n structure Optical management

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Adventitial Delivery of miR-145 to Treat Intimal Hyperplasia Post Vascular Injuries Through Injectable and In-Situ Self-Assembling Peptide Hydrogels

SSRN

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SSRN 2023年

作者： Zhao, Jing Wu, Shaofei Zhang, Mingqi Zhao, Meng Xu, Shihui Ji, Jian Ren, Kefeng Fu, Guosheng Fu, Jiayin Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of Cardiology Sir Run Run Shaw Hospital Zhejiang University Hangzhou310016 China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou310027 China Guangxi University of Chinese Medicine Nanning530001 China

Intimal hyperplasia is a common lesion that can be observed in diverse vascular diseases. Drug-eluting stents and drug-coated balloons, which can release anti-proliferative agents to inhibit smooth muscle cell (SMC) proliferation, are developed to prevent intimal hyperplasia. However, these intervention devices still cannot achieve satisfactory clinical outcomes. In contrast to endovascular drug delivery, vascular adventitial drug delivery is a new strategy. To develop a vascular adventitial drug delivery system to treat intimal hyperplasia post vascular injuries, we loaded miR-145-5p-agomir (miR-145) into an injectable and in-situ self-assembling RAD peptide hydrogel. In vitro data showed that the miR-145 could be well incorporated into the RAD peptide hydrogels and released in a slow and controlled manner. The released miR-145 could transfect SMCs successfully, and the transfected SMCs exhibited a reduced migration capacity and higher expressions of SMC contractile biomarkers as compared to the non-transfected SMCs. In vivo data showed that the retention of the miR-145 was greatly elongated by the RAD peptide hydrogels. In addition, the application of the miR-145-loaded RAD peptide hydrogels surrounding injured arteries decreased the proliferative SMCs, promoted the regeneration of endothelium, reduced the macrophage infiltration, inhibited the neointimal formation and prevented adverse ECM remodeling via downregulation of KLF4 expression. The RAD peptide hydrogels loaded with miR-145 can successfully reverse intimal hyperplasia after vascular injuries and thus hold great potential as an innovative extravascular drug delivery approach to treat vascular diseases. © 2023, The Authors. All rights reserved.

关键词： Peptides

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Controllable Secondary Through-Space Interaction and Clusteroluminescence

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CCS Chemistry 2023年第12期5卷 2832-2844页

作者： Zuping Xiong Jianyu Zhang Lei Wang Yuan Xie Yipu Wang Zujin Zhao Haoke Zhang Jing Zhi Sun Feihe Huang Ben Zhong Tang MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027 Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials ZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang UniversityHangzhou 311215 Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionThe Hong Kong University of Science and TechnologyHong Kong Center for AIE Research College of Materials Science and EngineeringShenzhen UniversityShenzhen 518061 State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular AggregatesSouth China University of TechnologyGuangzhou 51064 Centre of Healthcare Materials Shaoxing InstituteZhejiang UniversityShaoxing 312000 Stoddart Institute of Molecular Science Department of ChemistryZhejiang UniversityHangzhou 310058 School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen 518172

Nonconjugated clusteroluminogens(CLgens),such as proteins and polystyrene,have become increasingly important in *** show many advantages over traditional conjugated dyes with fused aromatic rings in biological ***,CLgens have historically been unheeded because of their weak visible emissions in the aggregate state,namely clusteroluminescence(CL).Changing the electronic structures of CLgens by precisely regulating the intramolecular throughspace interaction(TSI)to improve their photophysical properties remains an enormous ***,we propose a general strategy to construct a higher-level intramolecular TSI,namely secondary TSI constructed by the primary TSI and a TSI linker,in multi-aryl-substituted alkanes(MAAs).By introducing methyl and phenyl into 1,1,3,3-tetraphenylpropane,the modified MAAs show efficient CL with high luminescence quantum yield(-40%)and long emission wavelength(-530 nm).Then,comprehensive experiments and theoretical studies demonstrate that molecular rigidity and overlap of subunits play pivotal roles in improving these hierarchical *** work not only provides a feasible strategy to achieve controllable manipulation of hierarchical TSIs and CL but also establishes comprehensive TSI-based aggregate photophysics.

关键词： through-space interaction clusteroluminescence aggregation-induced emission alkanes electronic structures aggregate photophysics

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Porous Organic Polymer Interlayers Modulated Nanofiltration Membranes for Ultra-Permselective Li+ /Mg2+ Separation

SSRN

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SSRN 2023年

作者： Zhao, Shuzhen Cui, Wenshuo Shen, Qin Yao, Zhikan Fang, Chuanjie Zhang, Lin Zhu, Liping MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou310027 China MOE Engineering Research Center of Membrane and Water Treatment Technology Zhejiang University Hangzhou310027 China Key Laboratory of Biomass Chemical Engineering College of Chemical and Biological Engineering Zhejiang University Hangzhou310027 China

The ion-ion precise separation is of paramount importance but presents significant technical challenges. Achieving such an accurate separation utilizing nanofiltration (NF) membranes demands ion-selective channels with appropriate pore geometry structure and charge property. In this work, thinner polyamide (PA) NF membranes with narrower pore size distribution were fabricated via the porous organic polymer (POP) interlayer-mediated interfacial polymerization. The dual-rigid-distorted POP interlayers were incorporated in situ onto the substrates through azo-coupling reactions. The POP interlayers exhibited a high-density adsorption capacity of amine monomers and acted as a space manipulator that regulated their diffusion behavior into the oil phase, enabling their reaction with the acyl chloride. The synergistic effects engendered a uniform PA active layer and impeded further growth of the membrane, facilitating the generation of a thinner and a narrower pore size distribution PA active layer with a nanostripe surface. The prepared NF membranes showed an outstanding ion-ion separation factor of Li+/Mg2+ (up to 78.56), almost 18 times that of the pristine NF membrane (4.32), along with a two-fold increase in water permeance. Furthermore, the newly developed NF membranes demonstrate long-term stability under operational pressure, thus highlighting the promising potential of these NF membranes for extracting Li+ from salt-lake brines. © 2023, The Authors. All rights reserved.

关键词： Ions

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