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Materials and Carriers Development for Glucose-Responsive Insulin

Accounts of Materials Research 2022年第9期3卷 960-970页

作者： Yuejun Yao Kangfan Ji Yanfang Wang Zhen Gu Jinqiang Wang Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Zhejiang Laboratory of Systems&Precision Medicine Zhejiang University Medical CenterHangzhou 311121China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310009China

CONSPECTUS:Insulin replacement therapy is an essential and effective treatment strategy for controlling the blood glucose level(BGL)of people without sufficient endogenous insulin ***,insulin therapy faces challenges such as daily multiple injections and hypoglycemia risk arising from its narrow therapeutic index,which together leads to poor BGL ***,glucose-responsive insulin delivery systems that can mimicβ-cell function are developed to improve BGL control and reduce injection ***-responsive materials-based insulin delivery systems are competent in tightly controlling the BGL with an additional benefit of reducing the hypoglycemia risk.

关键词： endogenous injection narrow

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Visualized Degradation of CO_(2)-Based Unsaturated Polyesters toward Structure-Controlled and High-Value-Added Fluorophores

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CCS Chemistry 2022年第1期4卷 237-249页

作者： Bo Song Tianwen Bai Dongming Liu Rong Hu Dan Lu Anjun Qin Jun Ling Ben Zhong Tang State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular AggregatesSCUT-HKUST Joint Research InstituteAIE InstituteCenter for Aggregation-Induced EmissionSouth China University of Technology(SCUT)Guangzhou 510640 MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027 Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and ReconstructionInstitute for Advanced Studyand Department of Chemical and Biological EngineeringThe Hong Kong University of Science&Technology(HKUST)Clear Water BayKowloonHong Kong 999077

In comparing with traditional polymer degradation toward unknown or unvalued products(i.e.,downcycling),new methods to degrade polymers into monomers or high-value-added materials(i.e.,upcycling)are preferable for sustainable *** this work,CO_(2)-based linear and cross-linked unsaturated polyesters,that is,poly(alkynoate)s,were successfully degraded by benzamidine into diols and high-value-added pyrimidone or imidazolone derivatives through controlled reaction *** degradation process could be visualized under UV light via gradually increased luminescent intensity of the reaction mixtures and fluorescence patterns could be generated through microcontact printing of the stamp on the thin films of poly(alkynoate)***,the pyrimidone derivatives could be applied in bioimaging and inhibiting bacteria,and the imidazolone derivatives could be used for the detection and recovery of gold(III)ions from electronic waste and serve as the fluorescent sensor to detect in situ-generated amines from food ***,this work presents a visualized and high value productselective degradation to solve the end-of-life issue of polymers.

关键词： visualized degradation N-heterocyclic compounds aggregation-induced emission microcontact printing gold enrichment

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Spheroids of Endothelial Cells and Vascular Smooth Muscle Cells Promote Cell Migration in Hyaluronic Acid and Fibrinogen Composite Hydrogels

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Research 2020年第1期2020卷 1673-1687页

作者： Xingang Zuo Haolan Zhang Tong Zhou Yiyuan Duan Hao Shou Shan Yu Changyou Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative Medicine Zhejiang UniversityHangzhou 310058China

Cell migration plays a pivotal role in many pathological and physiological *** far,most of the studies have been focused on 2-dimensional cell adhesion and ***,the migration behaviors of cell spheroids in 3D hydrogels obtained by polymerization of methacrylated hyaluronic acid(HA-MA)and fibrinogen(Fg)with different ratios were *** Fg could be released to the medium gradually along with time prolongation,achieving the dynamic change of hydrogel structures and *** types of cell spheroids,i.e.,endothelial cell(EC),smooth muscle cell(SMC),and EC-SMC spheroids,were prepared with 10,000 cells in each,whose diameters were about 343,108,and 224μm,*** composite hydrogels with an intermediate ratio of Fg allowed the fastest 3D migration of cell *** ECs-SMCs migrated longest up to 3200μm at day 14,whereas the SMC spheroids migrated slowest with a distance of only~400μm at the same period of *** addition of free RGD or anti-CD44 could significantly reduce the migration distance,revealing that the cell-substrate interactions take the major roles and the migration is mesenchymal ***,addition of anti-N-cadherin and MMP inhibitors also slowed down the migration rate,demonstrating that the degradation of hydrogels and cell-cell interactions are also largely involved in the cell ***-PCR measurement showed that expression of genes related to cell adhesion and antiapoptosis,and angiogenesis was all upregulated in the EC-SMC spheroids than single EC or SMC spheroids,suggesting that the use of composite cell spheroids is more promising to promote cell-substrate interactions and maintenance of cell functions.

关键词： migration. migrate migration

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Fjord-Type AIEgens Based on Inherent Through-Space Conjugation

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CCS Chemistry 2024年第7期6卷 1739-1747页

作者： Ye-Qiang Han Yuan Xie Jianyu Zhang Shiyu Tan Haoke Zhang Ben Zhong Tang Jonathan L.Sessler Feihe Huang Stoddart Institute of Molecular Science Department of ChemistryZhejiang UniversityHangzhou 310058 Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials ZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang UniversityHangzhou 311215 MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310058 Center for AIE Research College of Materials Science and EngineeringShenzhen UniversityShenzhen 518061 Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionThe Hong Kong University of Science and TechnologyKowloonHong Kong 999077 School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Guangzhou 518172 Department of Chemistry The University of Texas at AustinAustinTexas 78712-1224 Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001

Through-space conjugation(TSC)is a noncovalently electronic interaction that is emerging as a potential complement to through-bond conjugation(TBC)-based strategies for constructing luminescent ***,the design of efficient luminogens based on TSC is currently challenging due to a lack of established structure-property *** is particularly true in the case of luminogens displaying aggregation-induced emission(AIE)*** this work,three terphenyl derivatives were prepared,and their photophysical properties were systemically *** was found that relative to the corresponding m-and p-linked analogues,the electronic interaction of TBC is weakened while the strength of TSC is commensurately enhanced in the constitutional isomer containing an o-linked fjordtype *** this set of luminogens,the presence of a fjord-type arrangement promotes a transformation from aggregation-caused quenching to *** investigations involving congeneric quaterphenyl and pentphenyl isomers support the universality of the fjord-type unit as a framework for synthesizing AIE-active luminogens(AIEgens)with inherent *** work not only provides a novel set of AIEgens but also establishes the utility of TSC in controlling the photophysical properties of nonconventional and twisted luminogens.

关键词： fjord-type through-space conjugation through-bond conjugation aggregation-induced emission luminescence twisted conformation

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Recent progress in organic solar cells(PartⅠmaterial science)

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Science China Chemistry 2022年第8期65卷 224-268页

作者： Yahui Liu Bowen Liu Chang-Qi Ma Fei Huang Guitao Feng Hongzheng Chen Jianhui Hou Lingpeng Yan Qingya Wei Qun Luo Qinye Bao Wei Ma Wei Liu Weiwei Li Xiangjian Wan Xiaotian Hu Yanchun Han Yaowen Li Yinhua Zhou Yingping Zou Yiwang Chen Yongfang Li Yongsheng Chen Zheng Tang Zhicheng Hu Zhi-Guo Zhang Zhishan Bo College of Textiles&Clothing State Key Laboratory of Bio-fibers and Eco-textilesQingdao UniversityQingdao 266071China Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of SciencesSuzhou 215123China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640China Beijing Advanced Innovation Center for Soft Matter Science and Engineering&State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100190China State Key Laboratory of Powder Metallurgy College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China School of Physics and Electronic Science East China Normal UniversityShanghai 200241China State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China State Key Laboratory and Institute of Elemento-Organic Chemistry Key Laboratory of Functional Polymer MaterialsCollege of ChemistryNankai UniversityTianjin 300071China College of Chemistry/Institute of Polymers and Energy Chemistry(IPEC) Nanchang UniversityNanchang 330031China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Laboratory of Advanced Optoelectronic Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Center for Advanced Low-Dimension Materials State Key Laboratory for Modification of Chemical Fibers and Polymer Material

During past several years,the photovoltaic performances of organic solar cells(OSCs)have achieved rapid progress with power conversion efficiencies(PCEs)over 18%,demonstrating a great practical application *** development of material science including conjugated polymer donors,oligomer-like organic molecule donors,fused and nonfused ring acceptors,polymer acceptors,single-component organic solar cells and water/alcohol soluble interface materials are the key research topics in OSC ***,the recent progress of these aspects is systematically ***,the current problems and future development are also discussed.

关键词： organic solar cells power conversion efficiency photovoltaic materials polymer solar cells

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Preparation of Pva/Cnts Film with High Humidity Sensitive Performance Based on Multi-Method Integration

SSRN

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SSRN 2023年

作者： Ni, Qingsheng Du, Miao Shan, Guorong Zheng, Qiang State Key Laboratory of Chemical Engineering College of Chemical and Biological Engineering Zhejiang University Hangzhou310027 China Institute of Zhejiang University-Quzhou Quzhou324000 China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou310027 China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan030000 China

Polyvinyl alcohol is a common water soluble polymer with a large number of hydroxyl groups on the side chain, which makes it hydrophilic. In this paper, a humidity sensitive PVA film with high stability and short equilibrium time was prepared by multi-method integration, i.e. crosslinking, foaming, spin coating and adding hydroxylated carbon nanotubes (CNTs). The effects of crosslinking structure, pore structure, spin coating speed and CNTs content ( ) on humidity sensitive performance were investigated. The crosslinking of PVA chains enhances the stability under cyclic test condition. Addition of foaming agent can generate pore structure to increase the water vapor exchange efficiency to improve the humidity response and recovery performance. CNTs promote the adsorption of water molecules in air through its high specific surface area and facilitates the dissociation of water through its hole carriers and hydroxyl groups, that decreases the resistance and enlarges the humidity response range of PVA/CNTs films. The content of CNTs has significant effect on the humidity sensitive performance of films by changing the viscosity of the precursor solution. The spin speed and synergistically determine the final foaming structure and the thickness of film. By the multi-method integration, we obtained a polymer matrix humidity sensitive film with excellent performances. i.e. high stability, short response and equilibrium time. © 2023, The Authors. All rights reserved.

关键词： Polyvinyl alcohols

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Organic metallic epsilon-near-zero materials with large ultrafast optical nonlinearity

arXiv

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arXiv 2022年

作者： Hu, Qili Yu, Xinlan Liu, Hongqi Qiu, Jiahuan Tang, Wei Liang, Sen Li, Linjun Du, Miao Jia, Junjun Ye, Hui State Key Laboratory of Modern Optical Instrumentation College of Optical Science and Engineering Zhejiang University Hangzhou China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang China Global Center for Science and Engineering Waseda University Shinjukuku Tokyo Japan

Epsilon-near-zero (ENZ) materials have shown significant potential for nonlinear optical applications due to their ultrafast hot carriers and consequent optical nonlinearity enhancement. Modified poly(3,4-ethylenedioxythiophene) (PEDOT) films show metallic characteristics and a resultant ENZ wavelength near 1550nm through polar solvent treatment and annealing. The metallic PEDOT film exhibits an intrinsic optical nonlinear response that is comparable to gold and 100-fold higher than typical inorganic semiconductor ENZ materials due to π-conjugated delocalized electrons. The excitation of hot carriers further enhances its optical nonlinearity factor by a factor of 22 at 1550 nm. Hot holes in metallic PEDOT films have a smaller enhancement multiple of carrier temperature and a longer relaxation time than hot electrons in inorganic ENZ materials due to the larger imaginary permittivity and hot-phonon bottleneck for carrier cooling. Our findings suggest that π-conjugated ENZ polymer may have unique ultrafast and nonlinear optical properties compared to inorganic ENZ materials, enabling new possibilities in on-chip nanophotonic devices, nonlinear optics, and plasmonics. © 2022, CC BY-NC-SA.

关键词： Optical properties

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Macroscopic assembled graphene nanofilms based room temperature ultrafast mid-infrared photodetectors

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InfoMat 2022年第6期4卷 129-140页

作者： Li Peng Lixiang Liu Sichao Du Srikrishna Chanakya Bodepudi Lingfei Li Wei Liu Runchen Lai Xiaoxue Cao Wenzhang Fang Yingjun Liu Xinyu Liu Jianhang Lv Muhammad Abid Junxue Liu Shengye Jin Kaifeng Wu Miao-Ling Lin Xin Cong Ping-Heng Tan Haiming Zhu Qihua Xiong Xiaomu Wang Weida Hu Xiangfeng Duan Bin Yu Zhen Xu Yang Xu Chao Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringInternational Research Center for X PolymersZhejiang UniversityHangzhouChina School of Micro-nanoelectronics State Key Laboratory of Silicon MaterialsHangzhou Global Scientific and Technological Innovation CenterZJU-UIUC Joint InstituteZhejiang UniversityHangzhouChina State Key Laboratory of Molecular Reaction Dynamics and Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianChina State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijingChina Department of Chemistry Zhejiang UniversityHangzhouChina Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological UniversitySingaporeSingapore National Laboratory of Solid State Microstructures Collaborative Innovation Center of Advanced MicrostructureSchool of Electronic Science and EngineeringNanjing UniversityNanjingChina State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghaiChina Department of Chemistry and Biochemistry California Nanosystems InstituteUniversity of CaliforniaLos AngelesCaliforniaUSA

Graphene with linear energy dispersion and weak electron-phonon interaction is highly anticipated to harvest hot electrons in a broad wavelength ***,the limited absorption and serious backscattering of hot-electrons result in inadequate quantum yields,especially in the mid-infrared ***,we report a macroscopic assembled graphene(nMAG)nanofilm/silicon heterojunction for ultrafast mid-infrared *** assembled Schottky diode works in 1.5-4.0μm at room temperature with fast response(20-30 ns,rising time,4 mm2 window)and high detectivity(1.61011 to 1.9109 Jones from 1.5 to 4.0μm)under the pulsed laser,outperforming single-layer-graphene/silicon photodetectors by 2-8 *** performances are attributed to the greatly enhanced photo-thermionic effect of electrons in nMAG due to its high light absorption(~40%),long carrier relaxation time(~20 ps),low work function(4.52 eV),and suppressed carrier number *** nMAG provides a long-range platform to understand the hot-carrier dynamics in bulk 2D materials,leading to broadband and ultrafast MIR active imaging devices at room temperature.

关键词： graphene nanofilm heterojunction macro-assembly mid-infrared photodetector photothermionic effect

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Gene-activated dermal equivalents to accelerate healing of diabetic chronic wounds by regulating inflammation and promoting angiogenesis

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Bioactive Materials 2020年第3期5卷 667-679页

作者： Dong Lou Yu Luo Qian Pang Wei-Qiang Tan Lie Ma MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027PR China Department of Plastic Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou310016PR China

Diabetic chronic wound,characterized by prolonged inflammation and impaired angiogenesis,has become one of the most serious challenges in clinic and pose a significant healthcare burden *** a great variety of wound dressings have been developed,few of encouraged achievements were obtained so *** this study,the gene-activated strategy was applied to enhance sustained expression of vascular endothelial growth factor(VEGF)and achieve better healing outcomes by regulating inflammation and promoting *** gene-activated bilayer dermal equivalents(Ga-BDEs),which has good biocompatibility,were fabricated by loading the nano-sized complexes of Lipofectamine 2000/plasmid DNA-encoding VEGF into a collagen-chitosan scaffold/silicone membrane bilayer dermal *** DNA complexes were released in a sustained manner and showed the effective transfection capacities to up-regulate the expression of VEGF in *** overcome cutaneous contraction of rodents and mimic the wound healing mechanisms of the human,a reformative rat model of full-thickness diabetic chronic wound was *** the treatment of Ga-BDEs,speeding wound healing was observed,which is accompanied by the accelerated infiltration and phenotype shift of macrophages and enhanced angiogenesis in early and late healing phases,*** proved that Ga-BDEs possess the functions of immunomodulation and pro-angiogenesis ***,the better regeneration outcomes,including deposition of oriented collagen and fast reepithelialization,were *** these results indicated that,being different from traditional pro-angiogenic concept,the up-regulated expression of VEGF by Ga-BDEs in a sustained manner shows versatile potentials for promoting the healing of diabetic chronic wounds.

关键词： Gene-activated dermal equivalent Vascular endothelial growth factor Inflammation Angiogenesis Diabetic chronic wounds

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Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor

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National Science Review 2024年第4期11卷 206-215页

作者： Ziyan Liao Jie Jiang Wei Wu Jiaqi Shi Yanfang Wang Yuejun Yao Tao Sheng Feng Liu Wei Liu Peng Zhao Feifei Lv Jie Sun Hongjun Li Zhen Gu National Key Laboratory of Advanced Drug Delivery and Release Systems College of Pharmaceutical Sciences Zhejiang University Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang University Liangzhu Laboratory Zhejiang University Bone Marrow Transplantation Center of the First Affiliated Hospital and Department of Cell Biology Zhejiang University School of Medicine Department of Medical Oncology The First Affiliated Hospital School of Medicine Zhejiang University Department of Laboratory Medicine The First Affiliated Hospital Zhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang University Jinhua Institute of Zhejiang University MOE Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang University Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University

The limited infiltration and persistence of chimeric antigen receptor(CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process of T-cell proliferation in lymph nodes. This scaffold gathers the function of loading,delivery, activation and expansion for CAR-T cells to enhance their therapeutic effects on solid tumors. This porous device is made from poly(lactic-co-glycolic acid) by a microfluidic technique with the modification of T-cell stimulatory signals, including anti-CD3, anti-CD28 antibodies, as well as cytokines. This scaffold fosters a 50-fold CAR-T cell expansion in vitro and a 15-fold cell expansion in vivo. Particularly, it maintains long-lasting expansion of CAR-T cells for up to 30 days in a cervical tumor model and significantly inhibits the tumor growth. This biomimetic delivery strategy provides a versatile platform of cell delivery and activation for CAR-T cells in treating solid tumors.

关键词： drug delivery cell therapy bioinspired biomaterials cancer immunotherapy

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