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How Traditional Chinese Medicine Can Play a Role In Nanomedicine? A Comprehensive Review of the Literature

International journal of nanomedicine 2025年 20卷 6289-6315页

作者： Chi Wang Kaixiang Ren Mei Yang Xiang Li Ningxi Li Peng Li Huang Yang Guangjian Zhang Xiaodan Wei Department of Thoracic Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an 710061 People's Republic of China. Key Laboratory of Enhanced Recovery After Surgery of Intergrated Chinese and Western Medicine Administration of Traditional Chinese Medicine of Shaanxi Province The First Affiliated Hospital of Xi'an Jiaotong University Xi'an 710061 People's Republic of China. Department of Ophthalmology the First Affiliated Hospital of Xi'an Jiaotong University Xi'an 710061 People's Republic of China. Mianyang Key Laboratory of Anesthesia and Neuroregulation Department of Anesthesiology Mianyang Central Hospital Mianyang 621000 People's Republic of China. Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 People's Republic of China. MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310003 People's Republic of China.

Traditional Chinese medicine (TCM), a time-honored practice rooted in natural therapeutics, has served as a cornerstone in safeguarding human health across millennia, aiding in disease mitigation and life vitality preservation. However, many TCM active ingredients suffer from poor solubility, low bioavailability, uncertain toxicity and weak targeting ability. Nanomedicine represents a modern scientific frontier, emerging from the precise engineering of unique nanoscale characteristics, with extensive applications encompassing targeted therapeutic delivery and diverse biomedical fields. Although TCM and nanomedicine diverge fundamentally in historical origins and disciplinary foundations, growing investigations demonstrate their synergistic potential. In this review, nanosized TCM has been revealed as an innovative therapeutic strategy with significant clinical value. Based on the biological activities and structural characteristics of TCM active ingredients, we classify them into two categories: natural nanostructured formulations for TCM and nano-drug delivery systems for TCM. A systematic and comprehensive analysis of preparations specific and functions to two classes of TCM nanomedicines is highlighted. Insights into the advantage of TCM nanomedicines are also introduced. Subsequently, the applications of TCM nanomedicines in the biomedical treatment, including anti-cancer, anti-inflammation and anti-bacterial are summarized. Finally, challenges and future research directions are emphasized, aiming to offer guidance for the modernization of TCM nanomedicines.

关键词： active ingredients biomedical treatment drug delivery traditional Chinese medicine

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MOF负载Weel抑制剂实现p53突变胆囊癌的合成致死靶向治疗

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Science Bulletin 2024年第9期69卷 1286-1301页

作者：郦仕杰 Sarun Juengpanich Win Topatana 谢天傲侯丽丹朱怡远陈佳东单煜凯韩依纳陆子毅陈天恩 Charlie Topatana 张斌曹佳胜胡家豪严加费陈迎鑫顾臻俞计成蔡秀军陈鸣宇 Department of General Surgery Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China School of Medicine Zhejiang UniversityHangzhou 310058China National Engineering Research Center of Innovation and Application of Minimally Invasive Instruments Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China School of Materials Science and Engineering Zhejiang UniversityHangzhou 310058China Department of Chemistry Zhejiang UniversityHangzhou 310016China Department of Pathology Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China International College Zhejiang UniversityHangzhou 310058China Institute of Advanced Magnetic Materials and International Research Center for EM Metamaterials College of Materials&Environmental EngineeringHangzhou Dianzi UniversityHangzhou 310018China Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Liangzhu Laboratory Zhejiang UniversityHangzhou 311121China Jinhua Institute of Zhejiang University Jinhua 321299China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Adavosertib(ADA)is a WEE1 inhibitor that exhibits a synthetic lethal effect on p53-mutated gallbladder cancer(GBC).However,drug resistance due to DNA damage response compensation pathways and high toxicity limits further ***,estrone-targeted ADA-encapsulated metal–organic frameworks(ADA@MOF-EPL)for GBC synthetic lethal treatment by inducing conditional factors are *** high expression of estrogen receptors in GBC enables ADA@MOF-EPL to quickly enter and accumulate near the cell nucleus through estrone-mediated endocytosis and release ADA to inhibit WEE1 upon entering the acidic tumor *** irradiation induces ADA@MOF-EPL to generate reactive oxygen species(ROS),which leads to a further increase in DNA damage,resulting in a higher sensitivity of p53-mutated cancer cells to WEE1 inhibitor and promoting cell death via conditional synthetic *** conditional factor induced by ADA@MOF-EPL further enhances the antitumor efficacy while significantly reducing systemic ***,ADA@MOF-EPL demonstrates similar antitumor abilities in other p53-mutated solid tumors,revealing its potential as a broad-spectrum antitumor drug.

关键词： Synthetic lethality Nanomedicine Sonodynamic therapy Gallbladder cancer Metal-organic frameworks DNA damage response

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Efficient Ceo2/Zno Heterojunction for Enhanced Heterogenous Photocatalytic Application

SSRN

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SSRN 2024年

作者： Li, Honglin Wu, Rong Ji, Jun Liu, Yue Zhao, Jiahui Sahar, Shafaq Zeb, Akif College of Chemistry and Material Engineering Chao Hu University Hefei238000 China School of Energy Materials and Chemical Engineering Hefei University Hefei City230601 China Key Laboratory of Resource Comprehensive Utilization of Chaohu University Chaohu University Hefei238000 China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University 866 Yuhangtang Rd Hangzhou310058 China Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy College of Materials Science and Engineering Hunan University Changsha410082 China Surface and Materials Technology Institute of Materials Engineering University of Siegen Paul-Bonatz-Straße 9-11 Siegen57076 Germany

Organic pollutants pose a significant challenge due to their toxicity and potential carcinogenicity, posing a severe threat to the environment and human health. Heterogeneous photocatalysts offer promising advantages over traditional water purification methods due to their tunable electronic properties such as bandgap, easy separation from the reaction solution and formidable nanostructures. Herein, we prepare a CeO2/ZnO heterostructure via simple hydrothermal synthesis. The electronic structure of this nanocomposite was tuned to achieve a band gap of ~2.94 eV, which was between the individual bandgaps of CeO2 and ZnO nanoparticles. In addition, the mixed valence character of Ce further enhanced the electronic properties of the CeO2/ZnO heterostructure. The photocatalytic performance of CeO2, ZnO and CeO2/ZnO heterostructure was evaluated and it was found that CeO2/ZnO heterostructure with a Zn/Ce ratio of 0.2 exhibited the highest photocatalytic activity and the degradation efficiency was 99.28% after irradiation for 60 min. It was mainly ascribed to the heterojunction structure of the CeO2/ZnO nanocomposite, leading to a higher separation efficiency of electron-hole pairs and generating more superoxide radicals, which in turn improved the photocatalytic activity effectively. © 2024, The Authors. All rights reserved.

关键词： II-VI semiconductors

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A 'Sandwich' Cell Culture Platform with NIR-Responsive Dynamic Stiffness to Modulate Macrophage Phenotypes

SSRN

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SSRN 2020年

作者： Yuan, Peiqi Luo, Yilun Luo, Yu Ma, Lie MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou310027 China

Considering the key roles of macrophages in tissue repair and immune therapy, designing smart biomaterials able to harness macrophage phenotypes on demand during the healing process has become a promising strategy. Here, a novel “sandwich” cell culture platform with near-infrared (NIR) responsive dynamic stiffness was fabricated to polarize macrophage in situ for revealing the relationship between macrophages phenotype and substrate stiffness dynamically. Under NIR irradiation, calcium ions (Ca2+) were diffused through the middle layer of IR780-mixed phase change material (PCM) due to the photo-thermal effect of IR780, resulting in the increase of hydrogel stiffness in situ by the crosslinking of the upper layer of hyaluronic acid-sodium alginate hydrogel (MA-HA&SA). The up-regulation of inducible nitric oxide synthase (iNOS) and tumor necrosis factor-α (TNF-α) were quantified by immunostaining and enzyme-linked immune sorbent assay (ELISA), respectively, indicating the transformation of macrophage from the anti-inflammatory to pro-inflammatory phenotype under dynamic stiffness. An increase of nuclear localization of Yes-associated-protein (YAP) confirmed that the mechanotransduction mechanism of the transition of macrophages phenotype. The modulation of macrophage phenotypes by dynamic stiffness without the stimuli of cytokines offers an effective and noninvasive strategy to manipulate immune reactions to achieve optimized healing or therapeutical outcomes. © 2020, The Authors. All rights reserved.

关键词： Macrophages

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Hypoxia-Responsive Microgels Act as an Intra-Articular Lubricant and Inflammatory Inhibitor for Osteoarthritis Therapy

SSRN

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SSRN 2024年

作者： Wang, Zhaoyi Yao, Shun-Yu Zhang, Yuxiang Li, Shifen Zhou, Tong Wang, Shuqin Guo, Dong-Sheng Gao, Changyou MOE Key Laboratory of Macromolecular Synthesis and Functionalization International Research Center for X Polymers Department of Polymer Science and Engineering Zhejiang University Hangzhou310027 China College of Chemistry Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials Ministry of Education Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and Engineering Nankai University Tianjin300071 China Department of Plastic Surgery Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou310020 China Center for Healthcare Materials Shaoxing Institute Zhejiang University Shaoxing312035 China Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine Zhejiang University Hangzhou310058 China

The reduced oxygen concentration is a distinctive feature of osteoarthritic (OA) cartilage, whereas the mechanical friction also contributes to the inflammatory hypoxia microenvironment of OA. Herein, novel hypoxia-responsive methylprednisolone (MP) delivery microgels combining the capability of reactive oxygen species (ROS) depletion and lubrication were constructed for regulating the microenvironment of OA. Methacrylate-modified sulfonated azocalix[4]arene (MACA) loaded with MP, the copolymers consisting of bioinspired lubricant 2-methacryloxyethyl phosphorylcholine (MPC), and polyethylene glycol-modified ROS-responsive poly(thioketal) (PEG-4PTK) were crosslinked together to construct the microgels. The zwitterionic MPC offered a lubrication effect, while the ROS-elimination was contributed by the PTK segments and the phenol groups in MACA. The microgels responsively released cargos in inflammatory environment and decreased inflammation by inhibiting the production of ROS and regulating the expression of inflammatory cytokines, and showed the lowest hypoxia-inducible factor-1α (HIF-1α) positive area and presented more deposition of glycosaminoglycans and collagen II with a smoother and integrated cartilage structure in therapy of OA in rats in vivo. © 2024, The Authors. All rights reserved.

关键词： Lubrication

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Near-infrared-irradiation-induced transformation of surface topography for sequential modulation of macrophage phenotypes to match tissue healing process 42

Near-infrared-irradiation-induced transformation of surface ...

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42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence

作者： Zheng, Xiaowen Xin, Liaobing Luo, Yilun Yang, Huang Ma, Lie Gao, Changyou MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou310027 China

ISBN: (纸本)9781510883901

Statement of Purpose: In a tissue healing process, macrophages exhibit a transition from a pro-inflammatory M1 phenotype at an early stage to an anti-inflammatory M2 phenotype at a later stage. Either excessive duration of M1 macrophages or excessive accumulation of M2 macrophages lead to dissatisfactory outcomes, such as chronic inflammation or fibrosis. Therefore, we fabricated a near-infrared (NIR) responsive poly (Ε-caprolactone) (PCL) substrates, which were able to transform its surface topography from flat to 8 μm-microgroove pattern, to sequentially modulate the macrophages phenotypes from M1 to M2 for a better matching of tissue healing process. The NIR-responsive substrates were prepared by chemically crosslinking PCL in the presence of gold nanorods (AuNRs). This work demonstrated macrophage phenotypes can be dynamically modulated by physical surface topography. This tissue-penetrative nature of NIR used to manipulate surface topography without second operations offers a promising strategy of modulating immune responses of the implants, matching tissue healing process and potentially facilitating tissue repair. © 2019 Omnipress - All rights reserved.

关键词： Surface topography

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Surface acoustic wave humidity sensors based on uniform and thickness controllable graphene oxide thin films formed by surface tension

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Microsystems & Nanoengineering 2019年第1期5卷 323-332页

作者： Xianhao Le Yihan Liu Li Peng Jintao Pang Zhen Xu Chao Gao Jin Xie State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang University310027HangzhouP.R.China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang University310027HangzhouP.R.China

Graphene oxide(GO)is a promising candidate for humidity sensing,and the uniformity and thickness of GO films are important for the reproducibility and test signal strength of humidity *** this paper,uniform and thicknesscontrollable GO films are first formed by the surface tension of different concentrations of GO solution and then transferred to surface acoustic wave(SAW)humidity *** GO film formation and transfer process has very good repeatability and stability,as evidenced by the humidity response of the *** the help of the uniform and highly oxidized GO film,the humidity sensors show a significantly high sensitivity(absolute sensitivity of 25.3 kHz/%RH and relative sensitivity of 111.7 p.p.m./%RH)in a wide test range from 10%RH to 90%RH with very little hysteresis(<1%RH).The sensors achieve good reversibility,excellent short-term repeatability and ***,the humidity sensors also show a fast response and recovery time of<10 s.

关键词： humidity wave surface

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A flexible electronic/smart hydrogel integrated system for real-time infection monitoring and dynamic treatment 42

A flexible electronic/smart hydrogel integrated system for r...

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42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence

作者： Pang, Qian Lou, Dong Gao, Changyou Ma, Lie MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou310027 China

ISBN: (纸本)9781510883901

Statement of Purpose: Wound management is a major clinical challenge in healthcare area. For current wound care strategies, the ‘‘Black Box’’ state of wound caused by the coverage of dressings makes it difficult to know infection in time, which may miss the best time for treatment [1]. Therefore, the ability to detect pathogenic infection in early stage and give proper treatment is of great importance to wound healing process [2]. Here, we fabricated a flexible electronic/smart hydrogel integrated system (Figure 1). This system includes two layers: the upper layer is a flexible electronic device with a temperature sensor and four LED 365nm lights, and the lower layer is a UV-responsive antibacterial hydrogel-based dressing. As temperature is an obvious marker of wound infection and may be used as an early predictor of infection before any other obvious changes. Therefore, we used a real-time temperature sensor to monitor the wound temperature and then the UV-responsive antibacterial hydrogel can be used to controllably release antibiotic under UV irradiation when the temperature was abnormal. © 2019 Omnipress - All rights reserved.

关键词： Hydrogels

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A novel matrix for endometrium regeneration by the recruitment and selective capture of endogenous mesenchymal stem cells 42

A novel matrix for endometrium regeneration by the recruitme...

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42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence

作者： Ma, Lie Zheng, Xiaowen Wang, Xuemei Xin, Liaobing Gao, Changyou MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou310027 China

ISBN: (纸本)9781510883901

Statement of Purpose: Recruitment of endogenous mesenchymal stem cells (MSCs) has become an attractive strategy for in situ tissue regeneration. However, it is of great importance to endow an implant with the specific affinity to MSCs, for many types of cells such as immune cells and fibroblasts can also be recruited, which might lead to fibrosis. Meanwhile, it is reported that stemness is highly related with adhesion area of MSCs. Aptamer 19S (Apt19S) and E7 peptides (EPLQLKM) have been demonstrated to have a specific affinity to MSCs. In this study, we first modified a piece of PEGylated glass with Apt19S as a model, through modulating the grafted amount of Apt19S, to obtain a balanced selective capture and stemness maintenance of MSCs. Secondly, pieces of glass spin-coated with collagen modified with different amounts of E7 peptides which are more cost-friendly were demonstrated to have a specific affinity of MSCs. A flow model was designed to simulate internal environment and further verify the selective capture capability of MSCs in vivo. Finally, the E7-modified collagen scaffolds accompanied with SDF-1α, which is a known factor for recruiting MSCs, were designed to facilitate endometrium regeneration and fertility restoration. The scaffolds without any exogenous stem cells were effective and safer, which provides a highly promising strategy for tissue regeneration. © 2019 Omnipress - All rights reserved.

关键词： Tissue regeneration

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Self-Assembled Macroscopic Structures of Graphene Oxide Fibers Through a Wet-Fusing Strategy

SSRN

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SSRN 2022年

作者： Wang, Jiaqing Li, Zheng Ming, Xin Li, Peng Chang, Dan Peng, Li Gao, Chao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Key Laboratory of Adsorption and Separation Materials and Technologies of Zhejiang Province International Research Center for X Polymers Zhejiang University 38 Zheda Road Hangzhou310027 China Research Institute of Frontier Technology ZJU-Hangzhou Global Scientific and Technological Innovation Centre School of Micro-Nano Electronics Zhejiang University 733 Jianshe San Road Hangzhou311215 China

Graphene assemblies exhibit prominent properties because of the high-performing graphene sheets serving as structural units as well as the ingenious design of assembled structures. However, the diversity of structural features is limited by the lack of creativity while keeping using graphene sheets as building blocks. Meanwhile, homogeneous architectures acquired from ordinary assembling strategies appear to be insufficient for several advanced applications. Here, using as-prepared 1D graphene oxide fibers as the basic structural elements, we achieve arbitrary graphene assemblies ranging from 2D papers to 3D aerogels through a wet-fusion method. The wet-fusing assembly is spontaneous and easily controllable which also provides strong interconnection between the unit fibers. Unlike the conventional homogeneous graphene assemblies, these fiber-assembled materials have hierarchical structures with programmable fibrous textures, thus are more flexible in characteristic design. Our methodology brings forward a way to expand the family of graphene assemblies and is also an efficient strategy to pursue functional graphene structures. © 2022, The Authors. All rights reserved.

关键词： Graphene

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